Birgitte Rahbek Kornum

Birgitte Rahbek Kornum

Guest Researcher, Associate Professor - Promotion Programme

ORCID: 0000-0002-2515-9451

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  1. Published

    Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis

    Ægidius, H. M., Veidal, S. S., Feigh, M., Hallenborg, P., Puglia, M., Pers, Tune H, Vrang, N., Jelsing, J., Kornum, Birgitte Rahbek, Blagoev, B. & Rigbolt, K. T. G., 2020, In: Scientific Reports. 10, 1, 12 p., 1148.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells

    Zager, A., Brandão, W. N., Margatho, R. O., Cruz, D. S. G., Peron, J. P., Tufik, S., Andersen, M. L., Moresco, M., Pizza, F., Plazzi, G., Kornum, Birgitte Rahbek & Palermo-Neto, J., 2018, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 81, p. 297-305 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. The wake-promoting drug Modafinil prevents motor impairment in sickness behavior induced by LPS in mice: Role for dopaminergic D1 receptor

    Zager, A., Brandão, W. N., Margatho, R. O., Peron, J. P., Tufik, S., Andersen, M. L., Kornum, Birgitte Rahbek & Palermo-Neto, J., 2018, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 81, p. 468-476 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy

    Winkelmann, J., Lin, L., Schormair, B., Kornum, Birgitte Rahbek, Faraco, J., Plazzi, G., Melberg, A., Cornelio, F., Urban, A. E., Pizza, F., Poli, F., Grubert, F., Wieland, T., Graf, E., Hallmayer, J., Strom, T. M. & Mignot, E., 15 May 2012, In: Human Molecular Genetics. 21, 10, p. 2205-10 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    TREATMENT OF CNS DISORDERS WITH SLEEP DISTURBANCES

    Wellendorph, Petrine, Kornum, Birgitte Rahbek & Frølund, Bente, 2020, Patent No. WO2020259787 , 30 Dec 2020, Priority date 28 Jun 2019, Priority No. DK2019PA70415 20190628

    Research output: Patent

  6. Published

    DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status

    Weiner Lachmi, K., Lin, L., Kornum, Birgitte Rahbek, Rico, T., Lo, B., Aran, A. & Mignot, E., Apr 2012, In: Human Immunology. 73, 4, p. 405-10 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Emerging therapeutic targets for narcolepsy

    Vringer, M. & Kornum, Birgitte Rahbek, 2023, In: Expert Opinion On Therapeutic Targets. 25, 7, p. 559-572 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  8. Published

    Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings

    Viste, R., Follin, L. F., Kornum, Birgitte Rahbek, Lie, B. A., Viken, M. K., Thorsby, P. M., Rootwelt, T., Christensen, J. A. E. & Knudsen-Heier, S., 2023, In: Sleep. 46, 3, 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11protein levels in narcolepsy type 1

    Viste, R., Viken, M. K., Lie, B. A., Juvodden, H. T., Nordstrand, S. E. H., Thorsby, P. M., Rootwelt, T., Kornum, Birgitte Rahbek & Knudsen-Heier, S., 2021, In: Sleep. 44, 8, 12 p., zsab062.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Narcolepsy type 1 patients have lower levels of effector memory CD4+ T cells compared to their siblings when controlling for H1N1-(Pandemrix™)-vaccination and HLA DQB1∗06:02 status

    Viste, R., Lie, B. A., Viken, M. K., Rootwelt, T., Knudsen-Heier, S. & Kornum, Birgitte Rahbek, 2021, In: Sleep Medicine. 85, p. 271-279 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients have increased muscle activity during REM and nrem sleep compared with their non-narcoleptic siblings

    Viste, R., Lie, B. A., Kornum, Birgitte Rahbek, Rootwelt, T. & Knudsen-Heier, S., 2022, In: Journal of Sleep Research. 31, Supplement 1, 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  12. Published

    Repeated measures of hypocretin-1 in Danish and Italian patients with narcolepsy and in controls

    Torstensen, E. W., Haubjerg Østerby, N. C., Pizza, F., Plazzi, G., Antelmi, E., Moresco, M., Mignot, E., Jørgensen, Niklas Rye, Christensen, G. L., Wanscher, B., Kornum, Birgitte Rahbek & Jennum, Poul, 2023, In: Sleep Medicine. 101, p. 213-220 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints

    Torstensen, E. W., Brinth, L. S., Mehlsen, J., Kornum, Birgitte Rahbek & Jennum, Poul, 2018, In: Danish Medical Journal. 65, 11, 4 p., A5510.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Repeated polysomnography and multiple sleep latency test in narcolepsy type 1 and other hypersomnolence disorders

    Torstensen, E. W., Haubjerg Østerby, N. C., Kornum, Birgitte Rahbek, Wanscher, B., Mignot, E., Barløse, Mads Christian Johannes & Jennum, Poul, 2023, In: Sleep Medicine. 110, p. 91-98 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Diagnostic value of actigraphy in hypersomnolence disorders

    Torstensen, E. W., Pickering, L., Kornum, Birgitte Rahbek, Wanscher, B., Baandrup, Lone & Jennum, Poul, 2021, In: Sleep Medicine. 85, p. 1-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

    Syvanen, S., Lindhe, O., Palner, M., Kornum, Birgitte Rahbek, Rahman, O., Langstrom, B., Knudsen, Gitte Moos & Hammarlund-Udenaes, M., 2009, In: Drug Metabolism and Disposition. 37, 3, p. 635-643 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Normal Morning Melanin-Concentrating Hormone Levels and No Association with Rapid Eye Movement or Non-Rapid Eye Movement Sleep Parameters in Narcolepsy Type 1 and Type 2

    Schrölkamp, Maren, Jennum, Poul, Gammeltoft, S., Holm, A., Kornum, Birgitte Rahbek & Knudsen, S., Feb 2017, In: Journal of Clinical Sleep Medicine. 13, 2, p. 235-243 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    In Vitro and In Vivo Evaluation of Pellotine: A Hypnotic Lophophora Alkaloid

    Poulie, C. B. M., Chan, C. B., Parka, A., Lettorp, M., Vos, J., Raaschou, A., Pottie, E., Bundgaard, M. S., Sørensen, L. M. E., Cecchi, C. R., Märcher-Rørsted, E., Bach, A., Herth, M. M., Decker, A., Jensen, A. A., Elfving, B., Kretschmann, A. C., Stove, C. P., Kohlmeier, K. A., Cornett, C. & 3 others, Janfelt, Christian, Kornum, Birgitte Rahbek & Kristensen, Jesper Langgaard, 2023, In: ACS Pharmacology & Translational Science. 6, 10, p. 1492-1507

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Non-invasive detection of narcolepsy type I phenotypical features and disease progression by continuous home-cage monitoring of activity in two mouse models: the HCRT-KO and DTA model

    Petersen, Louise Piilgaard, Rose, Laura, Justinussen, Jessica, Hviid, C. G., Lemcke, René, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2023, In: Sleep. 46, 9, 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Sex-related differences within sleep-wake dynamics, cataplexy, and EEG fast-delta power in a narcolepsy mouse model

    Petersen, Louise Piilgaard, Rose, Laura, Hviid, C. G., Kohlmeier, Kristi Anne & Kornum, Birgitte Rahbek, 2022, In: Sleep. 45, 7, 15 p., zsac058.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

    Pedersen, N. W., Holm, A., Kristensen, N. P., Bjerregaard, A., Bentzen, A. K., Marquard, A. M., Tamhane, T., Burgdorf, K. S., Ullum, H., Jennum, Poul, Knudsen, S., Hadrup, S. R. & Kornum, Birgitte Rahbek, 2019, In: Nature Communications. 10, p. 1-12 837.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    5-HT radioligands for human brain imaging with PET and SPECT

    Paterson, L. M., Kornum, Birgitte Rahbek, Nutt, D. J., Pike, V. W. & Knudsen, Gitte Moos, Jan 2013, In: Medicinal Research Reviews. 33, 1, p. 54-111 58 p.

    Research output: Contribution to journal › Review › Research › peer-review

  23. Published

    Does autoreactivity have a role in narcolepsy?

    Partinen, M., Kornum, Birgitte Rahbek, Plazzi, G., Jennum, Poul, Julkunen, I. & Vaarala, O., Nov 2014, In: Lancet Neurology. 13, 11, p. 1072-1073 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination

    Partinen, M., Kornum, Birgitte Rahbek, Plazzi, G., Jennum, Poul, Julkunen, I. & Vaarala, O., 2014, In: Lancet Neurology. 13, 6, p. 600-13

    Research output: Contribution to journal › Review › Research › peer-review

  25. Published

    Downregulation of hypocretin/orexin after H1N1 Pandemrix vaccination of adolescent mice

    Pagh-Berendtsen, Nicolai, Pavlovskyi, Artem, Flores Téllez, D., Jensen, Christine Egebjerg, Pedersen, Mie Gunni Kolmos, Justinussen, Jessica & Kornum, Birgitte Rahbek, 2024, In: Sleep. 47, 4, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

    Ollila, H. M., Sharon, E., Lin, L., Sinnott-Armstrong, N., Ambati, A., Yogeshwar, S. M., Hillary, R. P., Jolanki, O., Faraco, J., Einen, M., Luo, G., Zhang, J., Han, F., Yan, H., Dong, X. S., Li, J., Zhang, J., Hong, S. C., Kim, T. W., Dauvilliers, Y. & 31 others, Barateau, L., Lammers, G. J., Fronczek, R., Mayer, G., Santamaria, J., Arnulf, I., Knudsen-Heier, S., Bredahl, M. K. L., Thorsby, P. M., Plazzi, G., Pizza, F., Moresco, M., Crowe, C., Van den Eeden, S. K., Lecendreux, M., Bourgin, P., Kanbayashi, T., Martínez-Orozco, F. J., Peraita-Adrados, R., Benetó, A., Montplaisir, J., Desautels, A., Huang, Y. S., Jennum, Poul, Nevsimalova, S., Kemlink, D., Iranzo, A., Overeem, S., Wierzbicka, A., Kornum, Birgitte Rahbek & FinnGen, F., 2023, In: Nature Communications. 14, 1, 13 p., 2709.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy

    Ollila, H. M., Ravel, J-M., Han, F., Faraco, J., Lin, L., Zheng, X., Plazzi, G., Dauvilliers, Y., Pizza, F., Hong, S-C., Jennum, P., Knudsen, S., Kornum, B. R., Dong, X. S., Yan, H., Hong, H., Coquillard, C., Mahlios, J., Jolanki, O., Einen, M. & 15 others, Arnulf, I., Lavault, S., Högl, B., Frauscher, B., Crowe, C., Partinen, M., Huang, Y. S., Bourgin, P., Vaarala, O., Désautels, A., Montplaisir, J., Mack, S. J., Mindrinos, M., Fernandez-Vina, M. & Mignot, E., 8 Jan 2015, In: American Journal of Human Genetics. 96, 1, p. 136-46 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    A novel spatial Delayed Non-Match to Sample (DNMS) task in the Göttingen minipig

    Nielsen, T. R., Kornum, Birgitte Rahbek, Moustgaard, A. C., Gade, A., Lind, N. M. & Knudsen, Gitte Moos, 2008, In: Behavioural Brain Research. p. 93-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease

    Moresco, M., Lecciso, M., Ocadlikova, D., Filardi, M., Melzi, S., Kornum, Birgitte Rahbek, Antelmi, E., Pizza, F., Mignot, E., Curti, A. & Plazzi, G., 2018, In: Sleep Medicine. 44, p. 53-60 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Sandwich cortial lamination and single-cell analysis decodes the developing spatial processing system

    Liu, Y., Bergmann, T. B., Lee, J., Pfisterer, U. G., Handfield, L-F., Mori, Y., Asenjo Martinez, A., Lisa Vargas, I., Seemann, E. S., Lee, J. T. H., Patikis, N., Peralvo Vidal, J. M., Pihl, M., Kornum, B. R., Thomsen, P. D., Hyttel, P., Witter, M., Khodosevich, K., Gorodkin, J., Hemberg, M. & 2 others, Pers, Tune H & Hall, Vanessa Jane, 2019. 45 p.

    Research output: Contribution to conference › Paper › Communication

  31. Published

    GABAA receptor β1-subunit knock-out mice show increased delta power in NREM sleep and decreased theta power in REM sleep

    Lie, M. E. K., Falk-Petersen, C. B., Petersen, Louise Piilgaard, Griem-Krey, Nane, Wellendorph, Petrine & Kornum, Birgitte Rahbek, 2021, In: European Journal of Neuroscience. 54, 2, p. 4445-4455 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    The immunopathogenesis of narcolepsy type 1

    Liblau, R. S., Latorre, D., Kornum, Birgitte Rahbek, Dauvilliers, Y. & Mignot, E. J., 2024, In: Nature Reviews Immunology. 24, p. 33-48

    Research output: Contribution to journal › Review › Research › peer-review

  33. Published

    GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

    Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K., Teurlings, S. M. W. & 9 others, Chi, C. C., Gee, C. L., Frølund, Bente, Kornum, Birgitte Rahbek, van Woerden, G. M., Clausen, Rasmus Prætorius, Kuriyan, J., Clarkson, A. N. & Wellendorph, Petrine, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 p., e2108079118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus

    Lemcke, René, Jensen, Christine Egebjerg, Pagh-Berendtsen, Nicolai, Egerod, Kristoffer Lihme, Thomsen, Allan Randrup, Pers, Tune H, Christensen, Jan Pravsgaard & Kornum, Birgitte Rahbek, 2023, 31 p.

    Research output: Working paper › Preprint › Research

  35. Published

    Molecular consequences of peripheral Influenza A infection on cell populations in the murine hypothalamus

    Lemcke, René, Jensen, Christine Egebjerg, Pagh-Berendtsen, Nicolai, Egerod, Kristoffer Lihme, Thomsen, Allan Randrup, Pers, Tune H, Christensen, Jan Pravsgaard & Kornum, Birgitte Rahbek, 2023, In: eLife. 12, 28 p., RP87515.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemes

    Kornum, Birgitte Rahbek, Licht, C. L., Weikop, P., Knudsen, G. M. & Kleijn, S. A., 9 Jan 2006, In: Neuroscience Letters. 392, 1-2, p. 129-34 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    A pig model for studies of serotonergic mechanisms in memory disorders

    Kornum, Birgitte Rahbek, 2009, København: Museum Tusculanum. 69 p.

    Research output: Book/Report › Ph.D. thesis

  38. Published

    Absence of autoreactive CD4(+) T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot

    Kornum, Birgitte Rahbek, Burgdorf, Kristoffer Sølvsten, Holm, A., Ullum, H., Jennum, Poul & Knudsen, S., 2017, In: Journal of Neuroimmunology. 309, p. 7-11 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain

    Kornum, Birgitte Rahbek, Faraco, J. & Mignot, E., Dec 2011, In: Current Opinion in Neurobiology. 21, 6, p. 897-903 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  40. Association mellem narkolepsi og H1N1-influenza

    Kornum, Birgitte Rahbek, Knudsen, S., Gammeltoft, S. & Jennum, Poul, 2013, In: Ugeskrift for Laeger. 175, 12, p. 815

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Genetics of Human Sleep and Sleep Disorders

    Kornum, Birgitte Rahbek, 2017, Handbook of Neurobehavioural Genetics and Phenotyping. Tucci, V. (ed.). 1 ed. New Jersey: Wiley-Blackwell, p. 295-320 26 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education

  42. Published

    Sleep Disorders

    Kornum, Birgitte Rahbek & Mignot, E., 1 Jan 2015, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. Zigmond, M. J., Rowland, L. P. & Coyle, J. T. (eds.). London: Elsevier Science Inc., p. 585-611 27 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  43. Published

    Forstå din søvn: Hvad videnskaben siger om at sove godt, og hvordan du opnår det!

    Kornum, Birgitte Rahbek, 2019, 1 ed. København: Gyldendal. 205 p.

    Research output: Book/Report › Book

  44. Published

    Precipitants of Narcolepsy: Vaccines and Infections

    Kornum, Birgitte Rahbek, 2016, Narcolepsy: A Clinical Guide. 2 ed. Springer, p. 25-33 9 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education › peer-review

  45. Published

    Evaluation of the novel 5-HT4 receptor PET ligand (11C)SB207145 in the Göttingen minnipig

    Kornum, Birgitte Rahbek, Lind, N. M., Gillings, N. M., Marner, L., Andersen, F. & Knudsen, G. M., 2008, In: Comprehensive Medline. 1, p. 186-96 10 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  46. Published

    Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset

    Kornum, Birgitte Rahbek, Pizza, F., Knudsen, S., Plazzi, G., Jennum, Poul & Mignot, E., Oct 2015, In: Brain, Behavior, and Immunity. 49, p. 54-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Serum cytokine levels in Kleine-Levin syndrome

    Kornum, Birgitte Rahbek, Rico, T., Lin, L., Huang, Y., Arnulf, I., Jennum, Poul & Mignot, E., Aug 2015, In: Sleep Medicine. 16, 8, p. 961-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Narcolepsy Type I as an autoimmune disorder

    Kornum, Birgitte Rahbek, 2021, Handbook of Clinical Neurology. 1 ed. Elsevier, p. 161-172 12 p. (Handbook of Clinical Neurology, Vol. 181).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  49. Published

    Neurobioloy of sleep and circadian disorders

    Kornum, Birgitte Rahbek & Mignot, E., 2022, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition. M. J. Z., C. A. W. & M-F. C. (eds.). 2 ed. Elsevier, p. 635-658 24 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  50. Published

    The case for narcolepsy as an autoimmune disease

    Kornum, Birgitte Rahbek & Jennum, Poul, 2020, In: Expert Review of Clinical Immunology. 16, 3, p. 231-233 3 p.

    Research output: Contribution to journal › Review › Research › peer-review

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ID: 143987587