Nicolai Jacob Wewer Albrechtsen

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I have two major focus areas in my research and clinical work.

The first focus on the pathophysiology of metabolic diseases such as liver diseases. I am in particular interested in how our gastrointestinal tract regulates metabolism and how impaired inter-organ communication (the liver-alpha cell axis) contribute to development of comorbidities such as diabetes. To capture these dysmetabolic conditions I have developed and evaluate biochemical based measurement technologies that have enabled my research group to pinpoint disturbances and common pathways in diabetes and fatty liver disease.

The second focus on using state of the art mass-spectrometry based proteomics to study human disease and to explore the clinical applicability of such technology. I am currently the team leader of a visionary effort that bridges forefront technology from NNF Center of Protein Research to Denmark most specialized hospital, Rigshospitalet. Here, we together with several departments and clinicians utilizes this advanced technology to evaluate its clinical potential application for diagnostic, prognostics and disease monitoring.

Selected publications

1. Published

   The liver-alpha cell axis and type 2 diabetes

   Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Suppli, M. P., Janah, L., Gromada, J., Vilstrup, H., Knop, Filip Krag & Holst, Jens Juul, 2019, In: Endocrine Reviews. 40, 5, p. 1353-1366

   Research output: Contribution to journal › Review › Research › peer-review

2. Published

   Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis

   Winther-Sørensen, M., Galsgaard, K. D., Santos, A., Trammell, S. A. J., Sulek, K., Kuhre, R. E., Pedersen, J., Andersen, D. B., Hassing, A. S., Dall, M., Treebak, J. T., Gillum, M. P., Torekov, S. S., Windeløv, J. A., Hunt, J. E., Kjeldsen, S. A. S., Jepsen, S. L., Vasilopoulou, C. G., Knop, F. K., Ørskov, C. & 7 others, Werge, M. P., Bisgaard, Hanne Cathrine, Eriksen, P. L., Vilstrup, H., Gluud, Lise Lotte, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Molecular Metabolism. 42, 18 p., 101080.

   Research output: Contribution to journal › Journal article › Research › peer-review

3. Published

   Methods and Guidelines for Measurement of Glucagon in Plasma

   Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2019, In: International Journal of Molecular Sciences (Online). 20, 10 p., 5416.

   Research output: Contribution to journal › Review › Research › peer-review

4. Published

   Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

   Albrechtsen, Nicolai Jacob Wewer, Geyer, P. E., Doll, S., Treit, P. V., Bojsen-Møller, K. N., Martinussen, C., Jørgensen, N. B., Torekov, Signe Sørensen, Meier, F., Niu, Lili, Santos, A., Keilhauer, E. C., Holst, Jens Juul, Madsbad, Sten & Mann, Matthias, 2018, In: Cell Systems. 7, 6, p. 601-612

   Research output: Contribution to journal › Journal article › Research › peer-review

5. Published

   Proteomics reveals the effects of sustained weight loss on the human plasma proteome

   Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Tyanova, S., Grassl, N., Iepsen, E. P. W., Lundgren, J., Madsbad, Sten, Holst, Jens Juul, Torekov, Signe Sørensen & Mann, Matthias, 22 Dec 2016, In: Molecular Systems Biology. 12, 16 p., 901.

   Research output: Contribution to journal › Journal article › Research › peer-review

6. Published

   A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

   Batista, T. M., Jayavelu, A. K., Albrechtsen, Nicolai Jacob Wewer, Iovino, S., Lebastchi, J., Pan, H., Dreyfuss, J. M., Krook, A., Zierath, Juleen R, Mann, Matthias & Kahn, C. R., 2020, In: Cell Metabolism. 32, 5, p. 844-859.e5

   Research output: Contribution to journal › Journal article › Research › peer-review