Jesper Velgaard Olsen

Jesper Velgaard Olsen

Professor, Deputy Head of Centre, Professor

Member of:

    Jesper Olsen studied analytical chemistry in the group of Roman Zubarev at the University of Southern Denmark in Odense, and obtained his PhD in biochemistry and molecular biology in the laboratory of Matthias Mann. During his PhD he was involved in developing high-resolution mass spectrometry-based proteomics. He spent 4 years as a post-doctoral fellow at the Max Planck Institute for Biochemistry in Munich, where he developed a quantitative phosphoproteomics technology that was applied to global time-resolved analyses of cell signaling pathways in human cells. In 2009, Jesper was recruited back to Denmark to head a group at the newly established Novo Nordisk Foundation Center for Protein Research (CPR) at University of Copenhagen. In 2012, he was promoted to vice director of CPR and in 2014 full professor. Jesper has received a number of research awards including the Max Planck Institute for Biochemistry Junior Research Award and HUPO Young Investigator Award in Proteomic Sciences.

    Selected publications

    1. Published

      Rapid and site-specific deep phosphoproteome profiling by data-independent acquisition without the need for spectral libraries

      Bekker-Jensen, D. B., Bernhardt, O. M., Hogrebe, A., Martinez Del Val, Ana, Verbeke, L., Gandhi, T., Kelstrup, C. D., Reiter, L. & Olsen, Jesper Velgaard, 2020, In: Nature Communications. 11, 1, 12 p., 787.

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. Published

      Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

      Lundby, Alicia, Franciosa, Giulia, Emdal, Kristina Bennet, Refsgaard, J. C., Gnosa, S. P., Bekker-Jensen, D. B., Secher, A., Maurya, S. R., Paul, I., Mendez, B. L., Kelstrup, C. D., Francavilla, C., Kveiborg, Marie, Montoya, Guillermo, Jensen, Lars Juhl & Olsen, Jesper Velgaard, 2019, In: Cell. 179, 2, p. 543-560

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny

      Cappellini, E., Welker, F., Pandolfi, L., Ramos-Madrigal, J., Samodova, D., Rüther, P. L., Fotakis, A. K., Lyon, D., Moreno-Mayar, J. V., Bukhsianidze, M., Rakownikow Jersie-Christensen, R., Mackie, M., Ginolhac, A., Ferring, R., Tappen, M., Palkopoulou, E., Dickinson, M. R., Stafford, T. W., Chan, Y. L., Götherström, A. & 23 others, Nathan, S. K. S. S., Heintzman, P. D., Kapp, J. D., Kirillova, I., Moodley, Y., Agusti, J., Kahlke, R. D., Kiladze, G., Martínez-Navarro, B., Liu, Shanlin, Sandoval-Velasco, Marcela, Sinding, Mikkel Holger Strander, Kelstrup, C. D., Allentoft, Morten Erik, Orlando, L., Penkman, K., Shapiro, B., Rook, L., Dalén, L., Gilbert, M Thomas P, Olsen, Jesper Velgaard, Lordkipanidze, D. & Willerslev, Eske, 2019, In: Nature. 574, 7776, p. 103-107

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates

      Jakobsson, M. E., Małecki, J. M., Halabelian, L., Nilges, B. S., Pinto, R., Kudithipudi, S., Munk, S., Davydova, E., Zuhairi, F. R., Arrowsmith, C. H., Jeltsch, A., Leidel, S. A., Olsen, Jesper Velgaard & Falnes, P. Ø., 2018, In: Nature Communications. 9, 1, 3411.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling

      Batth, Tanveer Singh, Papetti, M., Pfeiffer, A., Tollenaere, M. A. X., Francavilla, C. & Olsen, Jesper Velgaard, 2018, In: Cell Reports. 22, 10, p. 2784-2796 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma

      Emdal, Kristina Bennet, Pedersen, Anna-Kathrine, Bekker-Jensen, D. B., Lundby, Alicia, Claeys, S., De Preter, K., Speleman, F., Francavilla, C. & Olsen, Jesper Velgaard, 20 Nov 2018, In: Science Signaling. 11, 557, p. 1-17 17 p., eaap9752.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Quantitative metaproteomics of medieval dental calculus reveals individual oral health status

      Jersie-Christensen, R. R., Lanigan, Liam Thomas, Lyon, D., Mackie, M., Midjord-Belstrøm, Daniel, Kelstrup, C. D., Fotaki, Anna Katerina, Willerslev, Eske, Lynnerup, Niels, Jensen, Lars Juhl, Cappellini, Enrico & Olsen, Jesper Velgaard, 2018, In: Nature Communications. 9, p. 1-12 4744.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Benchmarking common quantification strategies for large-scale phosphoproteomics

      Hogrebe, A., von Stechow, L., Bekker-Jensen, D. B., Weinert, B. T., Kelstrup, C. D. & Olsen, Jesper Velgaard, 2018, In: Nature Communications. 9, 1, p. 1-13 1045.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes

      Bekker-Jensen, D. B., Kelstrup, C. D., Batth, Tanveer Singh, Buch-Larsen, Sara Charlotte, Haldrup, C., Bramsen, J. B., Sørensen, K. D., Høyer, S., Ørntoft, T. F., Andersen, C. L., Nielsen, Michael Lund & Olsen, Jesper Velgaard, 2017, In: Cell Systems. 4, 6, p. 587-599, e1-e4 18 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking

      Francavilla, C., Papetti, M., Rigbolt, K. T. G., Pedersen, Anna-Kathrine, Sigurdsson, J. O., Cazzamali, G., Karemore, G., Blagoev, B. & Olsen, Jesper Velgaard, Jun 2016, In: Nature Structural and Molecular Biology. 23, 6, p. 608–618 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Analytic framework for peptidomics applied to large-scale neuropeptide identification

      Secher, A., Kelstrup, C. D., Conde-Frieboes, K. W., Pyke, C., Raun, K., Wulff, B. S. & Olsen, Jesper Velgaard, 2016, In: Nature Communications. 7, 10 p., 11436.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Rapid and Deep Proteomes by Faster Sequencing on a Benchtop Quadrupole Ultra-High-Field Orbitrap Mass Spectrometer

      Kelstrup, C. D., Jersie-Christensen, R. R., Batth, Tanveer Singh, Arrey, T. N., Kuehn, A., Kellmann, M. & Olsen, Jesper Velgaard, 28 Oct 2014, In: Journal of Proteome Research. 13, 12, p. 6187-95 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published

      Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

      Lundby, A., Rossin, E. J., Steffensen, A. B., Acha, M. R., Newton-Cheh, C., Pfeufer, A., Lynch, S. N., Olesen, S-P., Brunak, S., Ellinor, P. T., Jukema, J. W., Trompet, S., Ford, I., Macfarlane, P. W., Krijthe, B. P., Hofman, A., Uitterlinden, A. G., Stricker, B. H., Nathoe, H. M., Spiering, W. & 8 others, Daly, M. J., Asselbergs, F. W., van der Harst, P., Milan, D. J., de Bakker, P. I. W., Hansen, K. L., Olsen, Jesper Velgaard & The QT Interval International GWAS Consortium (QT-IGC), T. Q. I. I. G. C. (., 22 Jun 2014, In: Nature Methods. 11, 8, p. 868-874 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs

      Francavilla, C., Rigbolt, K. T. G., Emdal, Kristina Bennet, Carraro, G., Vernet, E., Bekker-Jensen, D. B., Streicher, W., Wikström, M., Sundström, M., Bellusci, S., Cavallaro, U., Blagoev, B. & Olsen, Jesper Velgaard, 26 Sep 2013, In: Molecular Cell. 51, 6, p. 707-22 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      Optimized Fast and Sensitive Acquisition Methods for Shotgun Proteomics on a Quadrupole Orbitrap Mass Spectrometer

      Kelstrup, C. D., Young, C., Lavallee, R., Nielsen, Michael Lund & Olsen, Jesper Velgaard, 2012, In: Journal of Proteome Research. p. 3487-3497 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    ID: 9925376