Palladium-catalyzed asymmetric allylic alkylation of a-aryl ketones
Research output: Contribution to journal › Journal article › Research › peer-review
Quaternary centers can be created asymmetrically in high enantiomeric excess by the proper choice of ligand and metal cation in the Pd-catalyzed asymmetric allylic alkylation of a-aryl ketones. A broad range of ketone enolates can be tolerated in the reaction, as illustrated by the synthesis of conformationally constrained ß-tetralone in 96% ee (see scheme, DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene).
Original language | English |
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Journal | Angewandte Chemie International Edition |
Volume | 41 |
Issue number | 18 |
Pages (from-to) | 3492-3495 |
Number of pages | 4 |
ISSN | 1433-7851 |
DOIs | |
Publication status | Published - 16 Sep 2002 |
Externally published | Yes |
ID: 45438013