Vanessa Jane Hall
Associate Professor
Leader of Group of Brain Development and Disease
The research group of Brain Development and Disease is driven by a fascination of the mind and its matter. The group focuses on the mechanisms involved in neurodevelopment, systemic inflammation, and neurodegenerative diseases such as dementia and Alzheimer’s disease.
We apply methods such as single cell RNA sequencing to understand the cellular diversity of the part of the brain where Alzheimer’s disease first strikes called the entorhinal cortex. Single cell RNA sequencing data has enabled us to develop a novel neuron (brain) cell type from pluripotent stem cells using an approach called direct programming. These cells may provide clues as to why some cells in the brain are more vulnerable to disease than others. Uncovering the cellular diversity of the brain provides extraordinary insight into the complexity of this organ and provides us new evidence for the function and origins of brain diseases.
Our lab is also interested in the importance of the systemic immune environment, especially the gut, its microbiota and infections, and the role these have in the onset of neurodegenerative diseases
Current Research Interests:
- Modeling Alzheimer's disease in a dish using pluripotent stem cells
- Determining the origins of Alzheimer's disease
- Understanding the development and evolution of the brain's spatial navigation.
- Developing clean meat using animal stem cells
Techniques we perform in the lab
- Multiomic technology development
- Single cell RNA sequencing
- Bioinformatics
- Microelectrode array and electrophysiological analyses of neurons
- Pluripotent and neural stem cell culture
- Histology and Immunohistochemistry
- MRI on brains
Current funding sources:
- DFF/IRFD
- Novo Nordisk Foundation
- Lundbeck Foundation
- Carlsberg Foundation
Funded projects:
Investigating development and evolution of the entorhinal cortex - ground zero for Alzheimer's disease
(Funded by Lundbeck Foundation) 5.000.000 DKK
Development of a novel technology, spatial connectomics (SpaiCon) for broad biological sciences
(Funded by Novo Nordisk Foundation) 5.000.000 DKK
Optimizing production of clean meat using stem cell technology and proteins extracted from animal waste (CleanMeat)
(Funded by DFF) 2.877.135 DKK
Teaching
Supervision:
PhDs
Main supervisor:
2022- Dorrotya Ralbovszki/University of Copenhagen
2018-2020 Tobias Bergmann/University of Copenhagen
2017 - 2019 Yong Liu/University of Copenhagen
Co-supervisor:
2014 – 2015 Carlota Pires/University of Copenhagen, Denmark
2011 – 2015 Dong Li: Submitted September 2015/University of Copenhagen, Denmark
2008 – 2011 Yu Gao/Uni of Copenhagen, Denmark: Now a postdoc at University of Wisconsin-Madison
2007 – 2010 Mikkel Rasmussen/Uni of Copenhagen, Denmark Now a postdoc at Bioneer A/S, Denmark developing iPSCs from patients.
Masters and Bachelors
Acted as main supervisor for several masters and bachelor students
Fields of interest
- Induced pluripotent stem cells
- Entorhinal cortex
- Neural development
- Single cell RNA sequencing
- Multiomic technologies
- Clean meat using stem cells
ID: 4234529
Most downloads
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3006
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Derivation and characterization of sleeping beauty transposon-mediated porcine induced pluripotent stem cells
Research output: Contribution to journal › Journal article › Research › peer-review
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2195
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Early embryonic development, assisted reproductive technologies, and pluripotent stem cell biology in domestic mammals
Research output: Contribution to journal › Journal article › Research › peer-review
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1003
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Early development of the porcine embryo: the importance of cell signalling in development of pluripotent cell lines
Research output: Contribution to journal › Journal article › Research › peer-review
Published