Birgitte Rahbek Kornum
Guest Researcher, Associate Professor - Promotion Programme
Molecular and Cellular Pharmacology
Jagtvej 160
2100 København Ø
Molecular Neuroscience
Blegdamsvej 3
2200 København N
- 2002
Attenuation and scatter correction in myocardial SPET: improved diagnostic accuracy in patients with suspected coronary artery disease.
Kjaer, A., Cortsen, A., Kornum, Birgitte Rahbek, Hasseldam, Henrik & Hesse, B., 2002, In: European Journal of Nuclear Medicine and Molecular Imaging. 29, 11, p. 1438-42 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain
Aznar, S., Qian, Z., Shah, R., Kornum, Birgitte Rahbek & Knudsen, Gitte Moos, 3 Jan 2003, In: Brain Research. 959, 1, p. 58-67 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemes
Kornum, Birgitte Rahbek, Licht, C. L., Weikop, P., Knudsen, G. M. & Kleijn, S. A., 9 Jan 2006, In: Neuroscience Letters. 392, 1-2, p. 129-34 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus
Kornum, Birgitte Rahbek, Weikop, Pia, Moller, A., Ronn, L. C. B., Knudsen, Gitte Moos & Aznar, S., 16 Feb 2006, In: Brain Research. 1073-1074, p. 262-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
The effect of the inter-phase delay interval in the spontaneous object recognition test for pigs
Kornum, Birgitte Rahbek, Thygesen, K. S., Nielsen, Thomas Rune, Knudsen, Gitte Moos & Lind, N. M., 6 Aug 2007, In: Behavioural Brain Research. 181, 2, p. 210-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
A novel spatial Delayed Non-Match to Sample (DNMS) task in the Göttingen minipig
Nielsen, T. R., Kornum, Birgitte Rahbek, Moustgaard, A. C., Gade, A., Lind, N. M. & Knudsen, Gitte Moos, 2008, In: Behavioural Brain Research. p. 93-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of the novel 5-HT4 receptor PET ligand (11C)SB207145 in the Göttingen minnipig
Kornum, Birgitte Rahbek, Lind, N. M., Gillings, N. M., Marner, L., Andersen, F. & Knudsen, G. M., 2008, In: Comprehensive Medline. 1, p. 186-96 10 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- 2009
- Published
A pig model for studies of serotonergic mechanisms in memory disorders
Kornum, Birgitte Rahbek, 2009, København: Museum Tusculanum. 69 p.Research output: Book/Report › Ph.D. thesis › Research
- Published
Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport
Syvanen, S., Lindhe, O., Palner, M., Kornum, Birgitte Rahbek, Rahman, O., Langstrom, B., Knudsen, Gitte Moos & Hammarlund-Udenaes, M., 2009, In: Drug Metabolism and Disposition. 37, 3, p. 635-643 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig
Kornum, Birgitte Rahbek, Lind, N. M., Gillings, N., Marner, Lisbeth, Andersen, F. & Knudsen, Gitte Moos, 1 Jan 2009, In: Journal of Cerebral Blood Flow and Metabolism. 29, 1, p. 186-96 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain
Kornum, Birgitte Rahbek, Stott, S. R. W., Mattsson, B., Wisman, L., Ettrup, A., Hermening, S., Knudsen, Gitte Moos & Kirik, D., 1 Mar 2010, In: Experimental Neurology. 222, 1, p. 70-85 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET
Ettrup, A., Palner, M., Gillings, N., Santini, M. A., Hansen, M., Kornum, Birgitte Rahbek, Rasmussen, L. K., Någren, K., Madsen, J., Begtrup, M. & Knudsen, Gitte Moos, 1 Nov 2010, In: Journal of Nuclear Medicine. 51, 11, p. 1763-1770Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
An approach for serotonin depletion in pigs: effects on serotonin receptor binding
Ettrup, A., Kornum, Birgitte Rahbek, Weikop, P. & Knudsen, Gitte Moos, 2011, In: Synapse. 65, 2, p. 136-45 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research
Kornum, Birgitte Rahbek & Knudsen, Gitte Moos, 2011, In: Neuroscience & Biobehavioral Reviews. 35, 3, p. 437-51 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Common variants in P2RY11 are associated with narcolepsy
Kornum, B. R., Kawashima, M., Faraco, J., Lin, L., Rico, T. J., Hesselson, S., Axtell, R. C., Kuipers, H., Weiner, K., Hamacher, A., Kassack, M. U., Han, F., Knudsen, S., Li, J., Dong, X., Winkelmann, J., Plazzi, G., Nevsimalova, S., Hong, S-C., Honda, Y. & 30 others, , Jan 2011, In: Nature Genetics. 43, 1, p. 66-71 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain
Kornum, Birgitte Rahbek, Faraco, J. & Mignot, E., Dec 2011, In: Current Opinion in Neurobiology. 21, 6, p. 897-903 7 p.Research output: Contribution to journal › Review › Research › peer-review
- 2012
- Published
Early IVIg treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiency
Knudsen, S., Biering-Sørensen, B., Kornum, Birgitte Rahbek, Petersen, E., Ibsen, J. D., Gammeltoft, S., Mignot, E. & Jennum, Poul, 2012, In: Neurology. 79, 1, p. 102-3 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy
Andlauer, O., Moore, H., Hong, S., Dauvilliers, Y., Kanbayashi, T., Nishino, S., Han, F., Silber, M. H., Rico, T., Einen, M., Kornum, Birgitte Rahbek, Jennum, Poul, Knudsen, S., Nevsimalova, S., Poli, F., Plazzi, G. & Mignot, E., 2012, In: Sleep. 35, 9, p. 1247-55FResearch output: Contribution to journal › Journal article › Research › peer-review
- Published
DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status
Weiner Lachmi, K., Lin, L., Kornum, Birgitte Rahbek, Rico, T., Lo, B., Aran, A. & Mignot, E., Apr 2012, In: Human Immunology. 73, 4, p. 405-10 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy
Winkelmann, J., Lin, L., Schormair, B., Kornum, Birgitte Rahbek, Faraco, J., Plazzi, G., Melberg, A., Cornelio, F., Urban, A. E., Pizza, F., Poli, F., Grubert, F., Wieland, T., Graf, E., Hallmayer, J., Strom, T. M. & Mignot, E., 15 May 2012, In: Human Molecular Genetics. 21, 10, p. 2205-10 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
Association mellem narkolepsi og H1N1-influenza
Kornum, Birgitte Rahbek, Knudsen, S., Gammeltoft, S. & Jennum, Poul, 2013, In: Ugeskrift for Laeger. 175, 12, p. 815Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hjernens regulering af søvn
Gammeltoft, S., Nordvang, A. H. & Kornum, Birgitte Rahbek, 2013, Søvn. Jennum, P. (ed.). 1 ed. København: Munksgaard , p. 39-50 12 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy
Faraco, J., Lin, L., Kornum, B. R., Kenny, E. E., Trynka, G., Einen, M., Rico, T. J., Lichtner, P., Dauvilliers, Y., Arnulf, I., Lecendreux, M., Javidi, S., Geisler, P., Mayer, G., Pizza, F., Poli, F., Plazzi, G., Overeem, S., Lammers, G. J., Kemlink, D. & 28 others, , 2013, In: P L o S Genetics (Online). 9, 2, 7 p., e1003270.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
5-HT radioligands for human brain imaging with PET and SPECT
Paterson, L. M., Kornum, Birgitte Rahbek, Nutt, D. J., Pike, V. W. & Knudsen, Gitte Moos, Jan 2013, In: Medicinal Research Reviews. 33, 1, p. 54-111 58 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy
De la Herrán-Arita, A. K., Kornum, Birgitte Rahbek, Mahlios, J., Jiang, W., Lin, L., Hou, T., Macaubas, C., Einen, M., Plazzi, G., Crowe, C., Newell, E. W., Davis, M. M., Mellins, E. D. & Mignot, E., 18 Dec 2013, In: Science Translational Medicine. 5, 216, p. 216ra176Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination
Partinen, M., Kornum, Birgitte Rahbek, Plazzi, G., Jennum, Poul, Julkunen, I. & Vaarala, O., 2014, In: Lancet Neurology. 13, 6, p. 600-13Research output: Contribution to journal › Review › Research › peer-review
- Published
Retraction of the research article: "CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy"
De la Herrán-Arita, A. K., Kornum, Birgitte Rahbek, Mahlios, J., Jiang, W., Lin, L., Hou, T., Macaubas, C., Einen, M., Plazzi, G., Crowe, C., Newell, E. W., Davis, M. M., Mellins, E. D. & Mignot, E., 30 Jul 2014, In: Science Translational Medicine. 6, 247, 247rt1.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
miRNA profiles in plasma from patients with sleep disorders reveal dysregulation of miRNAs in narcolepsy and other central hypersomnias
Holm, A., Bang-Berthelsen, C. H., Knudsen, S., Kornum, Birgitte Rahbek, Modvig, S., Jennum, Poul & Gammeltoft, S., Sep 2014, In: Sleep. 37, 9, p. 1525-1533 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does autoreactivity have a role in narcolepsy?
Partinen, M., Kornum, Birgitte Rahbek, Plazzi, G., Jennum, Poul, Julkunen, I. & Vaarala, O., Nov 2014, In: Lancet Neurology. 13, 11, p. 1072-1073 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
miRNA profiles in cerebrospinal fluid from patients with central hypersomnias
Holm, A., Bang-Berthelsen, C. H., Knudsen, S., Modvig, S., Kornum, Birgitte Rahbek, Gammeltoft, S. & Jennum, Poul, 15 Dec 2014, In: Journal of the Neurological Sciences. 347, 1-2, p. 199-204 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
EIF3G is associated with narcolepsy across ethnicities
Holm, A., Lin, L., Faraco, J., Mostafavi, S., Battle, A., Zhu, X., Levinson, D. F., Han, F., Gammeltoft, S., Jennum, Poul, Mignot, E. & Kornum, Birgitte Rahbek, 2015, In: European Journal of Human Genetics. 23, 11, p. 1573-80 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An optimized method for measuring hypocretin-1 peptide in the mouse brain reveals differential circadian regulation of hypocretin-1 levels rostral and caudal to the hypothalamus
Justinussen, Jessica, Holm, A. & Kornum, Birgitte Rahbek, 2015, In: Neuroscience. 310, p. 354-361 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sleep Disorders
Kornum, Birgitte Rahbek & Mignot, E., 1 Jan 2015, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. Zigmond, M. J., Rowland, L. P. & Coyle, J. T. (eds.). London: Elsevier Science Inc., p. 585-611 27 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy
Ollila, H. M., Ravel, J-M., Han, F., Faraco, J., Lin, L., Zheng, X., Plazzi, G., Dauvilliers, Y., Pizza, F., Hong, S-C., Jennum, P., Knudsen, S., Kornum, B. R., Dong, X. S., Yan, H., Hong, H., Coquillard, C., Mahlios, J., Jolanki, O., Einen, M. & 15 others, , 8 Jan 2015, In: American Journal of Human Genetics. 96, 1, p. 136-46 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Serum cytokine levels in Kleine-Levin syndrome
Kornum, Birgitte Rahbek, Rico, T., Lin, L., Huang, Y., Arnulf, I., Jennum, Poul & Mignot, E., Aug 2015, In: Sleep Medicine. 16, 8, p. 961-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Type 1 narcolepsy: a CD8+ T cell-mediated disease?
Degn, M. & Kornum, Birgitte Rahbek, Sep 2015, In: Annals of the New York Academy of Sciences. 1351, p. 80-88 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset
Kornum, Birgitte Rahbek, Pizza, F., Knudsen, S., Plazzi, G., Jennum, Poul & Mignot, E., Oct 2015, In: Brain, Behavior, and Immunity. 49, p. 54-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Cerebrospinal Fluid Hypocretin-1 (Orexin-A) Level Fluctuates with Season and Correlates with Day Length
Boddum, K., Hansen, M. H., Jennum, Poul & Kornum, Birgitte Rahbek, 2016, In: PloS one. 11, 3, 13 p., e0151288.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Precipitants of Narcolepsy: Vaccines and Infections
Kornum, Birgitte Rahbek, 2016, Narcolepsy: A Clinical Guide. 2 ed. Springer, p. 25-33 9 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education › peer-review
- Published
The European Narcolepsy Network (EU-NN) database
Khatami, R., Luca, G., Baumann, C. R., Bassetti, C. L., Bruni, O., Canellas, F., Dauvilliers, Y., Del Rio-Villegas, R., Feketeova, E., Ferri, R., Geisler, P., Högl, B., Jennum, P., Kornum, B. R., Lecendreux, M., Martins-da-Silva, A., Mathis, J., Mayer, G., Paiva, T., Partinen, M. & 11 others, , Jun 2016, In: Journal of Sleep Research. 25, 3, p. 356-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Monozygotic twins discordant for narcolepsy type 1 and multiple sclerosis
Jennum, Poul, Kornum, Birgitte Rahbek, Issa, N. M., Gammeltoft, S., Tommerup, Niels, Morling, Niels, Tümer, Asuman Zeynep & Knudsen, S., Aug 2016, In: Neurology: Neuroimmunology & Neuroinflammation. 3, 4, 2 p., e249.Research output: Contribution to journal › Letter › Research › peer-review
- Published
A critical look at the function of the P2Y11 receptor
Dreisig, K. & Kornum, Birgitte Rahbek, Sep 2016, In: Purinergic Signalling. 12, 3, p. 427-37 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Validation of antibodies for neuroanatomical localization of the P2Y receptor in macaque brain
Dreisig, K., Degn, M., Sund, L., Hadaczek, P., Samaranch, L., San Sebastian, W., Bankiewicz, K. & Kornum, Birgitte Rahbek, Dec 2016, In: Journal of Chemical Neuroanatomy. 78, p. 25-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurobasal media facilitates increased specificity of siRNA-mediated knockdown in primary cerebellar cultures
Gustafsson, J. R., Katsioudi, G., Issazadeh-Navikas, Shohreh & Kornum, Birgitte Rahbek, 1 Dec 2016, In: Journal of Neuroscience Methods. 274, p. 116-124 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Absence of autoreactive CD4(+) T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot
Kornum, Birgitte Rahbek, Burgdorf, Kristoffer Sølvsten, Holm, A., Ullum, H., Jennum, Poul & Knudsen, S., 2017, In: Journal of Neuroimmunology. 309, p. 7-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetics of Human Sleep and Sleep Disorders
Kornum, Birgitte Rahbek, 2017, Handbook of Neurobehavioural Genetics and Phenotyping. Tucci, V. (ed.). 1 ed. New Jersey: Wiley-Blackwell, p. 295-320 26 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
Narcolepsy
Kornum, Birgitte Rahbek, Knudsen, S., Ollila, H. M., Pizza, F., Jennum, Poul, Dauvilliers, Y. & Overeem, S., 2017, In: Nature Reviews. Disease Primers. 3, 19 p., 16100.Research output: Contribution to journal › Review › Research › peer-review
- Published
The evolutionary conserved microrna MIR-137 regulates gene expression and diurnal rhythm of the wake-promoting hypocretin neuropeptides
Holm, A., Moseholm, Kristine Frøsig, Justinussen, Jessica, Silahtaroglu, Asli, Adamantidis, A. & Kornum, Birgitte Rahbek, 2017, In: Sleep Medicine. 40, Supplement 1, p. E132-E133 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy
Jennum, Poul, Østergaard Pedersen, L., Czarna Bahl, J. M., Modvig, S., Fog, K., Holm, A., Kornum, Birgitte Rahbek & Gammeltoft, S., 1 Jan 2017, In: Sleep. 40, 1, 9 p., zsw006.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Normal Morning Melanin-Concentrating Hormone Levels and No Association with Rapid Eye Movement or Non-Rapid Eye Movement Sleep Parameters in Narcolepsy Type 1 and Type 2
Schrölkamp, Maren, Jennum, Poul, Gammeltoft, S., Holm, A., Kornum, Birgitte Rahbek & Knudsen, S., Feb 2017, In: Journal of Clinical Sleep Medicine. 13, 2, p. 235-243 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel method for evaluation of eye movements in patients with narcolepsy
Christensen, J. A. E., Kempfner, L., Leonthin, H. L., Hvidtfelt, M., Nikolic, M., Kornum, Birgitte Rahbek & Jennum, Poul, May 2017, In: Sleep Medicine. 33, p. 171-180 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sleep spindle density in narcolepsy
Christensen, J. A. E., Nikolic, M., Hvidtfelt, M., Kornum, Birgitte Rahbek & Jennum, Poul, Jun 2017, In: Sleep Medicine. 34, p. 40-49 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sleep-wake stability in narcolepsy patients with normal, low and unmeasurable hypocretin levels
Hansen, M. H., Kornum, Birgitte Rahbek & Jennum, Poul, Jun 2017, In: Sleep Medicine. 34, p. 1-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Rare missense mutations in P2RY11 in narcolepsy with cataplexy
Degn, M., Dauvilliers, Y., Dreisig, K., Lopez, R., Pfister, C., Pradervand, S., Kornum, Birgitte Rahbek & Tafti, M., 1 Jun 2017, In: Brain. 140, 6, p. 1657-1668 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
DNMT1 regulates expression of MHC class I in post-mitotic neurons
Gustafsson, J. R., Katsioudi, G., Degn, M., Ejlerskov, P., Issazadeh-Navikas, Shohreh & Kornum, Birgitte Rahbek, 2018, In: Molecular Brain. 11, 1, p. 1-16 16 p., 36.Research output: Contribution to journal › Journal article › Research › peer-review
Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease
Moresco, M., Lecciso, M., Ocadlikova, D., Filardi, M., Melzi, S., Kornum, Birgitte Rahbek, Antelmi, E., Pizza, F., Mignot, E., Curti, A. & Plazzi, G., 2018, In: Sleep Medicine. 44, p. 53-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human P2Y11 expression level affects human P2X7 receptor-mediated cell death
Dreisig, K., Sund, L., Dommer, M. W., Kristensen, N. P., Boddum, K., Viste, R., Fredholm, S., Ødum, Niels, Jäättelä, M., Skov, Søren & Kornum, Birgitte Rahbek, 2018, In: Frontiers in Immunology. 9, JUN, 12 p., 1159.Research output: Contribution to journal › Journal article › Research › peer-review
Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells
Zager, A., Brandão, W. N., Margatho, R. O., Cruz, D. S. G., Peron, J. P., Tufik, S., Andersen, M. L., Moresco, M., Pizza, F., Plazzi, G., Kornum, Birgitte Rahbek & Palermo-Neto, J., 2018, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 81, p. 297-305 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
N-terminal tagging of human P2X7 receptor disturbs calcium influx and dye uptake
Dreisig, K., Kristensen, N. P., Dommer, M. W., Jørgensen, N. R. & Kornum, Birgitte Rahbek, 2018, In: Purinergic Signalling. 14, 1, p. 83-90 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
The wake-promoting drug Modafinil prevents motor impairment in sickness behavior induced by LPS in mice: Role for dopaminergic D1 receptor
Zager, A., Brandão, W. N., Margatho, R. O., Peron, J. P., Tufik, S., Andersen, M. L., Kornum, Birgitte Rahbek & Palermo-Neto, J., 2018, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 81, p. 468-476 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints
Torstensen, E. W., Brinth, L. S., Mehlsen, J., Kornum, Birgitte Rahbek & Jennum, Poul, 2018, In: Danish Medical Journal. 65, 11, 4 p., A5510.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations
Dommer, M. W., Dreisig, K. & Kornum, Birgitte Rahbek, 2019, In: Pharmacological Reports. 71, 5, p. 926-928 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens
Pedersen, N. W., Holm, A., Kristensen, N. P., Bjerregaard, A., Bentzen, A. K., Marquard, A. M., Tamhane, T., Burgdorf, K. S., Ullum, H., Jennum, Poul, Knudsen, S., Hadrup, S. R. & Kornum, Birgitte Rahbek, 2019, In: Nature Communications. 10, p. 1-12 837.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CHARACTERIZATION OF REGULATORY NETWORKS BY MULTI-OMICS COMBINING PROTEOMICS WITH BULK AND SINGLE-CELL RNA SEQUENCING IN A DIET-INDUCED AND BIOPSY-CONFIRMED MOUSE MODEL OF NON-ALCOHOLIC STEATOHEPATITIS
AEgidius, H., Veidal, S., Feigh, M., Puglia, M., Hallenborg, P., Vrang, N., Jelsing, J., Kornum, Birgitte Rahbek, Blagoev, B. & Rigbolt, K., 2019, In: Hepatology. 70, Supplement 1, p. 1278A-1279A 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Forstå din søvn: Hvad videnskaben siger om at sove godt, og hvordan du opnår det!
Kornum, Birgitte Rahbek, 2019, 1 ed. København: Gyldendal. 205 p.Research output: Book/Report › Book › Communication
- Published
In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
Jiang, W., Birtley, J. R., Hung, S. C., Wang, W., Chiou, S. H., Macaubas, C., Kornum, Birgitte Rahbek, Tian, L., Huang, H., Adler, L., Weaver, G., Lu, L., Ilstad-Minnihan, A., Somasundaram, S., Ayyangar, S., Davis, M. M., Stern, L. J. & Mellins, E. D., 2019, In: Nature Communications. 10, 1, 17 p., 5247.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment
Bassetti, C. L. A., Adamantidis, A., Burdakov, D., Han, F., Gay, S., Kallweit, U., Khatami, R., Koning, F., Kornum, Birgitte Rahbek, Lammers, G. J., Liblau, R. S., Luppi, P. H., Mayer, G., Pollmaecher, T., Sakurai, T., Sallusto, F., Scammell, T. E., Tafti, M. & Dauvilliers, Y., 2019, In: Nature Reviews. Neurology. 15, 9, p. 519-539Research output: Contribution to journal › Review › Research › peer-review
- Published
Sandwich cortial lamination and single-cell analysis decodes the developing spatial processing system
Liu, Y., Bergmann, T. B., Lee, J., Pfisterer, U. G., Handfield, L-F., Mori, Y., Asenjo Martinez, A., Lisa Vargas, I., Seemann, E. S., Lee, J. T. H., Patikis, N., Peralvo Vidal, J. M., Pihl, M., Kornum, B. R., Thomsen, P. D., Hyttel, P., Witter, M., Khodosevich, K., Gorodkin, J., Hemberg, M. & 2 others, , 2019. 45 p.Research output: Contribution to conference › Paper › Communication
- Published
Unge forskere: S-løftebrud er en katastrofe for universiteterne
Aguirre, V., Andersen, C., Andersen, P. R., Bjørk, R., Clemmensen, C., Dalsgaard, P., Danbolt, M., Dimke, H., Engberg-Pedersen, A., Feliu, E., Jauffred, L., Jønsson, K., Kornum, B. R., Kropp, K., Laustsen, A., Levisen, C., Lock, N., Lomborg, S., Møller, N. M., Niss, K. & 5 others, , 2019Research output: Other contribution › Communication
- 2020
- Published
A CLASS OF SMALL-MOLECULE COMPOUNDS AND THEIR PRODRUGS FOR INTERVENTION WITH CAMK2A, AND THEIR USE IN ACUTE BRAIN INJURIES AND CENTRAL HYPERSOMNIAS
Frølund, Bente, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2020, Patent No. WO2020151795, 30 Jul 2020, Priority date 21 Jan 2019, Priority No. DK2019PA70040 20190121Research output: Patent
- Published
Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes
Hauglund, Natalie Linea, Kusk, P., Kornum, Birgitte Rahbek & Nedergaard, Maiken, 2020, In: Journal of Neuroscience. 40, 11, p. 2371-2380 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis
Ægidius, H. M., Veidal, S. S., Feigh, M., Hallenborg, P., Puglia, M., Pers, Tune H, Vrang, N., Jelsing, J., Kornum, Birgitte Rahbek, Blagoev, B. & Rigbolt, K. T. G., 2020, In: Scientific Reports. 10, 1, 12 p., 1148.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Narcolepsy type 1: What have we learned from immunology?
Kornum, Birgitte Rahbek, 2020, In: Sleep. 43, 10, zsaa055.Research output: Contribution to journal › Review › Research › peer-review
- Published
TREATMENT OF CNS DISORDERS WITH SLEEP DISTURBANCES
Wellendorph, Petrine, Kornum, Birgitte Rahbek & Frølund, Bente, 2020, Patent No. WO2020259787 , 30 Dec 2020, Priority date 28 Jun 2019, Priority No. DK2019PA70415 20190628Research output: Patent
- Published
The case for narcolepsy as an autoimmune disease
Kornum, Birgitte Rahbek & Jennum, Poul, 2020, In: Expert Review of Clinical Immunology. 16, 3, p. 231-233 3 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission
Bentsen, M. A., Rausch, D. M., Mirzadeh, Z., Muta, K., Scarlett, J. M., Brown, J. M., Herranz-Pérez, V., Baquero, A. F., Thompson, J., Alonge, K. M., Faber, C. L., Kaiyala, K. J., Bennett, C., Pyke, C., Ratner, C., Egerod, K. L., Holst, B., Meek, T. H., Kutlu, B., Zhang, Y. & 9 others, , 2020, In: Nature Communications. 11, 1, 4458.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Diagnostic value of actigraphy in hypersomnolence disorders
Torstensen, E. W., Pickering, L., Kornum, Birgitte Rahbek, Wanscher, B., Baandrup, Lone & Jennum, Poul, 2021, In: Sleep Medicine. 85, p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep
Lie, M. E. K., Falk-Petersen, C. B., Petersen, Louise Piilgaard, Griem-Krey, Nane, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2021, In: European Journal of Neuroscience. 54, 2, p. 4445-4455 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, , 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11protein levels in narcolepsy type 1
Viste, R., Viken, M. K., Lie, B. A., Juvodden, H. T., Nordstrand, S. E. H., Thorsby, P. M., Rootwelt, T., Kornum, Birgitte Rahbek & Knudsen-Heier, S., 2021, In: Sleep. 44, 8, 12 p., zsab062.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Narcolepsy Type I as an autoimmune disorder
Kornum, Birgitte Rahbek, 2021, Handbook of Clinical Neurology. 1 ed. Elsevier, p. 161-172 12 p. (Handbook of Clinical Neurology, Vol. 181).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Narcolepsy type 1 patients have lower levels of effector memory CD4+ T cells compared to their siblings when controlling for H1N1-(Pandemrix™)-vaccination and HLA DQB1∗06:02 status
Viste, R., Lie, B. A., Viken, M. K., Rootwelt, T., Knudsen-Heier, S. & Kornum, Birgitte Rahbek, 2021, In: Sleep Medicine. 85, p. 271-279 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pre-treatment of blood samples reveal normal blood hypocretin/orexin signal in narcolepsy type I
Aegidius, H. M., Kruse, L., Christensen, G. L., Lorentzen, M. P., Jørgensen, Niklas Rye, Moresco, M., Pizza, F., Plazzi, G., Jennum, Poul & Kornum, Birgitte Rahbek, 2021, In: Brain Communications. 3, 2, 13 p., 050.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients have increased muscle activity during REM and nrem sleep compared with their non-narcoleptic siblings
Viste, R., Lie, B. A., Kornum, Birgitte Rahbek, Rootwelt, T. & Knudsen-Heier, S., 2022, In: Journal of Sleep Research. 31, Supplement 1, 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Neurobioloy of sleep and circadian disorders
Kornum, Birgitte Rahbek & Mignot, E., 2022, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition. M. J. Z., C. A. W. & M-F. C. (eds.). 2 ed. Elsevier, p. 635-658 24 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming
Bergmann, T., Liu, Y., Skov, J., Mogus, L., Lee, J., Pfisterer, U., Handfield, L. F., Asenjo-Martinez, A., Lisa-Vargas, I., Seemann, S. E., Lee, J. T. H., Patikas, N., Kornum, B. R., Denham, M., Hyttel, P., Witter, M. P., Gorodkin, J., Pers, T. H., Hemberg, M., Khodosevich, K. & 1 others, , 2022, In: Frontiers in Cell and Developmental Biology. 10, 976549.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sex-related differences within sleep-wake dynamics, cataplexy, and EEG fast-delta power in a narcolepsy mouse model
Petersen, Louise Piilgaard, Rose, Laura, Hviid, C. G., Kohlmeier, Kristi Anne & Kornum, Birgitte Rahbek, 2022, In: Sleep. 45, 7, 15 p., zsac058.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio
Holm, A., Possovre, M. L., Bandarabadi, M., Moseholm, Kristine Frøsig, Justinussen, Jessica, Bozic, I., Lemcke, René, Arribat, Y., Amati, F., Silahtaroglu, Asli, Juventin, M., Adamantidis, A., Tafti, M. & Kornum, Birgitte Rahbek, 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 17, 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Emerging therapeutic targets for narcolepsy
Vringer, M. & Kornum, Birgitte Rahbek, 2023, In: Expert Opinion On Therapeutic Targets. 25, 7, p. 559-572 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Experimental sickness reduces hypocretin receptor 1 expression in the lateral hypothalamus and ventral tegmental area of female mice
Pedersen, Mie Gunni Kolmos, Pérez Arribas, Alba, Kornum, Birgitte Rahbek & Justinussen, Jessica, 2023, In: European Journal of Neuroscience. 58, 9, p. 4002-4010 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How hypocretin agonists may improve the quality of wake in narcolepsy
Justinussen, Jessica, Jensen, Christine Egebjerg & Kornum, Birgitte Rahbek, 2023, In: Trends in Molecular Medicine. 29, 1, p. 61-69 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid
Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, , 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings
Viste, R., Follin, L. F., Kornum, Birgitte Rahbek, Lie, B. A., Viken, M. K., Thorsby, P. M., Rootwelt, T., Christensen, J. A. E. & Knudsen-Heier, S., 2023, In: Sleep. 46, 3, 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus
Lemcke, René, Jensen, Christine Egebjerg, Pagh-Berendtsen, Nicolai, Egerod, Kristoffer Lihme, Thomsen, Allan Randrup, Pers, Tune H, Christensen, Jan Pravsgaard & Kornum, Birgitte Rahbek, 2023, 31 p.Research output: Working paper › Preprint › Research
- Published
Molecular consequences of peripheral Influenza A infection on cell populations in the murine hypothalamus
Lemcke, René, Jensen, Christine Egebjerg, Pagh-Berendtsen, Nicolai, Egerod, Kristoffer Lihme, Thomsen, Allan Randrup, Pers, Tune H, Christensen, Jan Pravsgaard & Kornum, Birgitte Rahbek, 2023, In: eLife. 12, 28 p., RP87515.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
Ollila, H. M., Sharon, E., Lin, L., Sinnott-Armstrong, N., Ambati, A., Yogeshwar, S. M., Hillary, R. P., Jolanki, O., Faraco, J., Einen, M., Luo, G., Zhang, J., Han, F., Yan, H., Dong, X. S., Li, J., Zhang, J., Hong, S. C., Kim, T. W., Dauvilliers, Y. & 31 others, , 2023, In: Nature Communications. 14, 1, 13 p., 2709.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-invasive detection of narcolepsy type I phenotypical features and disease progression by continuous home-cage monitoring of activity in two mouse models: the HCRT-KO and DTA model
Petersen, Louise Piilgaard, Rose, Laura, Justinussen, Jessica, Hviid, C. G., Lemcke, René, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2023, In: Sleep. 46, 9, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Repeated measures of hypocretin-1 in Danish and Italian patients with narcolepsy and in controls
Torstensen, E. W., Haubjerg Østerby, N. C., Pizza, F., Plazzi, G., Antelmi, E., Moresco, M., Mignot, E., Jørgensen, Niklas Rye, Christensen, G. L., Wanscher, B., Kornum, Birgitte Rahbek & Jennum, Poul, 2023, In: Sleep Medicine. 101, p. 213-220 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Repeated polysomnography and multiple sleep latency test in narcolepsy type 1 and other hypersomnolence disorders
Torstensen, E. W., Haubjerg Østerby, N. C., Kornum, Birgitte Rahbek, Wanscher, B., Mignot, E., Barløse, Mads Christian Johannes & Jennum, Poul, 2023, In: Sleep Medicine. 110, p. 91-98 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2024
- Published
Downregulation of hypocretin/orexin after H1N1 Pandemrix vaccination of adolescent mice
Pagh-Berendtsen, Nicolai, Pavlovskyi, Artem, Flores Téllez, D., Jensen, Christine Egebjerg, Pedersen, Mie Gunni Kolmos, Justinussen, Jessica & Kornum, Birgitte Rahbek, 2024, In: Sleep. 47, 4, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 143987587
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Monozygotic twins discordant for narcolepsy type 1 and multiple sclerosis
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DNMT1 regulates expression of MHC class I in post-mitotic neurons
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Human P2Y11 expression level affects human P2X7 receptor-mediated cell death
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