The solute carrier 6 family of transporters

Research output: Contribution to journalJournal articlepeer-review

The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.
Original languageEnglish
JournalBritish Journal of Pharmacology
Volume167
Issue number2
Pages (from-to)256-78
Number of pages23
DOIs
Publication statusPublished - 22 Aug 2012

    Research areas

  • Amino Acid Sequence, Animals, Biological Transport, Gene Expression Regulation, Humans, Membrane Transport Proteins, Neurotransmitter Agents, Protein Conformation

ID: 47292735