Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases
Research output: Contribution to journal › Journal article › Research › peer-review
Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.
|Nature Chemical Biology
|Number of pages
|Published - 2015