Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages
Research output: Contribution to journal › Journal article › Research › peer-review
The field of labeling electron-rich aryl compounds with nucleophilic [18F]fluoride has recently expanded with radiofluorination strategies that apply boronic esters or spirocyclic iodonium ylides as precursors. Herein, we present a direct comparison of these strategies by using nine chemically diverse model compounds. In general, spirocyclic iodonium ylides outperform the boronic esters.
Original language | English |
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Journal | European Journal of Organic Chemistry |
Volume | 2017 |
Issue number | 3 |
Pages (from-to) | 453-458 |
Number of pages | 6 |
ISSN | 1434-193X |
DOIs | |
Publication status | Published - 18 Jan 2017 |
- Comparative studies, Isotopic labeling, Nucleophilic substitution, Spiro compounds, Ylides
Research areas
ID: 177414671