Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery
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Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and (+)-Cocculidine, both found to be potent antagonists of the β2-containing nAChRs.
Original language | English |
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Journal | The Journal of Organic Chemistry |
Volume | 86 |
Issue number | 12 |
Pages (from-to) | 8248-8262 |
ISSN | 0022-3263 |
DOIs | |
Publication status | Published - 2021 |
ID: 270553746