New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

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  • Tomas Schmauck-Medina
  • Adrian Molière
  • Sofie Lautrup
  • Jianying Zhang
  • Stefan Chlopicki
  • Shuqin Cao
  • Casper Soendenbroe
  • Els Mansell
  • Mark Bitsch Vestergaard
  • Yosef Shiloh
  • Patricia L. Opresko
  • Jean Marc Egly
  • Thomas Kirkwood
  • Eric Verdin
  • Lynne S. Cox
  • Tinna Stevnsner
  • Evandro F. Fang

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.

Original languageEnglish
Issue number16
Pages (from-to)6829-6839
Number of pages11
Publication statusPublished - 2022

Bibliographical note

Publisher Copyright:
© 2022 Schmauck-Medina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    Research areas

  • Autophagy, Hallmarks of ageing, Healthspan, Longevity, Neurodegeneration

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