Birgitte Rahbek Kornum
Guest Researcher, Associate Professor - Promotion Programme
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
Molecular Neuroscience
Blegdamsvej 3
2200 København N
- 2024
- Published
Downregulation of hypocretin/orexin after H1N1 Pandemrix vaccination of adolescent mice
Pagh-Berendtsen, Nicolai, Pavlovskyi, Artem, Flores Téllez, D., Jensen, Christine Egebjerg, Pedersen, Mie Gunni Kolmos, Justinussen, Jessica & Kornum, Birgitte Rahbek, 2024, In: Sleep. 47, 4, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The immunopathogenesis of narcolepsy type 1
Liblau, R. S., Latorre, D., Kornum, Birgitte Rahbek, Dauvilliers, Y. & Mignot, E. J., 2024, In: Nature Reviews Immunology. 24, p. 33-48Research output: Contribution to journal › Review › Research › peer-review
- 2023
- Published
Emerging therapeutic targets for narcolepsy
Vringer, M. & Kornum, Birgitte Rahbek, 2023, In: Expert Opinion On Therapeutic Targets. 25, 7, p. 559-572 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Experimental sickness reduces hypocretin receptor 1 expression in the lateral hypothalamus and ventral tegmental area of female mice
Pedersen, Mie Gunni Kolmos, Pérez Arribas, Alba, Kornum, Birgitte Rahbek & Justinussen, Jessica, 2023, In: European Journal of Neuroscience. 58, 9, p. 4002-4010 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How hypocretin agonists may improve the quality of wake in narcolepsy
Justinussen, Jessica, Jensen, Christine Egebjerg & Kornum, Birgitte Rahbek, 2023, In: Trends in Molecular Medicine. 29, 1, p. 61-69 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid
Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, , 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings
Viste, R., Follin, L. F., Kornum, Birgitte Rahbek, Lie, B. A., Viken, M. K., Thorsby, P. M., Rootwelt, T., Christensen, J. A. E. & Knudsen-Heier, S., 2023, In: Sleep. 46, 3, 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus
Lemcke, René, Jensen, Christine Egebjerg, Pagh-Berendtsen, Nicolai, Egerod, Kristoffer Lihme, Thomsen, Allan Randrup, Pers, Tune H, Christensen, Jan Pravsgaard & Kornum, Birgitte Rahbek, 2023, 31 p.Research output: Working paper › Preprint › Research
- Published
Molecular consequences of peripheral Influenza A infection on cell populations in the murine hypothalamus
Lemcke, René, Jensen, Christine Egebjerg, Pagh-Berendtsen, Nicolai, Egerod, Kristoffer Lihme, Thomsen, Allan Randrup, Pers, Tune H, Christensen, Jan Pravsgaard & Kornum, Birgitte Rahbek, 2023, In: eLife. 12, 28 p., RP87515.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
Ollila, H. M., Sharon, E., Lin, L., Sinnott-Armstrong, N., Ambati, A., Yogeshwar, S. M., Hillary, R. P., Jolanki, O., Faraco, J., Einen, M., Luo, G., Zhang, J., Han, F., Yan, H., Dong, X. S., Li, J., Zhang, J., Hong, S. C., Kim, T. W., Dauvilliers, Y. & 31 others, , 2023, In: Nature Communications. 14, 1, 13 p., 2709.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-invasive detection of narcolepsy type I phenotypical features and disease progression by continuous home-cage monitoring of activity in two mouse models: the HCRT-KO and DTA model
Petersen, Louise Piilgaard, Rose, Laura, Justinussen, Jessica, Hviid, C. G., Lemcke, René, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2023, In: Sleep. 46, 9, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Repeated measures of hypocretin-1 in Danish and Italian patients with narcolepsy and in controls
Torstensen, E. W., Haubjerg Østerby, N. C., Pizza, F., Plazzi, G., Antelmi, E., Moresco, M., Mignot, E., Jørgensen, Niklas Rye, Christensen, G. L., Wanscher, B., Kornum, Birgitte Rahbek & Jennum, Poul, 2023, In: Sleep Medicine. 101, p. 213-220 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Repeated polysomnography and multiple sleep latency test in narcolepsy type 1 and other hypersomnolence disorders
Torstensen, E. W., Haubjerg Østerby, N. C., Kornum, Birgitte Rahbek, Wanscher, B., Mignot, E., Barløse, Mads Christian Johannes & Jennum, Poul, 2023, In: Sleep Medicine. 110, p. 91-98 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients have increased muscle activity during REM and nrem sleep compared with their non-narcoleptic siblings
Viste, R., Lie, B. A., Kornum, Birgitte Rahbek, Rootwelt, T. & Knudsen-Heier, S., 2022, In: Journal of Sleep Research. 31, Supplement 1, 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Neurobioloy of sleep and circadian disorders
Kornum, Birgitte Rahbek & Mignot, E., 2022, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition. M. J. Z., C. A. W. & M-F. C. (eds.). 2 ed. Elsevier, p. 635-658 24 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming
Bergmann, T., Liu, Y., Skov, J., Mogus, L., Lee, J., Pfisterer, U., Handfield, L. F., Asenjo-Martinez, A., Lisa-Vargas, I., Seemann, S. E., Lee, J. T. H., Patikas, N., Kornum, B. R., Denham, M., Hyttel, P., Witter, M. P., Gorodkin, J., Pers, T. H., Hemberg, M., Khodosevich, K. & 1 others, , 2022, In: Frontiers in Cell and Developmental Biology. 10, 976549.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sex-related differences within sleep-wake dynamics, cataplexy, and EEG fast-delta power in a narcolepsy mouse model
Petersen, Louise Piilgaard, Rose, Laura, Hviid, C. G., Kohlmeier, Kristi Anne & Kornum, Birgitte Rahbek, 2022, In: Sleep. 45, 7, 15 p., zsac058.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio
Holm, A., Possovre, M. L., Bandarabadi, M., Moseholm, Kristine Frøsig, Justinussen, Jessica, Bozic, I., Lemcke, René, Arribat, Y., Amati, F., Silahtaroglu, Asli, Juventin, M., Adamantidis, A., Tafti, M. & Kornum, Birgitte Rahbek, 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 17, 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Diagnostic value of actigraphy in hypersomnolence disorders
Torstensen, E. W., Pickering, L., Kornum, Birgitte Rahbek, Wanscher, B., Baandrup, Lone & Jennum, Poul, 2021, In: Sleep Medicine. 85, p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep
Lie, M. E. K., Falk-Petersen, C. B., Petersen, Louise Piilgaard, Griem-Krey, Nane, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2021, In: European Journal of Neuroscience. 54, 2, p. 4445-4455 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, , 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11protein levels in narcolepsy type 1
Viste, R., Viken, M. K., Lie, B. A., Juvodden, H. T., Nordstrand, S. E. H., Thorsby, P. M., Rootwelt, T., Kornum, Birgitte Rahbek & Knudsen-Heier, S., 2021, In: Sleep. 44, 8, 12 p., zsab062.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Narcolepsy Type I as an autoimmune disorder
Kornum, Birgitte Rahbek, 2021, Handbook of Clinical Neurology. 1 ed. Elsevier, p. 161-172 12 p. (Handbook of Clinical Neurology, Vol. 181).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Narcolepsy type 1 patients have lower levels of effector memory CD4+ T cells compared to their siblings when controlling for H1N1-(Pandemrix™)-vaccination and HLA DQB1∗06:02 status
Viste, R., Lie, B. A., Viken, M. K., Rootwelt, T., Knudsen-Heier, S. & Kornum, Birgitte Rahbek, 2021, In: Sleep Medicine. 85, p. 271-279 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pre-treatment of blood samples reveal normal blood hypocretin/orexin signal in narcolepsy type I
Aegidius, H. M., Kruse, L., Christensen, G. L., Lorentzen, M. P., Jørgensen, Niklas Rye, Moresco, M., Pizza, F., Plazzi, G., Jennum, Poul & Kornum, Birgitte Rahbek, 2021, In: Brain Communications. 3, 2, 13 p., 050.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
A CLASS OF SMALL-MOLECULE COMPOUNDS AND THEIR PRODRUGS FOR INTERVENTION WITH CAMK2A, AND THEIR USE IN ACUTE BRAIN INJURIES AND CENTRAL HYPERSOMNIAS
Frølund, Bente, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2020, Patent No. WO2020151795, 30 Jul 2020, Priority date 21 Jan 2019, Priority No. DK2019PA70040 20190121Research output: Patent
- Published
Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes
Hauglund, Natalie Linea, Kusk, P., Kornum, Birgitte Rahbek & Nedergaard, Maiken, 2020, In: Journal of Neuroscience. 40, 11, p. 2371-2380 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis
Ægidius, H. M., Veidal, S. S., Feigh, M., Hallenborg, P., Puglia, M., Pers, Tune H, Vrang, N., Jelsing, J., Kornum, Birgitte Rahbek, Blagoev, B. & Rigbolt, K. T. G., 2020, In: Scientific Reports. 10, 1, 12 p., 1148.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Narcolepsy type 1: What have we learned from immunology?
Kornum, Birgitte Rahbek, 2020, In: Sleep. 43, 10, zsaa055.Research output: Contribution to journal › Review › Research › peer-review
- Published
TREATMENT OF CNS DISORDERS WITH SLEEP DISTURBANCES
Wellendorph, Petrine, Kornum, Birgitte Rahbek & Frølund, Bente, 2020, Patent No. WO2020259787 , 30 Dec 2020, Priority date 28 Jun 2019, Priority No. DK2019PA70415 20190628Research output: Patent
- Published
The case for narcolepsy as an autoimmune disease
Kornum, Birgitte Rahbek & Jennum, Poul, 2020, In: Expert Review of Clinical Immunology. 16, 3, p. 231-233 3 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission
Bentsen, M. A., Rausch, D. M., Mirzadeh, Z., Muta, K., Scarlett, J. M., Brown, J. M., Herranz-Pérez, V., Baquero, A. F., Thompson, J., Alonge, K. M., Faber, C. L., Kaiyala, K. J., Bennett, C., Pyke, C., Ratner, C., Egerod, K. L., Holst, B., Meek, T. H., Kutlu, B., Zhang, Y. & 9 others, , 2020, In: Nature Communications. 11, 1, 4458.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations
Dommer, M. W., Dreisig, K. & Kornum, Birgitte Rahbek, 2019, In: Pharmacological Reports. 71, 5, p. 926-928 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
Pedersen, N. W., Holm, A., Kristensen, N. P., Bjerregaard, A., Bentzen, A. K., Marquard, A. M., Tamhane, T., Burgdorf, K. S., Ullum, H., Jennum, Poul, Knudsen, S., Hadrup, S. R. & Kornum, Birgitte Rahbek, 2019, In: Nature Communications. 10, p. 1-12 837.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CHARACTERIZATION OF REGULATORY NETWORKS BY MULTI-OMICS COMBINING PROTEOMICS WITH BULK AND SINGLE-CELL RNA SEQUENCING IN A DIET-INDUCED AND BIOPSY-CONFIRMED MOUSE MODEL OF NON-ALCOHOLIC STEATOHEPATITIS
AEgidius, H., Veidal, S., Feigh, M., Puglia, M., Hallenborg, P., Vrang, N., Jelsing, J., Kornum, Birgitte Rahbek, Blagoev, B. & Rigbolt, K., 2019, In: Hepatology. 70, Supplement 1, p. 1278A-1279A 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Forstå din søvn: Hvad videnskaben siger om at sove godt, og hvordan du opnår det!
Kornum, Birgitte Rahbek, 2019, 1 ed. København: Gyldendal. 205 p.Research output: Book/Report › Book › Communication
- Published
In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
Jiang, W., Birtley, J. R., Hung, S. C., Wang, W., Chiou, S. H., Macaubas, C., Kornum, Birgitte Rahbek, Tian, L., Huang, H., Adler, L., Weaver, G., Lu, L., Ilstad-Minnihan, A., Somasundaram, S., Ayyangar, S., Davis, M. M., Stern, L. J. & Mellins, E. D., 2019, In: Nature Communications. 10, 1, 17 p., 5247.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment
Bassetti, C. L. A., Adamantidis, A., Burdakov, D., Han, F., Gay, S., Kallweit, U., Khatami, R., Koning, F., Kornum, Birgitte Rahbek, Lammers, G. J., Liblau, R. S., Luppi, P. H., Mayer, G., Pollmaecher, T., Sakurai, T., Sallusto, F., Scammell, T. E., Tafti, M. & Dauvilliers, Y., 2019, In: Nature Reviews. Neurology. 15, 9, p. 519-539Research output: Contribution to journal › Review › Research › peer-review
- Published
Sandwich cortial lamination and single-cell analysis decodes the developing spatial processing system
Liu, Y., Bergmann, T. B., Lee, J., Pfisterer, U. G., Handfield, L-F., Mori, Y., Asenjo Martinez, A., Lisa Vargas, I., Seemann, E. S., Lee, J. T. H., Patikis, N., Peralvo Vidal, J. M., Pihl, M., Kornum, B. R., Thomsen, P. D., Hyttel, P., Witter, M., Khodosevich, K., Gorodkin, J., Hemberg, M. & 2 others, , 2019. 45 p.Research output: Contribution to conference › Paper › Communication
- Published
Unge forskere: S-løftebrud er en katastrofe for universiteterne
Aguirre, V., Andersen, C., Andersen, P. R., Bjørk, R., Clemmensen, C., Dalsgaard, P., Danbolt, M., Dimke, H., Engberg-Pedersen, A., Feliu, E., Jauffred, L., Jønsson, K., Kornum, B. R., Kropp, K., Laustsen, A., Levisen, C., Lock, N., Lomborg, S., Møller, N. M., Niss, K. & 5 others, , 2019Research output: Other contribution › Communication
- 2018
- Published
DNMT1 regulates expression of MHC class I in post-mitotic neurons
Gustafsson, J. R., Katsioudi, G., Degn, M., Ejlerskov, P., Issazadeh-Navikas, Shohreh & Kornum, Birgitte Rahbek, 2018, In: Molecular Brain. 11, 1, p. 1-16 16 p., 36.Research output: Contribution to journal › Journal article › Research › peer-review
Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease
Moresco, M., Lecciso, M., Ocadlikova, D., Filardi, M., Melzi, S., Kornum, Birgitte Rahbek, Antelmi, E., Pizza, F., Mignot, E., Curti, A. & Plazzi, G., 2018, In: Sleep Medicine. 44, p. 53-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human P2Y11 expression level affects human P2X7 receptor-mediated cell death
Dreisig, K., Sund, L., Dommer, M. W., Kristensen, N. P., Boddum, K., Viste, R., Fredholm, S., Ødum, Niels, Jäättelä, M., Skov, Søren & Kornum, Birgitte Rahbek, 2018, In: Frontiers in Immunology. 9, JUN, 12 p., 1159.Research output: Contribution to journal › Journal article › Research › peer-review
Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells
Zager, A., Brandão, W. N., Margatho, R. O., Cruz, D. S. G., Peron, J. P., Tufik, S., Andersen, M. L., Moresco, M., Pizza, F., Plazzi, G., Kornum, Birgitte Rahbek & Palermo-Neto, J., 2018, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 81, p. 297-305 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
N-terminal tagging of human P2X7 receptor disturbs calcium influx and dye uptake
Dreisig, K., Kristensen, N. P., Dommer, M. W., Jørgensen, N. R. & Kornum, Birgitte Rahbek, 2018, In: Purinergic Signalling. 14, 1, p. 83-90 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
The wake-promoting drug Modafinil prevents motor impairment in sickness behavior induced by LPS in mice: Role for dopaminergic D1 receptor
Zager, A., Brandão, W. N., Margatho, R. O., Peron, J. P., Tufik, S., Andersen, M. L., Kornum, Birgitte Rahbek & Palermo-Neto, J., 2018, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 81, p. 468-476 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints
Torstensen, E. W., Brinth, L. S., Mehlsen, J., Kornum, Birgitte Rahbek & Jennum, Poul, 2018, In: Danish Medical Journal. 65, 11, 4 p., A5510.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
Rare missense mutations in P2RY11 in narcolepsy with cataplexy
Degn, M., Dauvilliers, Y., Dreisig, K., Lopez, R., Pfister, C., Pradervand, S., Kornum, Birgitte Rahbek & Tafti, M., 1 Jun 2017, In: Brain. 140, 6, p. 1657-1668 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sleep spindle density in narcolepsy
Christensen, J. A. E., Nikolic, M., Hvidtfelt, M., Kornum, Birgitte Rahbek & Jennum, Poul, Jun 2017, In: Sleep Medicine. 34, p. 40-49 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sleep-wake stability in narcolepsy patients with normal, low and unmeasurable hypocretin levels
Hansen, M. H., Kornum, Birgitte Rahbek & Jennum, Poul, Jun 2017, In: Sleep Medicine. 34, p. 1-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 143987587
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Monozygotic twins discordant for narcolepsy type 1 and multiple sclerosis
Research output: Contribution to journal › Letter › Research › peer-review
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143
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DNMT1 regulates expression of MHC class I in post-mitotic neurons
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
141
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Human P2Y11 expression level affects human P2X7 receptor-mediated cell death
Research output: Contribution to journal › Journal article › Research › peer-review
Published