From powerhouse to perpetrator—mitochondria in health and disease

Research output: Contribution to journalReviewResearchpeer-review


In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect metabolism and mitochondrial function. On the other hand, mitochondrial pathologies can also lead to stress in the nucleus, and cause sensitivity to DNA-damaging agents. These are examples of how hallmarks of cancer and aging are connected and influenced by each other to protect humans from disease.

Original languageEnglish
Article number35
Issue number2
Number of pages15
Publication statusPublished - 2019

    Research areas

  • Cancer, DNA damage, Mitochondria, NAD, Nucleotide metabolism

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