Thor Grundtvig Theander
Professor
Centre for Medical Parasitology
Blegdamsvej 3, 2200 København N, Building: 07-11-17
CMP
Blegdamsvej 3B, 2200 København N, 07 Bygning 7, Building: 07-11-TR4
Member of:
CMP-BIOENGINEERING
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3D7-derived Plasmodium falciparum erythrocyte membrane protein 1 is a frequent target of naturally acquired antibodies recognizing protein domains in a particular pattern independent of malaria transmission intensity
Joergensen, L., Vestergaard, L. S., Turner, Louise, Magistrado, P., Lusingu, J. P., Lemnge, M., Theander, Thor Grundtvig & Jensen, Anja Ramstedt, 2007, In: Journal of Immunology. 178, 1, p. 428-35 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Baculovirus-expressed constructs induce immunoglobulin G that recognizes VAR2CSA on Plasmodium falciparum-infected erythrocytes
Barfod, Lea Klingenberg, Nielsen, Morten Agertoug, Turner, Louise, Dahlbäck, M., Jensen, Anja Ramstedt, Hviid, Lars, Theander, Thor Grundtvig & Salanti, Ali, 2006, In: Infection and Immunity. 74, 7, p. 4357-60 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens
Bygbjerg, Ib Christian, Theander, Thor Grundtvig, Andersen, B. J., Flachs, H., Jepsen, S. & Larsen, P. B., 1986, In: Tropical Medicine and Parasitology. 37, 3, p. 245-7 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro effects of artesunate and other antimalarial agents on the function of human lymphocytes and neutrophils
Chen, M., Kappel, M., Lemnge, M., Bygbjerg, Ib Christian, Theander, Thor Grundtvig & Kharazmi, A., 1994, In: Transplantation Proceedings. 26, 6, p. 3172-4 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro selection of Plasmodium falciparum 3D7 for expression of variant surface antigens associated with severe malaria in African children
Staalsoe, T., Nielsen, Morten Agertoug, Vestergaard, L. S., Jensen, Anja Ramstedt, Theander, Thor Grundtvig & Hviid, Lars, 2003, In: Parasite Immunology. 25, 8-9, p. 421-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo switching between variant surface antigens in human Plasmodium falciparum infection
Staalsoe, T., Hamad, A. A., Hviid, Lars, Elhassan, I. M., Arnot, D. E. & Theander, Thor Grundtvig, 2002, In: Journal of Infectious Diseases. 186, 5, p. 719-22 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis
Kemp, M., Kurtzhals, Jørgen, Bendtzen, K., Poulsen, L. K., Hansen, M. B., Koech, D. K., Kharazmi, A. & Theander, Thor Grundtvig, 1993, In: Infection and Immunity. 61, 3, p. 1069-73 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Leishmania donovani: an in vitro study of antimony-resistant amphotericin B-sensitive isolates
Sharief, A. H., Gasim Khalil, E. A., Theander, Thor Grundtvig, Kharazmi, A., Omer, S. A. & Ibrahim, M. E., 2006, In: Experimental Parasitology. 114, 4, p. 247-52 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Leishmania resistant to sodium stibogluconate: drug-associated macrophage-dependent killing
Ibrahim, M. E., Hag-Ali, M., el-Hassan, A. M., Theander, Thor Grundtvig & Kharazmi, A., 1994, In: Parasitology Reseach. 80, 7, p. 569-74 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Leishmania-specific T cells expressing interferon-¿(IFN-¿) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis
Kemp, K., Kemp, M., Kharazmi, A., Ismail, A., Kurtzhals, Jørgen, Hviid, Lars & Theander, Thor Grundtvig, 1999, In: Clinical and Experimental Immunology. 116, 3, p. 500-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes
Jensen, Anja Ramstedt, Magistrado, P., Sharp, S., Joergensen, L., Lavstsen, Thomas, Chiucchiuini, A., Salanti, Ali, Vestergaard, L. S., Lusingu, J. P., Hermsen, R., Sauerwein, R., Christensen, J., Nielsen, Morten Agertoug, Hviid, Lars, Sutherland, C., Staalsoe, T. & Theander, Thor Grundtvig, 2004, In: Journal of Experimental Medicine. 199, 9, p. 1179-90 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes - divide and conquer
Rask, T. S., Hansen, D. A., Theander, Thor Grundtvig, Gorm Pedersen, A. & Lavstsen, Thomas, 2010, In: P L o S Computational Biology. 6, 9Research output: Contribution to journal › Journal article › Research › peer-review
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Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression
Tuikue Ndam, N., Bischoff, E., Proux, C., Lavstsen, Thomas, Salanti, Ali, Guitard, J., Nielsen, Morten Agertoug, Coppée, J., Gaye, A., Theander, Thor Grundtvig, David, P. H. & Deloron, P., 2008, In: PLoS ONE. 3, 3, p. e1855Research output: Contribution to journal › Journal article › Research › peer-review
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Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity
Nielsen, Morten Agertoug, Staalsoe, T., Kurtzhals, Jørgen, Goka, B. Q., Dodoo, D., Alifrangis, Michael, Theander, Thor Grundtvig, Akanmori, B. D. & Hviid, Lars, 2002, In: Journal of Immunology. 168, 7, p. 3444-50 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasmodium falciparum: VAR2CSA expressed during pregnancy-associated malaria is partially resistant to proteolytic cleavage by trypsin
Nielsen, Morten Agertoug, Resende, M., Alifrangis, Michael, Turner, Louise, Hviid, Lars, Theander, Thor Grundtvig & Salanti, Ali, 2007, In: Experimental Parasitology. 117, 1, p. 1-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pseudomonas aeruginosa septicaemia in a patient with severe Plasmodium falciparum
Kharazmi, A., Høiby, Niels & Theander, Thor Grundtvig, 1987, In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 81, 1, p. 49-50 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Aotus nancymaae model predicts human immune response to the placental malaria vaccine candidate VAR2CSA
Doritchamou, J., Nielsen, M. A., Chêne, A., Viebig, N. K., Lambert, L. E., Sander, A. F., Semblat, J. P., Hundt, S., Orr-Gonzalez, S., Janitzek, C. M., Spiegel, A. J., Clemmensen, S. B., Thomas, M. L., Nason, M. C., Snow-Smith, M., Barnafo, E. K., Shiloach, J., Chen, B. B., Nadakal, S., Highsmith, K. & 15 others, , 2023, In: Lab Animal. 52, 12, p. 315-323Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo imaging of the buccal mucosa shows loss of the endothelial glycocalyx and perivascular hemorrhages in pediatric Plasmodium falciparum malaria
Lyimo, E., Haslund, L. E., Ramsing, T., Wang, Christian William, Efunshile, A. M., Manjurano, A., Makene, V., Lusingu, J., Theander, Thor Grundtvig, Kurtzhals, Jørgen, Paulsen, R. & Hempel, C., 2020, In: Infection and Immunity. 88, 3, e00679-19.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains
Jespersen, Jakob Schmidt, Wang, Christian William, Mkumbaye, S. I., Minja, D. T., Petersen, Bent, Turner, Louise, Petersen, J. E., Lusingu, J. P., Theander, Thor Grundtvig & Lavstsen, Thomas, 2016, In: EMBO Molecular Medicine. 8, 8, p. 839-850 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children
Lavstsen, Thomas, Turner, Louise, Saguti, F., Magistrado, P. A., Rask, T. S., Jespersen, Jakob Schmidt, Wang, Christian William, Berger, S. S., Baraka, V., Marquard, A. M., Seguin-Orlando, A., Willerslev, Eske, Gilbert, M Thomas P, Lusingu, J. P. A. & Theander, Thor Grundtvig, 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. E1791-E1800 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasmodium falciparum infection early in pregnancy has profound consequences for fetal growth
Schmiegelow, Christentze, Matondo, S., Minja, D. T. R., Resende, M., Pehrson, Caroline, Nielsen, B. B., Olomi, R., Nielsen, Morten Agertoug, Deloron, P., Salanti, Ali, Lusingu, J. & Theander, Thor Grundtvig, 19 Dec 2017, In: The Journal of Infectious Diseases. 216, 12, p. 1601-1610 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies
Bengtsson, A., Joergensen, L., Rask, T. S., Olsen, R. W., Andersen, M. A., Turner, Louise, Theander, Thor Grundtvig, Hviid, Lars, Higgins, M. K., Craig, A., Brown, A. & Jensen, Anja Ramstedt, 2013, In: Journal of Immunology. 190, 1, p. 240-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A VAR2CSA:CSP conjugate capable of inducing dual specificity antibody responses
Matondo, S., Thrane, Susan, Janitzek, C. M., Kavishe, R. A., Mwakalinga, S. B., Theander, Thor Grundtvig, Salanti, Ali, Nielsen, Morten Agertoug & Sander, Adam F. , 2017, In: African Health Sciences. 17, 2, p. 373-381 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A cVLP-based vaccine displaying full-length PCSK9 elicits a higher reduction in plasma PCSK9 than similar peptide-based cVLP vaccines
Goksøyr, L., Skrzypczak, M., Sampson, M., Nielsen, Morten Agertoug, Salanti, Ali, Theander, Thor Grundtvig, Remaley, A. T., Jongh, W. A. D. & Sander, Adam F. , 2023, In: Vaccines. 11, 1, 2.Research output: Contribution to journal › Journal article › Research › peer-review
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A longitudinal study of human antibody responses to Plasmodium falciparum rhoptry-associated protein 1 in a region of seasonal and unstable malaria transmission
Fonjungo, P. N., Elhassan, I. M., Cavanagh, D. R., Theander, Thor Grundtvig, Hviid, Lars, Roper, C., Arnot, D. E. & McBride, J. S., 1999, In: Infection and Immunity. 67, 6, p. 2975-85 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A longitudinal study of type-specific antibody responses to Plasmodium falciparum merozoite surface protein-1 in an area of unstable malaria in Sudan
Cavanagh, D. R., Elhassan, I. M., Roper, C., Robinson, V. J., Giha, H., Holder, A. A., Hviid, Lars, Theander, Thor Grundtvig, Arnot, D. E. & McBride, J. S., 1998, In: Journal of Immunology. 161, 1, p. 347-59 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A marked seasonality of malaria transmission in two rural sites in eastern Sudan
Hamad, A. A., Nugud, A. E. H. D., Arnot, D. E., Giha, H. A., Abdel-Muhsin, A. M. A., Satti, G. M. H., Theander, Thor Grundtvig, Creasey, A. M., Babiker, H. A. & Elnaiem, D. E. A., 2002, In: Acta Tropica. 83, 1, p. 71-82 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes
Bengtsson, D., Sowa, K. M., Salanti, Ali, Jensen, Anja Ramstedt, Joergensen, L., Turner, Louise, Theander, Thor Grundtvig & Arnot, D. E., 2008, In: Malaria Journal. 7, p. 101Research output: Contribution to journal › Journal article › Research › peer-review
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A new portable device for automatic controlled-gradient cryopreservation of blood mononuclear cells
Hviid, Lars, Albeck, G., Hansen, B., Theander, Thor Grundtvig & Talbot, A., 1993, In: Journal of Immunological Methods. 157, 1-2, p. 135-42 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A novel virus-like particle based vaccine platform displaying the placental malaria antigen VAR2CSA
Thrane, Susan, Janitzek, C. M., Agerbæk, Mette Ørskov, Ditlev, S. B., dos Santos Marques Resende, M., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Salanti, Ali & Sander, Adam F. , 2015, In: PloS one. 10, 11, 16 p., e0143071.Research output: Contribution to journal › Journal article › Research › peer-review
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A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants
Agnandji, S. T., Lell, B., Fernandes, J. F., Abossolo, B. P., Methogo, B. G. N. O., Kabwende, A. L., Adegnika, A. A., Mordmüller, B., Issifou, S., Kremsner, P. G., Sacarlal, J., Aide, P., Lanaspa, M., Aponte, J. J., Machevo, S., Acacio, S., Bulo, H., Sigauque, B., Macete, E., Alonso, P. & 31 others, , 2012, In: New England Journal of Medicine. 367, 24, p. 2284-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A progressive declining in the burden of malaria in north-eastern Tanzania
Mmbando, B. P., Vestergaard, L. S., Kitua, A. Y., Lemnge, M. M., Theander, Thor Grundtvig & Lusingu, J. P. A., 2010, In: Malaria Journal. 9, p. 216Research output: Contribution to journal › Journal article › Research › peer-review
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A proof-of-concept study for the design of a VLP-based combinatorial HPV and placental malaria vaccine
Janitzek, C. M., Peabody, J., Thrane, Susan, H R Carlsen, P., Theander, Thor Grundtvig, Salanti, Ali, Chackerian, B., Nielsen, Morten Agertoug & Sander, Adam F. , 2019, In: Scientific Reports. 9, 1, 10 p., 5260.Research output: Contribution to journal › Journal article › Research › peer-review
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A semi-automated multiplex high-throughput assay for measuring IgG antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasma
Cham, G. K. K., Kurtis, J., Lusingu, J., Theander, Thor Grundtvig, Jensen, Anja Ramstedt & Turner, Louise, 2008, In: Malaria Journal. 7, p. 108Research output: Contribution to journal › Journal article › Research › peer-review
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A simple, high-throughput method to detect Plasmodium falciparum single nucleotide polymorphisms in the dihydrofolate reductase, dihydropteroate synthase, and P. falciparum chloroquine resistance transporter genes using polymerase chain reaction- and enzyme-linked immunosorbent assay-based technology
Alifrangis, Michael, Enosse, S., Pearce, R., Drakeley, C., Roper, C., Khalil, I. F., Nkya, W. M., Rønn, A. M., Theander, Thor Grundtvig & Bygbjerg, Ib Christian, 2005, In: American Journal of Tropical Medicine and Hygiene. 72, 2, p. 155-62 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A sub-family of common and highly conserved Plasmodium falciparum var genes
Salanti, Ali, Jensen, Anja Ramstedt, Zornig, H. D., Staalsoe, T., Joergensen, L., Nielsen, Morten Agertoug, Khattab, A., Arnot, D. E., Klinkert, M. Q., Hviid, Lars & Theander, Thor Grundtvig, 2002, In: Molecular and Biochemical Parasitology. 122, 1, p. 111-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A vaccine displaying a trimeric influenza-A HA stem protein on capsid-like particles elicits potent and long-lasting protection in mice
Thrane, Susan, Aves, Kara-Lee, Uddbäck, Ida Elin Maria, Janitzek, C. M., Han, J., Yang, Y. R., Ward, A. B., Theander, Thor Grundtvig, Nielsen, Morten Agertoug, Salanti, Ali, Thomsen, Allan Randrup, Christensen, Jan Pravsgaard & Sander, Adam F. , 2020, In: Vaccines. 8, 3, 389.Research output: Contribution to journal › Journal article › Research › peer-review
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Accuracy of malaria rapid diagnostic tests in community studies and their impact on treatment of malaria in an area with declining malaria burden in north-eastern Tanzania
Ishengoma, D. S., Francis, F., Mmbando, B. P., Lusingu, J. P., Magistrado, P., Alifrangis, Michael, Theander, Thor Grundtvig, Bygbjerg, Ib Christian & Lemnge, M. M., 1 Jan 2011, In: Malaria Journal. 10, p. 176Research output: Contribution to journal › Journal article › Research › peer-review
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Acquisition of antibodies against endothelial protein C receptor-binding domains of Plasmodium falciparum erythrocyte membrane protein 1 in children with severe malaria
Rambhatla, J. S., Turner, Louise, Manning, L., Laman, M., Davis, T. M. E., Beeson, J. G., Mueller, I., Warrel, J., Theander, Thor Grundtvig, Lavstsen, Thomas & Rogerson, S. J., 2019, In: The Journal of Infectious Diseases. 219, 5, p. 808-818 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Activation of CD8-positive suppressor cells during the malaria season
Theander, Thor Grundtvig, Hviid, Lars, Abu-Zeid, Y. A., Abdulhadi, N. H., Saeed, B. O., Jakobsen, P. H., Jepsen, S., Bayoumi, R. A. & Jensen, J. B., 1993, In: Immunology and Infectious Diseases. 3, p. 97-102Research output: Contribution to journal › Journal article › Research › peer-review
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Activation of human T lymphocytes by Leishmania lipophosphoglycan
Kemp, M., Theander, Thor Grundtvig, Handman, E., Hey, A. S., Kurtzhals, Jørgen, Hviid, Lars, Sørensen, A. L., Were, J. O., Koech, D. K. & Kharazmi, A., 1991, In: Scandinavian Journal of Immunology. 33, 2, p. 219-24 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria
Pehrson, Caroline, Mathiesen, Line, Heno, K. K., Salanti, Ali, dos Santos Marques Resende, M., Dzikowski, R., Damm, Peter, Hansson, S. R., King, C. L., Schneider, H., Wang, Christian William, Lavstsen, Thomas, Theander, Thor Grundtvig, Knudsen, Lisbeth E. & Nielsen, Morten Agertoug, 26 May 2016, In: Malaria Journal. 15, 12 p., 292.Research output: Contribution to journal › Journal article › Research › peer-review
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Age-dependent association between IgG2 and IgG3 subclasses to Pf332-C231 antigen and protection from malaria, and induction of protective antibodies by sub-patent malaria infections, in Daraweesh
Giha, H. A., Nasr, A., Iriemenam, N. C., Balogun, H. A., Arnot, D., Theander, Thor Grundtvig, Troye-Blomberg, M., Berzins, K. & ElGhazali, G., 2010, In: Vaccine. 28, 7, p. 1732-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Altitude-dependent and -independent variations in Plasmodium falciparum prevalence in northeastern Tanzania
Drakeley, C. J., Carneiro, I., Reyburn, H., Malima, R., Lusingu, J. P. A., Cox, J., Theander, Thor Grundtvig, Nkya, W. M. M. M., Lemnge, M. M. & Riley, E. M., 2005, In: Journal of Infectious Diseases. 191, 10, p. 1589-98 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An antileishmanial chalcone from Chinese licorice roots
Christensen, Søren Brøgger, Ming, C., Andersen, L., Hjørne, U., Olsen, C. E., Cornett, Claus, Theander, Thor Grundtvig & Kharazmi, A., 1994, In: Planta Medica. 60, 2, p. 121-3 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Anaemia in the first trimester and poor physiological plasma expansion during pregnancy negatively impact foetal weight and newborn anthropometrics: An observational cohort study in Tanzania
Schmiegelow, Christentze, Møller, S. L., Yde, A. M., Nielsen, B. B., Hjort, Line, Theander, Thor Grundtvig, Lusingu, J. P. A., Minja, D. T. R. & Bygbjerg, Ib Christian, 2024, In: Tropical Medicine & International Health. 29, 3, p. 243-255 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Anemia in late pregnancy induces an adaptive response in fetoplacental vascularization
Moeller, S. L., Schmiegelow, Christentze, Larsen, L. G., Nielsen, K., Msemo, O. A., Lusingu, J. P. A., Minja, D. T. R., Theander, Thor Grundtvig, Bygbjerg, Ib Christian & Nyengaard, J. R., 2019, In: Placenta. 80, p. 49-58 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Anthropometric measurements can identify small for gestational age newborns: a cohort study in rural Tanzania
Paulsen, C. B., Nielsen, B. B., Msemo, O. A., Møller, S. L., Ekmann, J. R., Theander, Thor Grundtvig, Bygbjerg, Ib Christian, Lusingu, J. P. A., Minja, D. T. R. & Schmiegelow, Christentze, 2019, In: BMC Pediatrics. 19, 1, 10 p., 120.Research output: Contribution to journal › Journal article › Research › peer-review
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Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria
Jakobsen, P. H., Morris-Jones, S. D., Hviid, Lars, Theander, Thor Grundtvig, Høier-Madsen, M., Bayoumi, R. A. & Greenwood, B. M., 1993, In: Immunology. 79, 4, p. 653-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers
Turner, Louise, Wang, Christian William, Lavstsen, Thomas, Mwakalinga, S. B., Sauerwein, R. W., Hermsen, C. C. & Theander, Thor Grundtvig, 2011, In: P L o S One. 6, 12, p. e29025Research output: Contribution to journal › Journal article › Research › peer-review
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Antibodies to the N-terminal block 2 of Plasmodium falciparum merozoite surface protein 1 are associated with protection against clinical malaria
Cavanagh, D. R., Dodoo, D., Hviid, Lars, Kurtzhals, Jørgen, Theander, Thor Grundtvig, Akanmori, B. D., Polley, S., Conway, D. J., Koram, K. & McBride, J. S., 2004, In: Infection and Immunity. 72, 11, p. 6492-502 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibodies to variable Plasmodium falciparum-infected erythrocyte surface antigens are associated with protection from novel malaria infections
Giha, H. A., Staalsoe, T., Dodoo, D., Roper, C., Satti, G. M., Arnot, D. E., Hviid, Lars & Theander, Thor Grundtvig, 2000, In: Immunology Letters. 71, 2, p. 117-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children
Dodoo, D., Staalsoe, T., Giha, H., Kurtzhals, Jørgen, Akanmori, B. D., Koram, K., Dunyo, S., Nkrumah, F. K., Hviid, Lars & Theander, Thor Grundtvig, 2001, In: Infection and Immunity. 69, 6, p. 3713-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibody reactivities to glutamate-rich peptides of Plasmodium falciparum parasites in humans from areas of different malaria endemicity
Jakobsen, P. H., Theander, Thor Grundtvig, Hviid, Lars, Morris-Jones, S., Jensen, J. B., Bayoumi, R. A., Greenwood, B. M., Bygbjerg, Ib Christian & Heegaard, P. M., 1996, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 104, 10, p. 734-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibody reactivity to conserved linear epitopes of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
Staalsø, T., Khalil, E. A., Elhassan, I. M., Zijlstra, E. E., Elhassan, A. M., Giha, H. A., Theander, Thor Grundtvig & Jakobsen, P. H., 1998, In: Immunology Letters. 60, 2-3, p. 121-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibody responses to Rhoptry-Associated Protein-1 (RAP-1) of Plasmodium falciparum parasites in humans from areas of different malaria endemicity
Jakobsen, P. H., Kurtzhals, Jørgen, Riley, E. M., Hviid, Lars, Theander, Thor Grundtvig, Morris-Jones, S., Jensen, J. B., Bayoumi, R. A., Ridley, R. G. & Greenwood, B. M., 1997, In: Parasite Immunology. 19, 9, p. 387-93 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antigen-presenting cells in human cutaneous leishmaniasis due to Leishmania major
ElHassan, A. M., Gaafar, A. & Theander, Thor Grundtvig, 1995, In: Clinical and Experimental Immunology. 99, 3, p. 445-53 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to Plasmodium falciparum malaria
Giha, H. A., Nasr, A., Iriemenam, N. C., Arnot, D., Troye-Blomberg, M., Theander, Thor Grundtvig, Berzins, K., ElGhazali, G. & Pandey, J. P., 2009, In: Malaria Journal. 8, 1, p. 306Research output: Contribution to journal › Journal article › Research › peer-review
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Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani
Chen, M., Christensen, Søren Brøgger, Theander, Thor Grundtvig & Kharazmi, A., 1994, In: Antimicrobial Agents and Chemotherapy. 38, 6, p. 1339-44 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antiprotozoal compounds from Asparagus africanus
Oketch-Rabah, H. A., Dossaji, S. F., Christensen, S. B., Frydenvang, Karla Andrea, Lemmich, E., Cornett, Claus, Olsen, C. E., Chen, M., Kharazmi, A. & Theander, Thor Grundtvig, 1997, In: Journal of Natural Products. 60, 10, p. 1017-22 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx
Oketch-Rabah, H. A., Christensen, Søren Brøgger, Frydenvang, Karla Andrea, Dossaji, S. F., Theander, Thor Grundtvig, Cornett, Claus, Watkins, W. M., Kharazmi, A. & Lemmich, E., 1998, In: Planta Medica. 64, 6, p. 559-62 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria
Giha, H. A., Nasr, A., Ekström, M., Israelsson, E., Arambepola, G., Arnot, D., Theander, Thor Grundtvig, Troye-Blomberg, M., Berzins, K., Tornvall, P. & ElGhazali, G., 2010, In: Molecular Medicine. 16, 1-2, p. 27-33 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies
Derkach, A., Otim, I., Pfeiffer, R. M., Onabajo, O. O., Legason, I. D., Nabalende, H., Ogwang, M. D., Kerchan, P., Talisuna, A. O., Ayers, L. W., Reynolds, S. J., Nkrumah, F., Neequaye, J., Bhatia, K., Theander, Thor Grundtvig, Prokunina-Olsson, L., Turner, Louise, Goedert, J. J., Lavstsen, Thomas & Mbulaiteye, S. M., 2019, In: EBioMedicine. 39, p. 358-368 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial superglue enables easy development of efficient virus-like particle based vaccines
Thrane, Susan, Janitzek, C. M., Matondo, S., dos Santos Marques Resende, M., Gustavsson, Tobias, De Jongh, W. A., Clemmensen, S., Roeffen, W., van de Vegte-Bolmer, M., van Gemert, G. J., Sauerwein, R., Schiller, J. T., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Salanti, Ali & Sander, Adam F. , 27 Apr 2016, In: Journal of Nanobiotechnology. 14, 16 p., 30.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial superglue generates a full-length circumsporozoite protein virus-like particle vaccine capable of inducing high and durable antibody responses
Janitzek, C. M., Matondo, S., Thrane, Susan, Nielsen, Morten Agertoug, Kavishe, R., Mwakalinga, S. B., Theander, Thor Grundtvig, Salanti, Ali & Sander, Adam F. , 8 Nov 2016, In: Malaria Journal. 15, 9 p., 545.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biochemical characterization, localization and immunostimulating properties of a soluble glycoprotein, Ag1, isolated from in vitro cultures of Plasmodium falciparum
Jakobsen, P. H., Jepsen, S., Riley, E. M., Theander, Thor Grundtvig, Grellier, P., Lihme, A., Hviid, Lars, Dziegiel, Morten Hanefeld & Schrevel, J., 1990, In: Parasitology Reseach. 76, 8, p. 657-61 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biological and haematological safety profile of oral amodiaquine and chloroquine in healthy volunteers with or without Plasmodium falciparum infection in northeast Tanzania
Massaga, J. J., Lusingu, J. P., Makunde, R., Malebo, H. M., Chile, M. M., Akida, J. A., Lemnge, M. M., Rønn, A. M., Theander, Thor Grundtvig, Bygbjerg, Ib Christian & Kitua, A. Y., 2008, In: Tanzania Health Research Bulletin. 10, 3, p. 144-50 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice
Skeltved, Nanna, Nordmaj, Mie Anemone, Pagh-Berendtsen, Nicolai, Dagil, Robert, Stormer, E. M. R., Al-Nakouzi, N., Jiang, K., Aicher, A., Heeschen, C., Gustavsson, Tobias, Choudhary, Swati, Gögenur, Ismail, Christensen, Jan Pravsgaard, Theander, Thor Grundtvig, Daugaard, M., Salanti, Ali & Nielsen, Morten Agertoug, 2023, In: Journal of Experimental & Clinical Cancer Research. 42, 16 p., 106.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Blood monocyte oxidative burst activity in acute P. falciparum malaria
Nielsen, H. & Theander, Thor Grundtvig, 1989, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 97, 5, p. 469-71 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Burkitt lymphoma expresses oncofetal chondroitin sulfate without being a reservoir for placental malaria sequestration
Agerbaek, M. Ø., Bento Ayres Pereira, M. M., Clausen, T. M., Pehrson, C., Oo, H. Z., Spliid, C., Rich, J. R., Fung, V., Nkrumah, F., Neequaye, J., Biggar, R. J., Reynolds, S. J., Tosato, G., Pullarkat, S. T., Ayers, L. W., Theander, T. G., Daugaard, M., Bhatia, K., Nielsen, M. A., Mbulaiteye, S. M. & 1 others, , 2017, In: International Journal of Cancer. 140, 7, p. 1597–1608 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CD36 selection of 3D7 Plasmodium falciparum associated with severe childhood malaria results in reduced VAR4 expression
Magistrado, P., Staalsoe, T., Theander, Thor Grundtvig, Hviid, Lars & Jensen, Anja Ramstedt, 2008, In: Malaria Journal. 7, 1, p. 204Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity
Fougeroux, C., Goksøyr, L., Idorn, M., Soroka, V., Myeni, S. K., Dagil, R., Janitzek, C. M., Søgaard, M., Aves, K-L., Horsted, E. W., Erdogan, S. M., Gustavsson, T., Dorosz, J., Clemmensen, S., Fredsgaard, L., Thrane, S., Vidal-Calvo, E. E., Khalifé, P., Hulen, T. M., Choudhary, S. & 27 others, , 2021, In: Nature Communications. 12, 1, p. 324Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein
Bang-Christensen, S. R., Pedersen, R. S., Pereira, M. A., Clausen, T. M., Løppke, C., Sand, N. T., Ahrens, T. D., Jørgensen, A. M., Lim, Y. C., Goksøyr, L., Choudhary, S., Gustavsson, T., Dagil, R., Daugaard, M., Sander, A. F., Torp, M. H., Søgaard, M., Theander, T. G., Østrup, O., Lassen, U. & 3 others, , 2019, In: Cells. 8, 9, 21 p., 998.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-mediated immune responses to Plasmodium falciparum purified soluble antigens in sickle-cell trait subjects
Bayoumi, R. A., Abu-Zeid, Y. A., Abdulhadi, N. H., Saeed, B. O., Theander, Thor Grundtvig, Hviid, Lars, Ghalib, H. W., Nugud, A. H., Jepsen, S. & Jensen, J. B., 1990, In: Immunology Letters. 25, 1-3, p. 243-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell-mediated immune responses to soluble Plasmodium falciparum antigens in residents from an area of unstable malaria transmission in the Sudan
Hviid, Lars, Theander, Thor Grundtvig, Jakobsen, P. H., Abu-Zeid, Y. A., Abdulhadi, N. H., Saeed, B. O., Jepsen, S., Bayoumi, R. A. L., Bendtzen, K. & Jensen, J. B., 1990, In: APMIS. 98, 7-12, p. 594-604 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell-mediated immunity to Plasmodium falciparum infection: evidence against the involvement of cytotoxic lymphocytes
Theander, Thor Grundtvig, Andersen, B. J., Pedersen, B. K., Jepsen, S., Bygbjerg, Ib Christian, Hviid, Lars, Larsen, P. B. & Kharazmi, A., 1988, In: Scandinavian Journal of Immunology. 28, 1, p. 105-11 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cellular and humoral immune responses in a population from the Baringo District, Kenya to Leishmania promastigote lipophosphoglycan
Kurtzhals, Jørgen, Hey, A. S., Theander, Thor Grundtvig, Odera, E., Christensen, C. B., Githure, J. I., Koech, D. K., Schaefer, K. U., Handman, E. & Kharazmi, A., 1992, In: American Journal of Tropical Medicine and Hygiene. 46, 4, p. 480-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cellulose filtration of blood from malaria patients for improving ex vivo growth of Plasmodium falciparum parasites
Mkumbaye, S. I., Minja, D. T. R., Jespersen, Jakob Schmidt, Alifrangis, Michael, Kavishe, R. A., Mwakalinga, S. B., Lusingu, J. P., Theander, Thor Grundtvig, Lavstsen, Thomas & Wang, Christian William, 10 Feb 2017, In: Malaria Journal. 16, 1, 8 p., 69.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites
Dahlbäck, M., Lavstsen, Thomas, Salanti, Ali, Hviid, Lars, Arnot, D. E., Theander, Thor Grundtvig & Nielsen, Morten Agertoug, 2007, In: Malaria Journal. 6, p. 78Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the local and systemic immune responses in patients with cutaneous leishmaniasis due to Leishmania major
Gaafar, A., Veress, B., Permin, H., Kharazmi, A., Theander, Thor Grundtvig & el Hassan, A. M., 1999, In: Clinical Immunology. 91, 3, p. 314-20 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chondroitin sulphate A (CSA)-binding of single recombinant Duffy-binding-like domains is not restricted to Plasmodium falciparum Erythrocyte Membrane Protein 1 expressed by CSA-binding parasites
Resende, M., Ditlev, S. B., Nielsen, Morten Agertoug, Bodevin, S., Bruun, S., Pinto, V. V., Clausen, Henrik, Turner, Louise, Theander, Thor Grundtvig, Salanti, Ali & Dahlbäck, M., 2009, In: International Journal for Parasitology. 39, 11, p. 1195-204 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chronic Plasmodium falciparum infections in an area of low intensity malaria transmission in the Sudan
Hamad, A. A., El Hassan, I. M., El Khalifa, A. A., Ahmed, G. I., Abdelrahim, S. A., Theander, Thor Grundtvig & Arnot, D. E., 2000, In: Parasitology. 120 ( Pt 5), p. 447-56 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Clinical pattern of severe Plasmodium falciparum malaria in Sudan in an area characterized by seasonal and unstable malaria transmission
Giha, H. A., Elghazali, G., A-Elgadir, T. M. E., A-Elbasit, I. E., Eltahir, E. M., Baraka, O. Z., Khier, M. M., Adam, I., Troye-Blomberg, M., Theander, Thor Grundtvig & Elbashir, M. I., 2005, In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 99, 4, p. 243-51 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cloning, expression and antigenicity of the L. donovani reductase
Jensen, Anja Ramstedt, Kemp, K., Theander, Thor Grundtvig & Handman, E., 2001, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 109, 6, p. 461-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clustering of malaria treatment failure (TF) in Daraweesh: hints for host genetic susceptibility to TF with emphasis on immune-modulating SNPs
Giha, H. A., ElGhazali, G., Nasr, A., Iriemenam, N. C., Berzins, K., Troye-Blomberg, M., Theander, Thor Grundtvig & Arnot, D., 2010, In: Infection, Genetics and Evolution. 10, 4, p. 481-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines
Van Coillie, J., Pongracz, T., Šuštić, T., Wang, W., Nouta, J., Le Gars, M., Keijzer, S., Linty, F., Cristianawati, O., Keijser, J. B. D., Visser, R., van Vught, L. A., Slim, M. A., van Mourik, N., Smit, M. J., Sander, A., Schmidt, D. E., Steenhuis, M., Rispens, T., Nielsen, M. A. & 31 others, , 2023, In: iScience. 26, 9, p. 1-15 107619.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparison of functional assays used in the clinical development of a placental malaria vaccine
Pehrson, Caroline, Heno, K. K., Adams, Yvonne, dos Santos Marques Resende, M., Mathiesen, Line, Soegaard, M., de Jongh, W. A., Theander, Thor Grundtvig, Salanti, Ali & Nielsen, Morten Agertoug, 23 Jan 2017, In: Vaccine. 35, 4, p. 610-618 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Compounds useful in the diagnosis and treatment of pregnancy-associated malaria
Theander, Thor Grundtvig, Salanti, Ali, Hviid, Lars, Staalsø, Trine, Jensen, Anja Ramstedt, Lavstsen, Thomas & Dahlbäck, M., 2004, Patent No. WO2004067559 A1, Priority date 27 Jan 2003, Priority No. WO2004067559 A1Research output: Patent
- Published
Contact allergens in African countries: A review of published patch test studies
Bonefeld, N. M., Menné, T., Ahrensbøll-Friis, U., Gadsbøll, Anne-Sofie Østergaard, Wang, Christian William, Theander, Thor Grundtvig, Masenga, E. J., Mavura, D., Ødum, Niels, Bonefeld, Charlotte Menne & Geisler, Carsten, 2024, In: Contact Dermatitis. 90, 2, p. 103-109Research output: Contribution to journal › Review › Research › peer-review
- Published
Cord blood FGF-21 and GDF-15 levels are affected by maternal exposure to moderate to severe anemia and malaria
Hjort, Line, Albrechtsen, Nicolai Jacob Wewer, Minja, D., Rasmussen, C., Møller, S. L., Lusingu, J., Theander, Thor Grundtvig, Bygbjerg, Ib Christian, Schmiegelow, Christentze & Grunnet, Louise Groth, 2023, In: Journal of the Endocrine Society. 7, 10, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Wang, Kaituo, Dagil, Robert, Lavstsen, Thomas, Misra, S. K., Spliid, C. B., Wang, Yong, Gustavsson, Tobias, Sandoval, D. R., Vidal-Calvo, E. E., Choudhary, Swati, Agerbæk, Mette Ørskov, Lindorff-Larsen, Kresten, Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Sharp, J. S., Clausen, Thomas Mandel, Gourdon, Pontus Emanuel & Salanti, Ali, 2021, In: Nature Communications. 12, 1, 10 p., 2956.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytophilic antibodies to Plasmodium falciparum glutamate rich protein are associated with malaria protection in an area of holoendemic transmission
Lusingu, J. P. A., Vestergaard, L. S., Alifrangis, Michael, Mmbando, B. P., Theisen, M., Kitua, A. Y., Lemnge, M. M. & Theander, Thor Grundtvig, 2005, In: Malaria Journal. 4, p. 48Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families
Sander, Adam F. , Lavstsen, Thomas, Rask, T. S., Lisby, Michael, Salanti, Ali, Fordyce, S. L., Jespersen, Jakob Schmidt, Carter, R., Deitsch, K. W., Theander, Thor Grundtvig, Pedersen, A. G. & Arnot, D. E., 2014, In: Nucleic Acids Research. 42, 4, p. 2270-81 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Defence mechanisms and immune evasion in the interplay between the humane immune system and Plasmodium falciparum
Theander, Thor Grundtvig, 1992, In: Danish Medical Bulletin. 39, 1, p. 49-63 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Depressed natural killer cell activity in acute myocardial infarction
Klarlund, K., Pedersen, Bente Klarlund, Theander, Thor Grundtvig & Andersen, V., 1987, In: Clinical and Experimental Immunology. 70, 1, p. 209-16 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detection of VAR2CSA‐captured colorectal cancer cells from blood samples by real‐time reverse transcription PCR
Bang‐christensen, S. R., Katerov, V., Jørgensen, Amalie Mundt, Gustavsson, Tobias, Choudhary, Swati, Theander, Thor Grundtvig, Salanti, Ali, Allawi, H. T. & Agerbæk, Mette Ørskov, 2021, In: Cancers. 13, 23, 5881.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detection of antibodies to variant antigens on Plasmodium falciparum-infected erythrocytes by flow cytometry
Staalsoe, T., Giha, H. A., Dodoo, D., Theander, Thor Grundtvig & Hviid, Lars, 1999, In: Cytometry. Part B: Clinical Cytometry. 35, 4, p. 329-36 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Detection of very low level Plasmodium falciparum infections using the nested polymerase chain reaction and a reassessment of the epidemiology of unstable malaria in Sudan
Roper, C., Elhassan, I. M., Hviid, Lars, Giha, H., Richardson, W., Babiker, H., Satti, G. M., Theander, Thor Grundtvig & Arnot, D. E., 1996, In: American Journal of Tropical Medicine and Hygiene. 54, 4, p. 325-31 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Determinants of variant surface antigen antibody response in severe Plasmodium falciparum malaria in an area of low and unstable malaria transmission
A-Elgadir, T. M. E., Theander, Thor Grundtvig, Elghazali, G., Nielsen, Morten Agertoug, A-Elbasit, I. E., Adam, I., Troye-Blomberg, M., Elbashir, M. I. & Giha, H. A., 2006, In: Scandinavian Journal of Immunology. 63, 3, p. 232-40 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Developing Plasmodium falciparum malaria vaccines for populations living in areas with stable parasite transmission
Hviid, Lars & Theander, Thor Grundtvig, 2007, In: International Journal of Biotechnology. 9, 3/4, p. 292-300 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11256
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Real-time and label free determination of ligand binding-kinetics to primary cancer tissue specimens; a novel tool for the assessment of biomarker targeting
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Bacterial superglue enables easy development of efficient virus-like particle based vaccines
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Placental sequestration of Plasmodium falciparum malaria parasites is mediated by the interaction between VAR2CSA and chondroitin sulfate A on syndecan-1
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