Nikos Hatzakis

Nikos Hatzakis

Professor

ORCID: 0000-0003-4202-0328

Publication year:
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1 - 101 out of 101Page size: 500
  1. 2024
  2. Published

    Deconvoluting the Effect of Cell-Penetrating Peptides for Enhanced and Controlled Insertion of Large-Scale DNA Nanopores

    Zhang, X., Malle, M. G., Thomsen, R. P., Sørensen, R. S., Sørensen, Emily Claire Winther, Hatzakis, Nikos & Kjems, J., 2024, In: ACS Applied Materials and Interfaces. 16, 15, p. 18422−18433 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation

    Mortensen, Janni Støvring, Bohr, S. S. R., Krog, Lasse Skjoldborg, Bøtker, Johan Peter, Kapousidou, V., Saaby, Lasse, Hatzakis, Nikos, Nielsen, Hanne Mørck, Nguyen, Duc Ninh & Rønholt, Stine, 2024, In: Scientific Reports. 14, 1, 17 p., 7665.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Probing Activation and Conformational Dynamics of the Vesicle-Reconstituted β2 Adrenergic Receptor at the Single-Molecule Level

    Tutkus, M., Lundgaard, C. V., Veshaguri, S., Tønnesen, A., Hatzakis, Nikos, Rasmussen, Søren Gøgsig Faarup & Stamou, Dimitrios, 2024, In: Journal of Physical Chemistry B. 128, 9, p. 2124–2133 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Protein Tracking: Everything, everywhere, almost at once

    Kæstel-Hansen, Jacob & Hatzakis, Nikos, 2024, In: eLife. 13, 3 p., e95362.

    Research output: Contribution to journal › Editorial › Research › peer-review

  6. Published

    SEMORE: SEgmentation and MORphological fingErprinting by machine learning automates super-resolution data analysis

    Bender, S. W. B., Dreisler, M. W., Zhang, Min, Kæstel-Hansen, Jacob & Hatzakis, Nikos, 2024, In: Nature Communications. 15, 1, 13 p., 1763.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 2023
  8. Published

    Dimensional Reduction for Single-Molecule Imaging of DNA and Nucleosome Condensation by Polyamines, HP1α and Ki-67

    Benning, N. A., Kæstel-Hansen, Jacob, Rashid, F., Park, S., Urteaga, R. M., Liao, T., Hao, J., Berger, J. M., Hatzakis, Nikos & Ha, T., 2023, In: Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 127, 9, p. 1922–1931 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Direct observation and classification of heterogeneous protein aggregation in real-time through super-resolution and aggregational fingerprinting

    Bender, S., Kæstel-Hansen, Jacob, Zhang, Min & Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 16a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  10. Published

    Enhanced hexamerization of insulin via assembly pathway rerouting revealed by single particle studies

    Bohr, Freja Schmidt-Rasmussen, Bohr, S. S. R., Mishra, N. K., González-Foutel, N. S., Pinholt, H. D., Wu, S., Nielsen, E. M., Zhang, Min, Kjaergaard, M., Jensen, Knud Jørgen & Hatzakis, Nikos, 2023, In: Communications Biology . 6, 1, 14 p., 178.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Heterogeneous and Surface-Catalyzed Amyloid Aggregation Monitored by Spatially Resolved Fluorescence and Single Molecule Microscopy

    Zhou, X., Sinkjær, Anders Wilgaard, Zhang, Min, Pinholt, H. D., Nielsen, Hanne Mørck, Hatzakis, Nikos, van de Weert, Marco & Foderà, Vito, 2023, In: The Journal of Physical Chemistry Letters. 14, 4, p. 912-919

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    In vitro and in vivo immunogenicity assessment of protein aggregate characteristics

    Thorlaksen, C., Schultz, H. S., Gammelgaard, S. K., Jiskoot, W., Hatzakis, Nikos, Nielsen, F. S., Solberg, H., Foderà, Vito, Bartholdy, C. & Groenning, M., 2023, In: International Journal of Pharmaceutics. 631, 122490.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Making the undetectable detectable: Pushing limits of biomolecular recognition by ultra-sensitive multiplexed single-particle liposome readouts

    Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 231a-232a 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Rapid extraction of time-dependent behaviors of endo-lysosomal structures and their cargo aided by deep learning

    Kæstel-Hansen, Jacob, Kreutzberger, A., Kirchhausen, T. & Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 517a 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Realizing integration in structural biology: The 2022 ISBUC Annual Meeting

    Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Single-Particle Tracking of Thermomyces lanuginosus Lipase Reveals How Mutations in the Lid Region Remodel Its Diffusion

    Iversen, J. F., Bohr, S. S. R., Pinholt, H. D., Moses, M. E., Iversen, L., Christensen, S. M., Hatzakis, Nikos & Zhang, Min, 2023, In: Biomolecules. 13, 4, 11 p., 631.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 2022
  18. Published

    Biased metabolism via small-molecule ligands binding to P450 oxidoreductase

    Hatzakis, Nikos, Jensen, S. B., Thodberg, S., Parween, S., Moses, M. E., Hansen, C. C., Knudsen, C., Giudice, R. D., Lund, P. M., Castano, P., Bustamante, Y. G., Jorgennsen, F. S., Pandey, A. V., Laursen, Tomas & Møller, Birger Lindberg, 1 Feb 2022, In: Biophysical Journal. 121, 3, p. 52a 1 p., 250-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research

  19. Published

    A blind benchmark of analysis tools to infer kinetic rate constants from single-molecule FRET trajectories

    Goetz, M., Barth, A., Bohr, S. S-R., Boerner, R., Chen, J., Cordes, T., Erie, D. A., Gebhardt, C., Hadzic, M. C. A. S., Hamilton, G. L., Hatzakis, N. S., Hugel, T., Kisley, L., Lamb, D. C., de Lannoy, C., Mahn, C., Dunukara, D., de Ridder, D., Sanabria, H., Schimpf, J. & 9 others, Seidel, C. A. M., Sigel, R. K. O., Sletfjerding, M. B., Thomsen, J., Vollmar, L., Wanninger, S., Weninger, K. R., Xu, P. & Schmid, S., 2022, In: Nature Communications. 13, 1, 12 p., 5402.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Direct observation of heterogeneous formation of amyloid spherulites in real-time by super-resolution microscopy

    Zhang, Min, Pinholt, H., Zhou, X., Bohr, S., Banetta, L., Zaccone, A., Foderà, Vito & Hatzakis, Nikos, 2022, In: Communications Biology . 5, 1, 10 p., 850.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Direct observations of drug nanocarrier interactions and mobility within biological interfaces

    Bohr, S. S. R., Streck, S., Pinholt, H., Wan, F., Mcdowell, A., Nielsen, Hanne Mørck & Hatzakis, Nikos, 2022, In: Biophysical Journal. 121, 3, p. 72a-73a 2 p., 355-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  22. Published

    Morphological integrity of insulin amyloid-like aggregates depends on preparation methods and post-production treatments

    Thorlaksen, C., Stanciu, A., Neergaard, M. B., Hatzakis, Nikos, Foderà, Vito & Groenning, M., 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 179, p. 147-155 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)

    Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Robust Dual Optical Sensor for pH and Dissolved Oxygen

    Wang, L., Jensen, K., Hatzakis, Nikos, Zhang, Min & Sørensen, Thomas Just, 2022, In: ACS Sensors. 7, 5, p. 1506–1513

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Single Vesicle Fluorescence-Bleaching Assay for Multi-Parameter Analysis of Proteoliposomes by Total Internal Reflection Fluorescence Microscopy

    Veit, S., Paweletz, L. C., Bohr, S. S., Menon, A. K., Hatzakis, Nikos & Pomorski, Thomas Guenther, 2022, In: ACS applied materials & interfaces. 14, 26, p. 29659−29667 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Single-particle combinatorial multiplexed liposome fusion mediated by DNA

    Malle, M., Loffler, P., Bohr, S. S., Sletfjerding, M., Risgaard, N., Jensen, S., Zhang, Min, Hedegård, Per, Vogel, S. & Hatzakis, Nikos, 2022, In: Nature Chemistry. 14, 5, p. 558–565 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    The dopamine transporter antiports potassium to increase the uptake of dopamine

    Schmidt, S. G., Malle, M. G., Nielsen, A. K., Bohr, S. S., Pugh, Ciara Frances, Nielsen, Jeppe Cederholm, Poulsen, I. H., Rand, Kasper Dyrberg, Hatzakis, Nikos & Loland, Claus Juul, 2022, In: Nature Communications. 13, 1, 12 p., 2446.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. 2021
  29. Published

    Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase

    Jensen, S. B., Thodberg, S., Parween, S., Moses, M. E., Hansen, Cecilie Ida Cetti, Thomsen, J., Sletfjerding, M. B., Knudsen, C., Del Giudice, R., Lund, P. M., Castaño, P. R., Bustamante, Y. G., Velazquez, M. N. R., Jørgensen, Flemming Steen, Pandey, A. V., Laursen, Tomas, Møller, Birger Lindberg & Hatzakis, Nikos, 2021, In: Nature Communications. 12, 1, 14 p., 2260.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Carbohydrate-Derived Metal-Chelator-Triggered Lipids for Liposomal Drug Delivery

    Holmstrøm, T., Galsgaard Malle, M., Wu, S., Jensen, Knud Jørgen, Hatzakis, Nikos & Pedersen, Christian Marcus, 2021, In: Chemistry - A European Journal. 27, 23, p. 6917-6922 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Direct Observation of Anisotropy-Driven Formation of Amyloid Spherulites in Real-time by Super-resolution Microscopy

    Zhang, Min, Pinholt, H., Zhou, X., Bohr, S., Banetta, L., Zaccone, A., Foderà, Vito & Hatzakis, Nikos, 2021, 19 p.

    Research output: Working paper › Preprint › Research

  32. Published

    FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

    Lerner, E., Barth, A., Hendrix, J., Ambrose, B., Birkedal, V., Blanchard, S. C., Börner, R., Chung, H. S., Cordes, T., Craggs, T. D., Deniz, A. A., Diao, J., Fei, J., Gonzalez, R. L., Gopich, I. V., Ha, T., Hanke, C. A., Haran, G., Hatzakis, N. S., Hohng, S. & 27 others, Hong, S. C., Hugel, T., Ingargiola, A., Joo, C., Kapanidis, A. N., Kim, H. D., Laurence, T., Lee, N. K., Lee, T. H., Lemke, E. A., Margeat, E., Michaelis, J., Michalet, X., Myong, S., Nettels, D., Peulen, T. O., Ploetz, E., Razvag, Y., Robb, N. C., Schuler, B., Soleimaninejad, H., Tang, C., Vafabakhsh, R., Lamb, D. C., Seidel, C. A. M., Weiss, S. & Boudker, O., 2021, In: eLife. 10, 69 p., e60416.

    Research output: Contribution to journal › Review › Research › peer-review

  33. Published

    Interactions of Cell-Penetrating Peptide-Modified Nanoparticles with Cells Evaluated Using Single Particle Tracking

    Streck, S., Bohr, S. S., Birch, D., Rades, Thomas, Hatzakis, Nikos, McDowell, A. & Nielsen, Hanne Mørck, 2021, In: ACS Applied Bio Materials. 4, 4, p. 3155-3165 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Single-Molecule Study of Thermomyces lanuginosus Lipase in a Detergency Application System Reveals Diffusion Pattern Remodeling by Surfactants and Calcium

    Moses, M. E., Lund, P. M., Bohr, S. S., Iversen, J. F., Kæstel-Hansen, J., Kallenbach, A. S., Iversen, L., Christensen, S. M. & Hatzakis, Nikos, 2021, In: A C S Applied Materials and Interfaces. 13, 28, 9 p., 33704.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Single-particle diffusional fingerprinting: A machine-learning framework for quantitative analysis of heterogeneous diffusion

    Pinholt, H. D., Bohr, S. S. R., Iversen, J. F., Boomsma, Wouter & Hatzakis, Nikos, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 7 p., e2104624118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. 2020
  37. Published

    DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning

    Thomsen, J., Sletfjerding, M. B., Jensen, S. B., Stella, S., Paul, B., Malle, M. G., Montoya, Guillermo, Petersen, Troels Christian & Hatzakis, Nikos, Nov 2020, In: eLife. 9, 21 p., e60404.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Label-Free Fluorescence Quantification of Hydrolytic Enzyme Activity on Native Substrates Reveals How Lipase Function Depends on Membrane Curvature

    Bohr, S. S., Thorlaksen, C., Kühnel, R. M., Pomorski, Thomas Guenther & Hatzakis, Nikos, 16 Jun 2020, In: Langmuir. 36, 23, p. 6473-6481 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Direct Observation of CRISPR-Cas12 Conformational Sampling by SM FRET and Cryo EM Reveals how Conformational Activation Promotes Catalysis and Resetting of the Endonuclease Activity

    Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcon, P., Jensen, S. B., Moses, M. E., Montoya, Guillermo & Hatzakis, Nikos, 7 Feb 2020, In: Biophysical Journal. 118, 3, p. 223A-224A 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  40. Published

    Direct Observation of Sophorolipid Micelle Docking in Model Membranes and Cells by Single Particle Studies Reveals Optimal Fusion Conditions

    Singh, P. K., Bohr, S. S. & Hatzakis, Nikos, 2020, In: Biomolecules. 10, 9, 16 p., 1291.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    How Membrane Geometry Regulates Protein Sorting Independently of Mean Curvature

    Larsen, J. B., Rosholm, K. R., Kennard, C., Pedersen, S. L., Munch, H. K., Tkach, Vadym, Sakon, J. J., Bjornholm, T., Weninger, K. R., Bendix, Poul Martin, Jensen, Knud Jørgen, Hatzakis, Nikos, Uline, M. J. & Stamou, Dimitrios, 2020, In: ACS Central Science. 6, 7, p. 1159-1168 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs

    Wan, F., Bohr, S. S. R., Kłodzińska, S. N., Jumaa, H., Huang, Z., Nylander, T., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Sternberg, C., Hatzakis, Nikos & Nielsen, Hanne Mørck, 2020, In: ACS Applied Materials and Interfaces. 12, p. 380-389

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. 2019
  44. Published

    A large size-selective DNA nanopore with sensing applications

    Thomsen, R. P., Malle, M. G., Okholm, A. H., Krishnan, S., Bohr, S. S., Sørensen, R. S., Ries, O., Vogel, S., Simmel, F. C., Hatzakis, Nikos & Kjems, J., 2019, In: Nature Communications. 10, 1

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Direct observation of Thermomyces lanuginosus lipase diffusional states by Single Particle Tracking and their remodeling by mutations and inhibition

    Bohr, S. S., Lund, P. M., Kallenbach, A. S., Pinholt, H., Thomsen, J., Iversen, L., Svendsen, A., Christensen, S. M. & Hatzakis, Nikos, 2019, In: Scientific Reports. 9, 11 p., 16169.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Half-Life Extending Modifications of Peptide YY3-36 Direct Receptor-Mediated Internalization

    Bech, E. M., Kaiser, A., Bellmann-Sickert, K., Nielsen, S. S., Sørensen, K. K., Elster, L., Hatzakis, Nikos, Pedersen, S. L., Beck-Sickinger, A. G. & Jensen, Knud Jørgen, 2019, In: Molecular Pharmaceutics. 16, 8, p. 3665-3677

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Single Liposome Measurements for the Study of Proton-Pumping Membrane Enzymes Using Electrochemistry and Fluorescent Microscopy

    Mazurenko, I., Hatzakis, Nikos & Jeuken, L. J. C., 2019, In: Journal of Visualized Experiments. 144

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. 2018
  49. Published

    Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity

    Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcón, P., Jensen, S. B., Saligram, B., Moses, M. E., Hatzakis, Nikos & Montoya, Guillermo, 13 Dec 2018, In: Cell. 175, 7, p. 1856-1871.e21 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Direct observation of multiple conformational states in Cytochrome P450 oxidoreductase and their modulation by membrane environment and ionic strength

    Bavishi, K., Li, D., Eiersholt, S., Hooley, E. N., Petersen, Troels Christian, Møller, Birger Lindberg, Hatzakis, Nikos & Laursen, Tomas, 2018, In: Scientific Reports. 8, 9 p., 6817.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Functionalized Gold Nanoclusters Identify Highly Reactive Oxygen Species in Living Organisms

    Xie, Y., Xianyu, Y., Wang, N., Yan, Z., Liu, Y., Zhu, K., Hatzakis, Nikos & Jiang, X., 2018, In: Advanced Functional Materials. 28, 14, 7 p., 1702026.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. 2017
  53. Published

    Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells

    Rosholm, K. R., Leijnse, Natascha, Mantsiou, A., Tkach, Vadym, Pedersen, S. L., Wirth, V. F., Oddershede, L. B., Jensen, Knud Jørgen, Martinez, Karen Laurence, Hatzakis, Nikos, Bendix, Poul Martin, Callan-Jones, A. & Stamou, Dimitrios, 8 May 2017, In: Nature Chemical Biology. 13, 7, p. 724-729

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Effects of membrane curvature and pH on proton pumping activity of single cytochrome bo3 enzymes

    Li, M., Khan, S., Rong, H., Tuma, R., Hatzakis, Nikos & Jeuken, L. J. C., 2017, In: Biochimica et Biophysica Acta - Bioenergetics. 1858, 9, p. 763-770

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Membrane Curvature and Lipid Composition Synergize To Regulate N-Ras Anchor Recruitment

    Larsen, J. B., Kennard, C., Pedersen, S. L., Jensen, Knud Jørgen, Uline, M. J., Hatzakis, Nikos & Stamou, Dimitrios, 2017, In: Biophysical Journal. 113, 6, p. 1269-1279 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. 2016
  57. Published

    Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum

    Laursen, Tomas, Borch-Jensen, J., Baden, C. K., Bavishi, K., Torta, F., Martens, Helle Jakobe, Silvestro, D., Hatzakis, Nikos, Wenk, M. R., Dafforn, T. R., Olsen, C. E., Motawie, Mohammed Saddik, Hamberger, B. R., Møller, Birger Lindberg & Bassard, J. A., 2016, In: Science (New York, N.Y.). 354, 6314, p. 890-893 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Direct observation of proton pumping by a eukaryotic P-type ATPase

    Veshaguri, S., Christensen, S. F., Kemmer, G. C., Ghale, G., Møller, M. P., Lohr, C., Christensen, A. L., Justesen, B. H., Jørgensen, I. L., Schiller, J., Hatzakis, Nikos, Grabe, M., Pomorski, Thomas Guenther & Stamou, Dimitrios, 2016, In: Science. 351, 6280, p. 1469-1473 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Links of conformational sampling to functional plasticity and clinical phenotypes by single molecule studies

    Moses, M. E., Thodberg, S., Bavishi, K., Eiersholt, S., Li, D., Stamou, Dimitrios, Møller, Birger Lindberg, Laursen, Tomas & Hatzakis, Nikos, 2016, In: Biophysical Society. Annual Meeting. Abstracts. 110, 3, p. 397A 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  60. Published

    N-RAS lipid anchor adsorption to membranes as a function of lipid composition and curvature

    Larsen, J. B., Kennard, C., Pedersen, S. L., Jensen, Knud Jørgen, Hatzakis, Nikos, Uline, M. J. & Stamou, Dimitrios, 2016, In: Biophysical Society. Annual Meeting. Abstracts. 110, 3, p. 579A 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  61. Published

    Quantification of functional dynamics of membrane proteins reconstituted in nanodiscs membranes by single turnover functional readout

    Moses, M. E., Hedegård, Per & Hatzakis, Nikos, 2016, Single-molecule enzymology: fluorescence-based and high-throughput methods. Spies, M. & Chemla, Y. R. (eds.). Academic Press, p. 227-256 30 p. (Methods in Enzymology, Vol. 581).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  62. Published

    Resolving active ion transport at the single molecule level for the first time

    Veshaguri, S., Christensen, S. M., Kemmer, G. C., Møller, M. P., Ghale, G., Lohr, C., Christensen, A. L., Justesen, B. H., Jørgensen, I. L., Schiller, J., Hatzakis, Nikos, Grabe, M., Pomorski, Thomas Guenther & Stamou, Dimitrios, 2016, In: Biophysical Journal. 110, 3, p. 179A 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    tN-Ras, Synaptotagmin1 C2Ab, Annexinb12 and Amphiphysin NBAR can Discriminate Spherical from Cylindrical Membrane Curvature

    kpl171, kpl171, Larsen, J., Rosholm, K. R., Pedersenb, S. L., Munch, H. K., Tkach, Vadym, Sakon, J. J., Bjornholm, T., Weninger, K. R., Bendix, Poul Martin, Jensen, Knud Jørgen, Uline, M. J., Hatzakis, Nikos & Stamou, Dimitrios, 2016, In: Biophysical Journal. 110, 3, 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  64. 2015
  65. Published

    Membrane Curvature Regulates the Localization of G Protein Coupled Receptors and Ras Isoforms

    Stamou, Dimitrios, Rosholm, K. R., Damalas, A., Hatzakis, Nikos, Wirth, V. F., Martinez, Karen Laurence, Leijnse, Natascha, Oddershede, L. B., Bendix, Poul Martin & Pedersen, S. L., 27 Jan 2015, In: Biophysical Journal. 108, 2, p. 95a-96a

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

    Larsen, J. B., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Bjørnholm, T., Iversen, L., Uline, M., Szleifer, I., Jensen, Knud Jørgen, Hatzakis, Nikos & Stamou, Dimitrios, 2015, In: Nature Chemical Biology. 11, 3, p. 192-194 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Single enzyme experiments reveal a long-lifetime proton leak state in a heme-copper oxidase

    Li, M., Jørgensen, S. K., McMillan, D. G. G., Krzemiński, Ł., Daskalakis, N. N., Partanen, R. H., Tutkus, M., Tuma, R., Stamou, Dimitrios, Hatzakis, Nikos & Jeuken, L. J. C., 2015, In: Journal of the American Chemical Society. 137, 51, p. 16055-16063 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. 2014
  69. Published

    How membrane curvature drives the up-concentration of N-Ras proteins to ordered lipid domains: correlation of in vivo and in vitro experiments with mean field theory calculations and coarse grain simulations

    Hatzakis, Nikos, Larsen, J. B., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Koldsoe, H., Fowler, P., Uline, M. J., Szleifer, I. G., Bjørnholm, T., Sansom, M., Jensen, Knud Jørgen & Stamou, Dimitrios, 2014, In: Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 713a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  70. Published

    Shedding light on protein folding, structural and functional dynamics by single molecule studies

    Bavishi, K. & Hatzakis, Nikos, 2014, In: Molecules. 19, 12, p. 19407-19434 28 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  71. Published

    Single molecule activity measurements of cytochrome P450 oxidoreductase reveal the existence of two discrete functional states

    Laursen, Tomas, Singha, A., Rantzau, N., Tutkus, M., Borch-Jensen, J., Hedegård, Per, Stamou, Dimitrios, Møller, Birger Lindberg & Hatzakis, Nikos, 2014, In: ACS chemical biology. 9, 3, p. 630-634 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Single molecule insights on conformational selection and induced fit mechanism

    Hatzakis, Nikos, 2014, In: Biophysical Chemistry. 186, p. 46-54 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. 2013
  74. Published

    Single Enzyme Studies Reveal the Existence of Discrete Functional States for Monomeric Enzymes and How they are "Selected'' upon Allosteric Regulation

    Hatzakis, Nikos, Wei, L., Jørgensen, S. K., Kunding, A. H., Bolinger, P., Ehrlich, N., Makarov, I., Skjot, M., Svendsen, A., Hedegård, Per, Walsh, S. M. & Stamou, Dimitrios, 29 Jan 2013, In: Biophysical Journal. 104, 2, p. 231A-231A

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    Developing an Assay to Probe Activtion and Conformational Dynamics of beta 2-Adrenergic Receptor on Single Molecule Level

    Veshaguri, S., Tutkus, M., Lundgaard, C. V., Tonnesen, A., Mathiasen, Signe, Jorgensen, S. K., Iversen, L., Hatzakis, Nikos, Rasmussen, Søren Gøgsig Faarup & Stamou, Dimitrios, 2013, In: Biophysical Journal. 104, 2, 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  76. Published

    Insights in enzyme functional dynamics and activity regulation by single molecule studies

    Jørgensen, S. K. & Hatzakis, Nikos, 2013, In: Biophysical Reviews and Letters. 8, 3&4, p. 137-160 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Lipid-Anchored Ras is Sorted by Membrane Curvature Both In Vitro and in Living Cells

    Larsen, J., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Bjornholm, T., Jensen, Knud Jørgen, Kohnke, M., Abankwa, D., Alexandrov, K., Hatzakis, Nikos & Stamou, Dimitrios, 2013, In: Biophysical Journal. 104, 2, 1 p., 500-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  78. Published

    Single Proton Pump Activity Measurements on Single Vesicles for a Quinol Heme-Copper Oxidase

    Jorgensen, S. K., McMillan, D., Krzeminski, L., Stamou, Dimitrios, Jeuken, L. J. C. & Hatzakis, Nikos, 2013, In: Biophysical Journal. 104, 2, Sppl. 1, p. 277a-278a

    Research output: Contribution to journal › Conference abstract in journal › Research

  79. Published

    Sorting of tN-Ras by Membrane Curvature in Lipid Vesicles and Tubes

    Rosholm, K. R., Larsen, J., Pedersen, S. L., Munch, H. K., Jensen, Knud Jørgen, Hatzakis, Nikos & Stamou, Dimitrios, 2013, In: Biophysical Journal. 104, Supplement 1, p. 549A 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  80. 2012
  81. Published

    Creating a Proteoliposome Assay for Single Photosystem I Activity Assessment

    Jorgensen, S. K., Lassen, L. M. M., Kemmer, G., Pomorski, Thomas Guenther, Stamou, Dimitrios, Bjornholm, T., Jensen, P. E. & Hatzakis, Nikos, 2012, In: Biophysical Journal. 102, 3 Suppl 1, p. 626a-627a 1 p., 3180-Pos.

    Research output: Contribution to journal › Conference abstract in journal › Research

  82. Published

    Influence of the preparation route on the supramolecular organization of lipids in a vesicular system

    Elizondo, E., Larsen, J., Hatzakis, Nikos, Cabrera, I., Bjørnholm, T., Veciana, J., Stamou, Dimitrios & Ventosa, N., 2012, In: Journal of the American Chemical Society. 134, 4, p. 1918-1921 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Mixing subattolitre volumes in a quantitative and highly parallel manner with soft matter nanofluidics

    Christensen, S. M., Bolinger, P., Hatzakis, Nikos, Mortensen, M. W. & Stamou, Dimitrios, 2012, In: Nature Nanotechnology. 7, p. 51-55 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  84. Published

    Monitoring shifts in the conformation equilibrium of the membrane protein cytochrome P450 reductase (POR) in nanodiscs

    Wadsäter, M. H., Laursen, Tomas, Singha, A., Hatzakis, Nikos, Stamou, Dimitrios, Barker, R., Mortensen, Kell, Feidenhans'l, Robert Krarup, Møller, Birger Lindberg & Cardenas Gomez, M., 2012, In: Journal of Biological Chemistry. 287, 41, p. 34596-34603 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Observation of Inhomogeneity in the Lipid Composition of Individual Nanoscale Liposomes

    Larsen, J., Hatzakis, Nikos, Elizondo, E., Cabrera, I., Veciana, J., Ventosa, N. & Stamou, Dimitrios, 2012, In: Biophysical Journal. p. 426a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  86. Published

    Single enzyme studies reveal the existence of discrete functional states for monomeric enzymes and how they are "selected" upon allosteric regulation

    Hatzakis, Nikos, Wei, L., Jørgensen, S. K., Kunding, A. H., Makarov, I., Skjot, M., Svendsen, A., Hedegård, Per & Stamou, Dimitrios, 2012, In: Journal of the American Chemical Society. 134, 22, p. 9296-9302 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Soft Matter Based Nanofluidic Platform for Highly Parallel Mixing of Sub-Attoliter Total Volumes

    Christensen, S., Bolinger, P., Hatzakis, Nikos, Mortensen, M. W. & Stamou, Dimitrios, 2012, In: Biophysical Journal. 102, 3 Supplement 1, p. 600a-601a 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  88. Published

    Synergy of Liquid Ordered "Raft Like" Domains and Membrane Curvature in Promoting Sorting of Lipidated Proteins Such As NRas

    Hatzakis, Nikos, Larsen, J. K., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Jensen, Knud Jørgen & Stamou, Dimitrios, 2012, In: Biophysical Journal. 102, 3 Supplement 1, p. 18a-19a 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  89. 2011
  90. Published

    Observation of inhomogeneity in the lipid composition of individual nanoscale liposomes

    Larsen, J., Hatzakis, Nikos & Stamou, Dimitrios, 20 Jul 2011, In: Journal of the American Chemical Society. 133, 28, p. 10685-10687 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  91. Published

    A discrete number of activity states constitute an efficient mechanism to regulate enzymatic activity

    Hatzakis, Nikos, Wei, L., Jorgensen, S. K., Kunding, A., Hedegard, P. & Stamou, Dimitrios, 2011, In: European Biophysics Journal With Biophysics Letters. 40, suppl 1, p. S217 1 p.

    Research output: Contribution to journal › Journal article › Research

  92. Published

    Regulation of Enzymatic Activity Occurs by Selection of Discrete Activity States

    Hatzakis, Nikos, Wei, L., Jorgensen, S. K., Kunding, A. H., Hedegard, P. & Stamou, Dimitrios, 2011, In: Biophysical Journal. 100, 3 suppl 1, p. 194a 1 p.

    Research output: Contribution to journal › Journal article › Research

  93. Published

    Static and Dynamic Disorder Observed in the Phase Transition Behavior of Individual Small Unilamellar Vesicles

    Stamou, Dimitrios, Bendix, Poul Martin, Wibroe, P. P. & Hatzakis, Nikos, 2011, In: Biophysical Journal. 100, 3 suppl 1, p. 35a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  94. Published

    Synergy between membrane-curvature and liquid ordered phase-state effectively sorts amphiphilic protein-anchoring motifs

    Larsen, J., Jensen, M. B., Hatzakis, Nikos, Bhatia, V. K. & Stamou, Dimitrios, 2011, In: European Biophysics Journal. 40, Suppl 1, p. S200 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  95. 2010
  96. Published

    A unifying mechanism accounts for sensing of membrane curvature by BAR domains, amphipathic helices and membrane-anchored proteins

    Bhatia, V. K., Hatzakis, Nikos & Stamou, Dimitrios, Jun 2010, In: Seminars in Cell and Developmental Biology. 21, 4, p. 381-390 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Influence of Lipid Heterogeneity and Phase Behavior on Phospholipase A(2) Action at the Single Molecule Level

    Gudmand, M. J., Rocha, S., Hatzakis, Nikos, Peneva, K., Müllen , K., Stamou, Dimitrios, Uji-I, H., Hofkens , J., Bjørnholm, T. & Heimburg, Thomas Rainer, 5 May 2010, In: Biophysical Journal. 98, 9, p. 1873-82 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Influence of Lipid Heterogeneity and Phase Behavior on Phospholipase A2 Action at the Single Molecule Level: Biophysical Journal

    Hatzakis, Nikos, 2010, In: Biophysical Society. Annual Meeting. Abstracts.

    Research output: Contribution to journal › Conference abstract in journal › Research

  99. Published

    Optically Induced Linking of Protein and Nanoparticles to Gold Surfaces

    Moth-Poulsen, K., Kofod-Hansen, V., S. Kamounah, F., Hatzakis, Nikos, Stamou, Dimitrios, Schaumburg, K. & Christensen, Jørn Bolstad, 2010, In: Bioconjugate Chemistry. 21, p. 1056 1061 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  100. 2009
  101. Published

    How curved membranes recruit amphipathic helices and protein anchoring motifs

    Hatzakis, Nikos, Bhatia, V. K., Larsen, J., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A. H., Castillo Leon, J. J., Gether, Ulrik, Hedegård, Per & Stamou, Dimitrios, 2009, In: Nature Chemical Biology. 5, 11, p. 835-841 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  102. 2008
  103. Published

    The enzyme mechanism of nitrite reductase studied at single-molecule level

    Kuznetsova, S., Zauner, G., Aartsma, T., Engelkamp, H., Hatzakis, Nikos, Rowan, A., Nolte, R., Christianen, P. & Canters, G., 2008, In: Proceedings of the National Academy of Sciences USA (PNAS). 105, 9, p. 3250-3255

    Research output: Contribution to journal › Journal article › Research › peer-review

  104. Published

    β-Cyclodextrin-appended giant amphiphile: Aggregation to vesicle polymersomes and immobilisation of enzymes

    Felici, M., Marzá-Pérez, M., Hatzakis, Nikos, Nolte, R. J. M. & Feiters, M. C., 2008, In: Chemistry - A European Journal. 14, 32, p. 9914-9920 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  105. 2007

  106. Positional assembly of enzymes in polymersome nanoreactors for cascade reactions

    Vriezema, D. M., Garcia, P. M. L., Oltra, N. S., Hatzakis, Nikos, Kuiper, S. M., Nolte, R. J. M., Rowan, A. E. & van Hest, J. C. M., 2007, In: Angewandte Chemie International Edition. 46, 39, p. 7378-7382 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  107. 2006

  108. Bionanoconjugation via click chemistry: The creation of functional hybrids of lipases and gold nanoparticles

    Brennan, J. L., Hatzakis, Nikos, Tshikhudo, T. R., Dirvianskyte, N., Razumas, V., Patkar, S., Vind, J., Svendsen, A., Nolte, R. J. M., Rowan, A. E. & Brust, M., 2006, In: Bioconjugate Chemistry. 17, 6, p. 1373-1375 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  109. Do enzymes sleep and work?

    Engelkamp, H., Hatzakis, Nikos, Hofkens, J., De Schryver, F. C., Nolte, R. J. M. & Rowan, A. E., 2006, In: Chemical Communications. 9, p. 935-940 6 p.

    Research output: Contribution to journal › Review › Research › peer-review

  110. Published

    From single to multienzyme assemblies: Do enzymes sleep and work?

    Hatzakis, Nikos, Engelkamp, H., Nolte, R. & Rowan, A., 2006, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

    Research output: Contribution to journal › Journal article › Research

  111. Published

    Functional biohybrid amphiphiles

    Dirks, A. J., Hatzakis, Nikos, Cornelissen, J. J. L. M. & Nolte, R. J. M., 2006, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

    Research output: Contribution to journal › Conference abstract in journal › Research

  112. POLY 391-Assembly strategies for enzyme immobilization

    Lambermon, M., Hendriks, L. J., Schoffelen, S., Vos, M., Hatzakis, Nikos, Carette, N., Rowan, A. E., Cornelissen, J., Michon, T., Sommerdijk, N. A. J. M. & van Hest, J. C. M., 2006, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

    Research output: Contribution to journal › Conference abstract in journal › Research

  113. POLY 553-Biohybrid block copolymer architectures by "click" chemistry

    Opsteen, J. A., Dirks, A. J., van Berkel, S. S., Hatzakis, Nikos, Brinkhuis, R. P., Reijnders, M. E. G. & van Hest, J. C. M., 2006, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

    Research output: Contribution to journal › Conference abstract in journal › Research

  114. Synthesis and single enzyme activity of a clicked lipase-BSA hetero-dimer

    Hatzakis, Nikos, Engelkamp, H., Velonia, K., Hofkens, J., Christianen, P. C. M., Svendsen, A., Patkar, S. A., Vind, J., Maan, J. C., Rowan, A. E. & Nolte, R. J. M., 2006, In: Chemical Communications. 19, p. 2012-2014 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  115. 2005

  116. Preparation of biohybrid amphiphiles via the copper catalysed Huisgen [3 + 2] dipolar cycloaddition reaction

    Dirks, A. J., Van Berkel, S. S., Hatzakis, Nikos, Opsteen, J. A., Van Delft, F. L., Cornelissen, J. J. L. M., Rowan, A. E., Van Hest, J. C. M., Rutjes, F. P. J. T. & Nolte, R. J. M., 7 Sep 2005, In: Chemical Communications. 33, p. 4172-4174 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  117. Asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens

    Hatzakis, Nikos & Smonou, I., 2005, In: Bioorganic Chemistry. 33, 4, p. 325-337 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  118. Functional nano-sized assemblies from amphiphilic biohybrid macromolecules

    Cornelissen, J., Dirks, A., Reynhout, I., Opsteen, J., Hatzakis, Nikos, Sly, J., Rowan, A., van Hest, J. & Nolte, R., 2005, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

    Research output: Contribution to journal › Conference abstract in journal › Research

  119. 2004

  120. Enantioselectivity and diastereoselectivity in the transesterification of secondary alcohols mediated by feruloyl esterase from Humicola insolens

    Hatzakis, Nikos & Smonou, I., 2004, In: Tetrahedron Letters. 45, 13, p. 2755-2757 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  121. 2003

  122. Ferulic acid esterase from Humicola Insolens catalyzes enantioselective transesterification of secondary alcohols

    Hatzakis, Nikos, Daphnomili, D. & Smonou, I., 2003, In: Journal of Molecular Catalysis B: Enzymatic. 21, 4-6, p. 309-311 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  123. 2001

  124. Oxidation of benzyl alcohols by dimethyldioxirane. The question of concerted versus stepwise mechanisms probed by kinetic isotope effects

    Angelis, Y. S., Hatzakis, Nikos, Smonou, I. & Orfanopoulos, M., 2001, In: Tetrahedron Letters. 42, 22, p. 3753-3756 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 6090