Ole Maaløes Vej 5, 2200 København N., 03 Bygning 3, Building: 03-2-41
I teach on the following courses:
Gene technology (lectures, seminars, practicals), Protein Chemistry and Enzymology (lectures, practicals), Protein Science (lectures, seminars).
I supervise students on projects related to:
Protein chemistry, Molecular Biology, Cell Biology & Yeast Genetics.
Fields of interestIntracellular protein degradation, the 26S proteasome, the ubiquitin system, cellular redox control, protein folding, molecular chaperones.
Our research activity is primarily centered on intracellular protein degradation via the ubiquitin-proteasome pathway. The ubiquitin-proteasome system is highly conserved and is the major pathway for intracellular proteolysis in all eukaryotic cells. Accordingly, ubiquitin-dependent protein degradation plays a pivotal role in the turnover of key regulatory proteins involved in a series of cellular processes, including cell cycle control, signal transduction, and protein folding. For a number of years a focus area for us has been how abnormal or misfolded proteins are targeted for degradation. To this end, we use fission yeast and mammalian cells in tissue culture as model systems, combined with a series of genetic, biochemical and molecular cell biological methods. In addition, we collaborate closely with a number of other research groups both in Denmark and abroad.