Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

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Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.

Original languageEnglish
JournalNature Chemical Biology
Issue number3
Pages (from-to)192-194
Number of pages3
Publication statusPublished - 2015

ID: 131361806