Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages

Research output: Contribution to journalJournal articleResearchpeer-review

The field of labeling electron-rich aryl compounds with nucleophilic [18F]fluoride has recently expanded with radiofluorination strategies that apply boronic esters or spirocyclic iodonium ylides as precursors. Herein, we present a direct comparison of these strategies by using nine chemically diverse model compounds. In general, spirocyclic iodonium ylides outperform the boronic esters.

Original languageEnglish
JournalEuropean Journal of Organic Chemistry
Issue number3
Pages (from-to)453-458
Number of pages6
Publication statusPublished - 18 Jan 2017

    Research areas

  • Comparative studies, Isotopic labeling, Nucleophilic substitution, Spiro compounds, Ylides

ID: 177414671