Jesper Langgaard Kristensen
Professor
Medicinal Chemistry
Jagtvej 162
2100 København Ø
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Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors
Petersen, I. N., Crestey, F., Jensen, Anders A., Indurthi, D. C., Pedersen, H., Andreasen T., Jesper, Balle, T. & Kristensen, Jesper Langgaard, 9 Apr 2015, In: A C S Medicinal Chemistry Letters. 6, 4, p. 472-475 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis
Hansen, K. B., Clausen, Rasmus Prætorius, Bjerrum, E. J., Bechmann, C., Greenwood, J. R., Christensen, C., Kristensen, Jesper Langgaard, Egebjerg, J. & Bräuner, Hans, Dec 2005, In: Molecular Pharmacology. 68, 6, p. 1510-23Research output: Contribution to journal › Journal article › Research › peer-review
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Trans-cyclooctene-functionalized PeptoBrushes with improved reaction kinetics of the tetrazine ligation for pretargeted nuclear imaging: [Meeting Abstract]
Steen, J., Norregard, K., Johann, K., Jørgensen, Jesper Tranekjær, Svatunek, D., Birke, A., Edem, P., Rossin, R., Seidl, C., Schmid, F., Robillard, M., Mikula, H., Kristensen, Jesper Langgaard, Barz, M., Kjær, Andreas & Herth, Matthias Manfred, May 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S109-S110Research output: Contribution to journal › Conference abstract in journal › Research
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Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging
Stéen, E. J. L., Jørgensen, Jesper Tranekjær, Johann, K., Norregaard, K., Sohr, B., Svatunek, D., Birke, A., Shalgunov, Vladimir, Edem, P. E., Rossin, R., Seidl, C., Schmid, F., Robillard, M. S., Kristensen, Jesper Langgaard, Mikula, H., Barz, M., Kjær, Andreas & Herth, Matthias Manfred, 2020, In: ACS Nano. 14, 1, p. 568-584Research output: Contribution to journal › Journal article › Research › peer-review
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Towards the Dual Click F-18-labeling of Antibodies
Steen, J., Denk, C., Norregaard, K., Jorgensen, J., Rossin, R., Svatunek, D., Edem, P., Robillard, M., Kjær, Andreas, Kristensen, Jesper Langgaard, Mikula, H. & Herth, Matthias Manfred, 1 May 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Total synthesis of ascididemin via anionic cascade ring closure
Petersen, I. N., Crestey, F. & Kristensen, Jesper Langgaard, 2012, In: Chemical Communications. 48, 72, p. 9092-9094Research output: Contribution to journal › Journal article › Research › peer-review
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The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice
Odland, Anna Ulstein, Kristensen, Jesper Langgaard & Andreasen T., Jesper, 2021, In: Behavioural Pharmacology. 32, 5, p. 448-452Research output: Contribution to journal › Journal article › Research › peer-review
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The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH
Jensen, Anders A., Halberstadt, A. L., Marcher, Emil, Odland, Anna Ulstein, Chatha, M., Speth, N., Liebscher, G., Hansen, M., Bräuner, Hans, Palner, M., Andreasen T., Jesper & Kristensen, Jesper Langgaard, 2020, In: Biochemical Pharmacology. 177, 16 p., 113979.Research output: Contribution to journal › Journal article › Research › peer-review
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The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [11C]Cimbi-36 labeled in two positions
Johansen, A., Hansen, H. D., Svarer, C., Lehel, S., Leth-Petersen, S., Kristensen, Jesper Langgaard, Gillings, N. & Knudsen, Gitte Moos, Apr 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 4, p. 659-668Research output: Contribution to journal › Journal article › Research › peer-review
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The Alkaloids from Lophophora diffusa and Other “False Peyotes”
Chan, Camilla Bachmand, Poulie, Christian Bernard Matthijs, Wismann, S. S., Soelberg, Jens & Kristensen, Jesper Langgaard, 2021, In: Journal of Natural Products. 84, 8, p. 2398–2407Research output: Contribution to journal › Journal article › Research › peer-review
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The 5-hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation
Odland, Anna Ulstein, Jessen, L., Kristensen, Jesper Langgaard, Fitzpatrick, C. M. & Andreasen T., Jesper, 2021, In: Neuropharmacology. 183, 9 p., 107838.Research output: Contribution to journal › Journal article › Research › peer-review
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Textbook of Drug Design and Discovery: In vivo imaging in drug discovery
Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2017, Textbook of Drug Design and Discovery. Fifth edition ed. CRC PressResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors
Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, Michael, Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 19 Sep 2011, In: Angewandte Chemie International Edition. 50, 39, p. 9100-9103Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis, radiofluorination, and preliminary evaluation of the potential 5-HT2A receptor agonists [18 F]Cimbi-92 and [18 F]Cimbi-150
Edgar, F. G., Hansen, H. D., Leth-Petersen, S., Ettrup, A., Kristensen, Jesper Langgaard, Knudsen, Gitte Moos & Herth, Matthias Manfred, Oct 2017, In: Journal of Labelled Compounds and Radiopharmaceuticals. 60, 12, p. 586-591 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis, cross-coupling, and anionic cyclization of ortho-substituted naphthaleneboronic esters
Lysén, M., Madden, M., Kristensen, Jesper Langgaard, Vedsø, P., Zöllner, C. & Begtrup, M., 17 Oct 2006, In: Synthesis. 20, p. 3478-3484 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of tertiary benzamides via Pd-catalyzed coupling of arylboronic esters and carbamoyl chlorides
Lysén, M., Kelleher, S., Begtrup, M. & Kristensen, Jesper Langgaard, 24 Jun 2005, In: Journal of Organic Chemistry. 70, 13, p. 5342-5343 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of substituted 2-cyanoarylboronic esters
Lysén, M., Hansen, H. M., Begtrup, M. & Kristensen, Jesper Langgaard, 17 Mar 2006, In: Journal of Organic Chemistry. 71, 6, p. 2518-20 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of pentacyclic 13-azadibenzo[a,de]anthracenes via anionic cascade ring closure
Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 16 May 2003, In: Journal of Organic Chemistry. 68, 10, p. 4091-4092 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of ortho substituted arylboronic esters by in situ trapping of unstable lithio intermediates: 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-YL)Benzoic acid ethyl ester: [Benzoic acid, 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-, ethyl ester]
Kristensen, Jesper Langgaard, Lysén, M., Vedsø, P. & Begtrup, M., 1 Jan 2005, In: Organic Syntheses. 81, p. 134-139 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of novel azaxanthones derived from N-hydroxyazoles
Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 18 Mar 2002, In: Tetrahedron. 58, 12, p. 2397-2404 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of enantiopure 3-substituted morpholines
Bornholdt, J., Felding, J. & Kristensen, Jesper Langgaard, 2010, In: Journal of Organic Chemistry. 75, 21, p. 7454-7457Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of azaphenanthridines via anionic ring closure
Hansen, H. M., Lysén, M., Begtrup, M. & Kristensen, Jesper Langgaard, 17 Oct 2005, In: Tetrahedron. 61, 42, p. 9955-9960 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of RHPS4 via an anionic ring closing cascade
Kristensen, Jesper Langgaard, 2008, In: Tetrahedron Letters. 49, 15, p. 2351-2354Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of Pyridoacridines through Anionic Cascade Ring Closure
Petersen, I. N. & Kristensen, Jesper Langgaard, 1 Jan 2014, In: Synthesis. 46, p. 1469-1474 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of Ortho Substituted Arylboronic Esters by in Situ Trapping of Unstable Lithio Intermediates
Kristensen, Jesper Langgaard, Lysén, M., Vedsø, P. & Begtrup, M., 17 May 2001, In: Organic Letters. 3, 10, p. 1435-1437 3 p.Research output: Contribution to journal › Letter › Research › peer-review
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Synthesis of N-alkylated amino acids using fluorous-tagged hydroxylamines
Nielsen, S. D., Smith, G. P., Begtrup, M. & Kristensen, Jesper Langgaard, 22 Jul 2011, In: Tetrahedron. 67, 29, p. 5261-5267Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of 4-substituted 1-(benzyloxy)pyrazoles via iodine-magnesium exchange of 1-(benzyloxy)-4-iodopyrazole
Felding, J., Kristensen, Jesper Langgaard, Bjerregaard, T., Sander, L., Vedsø, P. & Begtrup, M., 28 May 1999, In: Journal of Organic Chemistry. 64, 11, p. 4196-4198 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis of (R)-(-)-2-fluoronorapomorphine - A precursor for the synthesis of (R)-(-)-2-fluoro-N-[C]propylnorapomorphine for evaluation as a dopamine D agonist ligand for PET investigations
Søndergaard, K., Kristensen, Jesper Langgaard, Gillings, N. & Begtrup, M., 14 Oct 2005, In: European Journal of Organic Chemistry. 20, p. 4428-4433 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists
Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner, Hans & Kristensen, Jesper Langgaard, 7 Jan 2014, In: A C S Chemical Neuroscience. 5, 3, p. 243-249 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and stability study of a new major metabolite of gamma-hydroxybutyric acid
Petersen, I. N., Kristensen, Jesper Langgaard, Tortzen, C., Breindahl, T. & Pedersen, D. S., 2013, In: Beilstein Journal of Organic Chemistry. 9, p. 641-646 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists
Hansen, M., Jacobsen, S. E., Plunkett, S., Liebscher, G. E., McCorvy, J. D., Bräuner, Hans & Kristensen, Jesper Langgaard, 2015, In: Bioorganic & Medicinal Chemistry. 23, 14, p. 3933-3937 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and pharmacological evaluation of DHβE analogs as neuronal nicotinic acetylcholine receptor antagonists
Jepsen, T. H., Jensen, Anders A., Lund, M. H., Glibstrup, E. & Kristensen, Jesper Langgaard, 2014, In: A C S Medicinal Chemistry Letters. 5, 7, p. 766-770 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and evaluation of [C-11]CIMBI-712 and [C-11]CIMBI-772
Andersen, V. L., Herth, Matthias Manfred, Hansen, H. D., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, May 2013, p. S101-S101.Research output: Contribution to conference › Conference abstract for conference › Research
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Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging
Herth, Matthias Manfred, Hansen, H. D., Ettrup, A. J., Dyssegaard, A., Lehel, S., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 2012, In: Bioorganic and Medicinal Chemistry. 20, 14, p. 4574-4581 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands
Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In: Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and characterisation of substrate-based peptides as inhibitors of histone demethylase KDM4C
Nielsen, S. D., Leurs, U., Bergner, M., Barris, S. A., Devkota, K., Meyer, K., Iaria, D., McCaughan, J., Lohse, B., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 13 Jun 2016, In: Protein and Peptide Letters. 23, 9, p. 772 - 776 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acidA receptor agonists
Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, Charlotte Grube, Nielsen, Birgitte, Kehler, J., Frydenvang, Karla Andrea, Kristensen, Jesper Langgaard, Balle, T., Jensen, Anders A., Kristiansen, Uffe & Frølund, Bente, 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 993-1006Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and binding studies of 2-arylapomorphines
Søndergaard, K., Kristensen, Jesper Langgaard, Palner, M., Gillings, N., Knudsen, Gitte Moos, Roth, B. & Begtrup, M., 21 Nov 2005, In: Organic & Biomolecular Chemistry. 3, 22, p. 4077-4081 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and application of a new fluorous-tagged ammonia equivalent
Nielsen, S. D., Smith, G., Begtrup, M. & Kristensen, Jesper Langgaard, 2010, In: Chemistry: A European Journal. 16, 15, p. 4557-4566Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and SAR study of a novel series of dopamine receptor agonists
Risgaard, R., Jensen, M., Jørgensen, M., Bang-Andersen, B., Christoffersen, C. T., Jensen, K. G., Kristensen, Jesper Langgaard & Püschl, A., 1 Jan 2014, In: Bioorganic and Medicinal Chemistry. 22, 1, p. 381-392Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT7 Receptor Imaging with PET
Herth, Matthias Manfred, Volk, B., Pallagi, K., Koefoed Bech, L., A. Antoni, F., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 31 Aug 2012, In: ACS Chemical Neuroscience. 3, 12, p. 1002-1007Research output: Contribution to journal › Journal article › Research › peer-review
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Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C
Leurs, U., Lohse, B., Rand, Kasper Dyrberg, Ming, S., Riise, E. S., Cole, P. A., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 11 Jul 2014, In: A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists
Pottie, E., Poulie, Christian Bernard Matthijs, Simon, Icaro A, Harpsøe, Kasper, D’Andrea, L., Komarov, I. V., Gloriam, David E., Jensen, Anders A., Kristensen, Jesper Langgaard & Stove, C. P., 2023, In: ACS Chemical Neuroscience. 14, 15, p. 2727–2742Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-ht2 receptors
Isberg, V., Paine, J., Leth-Petersen, S., Kristensen, Jesper Langgaard & Gloriam, David E., 2013, In: P L o S One. 8, 11, e78515.Research output: Contribution to journal › Journal article › Research › peer-review
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Stereoselective synthesis of highly substituted bicyclic γ-lactones using homoaldol addition of 1-(1-cycloalkenyl)methyl carbamates
Özlügedik, M., Kristensen, Jesper Langgaard, Reuber, J., Fröhlich, R. & Hoppe, D., 1 Oct 2004, In: Synthesis. 14, p. 2303-2316 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Snegleprotein øger forståelsen af vigtige receptorer i hjernen
Shahsavar, Azadeh, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael, Balle, T. & Kastrup, Jette Sandholm Jensen, 2012, In: Lægemiddelforskning. 2012, p. 48-50 3 p.Research output: Contribution to journal › Journal article › Communication
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Serotonin 2A receptor agonist binding in the human brain with [C]Cimbi-36
Ettrup, A., da Cunha-Bang, S., McMahon, B. P., Lehel, S., Dyssegaard, A., Skibsted, A. W., Jørgensen, Louise Møller, Hansen, M., Baandrup, A. O., Bache, S., Svarer, C., Kristensen, Jesper Langgaard, Gillings, N., Madsen, J. & Knudsen, Gitte Moos, 30 Apr 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, p. 1188-1196 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ring opening of pymisyl-protected aziridines with organocuprates
Bornholdt, J., Felding, J., Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 2010, In: Chemistry: A European Journal. 16, 41, p. 12474-12480Research output: Contribution to journal › Journal article › Research › peer-review
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Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors
Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Andersen, V. L., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 24 Feb 2014, In: Journal of Nuclear Medicine. 55, 4, p. 640-646Research output: Contribution to journal › Journal article › Research › peer-review
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Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers
Ettrup, A., Hansen, M., Santini, M. A., Paine, J. S., Gillings, N., Palner, M., Lehel, S., Herth, Matthias Manfred, Madsen, J., Kristensen, Jesper Langgaard, Begtrup, M. & Knudsen, Gitte Moos, 1 Apr 2011, In: European Journal of Nuclear Medicine and Molecular Imaging. 38, 4, p. 681-693Research output: Contribution to journal › Journal article › Research › peer-review
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Radiolabelling and PET brain imaging of the a1-adrenoceptor antagonist Lu AE43936
Risgaard, R., Ettrup, A. J., Balle, T., Dyssegaard, A., Hansen, H. D., Lehel, S., Madsen, J., Pedersen, H., Püschl, A., Badolo, L., Bang-Andersen, B., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Nuclear Medicine & Biology. 40, 1, p. 135-140 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Radiolabeling and in vivo evaluation of [11C]AGH-44: a potential lead structure to develop a positron emission tomography radioligand for the 5-HT7 receptor
L’Estrade, E. T., Petersen, I. N., Xiong, M., Hogendorf, A. S., Hogendorf, A., Kristensen, Jesper Langgaard, Kjær, Andreas, Bojarski, A. J., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos & Herth, Matthias Manfred, 1 Nov 2019, In: Journal of Radioanalytical and Nuclear Chemistry. 322, 2, p. 847-851 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pretargeted PET imaging using a dual click F-18-labeling strategy: [Meeting Abstract]
Steen, J., Denk, C., Jørgensen, Jesper Tranekjær, Norregard, K., Rossin, R., Wilkovitsch, M., Svatunek, D., Edem, P., Kuntner, C., Wanek, T., Robillard, M., Kristensen, Jesper Langgaard, Kjær, Andreas, Mikula, H. & Herth, Matthias Manfred, May 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S22-S23 O-08.Research output: Contribution to journal › Conference abstract in journal › Research
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Preparation of 5-acyl- and 5-aryl-substituted 1-(benzyloxy)pyrazoles via directed ortho-lithiation/transmetalation and palladium catalyzed cross- coupling
Kristensen, Jesper Langgaard, Begtrup, M. & Vedsø, P., 1 Nov 1998, In: Synthesis. 11, p. 1604-1608 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preclinical Safety Assessment of the 5-HT(2A) Receptor Agonist PET Radioligand [ (11)C]Cimbi-36
Ettrup, A., Holm, S., Hansen, M., Wasim, M., Santini, M. A., Palner, M., Madsen, J., Svarer, C., Kristensen, Jesper Langgaard & Knudsen, G. M., 10 Jan 2013, In: Molecular Imaging and Biology. 15, 4, p. 376-83Research output: Contribution to journal › Journal article › Research › peer-review
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Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro
Lohse, B., Helgstrand, C., Andersson, J. L., Leurs, U., Cloos, P. A. C., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 2 Jul 2013, In: P L o S One. 8, 7, p. e67653Research output: Contribution to journal › Journal article › Research › peer-review
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Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes
Andersen, V. L., Herth, Matthias Manfred, Lehel, S., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In: Tetrahedron Letters. 54, 3, p. 213-216 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Palladium-catalyzed asymmetric allylic alkylation of a-aryl ketones
Trost, B. M., Schroeder, G. M. & Kristensen, Jesper Langgaard, 16 Sep 2002, In: Angewandte Chemie International Edition. 41, 18, p. 3492-3495 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Palladium-Catalyzed Arylation and Acylation of 1-Benzyloxy-1,2,3-triazole Through a Directed Ortho Lithiation-Transmetalation Strategy.
Felding, J., Uhlmann, P., Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 1998, In: Synthesis. 8, p. 1181-1184 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)
Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 10 May 2013, IPC No. C07D 487/ 04 A I, Patent No. WO2013064153, Priority date 31 Oct 2011, Priority No. DK20110070591Research output: Patent
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PRODRUGS OF NAPROXEN AND DICLOFENAC
Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 17 Mar 2016, IPC No. A61K 45/ 06 A I, Patent No. US2016074523, Priority date 28 Apr 2014, Priority No. WO2014EP58530Research output: Patent
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Overcoming Energy Transfer for the Metallophotoredox Catalyzed Decarboxylative Alkenylation between Alkylcarboxylic Acids and Enol Triflates
Pedersen, S. K., Clementson, S., Kristensen, Jesper Langgaard, Jessing, M. & El-Chami, K., 2023, In: Chemistry: A European Journal. 29, 35, e202300265.Research output: Contribution to journal › Journal article › Research › peer-review
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Ortho lithiation-in situ borylation of substituted morpholine benzamides
Cederbalk, A., Lysén, M., Kehler, J. & Kristensen, Jesper Langgaard, 23 Mar 2017, In: Tetrahedron. 73, 12, p. 1576–1582 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Nye NMDA-receptor-ligander til udforskning af hjernen
Clausen, Rasmus Prætorius, Risgaard, R., Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2010, In: Dansk Kemi. 91, 6/7, p. 21-23Research output: Contribution to journal › Journal article › Communication
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Ny bioisoster kan skabe nye lægemidler
Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 2004, In: Lægemiddelforskning. 2004, p. 16-17Research output: Contribution to journal › Journal article › Communication
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Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages
Petersen, I. N., Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 18 Jan 2017, In: European Journal of Organic Chemistry. 2017, 3, p. 453-458 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acidA receptor ligands: synthesis, pharmacology, and structure-activity relationships
Møller, H. A., Sander, T., Kristensen, Jesper Langgaard, Nielsen, Birgitte, Krall, J., Bergmann, M. L., Christiansen, B., Balle, T., Jensen, Anders A. & Frølund, Bente, 2010, In: Journal of Medicinal Chemistry. 53, 8, p. 3417-3421Research output: Contribution to journal › Journal article › Research › peer-review
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Nonracemic, chiral homoenolate reagents derived from (cycloalk-1-enyl)methyl carbamates and evaluation of their configurational stabilities
Özlügedik, M., Kristensen, Jesper Langgaard, Wibbeling, B., Fröhlich, R. & Hoppe, D., 1 Jan 2002, In: European Journal of Organic Chemistry. 3, p. 414-427 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands
Clausen, Rasmus Prætorius, Christensen, C., Hansen, K. B., Greenwood, J. R., Jørgensen, L., Micale, N., Madsen, J. C., Nielsen, Birgitte, Egebjerg, J., Bräuner, Hans, Traynelis, S. F. & Kristensen, Jesper Langgaard, 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4179-87Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic fate of hallucinogenic NBOMes
Leth-Petersen, S., Gabel-Jensen, C., Gillings, N., Lehel, S., Hansen, H. D., Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In: Chemical Research in Toxicology. 29, 1, p. 96–100 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Medicindepot dannes efter injektion i leddet
Larsen, Susan Weng, Thing, M. A., Østergaard, Jesper, Kristensen, Jesper Langgaard, Hansen, M. & Larsen, C. S., 2013, In: Lægemiddelforskning. 2013, p. 38-40Research output: Contribution to journal › Journal article › Research
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Long-Acting Diclofenac Ester Prodrugs for Joint Injection: Kinetics, Mechanism of Degradation, and In Vitro Release From Prodrug Suspension
Mertz, Nina, Larsen, Susan Weng, Kristensen, Jesper Langgaard, Østergaard, Jesper & Larsen, C., 27 Jul 2016, In: Journal of Pharmaceutical Sciences. 105, 10, p. 3079–3087 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Locomotor effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in mice: psychostimulant effects, stereotypy, and sensitization
Berquist, M. D., Leth-Petersen, S., Kristensen, Jesper Langgaard & Fantegrossi, W. E., 2020, In: Psychopharmacology. 237, p. 431–442Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry
Steen, E. J. L., Jørgensen, Jesper Tranekjær, Denk, C., Battisti, Umberto Maria, Norregaard, K., Edem, P. E., Bratteby, K., Shalgunov, Vladimir, Wilkovitsch, M., Svatunek, D., Poulie, Christian Bernard Matthijs, Hvass, Lars, Simon, M., Wanek, T., Rossin, R., Robillard, M., Kristensen, Jesper Langgaard, Mikula, H., Kjær, Andreas & Herth, Matthias Manfred, 2021, In: ACS Pharmacology & Translational Science. 4, 2, p. 824-833 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [(11)C]E-55888
Hansen, H. D., Andersen, V. L., Lehel, S., Magnussen, J. H., Dyssegaard, A., Stroth, N., Kristensen, Jesper Langgaard, Knudsen, G. M. & Herth, Matthias Manfred, 1 May 2015, In: Bioorganic & Medicinal Chemistry Letters. 25, 9, p. 1901-4 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Investigation of the 2,5-dimethoxy motif in phenethylamine Serotonin 2A receptor agonists
Marcher, Emil, Halberstadt, A. L., Klein, A. K., Chatha, M., Jademyr, S., Jensen, Anders A. & Kristensen, Jesper Langgaard, 2020, In: ACS Chemical Neuroscience. 11, p. 1238-1244Research output: Contribution to journal › Letter › Research › peer-review
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Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice
Odland, Anna Ulstein, Kristensen, Jesper Langgaard & Andreasen T., Jesper, 2021, In: Behavioural Brain Research. 401, 5 p., 113093.Research output: Contribution to journal › Journal article › Research › peer-review
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Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT2A Receptor Agonist
Marcher, Emil, Nykodemová, J., Harpsøe, Kasper, Jensen, Anders A. & Kristensen, Jesper Langgaard, 2023, In: ACS Medicinal Chemistry Letters. 14, 3, p. 319–325Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibitors of histone demethylases
Lohse, B., Kristensen, Jesper Langgaard, Kristensen, L. H., Agger, K., Helin, K., Gajhede, Michael & Clausen, Rasmus Prætorius, 1 Feb 2011, In: Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C)
Leurs, U., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Lohse, B., 15 Sep 2012, In: Bioorganic & Medicinal Chemistry Letters. 22, 18, p. 5811-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ind i hjernen med nye stoffer
Clausen, Rasmus Prætorius, Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2009, In: Lægemiddelforskning. p. 34-36Research output: Contribution to journal › Journal article › Communication
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In vivo imaging in drug discovery
Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 19 Aug 2016, Textbook of Drug Design and Discovery, Fifth Edition. CRC Press, p. 19-135 117 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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In vivo effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in rodents: Drug discrimination and thermoregulation
Berquist, M. D., Leth-Petersen, S., Kristensen, Jesper Langgaard & Fantegrossi, W. E., 1 Mar 2020, In: Drug and Alcohol Dependence. 208, 8 p., 107850.Research output: Contribution to journal › Journal article › Research › peer-review
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In vivo PET imaging of cerebral 5-HT7 receptors with novel radioligands
Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Szabolcs, L., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, p. S126-S127Research output: Contribution to journal › Journal article › Research › peer-review
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In situ generation of the Ohira-Bestmann Reagent from stable sulfonyl azide: scalable synthesis of alkynes from aldehydes
Jepsen, T. H. & Kristensen, Jesper Langgaard, 12 Sep 2014, In: Journal of Organic Chemistry. 79, 19, p. 9423-9426 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid
Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, , 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507Research output: Contribution to journal › Journal article › Research › peer-review
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Improved radiosynthesis and preliminary in vivo evaluation of the 11 C-labeled tetrazine [ 11 C]AE-1 for pretargeted PET imaging
Stéen, E. J. L., Jørgensen, Jesper Tranekjær, Petersen, I. N., Nørregaard, K., Lehel, S., Shalgunov, Vladimir, Birke, A., Edem, P. E., L'Estrade, E. T., Hansen, H. D., Villadsen, J., Erlandsson, M., Ohlsson, T., Yazdani, A., Valliant, J. F., Kristensen, Jesper Langgaard, Barz, M., Knudsen, Gitte Moos, Kjær, Andreas & Herth, Matthias Manfred, 1 Jan 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 8, p. 986-990Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a new metabolite of GHB: gamma-hydroxybutyric acid glucuronide
Petersen, I. N., Tortzen, C., Kristensen, Jesper Langgaard, Pedersen, D. S. & Breindahl, T., Jun 2013, In: Journal of Analytical Toxicology. 37, 5, p. 291-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
IMIDAZOLE DERIVATIVES AS PRODRUGS OF DICLOFENAC
Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, JENSEN, H. & Østergaard, Jesper, 6 May 2016, IPC No. A61P 29/ 00 A I, Patent No. WO2016066612, Priority date 28 Oct 2014, Priority No. DK20140070657Research output: Patent
- Published
Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions
Johansen, A., Holm, S., Dall, B., Keller, S., Kristensen, Jesper Langgaard, Knudsen, Gitte Moos & Hansen, H. D., 2019, In: EJNMMI Research. 9, p. 1-10 10 p., 71.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histonhaler: et nyt mål inden for kræftbehandling
Kristensen, Jesper Langgaard, Lohse, B. & Clausen, Rasmus Prætorius, Dec 2010, In: Lægemiddelforskning. 2010, p. 7-9Research output: Contribution to journal › Journal article › Communication
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Heterocyclic pentafluorophenyl sulfonate esters as shelf stable alternatives to sulfonyl chlorides
Bornholdt, J., Fjære, K. W., Felding, J. & Kristensen, Jesper Langgaard, 2009, In: Tetrahedron. 65, 45, p. 9280-9284Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice
Fantegrossi, W. E., Gray, B. W., Bailey, J. M., Smith, D. A., Hansen, M. & Kristensen, Jesper Langgaard, Mar 2015, In: Psychopharmacology. 232, 6, p. 1039-47 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes
Bartuzi, D., Kędzierska, E., Targowska-Duda, K. M., Koszła, O., Wróbel, T. M., Jademyr, S., Karcz, T., Szczepańska, K., Stępnicki, P., Wronikowska-Denysiuk, O., Biała, G., Handzlik, J., Kristensen, Jesper Langgaard, Poso, A. & Kaczor, A. A., 2022, In: Scientific Reports. 12, 1, 14 p., 21192.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for alpha1-adrenoceptors
Kristensen, Jesper Langgaard, Pu¨schl, A., Jensen, M., Risgaard, R., Christoffersen, C. T., Bang-Andersen, B. & Balle, T., 2010, In: Journal of Medicinal Chemistry. 53, 19, p. 7021-7034Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs
Herth, Matthias Manfred, Andersen, V. L., Hansen, H. D., Stroth, N., Volk, B., Lehel, S., Dyssegaard, A., Ettrup, A., Svenningsson, P., Knudsen, G. M. & Kristensen, Jesper Langgaard, 13 Apr 2015, In: Journal of Medicinal Chemistry. 58, 8, p. 3631–3636 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery
Clementson, S., Matheu, S. A., Marcher, Emil, Pedersen, H., Jensen, Anders A., Clausen, Rasmus Prætorius, Vital, P., Glibstrup, E., Jessing, M. & Kristensen, Jesper Langgaard, 2021, In: The Journal of Organic Chemistry. 86, 12, p. 8248-8262Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum: Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids (Organic Letters (2006) 8 (3371))
Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 15 Oct 2010, In: Organic Letters. 12, 20, p. 4708 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Er psykedeliske stoffer uden bivirkninger mulige?
Kristensen, Jesper Langgaard, 16 Mar 2023, Videnskab.dk.Research output: Other contribution › Net publication - Internet publication › Communication
- Published
Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases
Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In: F E B S Letters. 585, 12, p. 1951-1956Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1305029
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Convenient access to F-18-labeled amines through the Staudinger reduction
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A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE
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Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C
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