Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells
Research output: Contribution to journal › Journal article › Research › peer-review
Tumour cells are characterized by aerobic glycolysis, which provides biomass for tumour proliferation and leads to extracellular acidification through efflux of lactate via monocarboxylate transporters (MCTs). Deficient and spasm-prone tumour vasculature causes variable hypoxia, which favours tumour cell survival and metastases. Brain metastases frequently occur in patients with advanced breast cancer.Effective treatment strategies are therefore needed against brain metastasis from breast carcinoma.
|Journal||Cellular oncology (Dordrecht)|
|Number of pages||11|
|Publication status||Published - Jun 2012|