Carbohydrate-Derived Metal-Chelator-Triggered Lipids for Liposomal Drug Delivery

Research output: Contribution to journalJournal articleResearchpeer-review

Liposomes are versatile three-dimensional, biomaterial-based frameworks that can spatially enclose a variety of organic and inorganic biomaterials for advanced targeted-delivery applications. Implementation of external-stimuli-controlled release of their cargo will significantly augment their wide application for liposomal drug delivery. This paper presents the synthesis of a carbohydrate-derived lipid, capable of changing its conformation depending on the presence of Zn2+: an active state in the presence of Zn2+ ions and back to an inactive state in the absence of Zn2+ or when exposed to Na2EDTA, a metal chelator with high affinity for Zn2+ ions. This is the first report of a lipid triggered by the presence of a metal chelator. Total internal reflection fluorescence microscopy and a single-liposome study showed that it indeed was possible for the lipid to be incorporated into the bilayer of stable liposomes that remained leakage-free for the fluorescent cargo of the liposomes. On addition of EDTA to the liposomes, their fluorescent cargo could be released as a result of the membrane-incorporated lipids undergoing a conformational change.

Original languageEnglish
JournalChemistry - A European Journal
Issue number23
Pages (from-to) 6917-6922
Number of pages6
Publication statusPublished - 2021

    Research areas

  • carbohydrates, drug delivery, lipids, liposomes, zinc

ID: 257870153