Interventions for age-related diseases: Shifting the paradigm

Research output: Contribution to journalReviewpeer-review


  • Inês Figueira
  • Adelaide Fernandes
  • Aleksandra Mladenovic Djordjevic
  • Lopez-Contreras, Andres
  • Catarina M Henriques
  • Colin Selman
  • Elisabete Ferreiro
  • Efstathios S Gonos
  • José Luis Trejo
  • Juhi Misra
  • Rasmussen, Lene Juel
  • Sara Xapelli
  • Timothy Ellam
  • Ilaria Bellantuono

Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.

Original languageEnglish
JournalMechanisms of Ageing and Development
Pages (from-to)69-92
Number of pages24
Publication statusPublished - Dec 2016

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