Lasse Saaby
Affiliated Associate Professor
CNS Drug Delivery and Barrier Modelling
Universitetsparken 2
2100 København Ø
Main research interests
I study drug compound permeation across biological barriers and the interplay with transport proteins to improve our understanding of these barriers and how they can be overcome through drug delivery.
My research is mainly focused on the blood-brain barrier and the role of efflux transporters. To this end, we develop cell culture models that mimick the human blood-brain barrier or over-express efflux transport proteins using human stem cells or immortalized cell lines. We use these cell models to study the dynamics of substrate-transporter interactions and explore new drug delivery concepts to improve brain delivery.
ID: 4863000
Most downloads
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185
downloads
Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates
Research output: Contribution to journal › Journal article › peer-review
Published -
159
downloads
The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
Research output: Contribution to journal › Journal article › peer-review
Published -
56
downloads
A novel derivative of thioridazine shows low toxicity and efficient activity against gram‐positive pathogens
Research output: Contribution to journal › Journal article › peer-review
Published