Ulrik Gether
Head of Department, Professor
Neuropharm and Genetics
Blegdamsvej 3, 2200 København N.
- 2024
- E-pub ahead of print
Role of dopamine neurons in familiarity
Fleury, S., Kolaric, R., Espera, J., Ha, Q., Tomaio, J., Gether, Ulrik, Sørensen, Andreas Toft & Mingote, S., 2024, (E-pub ahead of print) In: European Journal of Neuroscience.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transmembrane transporter proteins: Capturing transport in motion
Loland, Claus Juul, Wellendorph, Petrine, Pedersen, Stine Helene Falsig & Gether, Ulrik, 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 2, p. 203-205 3 p.Research output: Contribution to journal › Editorial › Research › peer-review
- 2023
- Published
Amphetamine-induced reverse transport of dopamine does not require cytosolic Ca2+
Støier, J. F., Konomi Pilkati, Ainoa, Apuschkin, Mia, Herborg, Freja & Gether, Ulrik, 2023, In: Journal of Biological Chemistry. 299, 8, 14 p., 105063.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Behavioral encoding across timescales by region-specific dopamine dynamics
Jørgensen, Søren Heide, Ejdrup, Aske Lykke, Lycas, M. D., Posselt, Leonie Pauline, Madsen, Kenneth Lindegaard, Tian, L., Dreyer, J. K., Herborg, Freja, Sørensen, Andreas Toft & Gether, Ulrik, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 7, 10 p., e2215230120.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity
Falk, S., Petersen, Jonas Odgaard, Svendsen, C. S. A., Leguizamon, Cesar Ramon Romero, Jørgensen, Søren Heide, Krauth, Nathalie, Ludwig, M. Q., Jørgensen, Kathrine Lundø, Roostalu, U., Hjort-Gregersen, G. S., Nielsen, D. A. G., Ejdrup, Aske Lykke, Pers, Tune H, Dmytriyeva, O., Hecksher-Soerensen, J., Gether, Ulrik, Kohlmeier, Kristi Anne & Clemmensen, Christoffer, 2023, In: Cell Reports. 42, 5, 18 p., 112466.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Theory of visual attention (TVA) applied to rats performing the 5-choice serial reaction time task: differential effects of dopaminergic and noradrenergic manipulations
Hervig, M. E. S., Toschi, C., Petersen, Anders, Vangkilde, Signe, Gether, Ulrik & Robbins, T. W., 2023, In: Psychopharmacology. 240, p. 41-58 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Within-Mice Comparison of Microdialysis and Fiber Photometry-Recorded Dopamine Biosensor during Amphetamine Response
Ejdrup, Aske Lykke, Wellbourne-Wood, J., Dreyer, J. K., Guldhammer, N., Lycas, M. D., Gether, Ulrik, Hall, B. J. & Sørensen, G., 2023, In: ACS Chemical Neuroscience. 14, 9, 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data
Ejdrup, Aske Lykke, Lycas, M. D., Lorenzen, N., Konomi Pilkati, Ainoa, Herborg, Freja, Madsen, Kenneth Lindegaard & Gether, Ulrik, 2022, In: Nature Communications. 13, 1, 4388.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis
Andersen, R. C., Schmidt, J. H., Rombach, J., Lycas, M. D., Christensen, N. R., Lund, V. K., Stapleton, D. S., Pedersen, S. S., Olsen, M. A., Stoklund, M., Noes-Holt, G., Nielsen, T. T. E., Keller, M. P., Jansen, A. M., Herlo, R., Pietropaolo, M., Simonsen, J. B., Kjærulff, O., Holst, B., Attie, A. D. & 2 others, , 2022, In: Journal of Clinical Investigation. 132, 5, e144904.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution
Schmidt, S. G., Gether, Ulrik & Loland, Claus Juul, 2022, In: Neurochemical Research. 47, p. 127–137 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors
Klein Herenbrink, Carmen, Støier, J. F., Reith, W. D., Dagra, A., Gregorek, M. A. C., Cola, R. B., Patriarchi, T., Li, Y., Tian, L., Gether, Ulrik & Herborg, Freja, 2022, In: Communications Biology . 5, 1, 578.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity
Lycas, M. D., Ejdrup, Aske Lykke, Sørensen, Andreas Toft, Haahr, N. O., Jørgensen, Søren Heide, Guthrie, D. A., Støier, J. F., Werner, C., Newman, A. H., Sauer, M., Herborg, Freja & Gether, Ulrik, 2022, In: Cell Reports. 40, 13, 27 p., 111431.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural basis of organic cation transporter-3 inhibition
Khanppnavar, B., Maier, J., Herborg, Freja, Gradisch, R., Lazzarin, E., Luethi, D., Yang, J. W., Qi, C., Holy, M., Jäntsch, K., Kudlacek, O., Schicker, K., Werge, Thomas, Gether, Ulrik, Stockner, T., Korkhov, V. M. & Sitte, H. H., 2022, In: Nature Communications. 13, 1, 13 p., 6714.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- 2021
- Published
Adaptive aspects of impulsivity and interactions with effects of catecholaminergic agents in the 5-choice serial reaction time task: implications for ADHD
Toschi, C., Hervig, M. E., Moazen, P., Parker, M. G., Dalley, J. W., Gether, Ulrik & Robbins, T. W., 2021, In: Psychopharmacology. 238, p. 2601–2615 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct-Pathway Spiny Projection Neuron Inhibition Evokes Transient Circuit Imbalance Manifested as Rotational Behavior
Christensen, M., Nørr, Søren Emil, Gether, Ulrik & Rickhag, Karl Mattias, 2021, In: Neuroscience. 453, p. 32-42 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation
Sørensen, G., Rickhag, Karl Mattias, Leo, D., Lycas, M. D., Ridderstrøm, P. H., Weikop, P., Lilja, J. H., Rifes, P., Herborg, Freja, Woldbye, David Paul Drucker, Wörtwein, Gitta, Gainetdinov, R. R., Fink-Jensen, Anders & Gether, Ulrik, 2021, In: Journal of Biological Chemistry. 297, 6, 101361.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals
Ducrot, C., Bourque, M., Delmas, C. V. L., Racine, A., Guadarrama Bello, D., Delignat-Lavaud, B., Domenic Lycas, M., Fallon, A., Michaud-Tardif, C., Burke Nanni, S., Herborg, Freja, Gether, Ulrik, Nanci, A., Takahashi, H., Parent, M. & Trudeau, L., 2021, In: FASEB Journal. 35, 8, 24 p., 21791.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease
Herborg, F., Jensen, K. L., Tolstoy, S., Arends, N., Posselt, L. P., Shekar, A., Aguilar, J., Lund, V. K., Erreger, K., Rickhag, M., Lycas, M. D., Lonsdale, M. N., Rahbek-Clemmensen, T., Sorensen, A. T., Newman, A. H., Lokkegaard, A., Kjaerulff, O., Werge, T., Moller, L. B., Matthies, H. J. G. & 4 others, , 2021, In: JCI insight. 6, 18, 21 p., 151496.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
It takes two-or more-to tango: Revisiting the role of dopamine transporter oligomerization
Gether, Ulrik & Sitte, H. H., 2021, In: Journal of Biological Chemistry. 296, 3 p., 100629.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rab2 drives axonal transport of dense core vesicles and lysosomal organelles
Lund, Viktor Karlovich, Lycas, M. D., Schack, A., Andersen, Rita Chan, Gether, Ulrik & Kjærulff, Ole, 2021, In: Cell Reports. 35, 2, 26 p., 108973.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain
Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, G., Jensen, K. L., Rathje, M., Jensen, D. B., Erlendsson, S., Bartling, C. R. O., Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, K., Arleth, L., Sørensen, A. T., Bach, A. & 5 others, , 2020, In: EMBO Molecular Medicine. 12, 6, 25 p., e11248.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor pharmacology-The next generation
Bräuner, Hans, Rosenkilde, Mette, Gether, Ulrik & Gloriam, David E., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, Supplement 6, p. 3-4 2 p.Research output: Contribution to journal › Editorial › Research
- Published
Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent
Jensen, M. E., Galli, A., Thomsen, M., Jensen, Kathrine Louise, Thomsen, G. K., Klausen, M. K., Vilsbøll, Tina, Christensen, Mikkel Bring, Holst, Jens Juul, Owens, A., Robertson, S., Daws, L., Zanella, D., Gether, Ulrik, Knudsen, Gitte Moos & Fink-Jensen, Anders, 2020, In: Neurochemistry International. 138, 9 p., 104772.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter
Guthrie, D. A., Klein Herenbrink, Carmen, Lycas, M. D., Ku, T., Bonifazi, A., Devree, B. T., Mathiasen, Signe, Javitch, J. A., Grimm, J. B., Lavis, L., Gether, Ulrik & Newman, A. H., 2020, In: ACS Chemical Neuroscience. 11, 20, p. 3288-3300 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
Plenge, P., Abramyan, A. M., Sørensen, G., Mork, A., Weikop, Pia, Gether, Ulrik, Bang-Andersen, B., Shi, L. & Loland, Claus Juul, 2020, In: Nature Communications. 11, 1, 12 p., 1491.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
Gotfryd, K., Boesen, T., Mortensen, Jonas Sigurd, Khelashvili, G., Quick, M., Terry, D. S., Missel, Julie Winkel, LeVine, M. V., Gourdon, Pontus Emanuel, Blanchard, S. C., Javitch, J. A., Weinstein, H., Loland, Claus Juul, Nissen, P. & Gether, Ulrik, 2020, In: Nature Communications. 11, 1, 14 p., 1005.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Conformational dynamics of the human serotonin transporter during substrate and drug binding
Möller, I. R., Slivacka, M., Nielsen, A. K., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 11 Apr 2019, In: Nature Communications. 10, 1, 1687.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors
DiCarlo, G. E., Aguilar, J. I., Matthies, H. J. G., Harrison, F. E., Bundschuh, K. E., West, A., Hashemi, P., Herborg, Freja, Rickhag, M., Chen, H., Gether, Ulrik, Wallace, M. T. & Galli, A., 2019, In: Journal of Clinical Investigation. 129, 8, p. 3407-3419 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemogenetic Targeting of Dorsomedial Direct-pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice
Kønig, A. B., Ciriachi, C., Gether, Ulrik & Rickhag, Karl Mattias, 2019, In: Neuroscience. 401, p. 106-116Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential effects of chemogenetic inhibition on dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task
Fitzpatrick, C. M., Runegaard, A. H., Christiansen, S. H., Hansen, Nikolaj Winther, Jørgensen, Søren Heide, McGirr, J. C., de Diego Ajenjo, A., Sørensen, Andreas Toft, Perrier, Jean-Francois Marie, Petersen, A., Gether, Ulrik, Woldbye, David Paul Drucker & Andreasen T., Jesper, 2019, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 90, 2, p. 264-276 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization
Runegaard, A. H., Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2019, In: Neuropharmacology. 161, 107663.Research output: Contribution to journal › Review › Research › peer-review
- Published
Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout
Giguère, N., Delignat-Lavaud, B., Herborg, Freja, Voisin, A., Li, Yuan, Jacquemet, V., Anand-Srivastava, M., Gether, Ulrik, Giros, B. & Trudeau, L., 2019, In: PLOS Genetics. 15, 8, 26 p., e1008352.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol
Runegaard, A. H., Jensen, Kathrine Louise, Wörtwein, Gitta & Gether, Ulrik, 2019, In: European Journal of Neuroscience. 50, 3, p. 2156-2163 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets
qrc243, qrc243, Thorsen, T. S., Vauquelin, G., Ammendrup-Johnsen, I., Wirth, V., Martinez, Karen Laurence, Teilum, Kaare, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2019, In: eLife. 8, p. 1-27 e39180.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges
Runegaard, A. H., Fitzpatrick, C. M., Woldbye, David Paul Drucker, Andreasen T., Jesper, Sørensen, Andreas Toft & Gether, Ulrik, 2019, In: Pharmacological Reviews. 71, 2, p. 123-156 34 p.Research output: Contribution to journal › Review › Research › peer-review
- 2018
- Published
An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1
Jensen, Rasmus Herlo Beenfeldt, Lund, Viktor Karlovich, Lycas, M. D., Jansen, A. M., Khelashvili, G., Andersen, Rita Chan, Bhatia, V., Pedersen, T. S., Albornoz, P. B. C., Johner, N., Ammendrup-Johnsen, I., Christensen, N. R., qrc243, qrc243, Stoklund, M., Larsen, J. B., Weinstein, H., Kjærulff, Ole, Stamou, Dimitrios, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2018, In: Cell Reports. 23, 7, p. 2056-2069 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An unsuspected role for organic cation transporter 3 in the actions of amphetamine
Mayer, F. P., Schmid, D., Owens, W. A., Gould, G. G., Apuschkin, Mia, Kudlacek, O., Salzer, I., Boehm, S., Chiba, P., Williams, P. H., Wu, H., Gether, Ulrik, Koek, W., Daws, L. C. & Sitte, H. H., 2018, In: Neuropsychopharmacology. 43, p. 2408-2417 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons
Runegaard, A. H., Sørensen, Andreas Toft, Fitzpatrick, C. M., Jørgensen, Søren Heide, Petersen, A. V., Hansen, Nikolaj Winther, Weikop, Pia, Andreasen T., Jesper, Mikkelsen, Jens D., Perrier, Jean-Francois Marie, Woldbye, David Paul Drucker, Rickhag, Karl Mattias, Wörtwein, Gitta & Gether, Ulrik, 2018, In: eNeuro. 5, 3, 26 p., e0345.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes
Herborg, Freja, Andreassen, T. F., Berlin, F., Loland, Claus Juul & Gether, Ulrik, 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7250-7262 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Obituary
Brøsen, K., Simonsen, U. & Gether, Ulrik, 2018, In: Basic & clinical pharmacology & toxicology. 123, 5, p. 521-522 2 p.Research output: Contribution to journal › Comment/debate › Communication
- Published
PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis
Jensen, Kathrine Louise, Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, Pia, Wörtwein, Gitta, Fink-Jensen, Anders, Madsen, Kenneth Lindegaard, Daws, L., Gether, Ulrik & Rickhag, Karl Mattias, 2018, In: eNeuro. 5, 3Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg
Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 2018, In: Science Advances. 4, 5, 12 p., eaar6179.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research
Jørgensen, Søren Heide, Fitzpatrick, C. M., Gether, Ulrik, Woldbye, David Paul Drucker & Sørensen, Andreas Toft, Nov 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 5, p. 373-381 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake
Jensen, Kathrine Louise, Runegaard, A. H., Weikop, Pia, Gether, Ulrik & Rickhag, Karl Mattias, Sep 2017, In: Journal of Visualized Experiments. 127, 10 p., e56093.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT
Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017Research output: Other contribution › Research
- Published
Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice
Thomsen, A. H. R., Jensen, Kathrine Louise, Fitzpatrick, C. M., Dencker, D., Weikop, Pia, Gether, Ulrik & Rickhag, Karl Mattias, Jan 2017, In: European Journal of Neuroscience. 45, 1, p. 121-128Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
qrc243, qrc243, Gotfryd, K., Larsen, F. H., Mortensen, Jonas Sigurd, Geiger, M., van Rossum, B., Oschkinat, H., Gether, Ulrik, Teilum, Kaare & Loland, Claus Juul, 2017, In: eLife. 6, 9 p., e19314.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer
Jacobsen, S. E., Gether, Ulrik & Bräuner, Hans, 2017, In: Scientific Reports. 7, 14 p., 46355.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurotransmitter Transporters: Structure, Function, and Drug Binding
Loland, Claus Juul & Gether, Ulrik, 2017, Textbook of Drug Design and Discovery. Stromgaard, K., Krogsgaard-Larsen, P. & Madsen, U. (eds.). 5 ed. Boca Raton: CRC Press, p. 233-248 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm
Runegaard, A. H., Jensen, Kathrine Louise, Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2017, In: Journal of Neuroscience Methods. 289, p. 85-92 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
Rahbek-Clemmensen, T., Lycas, M. D., qrc243, qrc243, Eriksen, J., Apuschkin, Mia, Vilhardt, Frederik, Jorgensen, T. N., Herborg, Freja & Gether, Ulrik, 2017, In: Nature Communications. 8, 14 p., 740.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway
Jacobsen, S. E., Ammendrup-Johnsen, I., Jansen, A. M., Gether, Ulrik, Madsen, Kenneth Lindegaard & Bräuner, Hans, 2017, In: The Journal of Biological Chemistry. 292, 17, p. 6910-6926Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task
Fitzpatrick, C. M., Caballero-Puntiverio, M., Gether, Ulrik, Habekost, Thomas, Bundesen, C., Vangkilde, Signe, Woldbye, David Paul Drucker, Andreasen T., Jesper & Petersen, Anders, 2017, In: Psychopharmacology. 234, 5, p. 845-855Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
The Environment Shapes the Inner Vestibule of LeuT
Sohail, A., Jayaraman, K., Venkatesan, S., Gotfryd, K., Daerr, M., Gether, Ulrik, Loland, Claus Juul, Wanner, K. T., Freissmuth, M., Sitte, H. H., Sandtner, W. & Stockner, T., Nov 2016, In: PLoS Computational Biology. 12, 11, 24 p., e1005197.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter
Billesbølle, C. B., Mortensen, Jonas Sigurd, Sohail, A., Schmidt, S. G., Shi, L., Sitte, H. H., Gether, Ulrik & Loland, Claus Juul, 28 Sep 2016, In: Nature Communications. 7, 12 p., 12755.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu(290)
Khelashvili, G., Schmidt, S. G., Shi, L., Javitch, J. A., Gether, Ulrik, Loland, Claus Juul & Weinstein, H., 16 Sep 2016, In: Journal of Biological Chemistry. 291, 38, p. 19786-19799Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function
Vuorenpää, A. E., Ammendrup-Johnsen, I., Jorgensen, T. N. & Gether, Ulrik, Sep 2016, In: Neurochemistry International. 98, p. 103-114Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural biology: Antidepressants at work
Caron, M. G. & Gether, Ulrik, 21 Apr 2016, In: Nature. 532, p. 320-321 2 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial
Knorr, Ulla Benedichte Søsted, Koefoed, P., Soendergaard, M. H. G., Vinberg, Maj, Gether, Ulrik, Gluud, C., Wetterslev, J., Winkel, P. & Kessing, Lars Vedel, Apr 2016, In: Acta Neuropsychiatrica. 28, 2, p. 101-109 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini
Vuorenpää, A. E., Jørgensen, T. N., Newman, A. H., Madsen, Kenneth Lindegaard, Scheinin, M. & Gether, Ulrik, 11 Mar 2016, In: Journal of Biological Chemistry. 291, 11, p. 5634-5651 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter
Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In: British Journal of Pharmacology. 173, 5, p. 925-936 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial
Knorr, Ulla Benedichte Søsted, Koefoed, P., Gluud, C., Wetterslev, J., Winkel, P., Gether, Ulrik, Vinberg, Maj & Kessing, Lars Vedel, 11 Jan 2016, In: Nordic Journal of Psychiatry. 70, 4, p. 297-302 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter: Sodium Symporter
Billesbolle, C. B., Kruger, M. B., Shi, L., Quick, M., Li, Z., Stolzenberg, S., Kniazeff, J., Gotfryd, K., Mortensen, Jonas Sigurd, Javitch, J. A., Weinstein, H., Loland, Claus Juul & Gether, Ulrik, 30 Oct 2015, In: Journal of Biological Chemistry. 290, 44, p. 26725-26738 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Optogenetik bringer neurale mekanismer frem i lyset og kan blive en ny terapiform
Axelsen, T. M., Navntoft, C. A. E., Christiansen, S. H., Dreyer, J. K., Sørensen, Jakob Balslev, Gether, Ulrik & Woldbye, David Paul Drucker, 17 Aug 2015, In: Ugeskrift for Laeger. 177, 34, p. 2-5 4 p., V06150501.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional regulation of amphetamine-induced efflux by CaMKII
Sitte, H. H., Steinkellner, T., Montgomery, T. R., Hofmaier, T., Kudlacek, O., Yang, J., Jung, G., Lubec, G., Gether, Ulrik, Freissmuth, M. & Pollak, D. D., Aug 2015, In: Amino Acids. 47, 8, p. 1659-1659 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Structure of dimeric and tetrameric complexes of the BAR domain protein PICK1 determined by small-angle X-Ray scattering
Karlsen, M. L., Thorsen, T. S., Johner, N., Ammendrup-Johnsen, I., qrc243, qrc243, Tian, X., Simonsen, J. B., Hoiberg-Nielsen, R., Christensen, N. M., Khelashvili, G., Streicher, W., Teilum, Kaare, Vestergaard, Bente, Weinstein, H., Gether, Ulrik, Arleth, Lise & Madsen, Kenneth Lindegaard, 7 Jul 2015, In: Structure. 23, 7, p. 1258-1270 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation
Rajamanickam, J., Annamalai, B., Rahbek-Clemmensen, T., Sundaramurthy, S., Gether, Ulrik, Jayanthi, L. D. & Ramamoorthy, S., 15 May 2015, In: Biochemical Journal. 468, 1, p. 177-190 14 p., BJ20140826.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors
Cartier, E., Hamilton, P. J., Belovich, A. N., Shekar, A., Campbell, N. G., Saunders, C., Andreassen, T. F., Gether, Ulrik, Veenstra-Vanderweele, J., Sutcliffe, J. S., Ulery-Reynolds, P. G., Erreger, K., Matthies, H. J. G. & Galli, A., Feb 2015, In: EBioMedicine. 2, 2, p. 135-146 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity
Apuschkin, Mia, Stilling, S., Rahbek-Clemmensen, T., Sørensen, G., Fortin, G., Herborg, Freja, Eriksen, J., Trudeau, L., Egerod, Kristoffer Lihme, Gether, Ulrik & Rickhag, Karl Mattias, 2015, In: European Journal of Neuroscience. 42, 7, p. 2438-2454 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amphetamine Action at the Cocaine- and Antidepressant-Sensitive Serotonin Transporter Is Modulated by αCaMKII
Steinkellner, T., Montgomery, T. R., Hofmaier, T., Kudlacek, O., Yang, J., Rickhag, Karl Mattias, Jung, G., Lubec, G., Gether, Ulrik, Freissmuth, M. & Sitte, H. H., 2015, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35, 21, p. 8258-8271 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters
Stolzenberg, S., Quick, M., Zhao, C., Gotfryd, K., Khelashvili, G., Gether, Ulrik, Loland, Claus Juul, Javitch, J. A., Noskov, S., Weinstein, H. & Shi, L., 2015, In: The Journal of Biological Chemistry. 290, 22, p. 13992-4003 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
In vivo amphetamine action is contingent on αCaMKII
Steinkellner, T., Mus, L., Eisenrauch, B., Constantinescu, A., Leo, D., Konrad, L., Rickhag, Karl Mattias, Sørensen, G., Efimova, E. V., Kong, E., Willeit, M., Sotnikova, T. D., Kudlacek, O., Gether, Ulrik, Freissmuth, M., Pollak, D. D., Gainetdinov, R. R. & Sitte, H. H., Oct 2014, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 39, 11, p. 2681-93 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells
da Silva Pinheiro, P. C., Jansen, A. M., de Wit, H., Tawfik, B., Madsen, Kenneth Lindegaard, Verhage, M., Gether, Ulrik & Sørensen, Jakob Balslev, 6 Aug 2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 32, p. 10688-700 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The second sodium site in the dopamine transporter controls cation permeability and is regulated by chloride
Borre, L., Andreassen, T. F., Shi, L., Weinstein, H. & Gether, Ulrik, 25 Jul 2014, In: The Journal of Biological Chemistry. 289, p. 25764-25773 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Missense dopamine transporter mutations associate with adult parkinsonism and ADHD
Hansen, F. H., Skjørringe, T., Yasmeen, S., Arends, N. V., Sahai, M. A., Erreger, K., Andreassen, T. F., Holy, M., Hamilton, P. J., Neergheen, V., Karlsborg, M., Newman, A. H., Pope, S., Heales, S. J. R., Friberg, L., Law, I., Pinborg, L. H., Sitte, H. H., Loland, C., Shi, L. & 5 others, , 1 Jul 2014, In: The Journal of Clinical Investigation. 124, 7, p. 3107-20 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Serotonin-induced down-regulation of cell surface serotonin transporter
Jørgensen, T. N., Christensen, P. M. & Gether, Ulrik, Jul 2014, In: Neurochemistry International. 73, p. 107-12 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation
Rahbek-Clemmensen, T., Bay, T., Eriksen, J., Gether, Ulrik & Jørgensen, T. N., 27 Jun 2014, In: The Journal of Biological Chemistry. 289, p. 23004-23019 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram
Kumar, V., Rahbek-Clemmensen, T., Billesbølle, C. B., Jorgensen, T. N., Gether, Ulrik & Newman, A. H., 12 Jun 2014, In: A C S Medicinal Chemistry Letters. 5, 6, p. 696-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reply to Wilkinson et al. Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling
Rathje, Mette, Fang, H., Bachman, J. L., Gether, Ulrik, Huganir, R. L. & Madsen, Kenneth Lindegaard, 21 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. E305 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/Discs-Large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands
qrc243, qrc243, Rathje, Mette, Heiðarsson, P. O., Poulsen, F. M., Madsen, Kenneth Lindegaard, Teilum, Kaare & Gether, Ulrik, 2014, In: Journal of Biological Chemistry. 289, 36, p. 25327-25340 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder
Hamilton, P. J., Campbell, N. G., Sharma, S., Erreger, K., Herborg, Freja, Saunders, C., Belovich, A. N., NIH ARRA Autism Sequencing Consortium, N. A. A. S. C., Sahai, M. A., Cook, E. H., Gether, Ulrik, McHaourab, H. S., Matthies, H. J. G., Sutcliffe, J. S. & Galli, A., Dec 2013, In: Molecular Psychiatry. 18, 12, p. 1315-23 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drosophila melanogaster: a novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter gene
Hamilton, P. J., Campbell, N. G., Sharma, S., Erreger, K., Herborg, Freja, Saunders, C., Belovich, A. N., Sahai, M. A., Cook, E. H., Gether, Ulrik, McHaourab, H. S., Matthies, H. J. G., Sutcliffe, J. S. & Galli, A., Dec 2013, In: Molecular Psychiatry. 18, 12, p. 1235Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel Tripod Amphiphiles for Membrane Protein Analysis
Chae, P. S., Kruse, A. C., Gotfryd, K., Rana, R. R., Cho, K. H., Rasmussen, Søren Gøgsig Faarup, Bae, H. E., Chandra, R., Gether, Ulrik, Guan, L., Kobilka, B. K., Loland, Claus Juul, Byrne, B. & Gellman, S. H., 2 Oct 2013, In: Chemistry: A European Journal. 19, 46Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Correction to "tandem facial amphiphiles for membrane protein stabilization"
Chae, P. S., Gotfryd, K., Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 28 Aug 2013, In: Journal of the American Chemical Society. 135, 34, p. 12922 1 p.Research output: Contribution to journal › Journal article › Research
- Published
AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons
Rathje, Mette, Fang, H., Bachman, J. L., Anggono, V., Gether, Ulrik, Huganir, R. L. & Madsen, Kenneth Lindegaard, 27 Aug 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 35, p. 14426-31 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
Holst, Birgitte, Madsen, Kenneth Lindegaard, Jansen, A. M., Jin, C., Rickhag, Karl Mattias, Lund, Viktor Karlovich, Jensen, M., Bhatia, V., Sørensen, G., Madsen, A. N., Xue, Z., Møller, S. K., Woldbye, David Paul Drucker, Qvortrup, Klaus, Huganir, R., Stamou, Dimitrios, Kjærulff, Ole & Gether, Ulrik, Apr 2013, In: P L o S Biology (Online). 11, 4, p. 1-25 25 p., e1001542.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study
Chae, P. S., Rana, R. R., Gotfryd, K., Rasmussen, Søren Gøgsig Faarup, Kruse, A. C., Cho, K. H., Capaldi, S., Carlsson, E., Kobilka, B., Loland, Claus Juul, Gether, Ulrik, Banerjee, S., Byrne, B., Lee, J. K. & Gellman, S. H., 21 Mar 2013, In: Chemical communications (Cambridge, England). 49, 23, p. 2287-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT
Simmons, K. J., Gotfryd, K., Billesbølle, C. B., Loland, Claus Juul, Gether, Ulrik, Fishwick, C. W. G. & Johnson, A. P., Mar 2013, In: Molecular Membrane Biology. 30, 2, p. 184-94 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter
Rickhag, Karl Mattias, Herborg, Freja, Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, K., Madsen, Kenneth Lindegaard, Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E., Gomeza, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Gether, Ulrik, 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association study of genetic variants in LPS-stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α cytokine response in a Danish Cohort
Larsen, M. H., Albrechtsen, Anders, Thørner, L. W., Werge, T., Hansen, T., Gether, Ulrik, Haastrup, E. & Ullum, H., 2013, In: PLOS ONE. 8, 6, 6 p., e66262.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.
Rickhag, Karl Mattias, Owens, W., Winkler, M., Strandfelt, K. N., Rathje, Mette, Sørensen, G., Andresen, B., Madsen, Kenneth Lindegaard, Nygaard Jørgensen, T., Wörtwein, Gitta, Woldbye, David Paul Drucker, Sitte, H. H., Daws, L. C. & Gether, Ulrik, 2013, In: Journal of Biological Chemistry. 288, p. 27534-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial
Knorr, Ulla Benedichte Søsted, Vinberg, Maj, Gether, Ulrik, Winkel, P., Gluud, C., Wetterslev, J. & Kessing, Lars Vedel, 30 Dec 2012, In: Psychiatry Research Review. 200, 2-3, p. 354-60 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter
Plenge, P., Shi, L., Beuming, T., Te, J., Newman, A. H., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 16 Nov 2012, In: The Journal of Biological Chemistry. 287, 47, p. 39316-26 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The solute carrier 6 family of transporters
Bröer, S. & Gether, Ulrik, 22 Aug 2012, In: British Journal of Pharmacology. 167, 2, p. 256-78 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins
Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, K., Kruse, A. C., Manglik, A., Cho, K. H., Nurva, S., Gether, Ulrik, Guan, L., Loland, Claus Juul, Byrne, B., Kobilka, B. K. & Gellman, S. H., 27 Jul 2012, In: Chemistry: A European Journal. 18, 31, p. 9485-90 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway
Madsen, Kenneth Lindegaard, Thorsen, T. S., Rahbek-Clemmensen, T., Eriksen, J. M. & Gether, Ulrik, 6 Apr 2012, In: The Journal of Biological Chemistry. 287, 15, p. 12293-308 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
Koefoed, P., Woldbye, D. P. D., Hansen, T. V. O., Eplov, L. F., Christiansen, S. H. O., Mors, O., Kessing, L. V., Werge, T., Kaipio, K., Pesonen, U., Fahmy, T., Mellerup, E. T., Jakobsen, K. D., Hansen, E. S., Knudsen, G. M., Bukh, J. D., Bock, C., Lindberg, C., Kristensen, A. S., Dam, H. & 6 others, , 23 Mar 2012, In: Acta Neuropsychiatrica. 24, 2, p. 81-90 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression: a randomized trial
Knorr, U., Vinberg, Maj, Mortensen, Erik Lykke, Winkel, P., Gluud, C., Wetterslev, J., Gether, Ulrik & Kessing, Lars Vedel, 29 Feb 2012, In: P L o S One. 7, 2, p. e31980 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding
Ammendrup-Johnsen, I., Thorsen, T. S., Gether, Ulrik & Madsen, Kenneth Lindegaard, 17 Jan 2012, In: Biochemistry. 51, 2, p. 586-96 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation
Kristensen, Anders Skov, Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Loland, Claus Juul, Strømgaard, Kristian & Gether, Ulrik, 1 Sep 2011, In: Pharmacological Reviews. 63, 3, p. 585-640 56 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain
Thorsen, T. S., Madsen, Kenneth Lindegaard, Dyhring, T., Bach, Anders, Peters, D., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 1 Aug 2011, In: Combinatorial Chemistry & High Throughput Screening. 14, 7, p. 590-600 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The binding sites for benztropines and dopamine in the dopamine transporter overlap
Jensen, H. B., Larsen, M. A. B., Mazier, S., Beuming, T., Weinstein, H., Shi, L., Loland, Claus Juul & Gether, Ulrik, 1 Jan 2011, In: Neuropharmacology. 60, 1, p. 182-90 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A randomized trial of the effect of escitalopram versus placebo on cognitive function in healthy first-degree relatives of patients with depression
Knorr, Ulla Benedichte Søsted, Vinberg, Maj, Gade, A., Winkel, P., Gluud, C., Wetterslev, J., Gether, Ulrik & Kessing, Lars Vedel, 2011, In: Therapeutic Advances in Psychopharmacology. 1, 5, p. 133-44 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes
Vaz, S. H., Jørgensen, T. N., Cristóvão-Ferreira, S., Duflot, S., Ribeiro, J. A., Gether, Ulrik & Sebastião, A. M., 2011, In: Journal of Biological Chemistry. 286, 47, p. 40464-76 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Copy number variations in affective disorders and meta-analysis
Olsen, L., Hansen, T., Djurovic, S., Haastrup, E., Albrecthsen, A., Hoeffding, L. K. E., Secher, A., Gustafsson, O., Jakobsen, K. D., Nielsen, Finn Cilius, Ullum, H., Morken, G., Agartz, I., Melle, I., Gether, Ulrik, Andreassen, O. A. & Werge, Thomas, 2011, In: Psychiatric Genetics. 21, 6, p. 319-322 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differences between early and late onset adult depression
Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Gether, Ulrik & Kessing, Lars Vedel, 2011, In: Clinical Practice and Epidemiology in Mental Health. 7, p. 140-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial
Knorr, Ulla Benedichte Søsted, Vinberg, Maj, Hansen, A., Klose, M., Feldt-Rasmussen, Ulla, Hilsted, Linda, Hasselstrøm, J., Gether, Ulrik, Winkel, P., Gluud, C., Wetterslev, J. & Kessing, Lars Vedel, 2011, In: P L o S One. 6, 6, p. e21224 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Clinical utility of Standardised Assessment of Personality - Abbreviated Scale (SAPAS) among patients with first episode depression
Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Gether, Ulrik & Kessing, Lars Vedel, 1 Dec 2010, In: Journal of Affective Disorders. 127, 1-3, p. 199-202 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tandem Facial Amphiphiles for Membrane Protein Stabilization
Chae, P. S., Gotfryd, K., Pacyna, J., Miercke, L. J. W., Rasmussen, Søren Gøgsig Faarup, Robbins, R. A., Rana, R. R., Loland, Claus Juul, Kobilka, B., Stroud, R., Byrne, B., Gether, Ulrik & Gellman, S. H., 1 Dec 2010, In: Journal of the American Chemical Society. 132, 47, p. 16750-2 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The influence of comorbid personality disorder and neuroticism on treatment outcome in first episode depression
Bock, C., Bukh, Jens Otto Drachmann, Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bock, C., Bukh, J. O. D., Vinberg, Maj, Kessing, Lars Vedel & Gether, U., 1 Jan 2010, In: Psychopathology. 43, 3, p. 197-204 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
BAR domains, amphipathic helices and membrane-anchored proteins use the same mechanism to sense membrane curvature
Madsen, Kenneth Lindegaard, Bhatia, V. K., Gether, Ulrik & Stamou, Dimitrios, 2010, In: FEBS Letters. 584, 9, p. 1848-55 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
David versus Goliath
Mollenhauer, J., Stamou, Dimitrios, Flyvbjerg, A., Wengel, J., Gether, Ulrik, Kjems, J., Bjørnholm, T. & Besenbacher, F., 2010, In: Nanomedicine: Nanotechnology, Biology and Medicine. 6, 4, p. 504-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gender Differences among Patients with a Single Depressive Episode
Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. O. D., Bock, C., Vinberg, Maj, Gether, U. & Kessing, Lars Vedel, 2010, In: Psychopathology. 43, 3, p. 159-169 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD
Thorsen, T. S., Madsen, Kenneth Lindegaard, Rebola, N., Rathje, Mette, Anggono, V., Bach, Anders, Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 1, p. 413-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins
Chae, P. S., Rasmussen, Søren Gøgsig Faarup, Rana, R. R., Gotfryd, K., Chandra, R., Goren, M. A., Kruse, A. C., Nurva, S., Loland, Claus Juul, Pierre, Y., Drew, D., Popot, J., Picot, D., Fox, B. G., Guan, L., Gether, Ulrik, Byrne, B., Kobilka, B. & Gellman, S. H., 2010, In: Nature Methods. 7, p. 1003-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons
Eriksen, J., Bjørn-Yoshimoto, Walden, Jørgensen, T. N., Newman, A. H. & Gether, Ulrik, 2010, In: Journal of Biological Chemistry. 285, 35, p. 27289-301 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges
Eriksen, J., Jørgensen, T. N. & Gether, Ulrik, 2010, In: Journal of Neurochemistry. 113, 1, p. 27-41 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1
Bach, Anders, Stuhr-Hansen, N., Thorsen, T. S., Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In: Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The N terminus of monoamine transporters is a lever required for the action of amphetamines
Sucic, S., Dallinger, S., Zdrazil, B., Weissensteiner, R., Jørgensen, T. N., Holy, M., Kudlacek, O., Seidel, S., Cha, J. H., Gether, Ulrik, Newman, A. H., Ecker, G. F., Freissmuth, M. & Sitte, H. H., 2010, In: Journal of Biological Chemistry. 285, 14, p. 10924-38 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation
Rasmussen, T. N., Plenge, P., Bay, T., Egebjerg, J. & Gether, Ulrik, 2009, In: Neuropharmacology. 57, 3, p. 287-94 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amphipathic motifs in BAR domains are essential for membrane curvature sensing
Bhatia, V. K., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A., Hedegård, Per, Gether, Ulrik & Stamou, Dimitrios, 2009, In: EMBO Journal. 28, 21, p. 3303-3314 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population
Lu, T. T., Lao, O., Nothnagel, M., Junge, O., Freitag-Wolf, S., Caliebe, A., Balascakova, M., Bertranpetit, J., Bindoff, L. A., Comas, D., Holmlund, G., Kouvatsi, A., Macek, M., Mollet, I., Nielsen, F., Parson, W., Palo, J., Ploski, R., Sajantila, A., Tagliabracci, A. & 14 others, , 2009, In: European Journal of Human Genetics. 17, 7, p. 967-75 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Do stressful life events predict medical treatment outcome in first episode of depression?
Bock, C., Bukh, J. D., Vinberg, Maj, Gether, Ulrik & Kessing, Lars Vedel, 2009, In: Social Psychiatry and Psychiatric Epidemiology. 44, p. 752-760Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does bereavement-related first episode depression differ from other kinds of first depressions?
Kessing, Lars Vedel, Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj & Gether, U., 2009, In: Social Psychiatry and Psychiatric Epidemiology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elucidating Conformational Changes in the {gamma}-Aminobutyric Acid Transporter-1
Meinild, A., Loo, D. D. F., Hansen, S. S., Gether, Ulrik & MacAulay, Nanna, 2009, In: Journal of Biological Chemistry. 284, 24, p. 16226-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How curved membranes recruit amphipathic helices and protein anchoring motifs
Hatzakis, Nikos, Bhatia, V. K., Larsen, J., Madsen, Kenneth Lindegaard, Bolinger, P., Kunding, A. H., Castillo Leon, J. J., Gether, Ulrik, Hedegård, Per & Stamou, Dimitrios, 2009, In: Nature Chemical Biology. 5, 11, p. 835-841 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction between genetic polymorphisms and stressful life events in first episode depression
Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Werge, Thomas, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, U. & Kessing, Lars Vedel, 2009, In: Journal of Affective Disorders. 119, 1-3, p. 107-15 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Introducing tetraCys motifs at two different sites results in a functional dopamine transporter
Orun, O., Rasmussen, S. & Gether, Ulrik, 2009, In: Acta Biologica Hungarica. 60, 1, p. 15-25 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurotransmitter transporters: structure and function
Loland, Claus Juul & Gether, Ulrik, 2009, Texbook of Drug Design and Discovery. Madsen, U., Krogsgaard-Larsen, P. & Stromgaard, K. (eds.). 4 ed. Taylor & FrancisResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment
Bukh, Jens Otto Drachmann, Bock, C., Vinberg, Maj, Werge, Thomas, Gether, Ulrik, Kessing, Lars Vedel, Bukh, J. D., Bock, C., Vinberg, Maj, Werge, Thomas, Gether, U. & Kessing, Lars Vedel, 2009, In: European Neuropsychopharmacology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system
Jansen, A. M., Nässel, D. R., Madsen, Kenneth Lindegaard, Jung, A. G., Gether, Ulrik & Kjærulff, Ole, 2009, In: Journal of Comparative Neurology. 517, 3, p. 313-32 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression
Knorr, Ulla Benedichte Søsted, Vinberg, Maj, Klose, M., Feldt-Rasmussen, Ulla, Hilsted, Linda, Gade, A., Haastrup, E., Paulson, Olaf B., Wetterslev, J., Gluud, C., Gether, Ulrik & Kessing, Lars Vedel, 2009, In: Trials. 10, p. 66Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Validity of the diagnosis of a single depressive episode in a case register
Bock, C., Bukh, Jens Otto Drachmann, Vinberg, Maj, Gether, Ulrik, Kessing, Lars Vedel, Bock, C., Bukh, J. D., Vinberg, Maj, Gether, U. & Kessing, Lars Vedel, 2009, In: Clinical Practice and Epidemiology in Mental Health. 5, p. 4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs
Eriksen, J., Rasmussen, Søren Gøgsig Faarup, Jørgensen, T. N., Vaegter, C. B., Cha, J. H., Zou, M., Newman, A. H. & Gether, Ulrik, 2009, In: Journal of Neuroscience. 29, 21, p. 6794-808 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
An intracellular interaction network regulates conformational transitions in the dopamine transporter.
Kniazeff, J., Shi, L., Loland, Claus Juul, Javitch, J. A., Weinstein, H. & Gether, Ulrik, 2008, In: Journal of Biological Chemistry. 283, 25, p. 17691-701 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Are life events prior to first episode of major depression a predictor of medical treatment outcome?
Bock, C., Bukh, J. D., Christensen, M. V., Gether, Ulrik & Kessing, L. V., 2008, In: European Psychiatry. 23, Suppl. 2, p. S200-S200Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Correlation between genetic and geographic structure in Europe
Lao, O., Lu, T. T., Nothnagel, M., Junge, O., Freitag-Wolf, S., Caliebe, A., Balascakova, M., Bertranpetit, J., Bindoff, L. A., Comas, D., Holmlund, G., Kouvatsi, A., Macek, M., Mollet, I., Parson, W., Palo, J., Ploski, R., Sajantila, A., Tagliabracci, A., Gether, U. & 13 others, , 2008, In: Current Biology. 18, 16, p. 1241-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic Polymorphisms and the outcome of antidepressant Treatment
Bukh, J. D., Bock, C., Christensen, M. V., Gether, Ulrik & Kessing, L. V., 2008, In: European Psychiatry. 23, p. S200-S200Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycine transporter dimers - Evidence for occurrence in the plasma membrane
Bartholomaeus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, Ulrik, Sitte, H. H., Betz, H. & Eulenburg, V., 2008, In: Journal of Biological Chemistry. 283, 16, p. 10978-10991 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycine transporter dimers: evidence for occurrence in the plasma membrane
Bartholomäus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, Ulrik, Sitte, H. H., Betz, H. & Eulenburg, V., 2008, In: Journal of Biological Chemistry. 283, 16, p. 10978-91 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1
Bassan, M., Liu, H., Madsen, Kenneth Lindegaard, Armsen, W., Zhou, J., Desilva, T., Chen, W., Paradise, A., Brasch, M. A., Staudinger, J., Gether, Ulrik, Irwin, N. & Rosenberg, P. A., 2008, In: European Journal of Neuroscience. 27, 1, p. 66-82 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane localization is critical for activation of the PICK1 BAR domain
Madsen, Kenneth Lindegaard, Eriksen, J., Milan-Lobo, L., Han, D. S., Niv, M. Y., Ammendrup-Johnsen, I., Henriksen, U., Bhatia, V. K., Stamou, Dimitrios, Sitte, H. H., McMahon, H. T., Weinstein, H. & Gether, Ulrik, 2008, In: Traffic - International Journal of Intracellular Transport. 9, 8, p. 1327-43 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane localization is critical for activation of the PICK1BAR domain
Madsen, K. L., Eriksen, J., Milan-Lobo, L., Han, D. S., Niv, M. Y., mmendrup-Johnsen, I., Henriksen, U., Bhatia, V. K., Stamou, Dimitrios, Sitte, H. H., McMahon, H. T., Weinstein, H. & Gether, Ulrik, 2008, In: Traffic - International Journal of Intracellular Transport. 9, 8, p. 1327-1343 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling
Klewe, I. V., Nielsen, S. M., Tarpø, L., Urizar, E., Dipace, C., Javitch, J. A., Gether, Ulrik, Egebjerg, J. & Christensen, K. V., 2008, In: Neuropharmacology. 54, 8, p. 1215-1222 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reliability of clinical ICD-10 diagnoses among electroconvulsive therapy patients with chronic affective disorders
Jakobsen, K. D., Hansen, T. F., Dam, H., Larsen, E. B., Gether, Ulrik & Werge, Thomas, 2008, In: European Journal of Psychiatry. 22, 3, p. 161-172 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux
Binda, F., Dipace, C., Bowton, E., Robertson, S. D., Lute, B. J., Fog, J. U., Zhang, M., Sen, N., Colbran, R. J., Gnegy, M. E., Gether, Ulrik, Javitch, J. A., Erreger, K. & Galli, A., 2008, In: Molecular Pharmacology. 74, 4, p. 1101-1108 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The binding sites for cocaine and dopamine in the dopamine transporter overlap.
Beuming, T., Kniazeff, J., Bergmann, M. L., Shi, L., Gracia, L., Raniszewska, K., Newman, A. H., Javitch, J. A., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 2008, In: Nature Neuroscience. 11, 7, p. 780-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites
Plenge, P., Gether, Ulrik & Rasmussen, Søren Gøgsig Faarup, 2007, In: European Journal of Pharmacology. 567, 1-2, p. 1-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching
Adkins, E. M., Samuvel, D. J., Fog, J. U., Eriksen, J., Jayanthi, L. D., Vaegter, C. B., Ramamoorthy, S. & Gether, Ulrik, 2007, In: Biochemistry. 46, 37, p. 10484-97 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors.
Loland, Claus Juul, Desai, R. I., Zou, M., Cao, J., Grundt, P., Gerstbrein, K., Sitte, H. H., Newman, A. H., Katz, J. L. & Gether, Ulrik, 2007, In: Molecular Pharmacology. 73, 3, p. 813-23 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Neurotransmitter transporters: molecular function of important drug targets
Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, Arne, Jul 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-83 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport
Fog, J. U., Khoshbouei, H., Holy, M., Owens, W. A., Vaegter, C. B., Sen, N., Nikandrova, Y., Bowton, E., McMahon, D. G., Colbran, R. J., Daws, L. C., Sitte, H. H., Javitch, J. A., Galli, A. & Gether, Ulrik, 2006, In: Neuron. 51, 4, p. 417-429 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype
Martinat, C., Bacci, J., Leete, T., Kim, J., Vanti, W. B., Newman, A. H., Cha, J. H., Gether, Ulrik, Wang, H. & Abeliovich, A., 2006, In: Proceedings of the National Academy of Science of the United States of America. 103, 8, p. 2874-2879 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding (vol 279, pg 3228, 2004)
Loland, C. J., Granas, C., Javitch, J. A. & Gether, Ulrik, 2006, In: Journal of Biological Chemistry. 281, 35, p. 25867-25867Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanisms of GPCR activation
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2006, G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive ActivityG Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity. 2006: Wiley, Vol. 24. p. 27-42 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- Published
Neurotransmitter transporters: molecular function of important drug targets
Gether, Ulrik, Andersen, P. H., Larsson, O. M. & Schousboe, A., 2006, In: Trends in Pharmacological Sciences. 27, 7, p. 375-383 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization
Jayanthi, L. D., Annamalai, B., Samuvel, D. J., Gether, Ulrik & Ramamoorthy, S., 2006, In: Journal of Biological Chemistry. 281, 33, p. 23326-40 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of dopamine transporter trafficking by intracellular amphetamine.
Kahlig, K. M., Lute, B. J., Wei, Y., Loland, Claus Juul, Gether, Ulrik, Javitch, J. A. & Galli, A., 2006, In: Molecular Pharmacology. 70, 2, p. 542-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zn2+ modulation of neurotransmitter transporters
Nørgaard-Nielsen, K. & Gether, Ulrik, 2006, In: Handbook of Experimental Pharmacology. 175, p. 1-22 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter
Cha, J. H., Zou, M., Adkins, E. M., Rasmussen, Søren Gøgsig Faarup, Loland, Claus Juul, Schoenenberger, B., Gether, Ulrik & Newman, A. H., 1 Dec 2005, In: Journal of Medicinal Chemistry. 48, 24, p. 7513-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2
Henriksen, U. B., Fog, J. U., Litman, Thomas & Gether, Ulrik, 4 Nov 2005, In: Journal of Biological Chemistry. 280, 44, p. 36926-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8
Kniazeff, J., Loland, Claus Juul, Goldberg, N., Quick, M., Das, S., Sitte, H. H., Javitch, J. A. & Gether, Ulrik, Nov 2005, In: Neuropharmacology. 49, 6, p. 715-23 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2
Henriksen, U. B., Gether, Ulrik & Litman, Thomas, 1 Apr 2005, In: Journal of Cell Science. 118, Pt 7, p. 1417-26 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Purification and fluorescent labeling of the human serotonin transporter
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 8 Mar 2005, In: Biochemistry. 44, 9, p. 3494-505 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
Madsen, Kenneth Lindegaard, Beuming, T., Niv, M. Y., Chang, C., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In: Journal of Biological Chemistry. 280, 21, p. 20539-48 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular determinants for the complex binding specifity of the PDZ domain in PICK1
Madsen, K. L., Beuming, T., Niv, M. Y., Chang, C. W., Dev, K. K., Weinstein, H. & Gether, Ulrik, 2005, In: Journal of Biological Chemistry. Vol. 280, no. 21, p. 20539-48Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding
Loland, Claus Juul, Grånäs, C., Javitch, J. A. & Gether, Ulrik, 30 Jan 2004, In: The Journal of Biological Chemistry. 279, 5, p. 3228-38 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insights from endogenous and engineered Zn2+-binding sites in monoanine transporters
Loland, Claus Juul & Gether, Ulrik, 2004, Molecular Neuropharmacology: Strategies and Methods. p. 191-213Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Intracellular residues in the dopamine transporter critical for conformational isomerization, molecular gating and cocaine binding
Loland, Claus Juul, Granas, C., Javitc, J. & Gether, Ulrik, 2004, In: Journal of Biological Chemistry. Vol. 279, no. 5, p. 3228-38Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ doamin interactions
Bjerggaard, C., Fog, J. U., Hastrup-Nielsen, H., Madsen, K., Loland, Claus Juul, Javitch, J. & Gether, Ulrik, 2004, In: Journal of Neuroscience. Vol. 24, no. 31, p. 7024-36Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions
Bjerggaard, C., Fog, J. U., Hastrup, H., Madsen, Kenneth Lindegaard, Loland, C. J., Javitch, J. A. & Gether, Ulrik, 2004, In: Journal of Neuroscience. 24, 31, p. 7024-36 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zinc Potentiates an Uncoupled Anion Conductance Associated with the Dopamine Transporter
Meinild, A., Sitte, H. H. & Gether, Ulrik, 2004, In: Journal of Biological Chemistry. 279, 48, p. 49671-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Probing dopamine transporter structure and function by Zn2+-site engineering
Loland, Claus Juul, Norgaard-Nielsen, K. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 187-97 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy
Rasmussen, Søren Gøgsig Faarup, Adkins, E. M., Carroll, F. I., Maresch, M. J. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 13-22 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter
Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 15 Aug 2003, In: The Journal of Biological Chemistry. 278, 33, p. 30587-96 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 14 Feb 2003, In: The Journal of Biological Chemistry. 278, 7, p. 4990-5000 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence for distinct sodium-, dopamine-, cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine
Norregaard, L., Loland, Claus Juul & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (33), p. 30587-96Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter interanalization
Granas, C., Ferrer, J., Loland, Claus Juul, Javitch, J. A. & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. Vol. 278 (7), p. 4990-5000Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing dopamine transporter structure and function y Zn2+ site engineering
Loland, Claus Juul, Nørgaard-Nielsen, K. & Gether, Ulrik, 2003, In: European Journal of Pharmacology. Vol. 479, no 1-3, p. 187-97Research output: Contribution to journal › Review › Research › peer-review
- Published
Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.
MacAulay, Nanna, Meinild, A., Zeuthen, Thomas & Gether, Ulrik, 2003, In: Journal of Biological Chemistry. 278, 31, p. 28771-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1
MacAulay, Nanna, Zeuthen, Thomas & Gether, Ulrik, 15 Oct 2002, In: Journal of Physiology. 544, Pt 2, p. 447-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zn(2+) site engineering at the oligomeric interface of the dopamine transporter
Norgaard-Nielsen, K., Norregaard, L., Hastrup, H., Javitch, J. A. & Gether, Ulrik, 31 Jul 2002, In: FEBS Letters. 524, 1-3, p. 87-91 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of zinc ions in reverse transport mediated by monoamine transporters
Scholze, P., Nørregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 14 Jun 2002, In: Journal of Biological Chemistry. 277, 24, p. 21505-13 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 5 Feb 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 3, p. 1683-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational basis for the Li+- induced leak current in the rat ¿- aminobutyric acid (GABA) transporter- 1
MacAulay, Nanna, Zeuthen, Thomas & Gether, Ulrik, 2002, In: Journal of Physiology. 544, 2, p. 447-458Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation of an activating ZN(2+) switch in the dopamine transporter: Mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle
Loland, Claus Juul, Norregaard, L., Litman, Thomas & Gether, Ulrik, 2002, In: Proceedings of the National Academy of Science of the United States of America. vol. 99(3), p. 1683-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes
MacAulay, Nanna, Gether, Ulrik, Klærke, Dan Arne & Zeuthen, Thomas, 2002, In: Journal of Physiology. 542, 3, p. 817-828 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural basis for activation of G-protein-coupled receptors.
Gether, Ulrik, Asmar, F., Meinild, A. K. & Rasmussen, Søren Gøgsig Faarup, 2002, In: Basic & Clinical Pharmacology & Toxicology. 91, 6, p. 304-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of zine ions in reverse transport mediated by monoamine transporters
Scholze, P., Norregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 2002, In: Journal of Biological Chemistry. 277, p. 21505-21513Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Understanding G-protein coupled receptors and their role in the CNS
Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2002, Structural mechanics of GPCR activation. p. 43-62Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- Published
Use of fluorescence spectroscopy to study conformational changes in the beta 2-adrenoceptor
Kobilka, B. K. & Gether, Ulrik, 2002, In: Methods in Enzymology. 343, 343, p. 170-182 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Zn(2+) site engineering oat the oligomeric interface of the dopamine transporter
Nørgaard-Nielsen, K., Norregaard, L., Hastrup-Nielsen, H., Javitch, J. A. & Gether, Ulrik, 2002, In: FEBS Letters. vol. 524(1-3), p. 87-91Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
Ballesteros, J. A., Jensen, A. D., Liapakis, G., Rasmussen, Søren Gøgsig Faarup, Shi, L. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (31), p. 29171-29177Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling
Jensen, A. D., Guarnieri, F., Rasmussen, Søren Gøgsig Faarup, Asmar, F., Ballesteros, J. A. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (12), p. 9279-9290Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter
Rasmussen, Søren Gøgsig Faarup, Carroll, F. I., Maresch, M. J., Jensen, A. D. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (7), p. 4717-4723Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites
Gether, Ulrik, Norregaard, L. & Loland, Claus Juul, 2001, In: Life Sciences. 68 (19-20), p. 2187-2198Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Engineered Zn(2+)switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents
MacAulay, Nanna, Bendahan, A., Loland, Claus Juul, Zeuthen, Thomas, Kanner, B. I. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276, p. 40476-40485Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations
Seifert, R., Wenzel-Seifert, K., Gether, Ulrik & Kobilka, B. K., 2001, In: Journal of Pharmacology and Experimental Therapeutics. 297 (3), p. 1218-1226Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites
Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J. A., Weinstein, H. & Gether, Ulrik, 2001, In: Biochemistry. 39 (51), p. 15836-15846Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Water transport by the human Na+-coupled glutamate cotransporter expressed in Xenopus oocytes
MacAulay, Nanna, Gether, Ulrik, Klaerke, D. A. & Zeuthen, T., 2001, In: Journal of Physiology. 530 (Pt 3), p. 367-378Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites
Norregaard, L., Visiers, I., Loland, Claus Juul, Ballesteros, J., Weinstein, H. & Gether, Ulrik, 26 Dec 2000, In: Biochemistry. 39, 51, p. 15836-15846 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessing adrenergic receptor conformation using chemically reactive fluorescent probes
Jensen Dam, A. & Gether, Ulrik, 2000, Methods in Molecular Biology, vol.126: Adrenergic Receptors Protocols. Totowa, NJ: Humana Press, p. 345-359Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
The effect of pH on ß2 adrenoceptor function
Pejman, G., Hans, S., Roland, S., Tae Weon, L., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik & Kobilka, B. K., 2000, In: Journal of Biological Chemistry. 5, Vol. 275, p. 3121-3127Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Uncovering molecular mechanism involved in activation of G protein-coupled receptors
Gether, Ulrik, 2000, In: Endocrine Reviews. 21(1), p. 90-113Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Assessing adrenergic receptor using chemically reactive fluorescent probes
Dam Jensen, A. & Gether, Ulrik, 1999, In Adrenergic Receptor Protocols, in the Methods for Molecular Biology. Humana Press, p. 345-361Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor
Kobilka, B. K., Gether, Ulrik, Seifert, R., Lin, S. & Ghanouni, P., 1999, In: Journal of Receptors and Signal Transduction. 19, p. 293-300Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.
Loland, Claus Juul, Norregaard, L. & Gether, Ulrik, 1999, In: Journal of Biological Chemistry. 274, 52, p. 36928-34 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct assessment of conformational changes in G protein coupled receptors using fluorescence spectroscopy
Gether, Ulrik & Kobilka, B. K., 1999, In Signal Transduction - A practical Approach, in The practical Approach series, 2nd edition. Oxford: Oxford University Press, p. 01-17Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations
Seifert, R., Gether, Ulrik, Wenzel-Seifert, K. & Kobilka, B. K., 1999, In: Molecular Pharmacology. 56, p. 348-358Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-Gsalpha fusion protein
Seifert, R., Wenzel-Seifert, K., Gether, Ulrik, Lam, V. T. & Kobilka, B. K., 1999, In: European Journal of Biochemistry. 260, p. 661-666Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fluorescence spectrosocpy analysis of conformational changes in the Β2 adrenergic receptor
Gether, Ulrik, 1999, In Structure/Function of G-protein coupled receptors, in the Receptor Biochemistry and Methodology. New York: Wiley, p. 315-334Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Mutation of a conserved aspartic acid in the Beta2 adrenergic recptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment VI
Rasmussen, Søren Gøgsig Faarup, Dam Jensen, A., Ghanouni, P., Liapakis, G., Javitch, J. & Gether, Ulrik, 1999, In: Molecular Pharmacology. 56, p. 175-184Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
Delineation of an endogenous zinc-binding site in the human dopamine transporter.
Norregaard, L., Frederiksen, D., Nielsen, E. Ø. & Gether, Ulrik, 1998, In: EMBO Journal. 17, p. 4266-4273Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
- Published
Molecular mechanism of action of non-peptide ligands for peptide receptors
Schwartz, Thue W., Gether, Ulrik, Schambye, H. T. & Hjorth, Siv Annegrethe, Oct 1995, In: Current Pharmaceutical Design. 1, 3, p. 325-342 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1990
- Published
Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase
Aakerlund, L., Gether, Ulrik, Fuhlendorff, J., Schwartz, Thue W. & Thastrup, Ole, 1990, In: F E B S Letters. 260, 1, p. 73-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist
Fuhlendorff, J., Gether, Ulrik, Aakerlund, L., Langeland-Johansen, N., Thøgersen, H., Melberg, S. G., Olsen, U. B., Thastrup, Ole & Schwartz, Thue W., 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 1, p. 182-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1987
- Published
High-performance liquid chromatography of phenylthiocarbamyl derivatives of amino acids and side-chain derivatized amino acids.
O'Hare, M., Tortora, O., Gether, Ulrik, Nielsen, Henrik & Schwartz, Thue W., Mar 1987, In: Journal of Chromatography.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11898
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3096
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Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression
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2903
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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
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1687
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Genome-wide association study of genetic variants in LPS-stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α cytokine response in a Danish Cohort
Research output: Contribution to journal › Journal article › Research › peer-review
Published