Blanca I. Aldana

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Primary fields of research

Unraveling central disease mechanisms to identify novel metabolic therapeutic targets in neurodegenerative disorders with the ultimate goal to improve patient treatment. We work to better understand energy metabolism in the brain, mainly centered on glia, and its impact on major neurological disorders (e.g. epilepsy, Alzheimer´s disease and Frontotemporal dementia). Neuropharmacology of brain diseases targeting microglia and astrocyte receptors. My current research focuses on microglia cells and their immunometabolic and neurochemical interactions with astrocytes and neurons. Lately we take advantage of neuropharmacological approaches to modulate glia metabolism and function by targeting a diverse range of receptors. Expertise in brain cell lines and primary cultures of brain cells, transgenic animal models and cutting-edge cell-based model systems such as human induced pluripotent stem cells, as well as high-output biochemical analytical methods including mass spectrometry (GCMS), liquid chromatography (HPLC) and live-cell bioenergetics (Seahorse Analyses).

Current research

1. MOLECULAR AND CELLULAR MECHANISMS OF BRAIN ENERGY AND AMINO ACID METABOLISM:

Elucidate the molecular and cellular pathways regulating energy intake and expenditure in the brain, with a particular focus on the roles of glial cells (microglia and astrocytes) in neuronal energy and amino acid metabolism. Investigate the functional interactions between glia and neurons under physiological conditions to characterize the dynamics of brain energy homeostasis.

1. PATHOPHYSIOLOGY OF GLIAL ENERGY METABOLISM IN NEURODEGENERATION:

Identify and characterize key alterations in glial energy metabolism associated with neurodegenerative diseases, particularly Alzheimer´s disease. Explore how these metabolic disruptions contribute to neuroinflammation, neuronal dysfunction and disease progression, aiming to uncover potential therapeutic targets for Alzheimer´s disease and related dementias (FTD, PD).

1. MECHANISTIC INSIGHTS INTO THE EFFECTS OF SCFAS AND MCFAS ON BRAIN METABOLISM:

Investigate the mechanisms of action of short-chain and medium-chain fatty acids (SCFAs and MCFAs) on brain function, employing pharmacological tools to target glial and neuronal metabolic pathways. Assess their effects in both healthy and neurodegenerative contexts, with the goal of identifying dysregulated pathways susceptible to metabolic interventions and potential novel therapeutic strategies.

Teaching

My teaching philosophy is rooted in the beliefs that as researchers is our responsibility to share knowledge and that education should inspire curiosity, foster critical thinking, and cultivate a deep understanding of the subject matter. I strive to create an engaging and inclusive learning environment where students feel encouraged to explore complex concepts and ask questions that drive their intellectual growth. By integrating cutting-edge research with foundational knowledge, I aim to bridge the gap between theory and practice, preparing students for real-world challenges. I emphasize active learning and collaborative problem-solving, encouraging students to think independently while fostering a sense of community within the classroom. My goal is to equip students with the skills and confidence to become lifelong learners and contributors to the scientific community.