Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings

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  • Rannveig Viste
  • Louise F. Follin
  • Kornum, Birgitte Rahbek
  • Benedicte A. Lie
  • Marte K. Viken
  • Per M. Thorsby
  • Terje Rootwelt
  • Julie A. E. Christensen
  • Stine Knudsen-Heier

Study Objectives Narcolepsy type 1 (NT1) is characterized by unstable sleep-wake and muscle tonus regulation during sleep. We characterized dream enactment and muscle activity during sleep in a cohort of post-H1N1 NT1 patients and their siblings, and analyzed whether clinical phenotypic characteristics and major risk factors are associated with increased muscle activity. Methods RBD symptoms and polysomnography m. tibialis anterior electromyographical signals [long (0.5-15 s); short (0.1-0.49 s)] were compared between 114 post-H1N1 NT1 patients and 89 non-narcoleptic siblings. Association sub-analyses with RBD symptoms, narcoleptic symptoms, CSF hypocretin-1 levels, and major risk factors [H1N1-(Pandemrix)-vaccination, HLA-DQB1*06:02-positivity] were performed. Results RBD symptoms, REM and NREM long muscle activity indices and REM short muscle activity index were significantly higher in NT1 patients than siblings (all p < 0.001). Patients with undetectable CSF hypocretin-1 levels (

Original languageEnglish
JournalSleep
Volume46
Issue number3
Number of pages14
ISSN0161-8105
DOIs
Publication statusPublished - 2023

    Research areas

  • Narcolepsy type 1, NT1, post Pandemrix NT1, muscle activity in sleep, leg movements in sleep, periodic leg movements, dream enactment, REM sleep behavior disorder, CSF hypocretin-1 deficiency, disease continuum in first-degree relatives, RESTLESS LEGS SYNDROME, CSF HYPOCRETIN-1 LEVELS, REM-SLEEP, POST-H1N1 VACCINATION, CHILDHOOD NARCOLEPSY, NORWEGIAN CHILDREN, H1N1 INFLUENZA, T-CELLS, MOVEMENTS, DIAGNOSIS

ID: 335955894