Inhibitors of histone demethylases

Research output: Contribution to journalReviewResearchpeer-review

Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared. Most of the inhibitors are either previously reported inhibitors of related enzymes or compounds derived from these. Development in terms of selectivity and potency is still pertinent. Several reports on the development of functional assays have been published.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry
Issue number12
Pages (from-to)3625-3636
Number of pages11
Publication statusPublished - 1 Feb 2011

ID: 33531805