Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. 2020
  2. Published

    Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells

    Møller, S. H., Mellergaard, Maiken, Madsen, M., Bermejo, A. V., Jepsen, Stine Dam, Hansen, M. H., Høgh, R. I., Aldana Garcia, Blanca Irene, Madsen, Claus Desler, Rasmussen, Lene Juel, Sustarsic, Elahu Gosney, Gerhart-Hines, Zach, Daskalaki, E., Wheelock, C. E., Hiron, T. K., Lin, D., O'Callaghan, C. A., Wandall, Hans H., Andresen, Lars & Skov, Søren, 2020, In : Frontiers in Immunology. 11, 22 p., 1968.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours

    Harpelunde Poulsen, K., Nielsen, J. E., Grønkær Toft, B., Joensen, Ulla Nordström, Rasmussen, Lene Juel, Blomberg Jensen, M., Mitchell, R. T., Juul, Anders, Rajpert-De Meyts, E. & Jørgensen, Anders, 2020, In : BMC Cancer. 20, 1, 14 p., 349.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

    Duan, Shunlei, Han, Xuerui, Akbari, Mansour, Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 2020, In : Nucleic Acids Research. 48, 12, p. 6530–6546

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Mitochondrial Function in Gilles de la Tourette Syndrome Patients With and Without Intragenic IMMP2L Deletions

    Bjerregaard, V. A., Schönewolf-Greulich, B., Rasmussen, Lene Juel, Madsen, Claus Desler & Tümer, Asuman Zeynep, 2020, In : Frontiers in Neurology. 11, 9 p., 163.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published
  7. Published

    Simvastatin improves mitochondrial respiration in peripheral blood cells

    Durhuus, J. A., Hansson, Svenja, Morville, T., Kuhlman, A. B., Dohlmann, T. L., Larsen, Steen, Helge, Jørn Wulff, Angleys, M., Muniesa-Vargas, A., Bundgaard, J. R., Hickson, Ian David, Dela, Flemming, Madsen, Claus Desler & Rasmussen, Lene Juel, 2020, In : Scientific Reports. 10, 1, 17012.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease

    Navarro, J. F., Croteau, D. L., Jurek, A., Andrusivova, Z., Yang, B., Wang, Y., Ogedegbe, B., Riaz, T., Støen, M., Madsen, Claus Desler, Rasmussen, Lene Juel, Tønjum, T., Galas, M. C., Lundeberg, J. & Bohr, Vilhelm, 2020, In : iScience. 23, 10, 42 p., 101556.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    TIP60 in aging and neurodegeneration

    Li, Zhiquan & Rasmussen, Lene Juel, 2020, In : Ageing Research Reviews. 64, 101195.

    Research output: Contribution to journalReviewResearchpeer-review

  10. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, Linda Hildegard, Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In : Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome

    Drost, M., Tiersma, Y., Glubb, D., Kathe, S., van Hees, S., Calléja, F., Zonneveld, J. B. M., Boucher, K. M., Ramlal, R. P. E., Thompson, B. A., Rasmussen, Lene Juel, Greenblatt, M. S., Lee, A., Spurdle, A. B., Tavtigian, S. V. & de Wind, N., 2020, In : Genetics in Medicine. 22, p. 847–856

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2019
  13. Published

    A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis

    Hasan-Olive, M. M., Lauritzen, K. H., Ali, M., Rasmussen, Lene Juel, Storm-Mathisen, J. & Bergersen, Linda Hildegard, 2019, In : Neurochemical Research. 44, 1, p. 22-37 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome

    Drost, M., Tiersma, Y., Thompson, B. A., Frederiksen, J. H., Keijzers, Guido, Glubb, D., Kathe, S., Osinga, J., Westers, H., Pappas, L., Boucher, K. M., Molenkamp, S., Zonneveld, J. B., van Asperen, C. J., Goldgar, D. E., Wallace, S. S., Sijmons, R. H., Spurdle, A. B., Rasmussen, Lene Juel, Greenblatt, M. S., de Wind, N. & Tavtigian, S. V., 2019, In : Genetics in Medicine. 21, p. 1486–1496

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    From powerhouse to perpetrator—mitochondria in health and disease

    Fakouri, N. B., Hansen, T. L., Madsen, Claus Desler, Anugula, Sharath & Rasmussen, Lene Juel, 2019, In : Biology. 8, 2, 15 p., 35.

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    MERTK Acts as a costimulatory receptor on human cd8 t cells

    Peeters, M. J. W., Dulkeviciute, D., Draghi, A., Ritter, C., Rahbech, A., Skadborg, S. K., Seremet, T., Simoes, A. M. C., Martinenaite, E., Halldorsdottir, H. R., Andersen, Mads Hald, Olofsson, G. H., Svane, Inge Marie, Rasmussen, Lene Juel, Met, Özcan, Becker, J. C., dqp123, dqp123, Madsen, Claus Desler & thor Straten, Per, 2019, In : Cancer Immunology Research. 7, 9, p. 1472-1484 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Mitochondrial oxidative phosphorylation capacity of cryopreserved cells

    Lauridsen, P. E., Rasmussen, Lene Juel & Madsen, Claus Desler, 2019, In : Mitochondrion. 47, p. 47-53 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia

    Bundgaard, A., Qvortrup, Klaus, Rasmussen, Lene Juel & Fago, A., 2019, In : Journal of Experimental Biology. 222, 11, 9 p., jeb200410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2018
  20. Published

    Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus

    Thomsen, Kirsten Joan, Yokota, T., Hasan-Olive, M. M., Sherazi, N., Fakouri, N. B., Madsen, Claus Desler, Regnell, C. E., Larsen, S., Rasmussen, Lene Juel, Dela, Flemming, Bergersen, Linda Hildegard & Lauritzen, Martin, 2018, In : Neurobiology of Aging. 61, p. 215-224 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms

    Jakobsen, Emil, Lange, S. C., Andersen, Jens Velde, Madsen, Claus Desler, Kihl, H. F., Hohnholt, M., Stridh, M. H., Rasmussen, Lene Juel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, 2018, In : Biochemical Pharmacology. 155, p. 92-101 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    The role of mitochondrial dysfunction in the progression of Alzheimer’s disease

    Madsen, Claus Desler, Lillenes, M. S., Tønjum, T. & Rasmussen, Lene Juel, 2018, In : Current Medicinal Chemistry. 25, 40, p. 5578 - 5587

    Research output: Contribution to journalReviewResearchpeer-review

  23. 2017
  24. Published

    Bacterial infection increases risk of carcinogenesis by targeting mitochondria

    Strickertsson, J. A. B., Madsen, Claus Desler & Rasmussen, Lene Juel, Dec 2017, In : Seminars in Cancer Biology. 47, p. 95-100 6 p.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro

    Liu, D., Frederiksen, J. H., Liberti, S. E., Lützen, A., Keijzers, Guido, Pena-Diaz, J. & Rasmussen, Lene Juel, 19 Sep 2017, In : Nucleic Acids Research. 45, 16, p. 9427-9440 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    DNA mismatch repair and its many roles in eukaryotic cells

    Liu, D., Keijzers, Guido & Rasmussen, Lene Juel, Jul 2017, In : Mutation Research - Reviews in Mutation Research. 773, p. 174-187 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

    Nielsen, S. V., Stein, Amelie, Dinitzen, A. B., Papaleo, E., Tatham, M. H., Poulsen, E. G., Kassem, M. M., Rasmussen, Lene Juel, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 19 Apr 2017, In : PLoS Genetics. 13, 4, 26 p., e1006739.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis

    Kermanizadeh, A., Jantzen, K., Ward, M. B., Durhuus, J. A., Rasmussen, Lene Juel, Loft, Steffen & Møller, Peter, Mar 2017, In : Nanotoxicology. 11, 2, p. 184-200 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    EXO1 (Exonuclease 1)

    Rasmussen, Lene Juel & Keijzers, Guido, 5 Jan 2017, Encyclopedia of Signaling Molecules . Choi, S. (ed.). New York: Springer, 7 p.

    Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearch

  30. Published

    Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage

    Hopkinson, B. M., Madsen, Claus Desler, Kalisz, M., Vestentoft, P. S., Rasmussen, Lene Juel & Bisgaard, Hanne Cathrine, 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 11 p., 5080128.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Disturbed mitochondrial function restricts glutamate uptake in the human Müller glia cell line, MIO-M1

    Vohra, Rupali, Gurubaran, I. S., Henriksen, U., Bergersen, Linda Hildegard, Rasmussen, Lene Juel, Desler, C., Jensen, Dorte Skytt & Kolko, Miriam, 2017, In : Mitochondrion. 36, p. 52-59

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions

    Martín-Pardillos, A., Tsaalbi-Shtylik, A., Chen, S., Lazare, S., Van Os, R. P., Dethmers-Ausema, A., Fakouri, N. B., Bosshard, M., Aprigliano, R., Van Loon, B., Salvatori, D. C. F., Hashimoto, K., Van Der Spek, C. D., Moriya, M., Rasmussen, Lene Juel, De Haan, G., Raaijmakers, M. H. G. P. & De Wind, N., 2017, In : Blood. 130, 13, p. 1523-1534 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours

    Rudolph, C., Melau, C., Nielsen, J. E., Jensen, K. V., Liu, D., Pena-Diaz, J., Meyts, E. R., Rasmussen, Lene Juel & Jorgensen, A., 2017, In : Cellular Oncology. 40, 4, p. 341-355

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Madsen, Claus Desler, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, Linda Hildegard & Rasmussen, Lene Juel, 2017, In : Scientific Reports. 7, 14 p., 12480.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2016
  36. Published

    A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression

    Syed, S., Madsen, Claus Desler, Rasmussen, Lene Juel & Schmidt, K. H., Dec 2016, In : P L o S Genetics. 12, 12, 28 p., e1006451.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Interventions for age-related diseases: Shifting the paradigm

    Figueira, I., Fernandes, A., Mladenovic Djordjevic, A., Lopez-Contreras, Andres, Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, Lene Juel, Xapelli, S., Ellam, T. & Bellantuono, I., Dec 2016, In : Mechanisms of Ageing and Development. 160, p. 69-92 24 p.

    Research output: Contribution to journalReviewResearchpeer-review

  38. Published

    Exonuclease 1 and its versatile roles in DNA repair

    Keijzers, Guido, Liu, D. & Rasmussen, Lene Juel, 5 Aug 2016, In : Critical Reviews in Biochemistry and Molecular Biology. 51, 6, p. 440–451 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

    Lu, H., Shamanna, R. A., Keijzers, Guido, Anand, R., Rasmussen, Lene Juel, Cejka, P., Croteau, D. L. & Bohr, Vilhelm, 28 Jun 2016, In : Cell Reports. 16, 1, p. 161-173 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Acquired Localized Cutis Laxa due to Increased Elastin Turnover

    Nygaard, R. H., Maynard, S., Schjerling, P., Kjær, M., Qvortrup, Klaus, Bohr, Vilhelm, Rasmussen, Lene Juel, Jemec, Gregor & Heidenheim, M., 14 Jun 2016, In : Case Reports in Dermatology. 8, 1, p. 42-51 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Oxidative Stress-Induced Dysfunction of Muller Cells During Starvation

    Toft-Kehler, A. K., Gurubaran, I. S., Madsen, Claus Desler, Rasmussen, Lene Juel, Jensen, Dorte Skytt & Kolko, Miriam, May 2016, In : Investigative Ophthalmology & Visual Science. 57, 6, p. 2721-2728

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Approaches to diagnose DNA mismatch repair gene defects in cancer

    Peña-Diaz, J. & Rasmussen, Lene Juel, Feb 2016, In : DNA Repair. 38, p. 147-154 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published
  44. 2015
  45. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline

    Madsen, Claus Desler, Frederiksen, J. H., Olsen, M. N. A., Maynard, S., Keijzers, Guido, Fagerlund, B., Mortensen, Erik Lykke, Osler, Merete, Lauritzen, Martin, Bohr, Vilhelm & Rasmussen, Lene Juel, Nov 2015, In : Mitochondrion. 25, p. 34-7 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients

    Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, Guido, Hansen, Åse Marie, Madsen, Claus Desler, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In : Aging. 7, 10, p. 793-815 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure

    Lauritzen, K. H., Kleppa, L., Aronsen, J. M., Eide, L., Carlsen, H., Haugen, O. P., Sjaastad, I., Klungland, A., Rasmussen, Lene Juel, Attramadal, H., Storm-Mathisen, J. & Bergersen, Linda Hildegard, 1 Aug 2015, In : American Journal of Physiology: Heart and Circulatory Physiology. 309, 3, p. H434-H449 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

    Lopez-Contreras, Andres, Specks, J., Barlow, J. H., Ambrogio, C., Madsen, Claus Desler, Vikingsson, S., Rodrigo-Perez, S., Green, H., Rasmussen, Lene Juel, Murga, M., Nussenzweig, A. & Fernandez-Capetillo, O., 1 Apr 2015, In : Genes & Development. 29, 7, p. 690-5 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    The challenges of human population ageing

    Sander, M., Oxlund, Bjarke, Jespersen, Astrid Pernille, Krasnik, Allan, Mortensen, Erik Lykke, Westendorp, Rudi GJ & Rasmussen, Lene Juel, Mar 2015, In : Age and Ageing. 44, 2, p. 185-7 3 p.

    Research output: Contribution to journalJournal articleCommunication

  50. Published

    Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance

    Maynard, S., Keijzers, Guido, Hansen, Åse Marie, Osler, Merete, Molbo, Drude, Bendix, L., Møller, Peter, Loft, Steffen, Moreno-Villanueva, M., Bürkle, A., Hvitby, C. P., Schurman, S. H., Stevnsner, T. V., Rasmussen, Lene Juel, Avlund, K. & Bohr, Vilhelm, Jan 2015, In : Acta Physiologica (Print). 213, 1, p. 156-170 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Mitochondria in health and disease: 3rd annual conference of society for mitochondrial research and medicine - 19-20 december 2013 - bengaluru, India

    Durhuus, J. A., Madsen, Claus Desler & Rasmussen, Lene Juel, Jan 2015, In : Mitochondrion. 20, p. 7-12 6 p.

    Research output: Contribution to journalConference articleResearchpeer-review

  52. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures

    Keijzers, Guido, Bohr, Vilhelm & Rasmussen, Lene Juel, 2015, In : Bioscience Reports. 35, 3, 13 p., e00206.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. 2014
  54. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

    Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In : European Biophysics Journal. 43, 10-11, p. 509-516

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    The role of RecQ helicases in non-homologous end-joining

    Keijzers, Guido, Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In : Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  56. Published

    Enterococcus faecalis Infection and Reactive Oxygen Species Down-Regulates the miR-17-92 Cluster in Gastric Adenocarcinoma Cell Culture

    Strickertsson, J. A. B., Rasmussen, Lene Juel & Friis-Hansen, L., 28 Aug 2014, In : Genes. 5, 3, p. 726-38 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Impact of bacterial infections on aging and cancer: Impairment of DNA repair and mitochondrial function of host cells

    Strickertsson, J. A. B., Madsen, Claus Desler & Rasmussen, Lene Juel, Aug 2014, In : Experimental Gerontology. 56, p. 164-174 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein

    Dominguez-Valentin, M., Drost, M., Therkildsen, C., Rambech, E., Ehrencrona, H., Angleys, M., Lau Hansen, T., de Wind, N., Nilbert, Mef Christina & Rasmussen, Lene Juel, Jul 2014, In : Molecular Genetics & Genomic Medicine. 2, 4, p. 352-355 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Mitochondria in biology and medicine--2012

    Madsen, Claus Desler & Rasmussen, Lene Juel, May 2014, In : Mitochondrion. 16, p. 2-6 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  60. Published

    Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome

    Rasmussen, Lene Juel & Heinen, C. D., 15 Apr 2014

    Research output: Other contributionNet publication - Internet publicationCommunication

  61. Published

    Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

    Thompson, B. A., Spurdle, A. B., Plazzer, J., Greenblatt, M. S., Akagi, K., Al-Mulla, F., Bapat, B., Bernstein, I., Capellá, G., den Dunnen, J. T., du Sart, D., Fabre, A., Farrell, M. P., Farrington, S. M., Frayling, I. M., Frebourg, T., Goldgar, D. E., Heinen, C. D., Holinski-Feder, E., Kohonen-Corish, M., Robinson, K. L., Leung, S. Y., Martins, A., Moller, P., Morak, M., Nystrom, M., Peltomaki, P., Pineda, M., Qi, M., Ramesar, R., Rasmussen, Lene Juel, Royer-Pokora, B., Scott, R. J., Sijmons, R., Tavtigian, S. V., Tops, C. M., Weber, T., Wijnen, J., Woods, M. O., Macrae, F., Genuardi, M., Castillejo, A., Sexton, A., Chan, A. K. W., Viel, A., Blanco, A., French, A., Laner, A., Wagner, A., van den Ouweland, A. & on behalf of InSiGHT, O. B. O. I., Feb 2014, In : Nature Genetics. 46, 2, p. 107-115 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Introducing the hypothome: a way to integrate predicted proteins in interactomes

    Madsen, Claus Desler, Zambach, S., Suravajhala, P. & Rasmussen, Lene Juel, 2014, In : International Journal of Bioinformatics Research and Applications. 10, 6, p. 647-52 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. 2013
  64. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells

    Maynard, S., Keijzers, Guido, Gram, M., Madsen, Claus Desler, Bendix, L., Budtz-Joergensen, Esben, Molbo, Drude, Croteau, D. L., Osler, Merete, Stevnsner, T. V., Rasmussen, Lene Juel, Dela, Flemming, Avlund, K. & Bohr, Vilhelm, 30 Nov 2013, In : Aging. p. 850-864 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population

    Rasmussen, Lene Juel, Shiloh, Y., Bergersen, Linda Hildegard, Sander, M., Bohr, Vilhelm & Tønjum, T., Oct 2013, In : Mechanisms of Ageing and Development. 134, 10, p. 427-33 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 4 Jun 2013, In : Proceedings of the National Academy of Science of the United States of America. 110, 23, p. 9403-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Response to: Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance

    Rasmussen, Lene Juel, Heinen, C. D., Royer-Pokora, B., Drost, M., Tavtigian, S., Hofstra, R. M. W. & de Wind, N., Jun 2013, In : Human Mutation. 34, 6, p. 923-4 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells

    Machado, A. M. D., Desler, C., Boggild, S., Strickertsson, J. A. B., Friis-Hansen, L., Figueiredo, C., Seruca, R. & Rasmussen, Lene Juel, 2013, In : Mechanisms of Ageing and Development. 134, 10, p. 460-466 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells

    Strickertsson, J. A. B., Madsen, Claus Desler, Martin-Bertelsen, T., Machado, A. M. D., Wadstrøm, T., Winther, Ole, Rasmussen, Lene Juel & Friis-Hansen, L., 2013, In : PLOS ONE. 8, 4, p. 1-13 13 p., e63147.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients

    Petersen, S. M., Dandanell, M., Rasmussen, Lene Juel, Gerdes, Anne-Marie Axø, Krogh, L. N., Bernstein, I., Okkels, H., Wikman, F., Nielsen, Finn Cilius & Hansen, T. V. O., 2013, In : BMC Medical Genetics. 14, p. 103

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 23, p. 9403-9408 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Natural selection of mitochondria during somatic lifetime promotes healthy aging

    Rodell, A., Rasmussen, Lene Juel, Bergersen, Linda Hildegard, Singh, K. K. & Gjedde, Albert, 2013, In : Frontiers in Neuroenergetics. 5, p. 1-6 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. 2012
  74. Published

    Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients

    Andersen, S. D., Liberti, S. E., Lützen, A., Drost, M., Bernstein, I., Nilbert, Mef Christina, Dominguez, M., Nyström, M., Hansen, T. V. O., Christoffersen, J. W., Jäger, A. C., de Wind, N., Nielsen, Finn Cilius, Tørring, P. M. & Rasmussen, Lene Juel, Dec 2012, In : Human Mutation. 33, 12, p. 1647-1655 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Pathological assessment of mismatch repair gene variants in Lynch syndrome: Past, present, and future

    Rasmussen, Lene Juel, Heinen, C. D., Royer-Pokora, B., Drost, M., Tavtigian, S., Hofstra, R. M. W. & de Wind, N., Dec 2012, In : Human Mutation. 33, 12, p. 1617-25 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

    Jantzen, K., Roursgaard, Martin, Madsen, Claus Desler, Loft, Steffen, Rasmussen, Lene Juel & Møller, Peter, Nov 2012, In : Mutagenesis. 27, 6, p. 693-701 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

    Jensen, M. B., Dunn, C. A., Keijzers, Guido, Kulikowicz, T., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2012, In : Aging. 4, 11, p. 790-802 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays

    Heinen, C. D. & Rasmussen, Lene Juel, Jul 2012, In : Hereditary Cancer in Clinical Practice. 10, 1, p. 9

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Mitochondria in biology and medicine

    Madsen, Claus Desler & Rasmussen, Lene Juel, Jul 2012, In : Mitochondrion. 12, 4, p. 472-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells

    Cheng, C., Edin, N. F. J., Lauritzen, K. H., Aspmodal, I., Christoffersen, S., Jian, L., Rasmussen, Lene Juel, Pettersen, E. O., Xiaoqun, G. & Bergersen, Linda Hildegard, Jun 2012, In : Cellular oncology (Dordrecht). 35, 3, p. 217-27 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

    Andersen, S. D., Keijzers, Guido, Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In : D N A Repair. 11, 3, p. 267-77 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants

    Drost, M., Zonneveld, J. B. M., van Hees, S., Rasmussen, Lene Juel, Hofstra, R. M. W. & de Wind, N., 2012, In : Human Mutation. 33, 3, p. 488-94 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Genome-wide screens for expressed hypothetical proteins

    Madsen, Claus Desler, Durhuus, J. A. & Rasmussen, Lene Juel, 2012, In : Methods in molecular biology (Clifton, N.J.). 815, p. 25-38 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

    Hansen, T. L., Rasmussen, Lene Juel, Madsen, Claus Desler, Frederiksen, J. B., Espersen, M. L. M. & Singh, K. K., 2012, In : Journal of Aging Research. 2012, p. 192503 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. 2011
  86. Published

    Aging, longevity and health

    Rasmussen, Lene Juel, Sander, M., Wewer, Ulla M. & Bohr, Vilhelm, 23 Jul 2011, In : Mechanisms of Ageing and Development. p. 522-32 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    The importance of mitochondrial DNA in aging and cancer

    Madsen, Claus Desler, Espersen, M. L. M., Singh, K. K. & Rasmussen, Lene Juel, 30 Mar 2011, In : Journal of Aging Research. 2011, p. 407536

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

    Liberti, S. E., Andersen, S. D., Wang, J., May, A., Miron, S., Perderiset, M., Keijzers, Guido, Nielsen, Finn Cilius, Charbonnier, J., Bohr, Vilhelm & Rasmussen, Lene Juel, 2 Jan 2011, In : DNA Repair. 10, 1, p. 73-86 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste

    Bouchami, O., Sghaier, H., Madsen, Claus Desler, Lazim, H., Saidi, M., Rasmussen, Lene Juel & Ben Hassan, A., 2011, In : Annals of Microbiology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. 2010
  91. Published

    The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism

    Madsen, Claus Desler, Lykke, A. & Rasmussen, Lene Juel, 1 Jan 2010, In : Journal of Nucleic Acids. 2010

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Helicobacter pylori infection generates genetic instability in gastric cells

    Machado, A. M. D., Figueiredo, C., Seruca, R. & Rasmussen, Lene Juel, 2010, In : BBA General Subjects. 1806, 1, p. 58-65 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage

    Skovgaard, T., Rasmussen, Lene Juel & Munch-Petersen, B., 2010, In : Nucleosides, Nucleotides and Nucleic Acids. 29, 4-6, p. 347-51 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. 2009
  95. Published

    Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome

    Ou, J., Rasmussen, M., Westers, H., Andersen, S. D., Jager, P. O., Kooi, K. A., Niessen, R. C., Eggen, B. J. L., Nielsen, Finn Cilius, Kleibeuker, J. H., Sijmons, R. H., Rasmussen, Lene Juel & Hofstra, R. M. W., 2009, In : Genes, Chromosomes & Cancer. 48, 4, p. 340-50 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair

    Dherin, C., Gueneau, E., Francin, M., Nunez, M., Miron, S., Liberti, S. E., Rasmussen, Lene Juel, Zinn-Justin, S., Gilquin, B., Charbonnier, J. & Boiteux, S., 2009, In : Molecular and Cellular Biology. 29, 3, p. 907-18 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases

    Larsen, N. B., Heiberg Engel, P. J., Rasmussen, M. & Rasmussen, Lene Juel, 2009, In : Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 11, p. 839-48 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells

    Machado, A. M. D., Figueiredo, C., Touati, E., Máximo, V., Sousa, S., Michel, V., Carneiro, F., Nielsen, Finn Cilius, Seruca, R. & Rasmussen, Lene Juel, 2009, In : Clinical Cancer Research. 15, 9, p. 2995-3002 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    In Silico screening for functional candidates amongst hypothetical proteins

    Madsen, Claus Desler, Suravajhala, P., Sanderhoff, M., Rasmussen, M. & Rasmussen, Lene Juel, 2009, In : BMC Bioinformatics. 10, p. 289

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

    de Souza-Pinto, N. C., Mason, P. A., Hashiguchi, K., Weissman, L., Tian, J., Guay, D., Lebel, M., Stevnsner, T. V., Rasmussen, Lene Juel & Bohr, V. A., 2009, In : DNA Repair. 8, 6, p. 704-19 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. Published

    Nuclear translocation contributes to regulation of DNA excision repair activities

    Knudsen, N. Ø., Andersen, S. D., Lützen, A., Nielsen, Finn Cilius & Rasmussen, Lene Juel, 2009, In : DNA Repair. 8, 6, p. 682-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. Published

    Repair of DNA damage induced by anthanthrene, a polycyclic aromatic hydrocarbon (PAH) without bay or fjord regions

    Madsen, Claus Desler, Johannessen, C. & Rasmussen, Lene Juel, 2009, In : Chemico-Biological Interactions. 177, 3, p. 212-7 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  103. 2008
  104. Published

    Functional analysis of HNPCC-related missense mutations in MSH2

    Lützen, A., de Wind, N., Georgijevic, D., Nielsen, Finn Cilius & Rasmussen, Lene Juel, 14 Oct 2008, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 645, 1-2, p. 44-55 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  105. 2007
  106. Mitochondria as determinant of nucleotide pools and chromosomal stability

    Desler, C., Munch-Petersen, B., Stevnsner, T., Matsui, S., Kulawiec, M., Singh, K. K. & Rasmussen, Lene Juel, 1 Dec 2007, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 625, 1-2, p. 112-24 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  107. Published

    Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)

    Knudsen, N. Ø., Nielsen, Finn Cilius, Vinther, L., Bertelsen, R., Holten-Andersen, S., Liberti, S. E., Hofstra, R., Kooi, K. & Rasmussen, Lene Juel, 2007, In : Nucleic Acids Research. 35, 8, p. 2609-19 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  108. 2006
  109. The role of mitochondrial dNTP levels in cells with reduced TK2 activity

    Desler, C., Munch-Petersen, B. & Rasmussen, Lene Juel, 2006, In : Nucleosides, nucleotides & nucleic acids. 25, 9-11, p. 1171-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  110. 2004
  111. Cadmium inhibits human DNA mismatch repair in vivo

    Lützen, A., Liberti, S. E. & Rasmussen, Lene Juel, 13 Aug 2004, In : Biochemical and Biophysical Research Communications. 321, 1, p. 21-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  112. Is hEXO1 a cancer predisposing gene?

    Liberti, S. E. & Rasmussen, Lene Juel, Aug 2004, In : Molecular Cancer Research. 2, 8, p. 427-32 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  113. 2000
  114. The LipB protein is a negative regulator of dam gene expression in Escherichia coli

    Vaisvila, R., Rasmussen, Lene Juel, Løbner-Olesen, Anders, von Freiesleben, U. & Marinus, M. G., 2000, In : Biochimica et Biophysica Acta, Gene Structure and Expression. 1494, 1-2, p. 43-53 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  115. 1995
  116. Growth-rate-dependent transcription initiation from the dam P2 promoter

    Rasmussen, Lene Juel, Løbner-Olesen, Anders & Marinus, M. G., 1995, In : Gene. 157, 1-2, p. 213-215 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  117. 1994
  118. Published

    Novel growth rate control of dam gene expression in Escherichia coli

    Rasmussen, Lene Juel, Marinus, M. G. & Løbner-Olesen, Anders, 1994, In : Molecular Microbiology. 12, 4, p. 631-638 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 13558388