Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages
Research output: Contribution to journal › Journal article › Research › peer-review
The field of labeling electron-rich aryl compounds with nucleophilic [18F]fluoride has recently expanded with radiofluorination strategies that apply boronic esters or spirocyclic iodonium ylides as precursors. Herein, we present a direct comparison of these strategies by using nine chemically diverse model compounds. In general, spirocyclic iodonium ylides outperform the boronic esters.
| Original language | English |
|---|---|
| Journal | European Journal of Organic Chemistry |
| Volume | 2017 |
| Issue number | 3 |
| Pages (from-to) | 453-458 |
| Number of pages | 6 |
| ISSN | 1434-193X |
| DOIs | |
| Publication status | Published - 18 Jan 2017 |
- Comparative studies, Isotopic labeling, Nucleophilic substitution, Spiro compounds, Ylides
Research areas
ID: 177414671