Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx
Research output: Contribution to journal › Journal article › Research › peer-review
Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major antiplasmodial principle. An X-ray crystallographic analysis established the absolute configuration and some signals in the NMR spectra were reassigned. 16,17-Dihydrobrachycalyxolide (1) elicited a strong antiplasmodial and antileishmanial activity but also a high toxicity against human lymphocytes.
Original language | English |
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Journal | Planta Medica |
Volume | 64 |
Issue number | 6 |
Pages (from-to) | 559-62 |
Number of pages | 3 |
ISSN | 0032-0943 |
Publication status | Published - 1998 |
Bibliographical note
Keywords: Animals; Antiprotozoal Agents; Cell Survival; Humans; Leishmania major; Lymphocytes; Models, Molecular; Molecular Conformation; Molecular Structure; Plant Extracts; Plant Leaves; Plants, Medicinal; Sesquiterpenes, Germacrane
ID: 6765996