Neurobioloy of sleep and circadian disorders

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Mammalian sleep has evolved under the influence of the day–night cycle and in response to reproductive needs, food seeking, and predator escape, resulting in circadian (predictive) and homeostatic (reactive) regulation. A molecular clock characterized by transcription/translation feedback loops mediates circadian regulation of sleep. Misalignment with the rhythm of the sun results in circadian rhythm disorders and jet lag. The molecular basis of homeostatic sleep regulation is mostly unknown. A network of mutually inhibitory brain nuclei regulates sleep states and sleep–wake transitions. Abnormalities in these networks create sleep disorders, for example, rapid eye movement sleep behavior disorder, sleep walking, or narcolepsy. Physiological changes associated with sleep can also be imbalanced, resulting in excess movements such as periodic leg movements during sleep or abnormal breathing in obstructive sleep apneas. As every organ in the body is affected by sleep directly or indirectly, sleep and sleep-associated disorders are frequent and only now starting to be understood.

Original languageEnglish
Title of host publicationNeurobiology of Brain Disorders : Biological Basis of Neurological and Psychiatric Disorders, Second Edition
EditorsMichael J. Zigmond , Clayton A. Wiley , Marie-Francoise Chesselet
Number of pages24
Publication date2022
ISBN (Print)9780323898256
ISBN (Electronic)9780323856546
Publication statusPublished - 2022

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc. All rights reserved.

    Research areas

  • Circadian rhythm, Dopamine, Dreaming, GABA, Kleine–Levin syndrome, Narcolepsy, Rapid eye movement behavior disorder, Restless legs syndrome, Serotonin, Sleep, Sleep homeostasis

ID: 326842036