Birgitte Rahbek Kornum

Birgitte Rahbek Kornum

Guest Researcher, Associate Professor - Promotion Programme


  1. 2024
  2. Published

    Downregulation of hypocretin/orexin after H1N1 Pandemrix vaccination of adolescent mice

    Pagh-Berendtsen, Nicolai, Pavlovskyi, Artem, Flores Téllez, D., Jensen, Christine Egebjerg, Pedersen, Mie Gunni Kolmos, Justinussen, Jessica & Kornum, Birgitte Rahbek, 2024, In: Sleep. 47, 4, 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The immunopathogenesis of narcolepsy type 1

    Liblau, R. S., Latorre, D., Kornum, Birgitte Rahbek, Dauvilliers, Y. & Mignot, E. J., 2024, In: Nature Reviews Immunology. 24, p. 33-48

    Research output: Contribution to journalReviewResearchpeer-review

  4. 2023
  5. Published

    Emerging therapeutic targets for narcolepsy

    Vringer, M. & Kornum, Birgitte Rahbek, 2023, In: Expert Opinion On Therapeutic Targets. 25, 7, p. 559-572 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    Experimental sickness reduces hypocretin receptor 1 expression in the lateral hypothalamus and ventral tegmental area of female mice

    Pedersen, Mie Gunni Kolmos, Pérez Arribas, Alba, Kornum, Birgitte Rahbek & Justinussen, Jessica, 2023, In: European Journal of Neuroscience. 58, 9, p. 4002-4010 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    How hypocretin agonists may improve the quality of wake in narcolepsy

    Justinussen, Jessica, Jensen, Christine Egebjerg & Kornum, Birgitte Rahbek, 2023, In: Trends in Molecular Medicine. 29, 1, p. 61-69 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  8. Published

    In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid

    Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, Janfelt, Christian, Kornum, Birgitte Rahbek & Kristensen, Jesper Langgaard, 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings

    Viste, R., Follin, L. F., Kornum, Birgitte Rahbek, Lie, B. A., Viken, M. K., Thorsby, P. M., Rootwelt, T., Christensen, J. A. E. & Knudsen-Heier, S., 2023, In: Sleep. 46, 3, 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published
  11. Published
  12. Published

    Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

    Ollila, H. M., Sharon, E., Lin, L., Sinnott-Armstrong, N., Ambati, A., Yogeshwar, S. M., Hillary, R. P., Jolanki, O., Faraco, J., Einen, M., Luo, G., Zhang, J., Han, F., Yan, H., Dong, X. S., Li, J., Zhang, J., Hong, S. C., Kim, T. W., Dauvilliers, Y. & 31 others, Barateau, L., Lammers, G. J., Fronczek, R., Mayer, G., Santamaria, J., Arnulf, I., Knudsen-Heier, S., Bredahl, M. K. L., Thorsby, P. M., Plazzi, G., Pizza, F., Moresco, M., Crowe, C., Van den Eeden, S. K., Lecendreux, M., Bourgin, P., Kanbayashi, T., Martínez-Orozco, F. J., Peraita-Adrados, R., Benetó, A., Montplaisir, J., Desautels, A., Huang, Y. S., Jennum, Poul, Nevsimalova, S., Kemlink, D., Iranzo, A., Overeem, S., Wierzbicka, A., Kornum, Birgitte Rahbek & FinnGen, F., 2023, In: Nature Communications. 14, 1, 13 p., 2709.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published
  14. Published

    Repeated measures of hypocretin-1 in Danish and Italian patients with narcolepsy and in controls

    Torstensen, E. W., Haubjerg Østerby, N. C., Pizza, F., Plazzi, G., Antelmi, E., Moresco, M., Mignot, E., Jørgensen, Niklas Rye, Christensen, G. L., Wanscher, B., Kornum, Birgitte Rahbek & Jennum, Poul, 2023, In: Sleep Medicine. 101, p. 213-220 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Repeated polysomnography and multiple sleep latency test in narcolepsy type 1 and other hypersomnolence disorders

    Torstensen, E. W., Haubjerg Østerby, N. C., Kornum, Birgitte Rahbek, Wanscher, B., Mignot, E., Barløse, Mads Christian Johannes & Jennum, Poul, 2023, In: Sleep Medicine. 110, p. 91-98 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2022
  17. Published

    H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients have increased muscle activity during REM and nrem sleep compared with their non-narcoleptic siblings

    Viste, R., Lie, B. A., Kornum, Birgitte Rahbek, Rootwelt, T. & Knudsen-Heier, S., 2022, In: Journal of Sleep Research. 31, Supplement 1, 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  18. Published

    Neurobioloy of sleep and circadian disorders

    Kornum, Birgitte Rahbek & Mignot, E., 2022, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition. M. J. Z., C. A. W. & M-F. C. (eds.). 2 ed. Elsevier, p. 635-658 24 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  19. Published

    Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming

    Bergmann, T., Liu, Y., Skov, J., Mogus, L., Lee, J., Pfisterer, U., Handfield, L. F., Asenjo-Martinez, A., Lisa-Vargas, I., Seemann, S. E., Lee, J. T. H., Patikas, N., Kornum, B. R., Denham, M., Hyttel, P., Witter, M. P., Gorodkin, J., Pers, T. H., Hemberg, M., Khodosevich, K. & 1 others, Hall, Vanessa Jane, 2022, In: Frontiers in Cell and Developmental Biology. 10, 976549.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Sex-related differences within sleep-wake dynamics, cataplexy, and EEG fast-delta power in a narcolepsy mouse model

    Petersen, Louise Piilgaard, Rose, Laura, Hviid, C. G., Kohlmeier, Kristi Anne & Kornum, Birgitte Rahbek, 2022, In: Sleep. 45, 7, 15 p., zsac058.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio

    Holm, A., Possovre, M. L., Bandarabadi, M., Moseholm, Kristine Frøsig, Justinussen, Jessica, Bozic, I., Lemcke, René, Arribat, Y., Amati, F., Silahtaroglu, Asli, Juventin, M., Adamantidis, A., Tafti, M. & Kornum, Birgitte Rahbek, 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 17, 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2021
  23. Published

    Diagnostic value of actigraphy in hypersomnolence disorders

    Torstensen, E. W., Pickering, L., Kornum, Birgitte Rahbek, Wanscher, B., Baandrup, Lone & Jennum, Poul, 2021, In: Sleep Medicine. 85, p. 1-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep

    Lie, M. E. K., Falk-Petersen, C. B., Petersen, Louise Piilgaard, Griem-Krey, Nane, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2021, In: European Journal of Neuroscience. 54, 2, p. 4445-4455 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

    Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, Chi, C. C., Gee, C. L., Frølund, Bente, Kornum, Birgitte Rahbek, van Woerden, G. M., Clausen, Rasmus Prætorius, Kuriyan, J., Clarkson, A. N. & Wellendorph, Petrine, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11protein levels in narcolepsy type 1

    Viste, R., Viken, M. K., Lie, B. A., Juvodden, H. T., Nordstrand, S. E. H., Thorsby, P. M., Rootwelt, T., Kornum, Birgitte Rahbek & Knudsen-Heier, S., 2021, In: Sleep. 44, 8, 12 p., zsab062.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Narcolepsy Type I as an autoimmune disorder

    Kornum, Birgitte Rahbek, 2021, Handbook of Clinical Neurology. 1 ed. Elsevier, p. 161-172 12 p. (Handbook of Clinical Neurology, Vol. 181).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  28. Published

    Narcolepsy type 1 patients have lower levels of effector memory CD4+ T cells compared to their siblings when controlling for H1N1-(Pandemrix™)-vaccination and HLA DQB1∗06:02 status

    Viste, R., Lie, B. A., Viken, M. K., Rootwelt, T., Knudsen-Heier, S. & Kornum, Birgitte Rahbek, 2021, In: Sleep Medicine. 85, p. 271-279 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Pre-treatment of blood samples reveal normal blood hypocretin/orexin signal in narcolepsy type I

    Aegidius, H. M., Kruse, L., Christensen, G. L., Lorentzen, M. P., Jørgensen, Niklas Rye, Moresco, M., Pizza, F., Plazzi, G., Jennum, Poul & Kornum, Birgitte Rahbek, 2021, In: Brain Communications. 3, 2, 13 p., 050.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2020
  31. Published
  32. Published

    Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes

    Hauglund, Natalie Linea, Kusk, P., Kornum, Birgitte Rahbek & Nedergaard, Maiken, 2020, In: Journal of Neuroscience. 40, 11, p. 2371-2380 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis

    Ægidius, H. M., Veidal, S. S., Feigh, M., Hallenborg, P., Puglia, M., Pers, Tune H, Vrang, N., Jelsing, J., Kornum, Birgitte Rahbek, Blagoev, B. & Rigbolt, K. T. G., 2020, In: Scientific Reports. 10, 1, 12 p., 1148.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Narcolepsy type 1: What have we learned from immunology?

    Kornum, Birgitte Rahbek, 2020, In: Sleep. 43, 10, zsaa055.

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    TREATMENT OF CNS DISORDERS WITH SLEEP DISTURBANCES

    Wellendorph, Petrine, Kornum, Birgitte Rahbek & Frølund, Bente, 2020, Patent No. WO2020259787 , 30 Dec 2020, Priority date 28 Jun 2019, Priority No. DK2019PA70415 20190628

    Research output: Patent

  36. Published

    The case for narcolepsy as an autoimmune disease

    Kornum, Birgitte Rahbek & Jennum, Poul, 2020, In: Expert Review of Clinical Immunology. 16, 3, p. 231-233 3 p.

    Research output: Contribution to journalReviewResearchpeer-review

  37. Published

    Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission

    Bentsen, M. A., Rausch, D. M., Mirzadeh, Z., Muta, K., Scarlett, J. M., Brown, J. M., Herranz-Pérez, V., Baquero, A. F., Thompson, J., Alonge, K. M., Faber, C. L., Kaiyala, K. J., Bennett, C., Pyke, C., Ratner, C., Egerod, K. L., Holst, B., Meek, T. H., Kutlu, B., Zhang, Y. & 9 others, Sparso, T., Grove, K. L., Morton, G. J., Kornum, Birgitte Rahbek, García-Verdugo, J. M., Secher, A., Jorgensen, R., Schwartz, M. W. & Pers, Tune H, 2020, In: Nature Communications. 11, 1, 4458.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. 2019
  39. Published

    Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations

    Dommer, M. W., Dreisig, K. & Kornum, Birgitte Rahbek, 2019, In: Pharmacological Reports. 71, 5, p. 926-928 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

    Pedersen, N. W., Holm, A., Kristensen, N. P., Bjerregaard, A., Bentzen, A. K., Marquard, A. M., Tamhane, T., Burgdorf, K. S., Ullum, H., Jennum, Poul, Knudsen, S., Hadrup, S. R. & Kornum, Birgitte Rahbek, 2019, In: Nature Communications. 10, p. 1-12 837.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    CHARACTERIZATION OF REGULATORY NETWORKS BY MULTI-OMICS COMBINING PROTEOMICS WITH BULK AND SINGLE-CELL RNA SEQUENCING IN A DIET-INDUCED AND BIOPSY-CONFIRMED MOUSE MODEL OF NON-ALCOHOLIC STEATOHEPATITIS

    AEgidius, H., Veidal, S., Feigh, M., Puglia, M., Hallenborg, P., Vrang, N., Jelsing, J., Kornum, Birgitte Rahbek, Blagoev, B. & Rigbolt, K., 2019, In: Hepatology. 70, Supplement 1, p. 1278A-1279A 2 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  42. Published

    Forstå din søvn: Hvad videnskaben siger om at sove godt, og hvordan du opnår det!

    Kornum, Birgitte Rahbek, 2019, 1 ed. København: Gyldendal. 205 p.

    Research output: Book/ReportBookCommunication

  43. Published

    In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

    Jiang, W., Birtley, J. R., Hung, S. C., Wang, W., Chiou, S. H., Macaubas, C., Kornum, Birgitte Rahbek, Tian, L., Huang, H., Adler, L., Weaver, G., Lu, L., Ilstad-Minnihan, A., Somasundaram, S., Ayyangar, S., Davis, M. M., Stern, L. J. & Mellins, E. D., 2019, In: Nature Communications. 10, 1, 17 p., 5247.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment

    Bassetti, C. L. A., Adamantidis, A., Burdakov, D., Han, F., Gay, S., Kallweit, U., Khatami, R., Koning, F., Kornum, Birgitte Rahbek, Lammers, G. J., Liblau, R. S., Luppi, P. H., Mayer, G., Pollmaecher, T., Sakurai, T., Sallusto, F., Scammell, T. E., Tafti, M. & Dauvilliers, Y., 2019, In: Nature Reviews. Neurology. 15, 9, p. 519-539

    Research output: Contribution to journalReviewResearchpeer-review

  45. Published

    Sandwich cortial lamination and single-cell analysis decodes the developing spatial processing system

    Liu, Y., Bergmann, T. B., Lee, J., Pfisterer, U. G., Handfield, L-F., Mori, Y., Asenjo Martinez, A., Lisa Vargas, I., Seemann, E. S., Lee, J. T. H., Patikis, N., Peralvo Vidal, J. M., Pihl, M., Kornum, B. R., Thomsen, P. D., Hyttel, P., Witter, M., Khodosevich, K., Gorodkin, J., Hemberg, M. & 2 others, Pers, Tune H & Hall, Vanessa Jane, 2019. 45 p.

    Research output: Contribution to conferencePaperCommunication

  46. Published

    Unge forskere: S-løftebrud er en katastrofe for universiteterne

    Aguirre, V., Andersen, C., Andersen, P. R., Bjørk, R., Clemmensen, C., Dalsgaard, P., Danbolt, M., Dimke, H., Engberg-Pedersen, A., Feliu, E., Jauffred, L., Jønsson, K., Kornum, B. R., Kropp, K., Laustsen, A., Levisen, C., Lock, N., Lomborg, S., Møller, N. M., Niss, K. & 5 others, Pedersen, B. P., Pristed, B. B., Sørensen, Thomas Just, Ulstrup, S. & Vallgårda, Karen Asta Arnfred, 2019

    Research output: Other contributionCommunication

  47. 2018
  48. Published

    DNMT1 regulates expression of MHC class I in post-mitotic neurons

    Gustafsson, J. R., Katsioudi, G., Degn, M., Ejlerskov, P., Issazadeh-Navikas, Shohreh & Kornum, Birgitte Rahbek, 2018, In: Molecular Brain. 11, 1, p. 1-16 16 p., 36.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease

    Moresco, M., Lecciso, M., Ocadlikova, D., Filardi, M., Melzi, S., Kornum, Birgitte Rahbek, Antelmi, E., Pizza, F., Mignot, E., Curti, A. & Plazzi, G., 2018, In: Sleep Medicine. 44, p. 53-60 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Human P2Y11 expression level affects human P2X7 receptor-mediated cell death

    Dreisig, K., Sund, L., Dommer, M. W., Kristensen, N. P., Boddum, K., Viste, R., Fredholm, S., Ødum, Niels, Jäättelä, M., Skov, Søren & Kornum, Birgitte Rahbek, 2018, In: Frontiers in Immunology. 9, JUN, 12 p., 1159.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells

    Zager, A., Brandão, W. N., Margatho, R. O., Cruz, D. S. G., Peron, J. P., Tufik, S., Andersen, M. L., Moresco, M., Pizza, F., Plazzi, G., Kornum, Birgitte Rahbek & Palermo-Neto, J., 2018, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 81, p. 297-305 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. N-terminal tagging of human P2X7 receptor disturbs calcium influx and dye uptake

    Dreisig, K., Kristensen, N. P., Dommer, M. W., Jørgensen, N. R. & Kornum, Birgitte Rahbek, 2018, In: Purinergic Signalling. 14, 1, p. 83-90 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. The wake-promoting drug Modafinil prevents motor impairment in sickness behavior induced by LPS in mice: Role for dopaminergic D1 receptor

    Zager, A., Brandão, W. N., Margatho, R. O., Peron, J. P., Tufik, S., Andersen, M. L., Kornum, Birgitte Rahbek & Palermo-Neto, J., 2018, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 81, p. 468-476 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints

    Torstensen, E. W., Brinth, L. S., Mehlsen, J., Kornum, Birgitte Rahbek & Jennum, Poul, 2018, In: Danish Medical Journal. 65, 11, 4 p., A5510.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. 2017
  56. Rare missense mutations in P2RY11 in narcolepsy with cataplexy

    Degn, M., Dauvilliers, Y., Dreisig, K., Lopez, R., Pfister, C., Pradervand, S., Kornum, Birgitte Rahbek & Tafti, M., 1 Jun 2017, In: Brain. 140, 6, p. 1657-1668 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Sleep spindle density in narcolepsy

    Christensen, J. A. E., Nikolic, M., Hvidtfelt, M., Kornum, Birgitte Rahbek & Jennum, Poul, Jun 2017, In: Sleep Medicine. 34, p. 40-49 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Sleep-wake stability in narcolepsy patients with normal, low and unmeasurable hypocretin levels

    Hansen, M. H., Kornum, Birgitte Rahbek & Jennum, Poul, Jun 2017, In: Sleep Medicine. 34, p. 1-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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