Jesper Velgaard Olsen

Jesper Velgaard Olsen

Professor, Deputy Head of Centre

ORCID: 0000-0002-4747-4938

Jesper Olsen studied analytical chemistry in the group of Roman Zubarev at the University of Southern Denmark in Odense, and obtained his PhD in biochemistry and molecular biology in the laboratory of Matthias Mann. During his PhD he was involved in developing high-resolution mass spectrometry-based proteomics. He spent 4 years as a post-doctoral fellow at the Max Planck Institute for Biochemistry in Munich, where he developed a quantitative phosphoproteomics technology that was applied to global time-resolved analyses of cell signaling pathways in human cells. In 2009, Jesper was recruited back to Denmark to head a group at the newly established Novo Nordisk Foundation Center for Protein Research (CPR) at University of Copenhagen. In 2012, he was promoted to vice director of CPR and in 2014 full professor. Jesper has received a number of research awards including the Max Planck Institute for Biochemistry Junior Research Award and HUPO Young Investigator Award in Proteomic Sciences.

Selected publications

  1. Published

    Rapid and site-specific deep phosphoproteome profiling by data-independent acquisition without the need for spectral libraries

    Bekker-Jensen, D. B., Bernhardt, O. M., Hogrebe, A., Martinez Del Val, Ana, Verbeke, L., Gandhi, T., Kelstrup, C. D., Reiter, L. & Olsen, Jesper Velgaard, 2020, In: Nature Communications. 11, 1, 12 p., 787.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

    Lundby, Alicia, Franciosa, Giulia, Emdal, Kristina Bennet, Refsgaard, J. C., Gnosa, S. P., Bekker-Jensen, D. B., Secher, A., Maurya, S. R., Paul, I., Mendez, B. L., Kelstrup, C. D., Francavilla, C., Kveiborg, Marie, Montoya, Guillermo, Jensen, Lars Juhl & Olsen, Jesper Velgaard, 2019, In: Cell. 179, 2, p. 543-560

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny

    Cappellini, Enrico, Welker, Frido, Pandolfi, L., Ramos Madrigal, Jazmin, Samodova-Sommer, Diana, Rüther, P. L., Fotaki, Anna Katerina, Lyon, D., Moreno Mayar, J. Víctor, Bukhsianidze, M., Rakownikow Jersie-Christensen, R., Mackie, M., Ginolhac, A., Ferring, R., Tappen, M., Palkopoulou, E., Dickinson, M. R., Stafford, T. W., Chan, Y. L., Götherström, A., Nathan, S. K. S. S., Heintzman, P. D., Kapp, J. D., Kirillova, I., Moodley, Y., Agusti, J., Kahlke, R. D., Kiladze, G., Martínez-Navarro, B., Liu, Shanlin, Sandoval-Velasco, Marcela, Sinding, Mikkel Holger Strander, Kelstrup, C. D., Allentoft, Morten Erik, Orlando, L., Penkman, K., Shapiro, B., Rook, L., Dalén, L., Gilbert, M Thomas P, Olsen, Jesper Velgaard, Lordkipanidze, D. & Willerslev, Eske, 2019, In: Nature. 574, 7776, p. 103-107

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates

    Jakobsson, M. E., Małecki, J. M., Halabelian, L., Nilges, B. S., Pinto, R., Kudithipudi, S., Munk, S., Davydova, E., Zuhairi, F. R., Arrowsmith, C. H., Jeltsch, A., Leidel, S. A., Olsen, Jesper Velgaard & Falnes, P. Ø., 2018, In: Nature Communications. 9, 1, 3411.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling

    Batth, Tanveer Singh, Papetti, M., Pfeiffer, A., Tollenaere, M. A. X., Francavilla, C. & Olsen, Jesper Velgaard, 2018, In: Cell Reports. 22, 10, p. 2784-2796 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

    Emdal, Kristina Bennet, Pedersen, Anna-Kathrine, Bekker-Jensen, D. B., Lundby, Alicia, Claeys, S., De Preter, K., Speleman, F., Francavilla, C. & Olsen, Jesper Velgaard, 20 Nov 2018, In: Science Signaling. 11, 557, p. 1-17 17 p., eaap9752.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Quantitative metaproteomics of medieval dental calculus reveals individual oral health status

    Jersie-Christensen, R. R., Lanigan, Liam Thomas, Lyon, D., Mackie, M., Midjord-Belstrøm, Daniel, Kelstrup, C. D., Fotaki, Anna Katerina, Willerslev, Eske, Lynnerup, Niels, Jensen, Lars Juhl, Cappellini, Enrico & Olsen, Jesper Velgaard, 2018, In: Nature Communications. 9, p. 1-12 4744.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Benchmarking common quantification strategies for large-scale phosphoproteomics

    Hogrebe, A., von Stechow, L., Bekker-Jensen, D. B., Weinert, Brian Tate, Kelstrup, C. D. & Olsen, Jesper Velgaard, 2018, In: Nature Communications. 9, 1, p. 1-13 1045.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes

    Bekker-Jensen, D. B., Kelstrup, C. D., Batth, Tanveer Singh, Buch-Larsen, Sara Charlotte, Haldrup, C., Bramsen, J. B., Sørensen, K. D., Høyer, S., Ørntoft, T. F., Andersen, C. L., Nielsen, Michael Lund & Olsen, Jesper Velgaard, 2017, In: Cell Systems. 4, 6, p. 587-599, e1-e4 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking

    Francavilla, C., Papetti, M., Rigbolt, K. T. G., Pedersen, Anna-Kathrine, Sigurdsson, J. O., Cazzamali, G., Karemore, Gopal, Blagoev, B. & Olsen, Jesper Velgaard, Jun 2016, In: Nature Structural and Molecular Biology. 23, 6, p. 608–618 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Analytic framework for peptidomics applied to large-scale neuropeptide identification

    Secher, A., Kelstrup, C. D., Conde-Frieboes, K. W., Pyke, C., Raun, K., Wulff, B. S. & Olsen, Jesper Velgaard, 2016, In: Nature Communications. 7, 10 p., 11436.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Rapid and Deep Proteomes by Faster Sequencing on a Benchtop Quadrupole Ultra-High-Field Orbitrap Mass Spectrometer

    Kelstrup, C. D., Jersie-Christensen, R. R., Batth, Tanveer Singh, Arrey, T. N., Kuehn, A., Kellmann, M. & Olsen, Jesper Velgaard, 28 Oct 2014, In: Journal of Proteome Research. 13, 12, p. 6187-95 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

    Lundby, Alicia, Rossin, E. J., Steffensen, Annette Buur, Acha, M. R., Newton-Cheh, C., Pfeufer, A., Lynch, S. N., Olesen, Søren-Peter, Brunak, Søren, Ellinor, P. T., Jukema, J. W., Trompet, S., Ford, I., Macfarlane, P. W., Krijthe, B. P., Hofman, A., Uitterlinden, A. G., Stricker, B. H., Nathoe, H. M., Spiering, W., Daly, M. J., Asselbergs, F. W., van der Harst, P., Milan, D. J., de Bakker, P. I. W., Hansen, K. L., Olsen, Jesper Velgaard & The QT Interval International GWAS Consortium (QT-IGC), T. Q. I. I. G. C. (., 22 Jun 2014, In: Nature Methods. 11, 8, p. 868-874 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs

    Francavilla, C., Rigbolt, K. T. G., Emdal, Kristina Bennet, Carraro, G., Vernet, E., Bekker-Jensen, D. B., Streicher, W., Wikström, M., Sundström, M., Bellusci, S., Cavallaro, U., Blagoev, B. & Olsen, Jesper Velgaard, 26 Sep 2013, In: Molecular Cell. 51, 6, p. 707-22 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Optimized Fast and Sensitive Acquisition Methods for Shotgun Proteomics on a Quadrupole Orbitrap Mass Spectrometer

    Kelstrup, C. D., Young, C., Lavallee, R., Nielsen, Michael Lund & Olsen, Jesper Velgaard, 2012, In: Journal of Proteome Research. p. 3487-3497 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 9925376