Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases
Research output: Contribution to journal › Journal article › Research › peer-review
Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.
Original language | English |
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Journal | Nature Chemical Biology |
Volume | 11 |
Issue number | 3 |
Pages (from-to) | 192-194 |
Number of pages | 3 |
ISSN | 1552-4450 |
DOIs | |
Publication status | Published - 2015 |
ID: 131361806