Birthe Brandt Kragelund

Checkpoint activation by Spd1: a competition-based system relying on tandem disordered PCNA binding motifs

Olsen, Johan Gotthardt, Prestel, Andreas, Kassem, N., Broendum, S. S., Hossain, Mohammad Shamim, Simonsen, Signe, Grysbæk, M., Mortensen, J., Rytkjær, L. L., Haxholm, G. W., Marabini, R., Holmberg, Christian, Carr, A. M., Crehuet, R., Nielsen, Olaf & Kragelund, Birthe Brandt, 2024, In: Nucleic acids symposium series. 52, 4, p. 2030–2044 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2

Bjarnason, S., McIvor, J. A. P., Prestel, Andreas, Demény, K. S., Bullerjahn, J. T., Kragelund, Birthe Brandt, Mercadante, D. & Heidarsson, P. O., 2024, In: Nature Communications. 15, 1, 16 p., 1445.

Research output: Contribution to journal › Journal article › Research › peer-review

Molecular switching in transcription through splicing and proline-isomerization regulates stress responses in plants

Theisen, Frederik Friis, Prestel, Andreas, Elkjær, Steffie Martina H, Leurs, Y. H. A., Morffy, N., Strader, L. C., O'Shea, Charlotte, Teilum, Kaare, Kragelund, Birthe Brandt & Skriver, Karen, 2024, In: Nature Communications. 15, 1, 13 p., 592.

Research output: Contribution to journal › Journal article › Research › peer-review

Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction

Weidner, P., Saar, D., Söhn, M., Schroeder, T., Yu, Y., Zöllner, F. G., Ponelies, N., Zhou, X., Zwicky, A., Rohrbacher, F. N., Pattabiraman, V. R., Tanriver, M., Bauer, A., Ahmed, H., Ametamey, S. M., Riffel, P., Seger, R., Bode, J. W., Wade, R. C., Ebert, M. P. A. & 2 others, Kragelund, Birthe Brandt & Burgermeister, E., 2024, In: Cancer Letters. 588, 19 p., 216783.

Research output: Contribution to journal › Journal article › Research › peer-review

PPARγ antagonists induce aromatase transcription in adipose tissue cultures

Ardenkjær-Skinnerup, J., Saar, Daniel, Petersen, Patricia Stephanie S, Pedersen, M., Svingen, T., Kragelund, Birthe Brandt, Hadrup, N., Ravn-Haren, G., Emanuelli, Brice, Brown, K. A. & Vogel, U., 2024, In: Biochemical Pharmacology. 222, 13 p., 116095.

Research output: Contribution to journal › Journal article › Research › peer-review

The molecular basis for cellular function of intrinsically disordered protein regions

Holehouse, A. S. & Kragelund, Birthe Brandt, 2024, In: Nature Reviews Molecular Cell Biology. 25, p. 187–211 25 p.

Research output: Contribution to journal › Review › Research › peer-review

Modeling of flexible membrane-bound biomolecular complexes for solution small-angle scattering

Barclay, A., Kragelund, Birthe Brandt, Arleth, Lise & Pedersen, Martin Cramer, Apr 2023, In: Journal of Colloid and Interface Science. 635, p. 611-621 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

Pesce, Francesco, Newcombe, Estella Anne, Seiffert, P., Tranchant, E. E., Olsen, Johan Gotthardt, Grace, C. R., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2023, In: Biophysical Journal. 122, 2, p. 310-321 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Comment on “Intrinsic protein disorder uncouples affinity from binding specificity”

Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2023, In: Protein Science. 32, 4, 2 p., e4602.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Conformational entropy in molecular recognition of intrinsically disordered proteins

Skriver, Karen, Theisen, Frederik Friis & Kragelund, Birthe Brandt, 2023, In: Current Opinion in Structural Biology. 83, 8 p., 102697.

Research output: Contribution to journal › Review › Research › peer-review

Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime

Elkjær, Steffie Martina H, Due, Amanda Duncan, Christensen, L. F., Theisen, Frederik Friis, Staby, L., Kragelund, Birthe Brandt & Skriver, Karen, 2023, In: Communications Biology . 6, 11 p., 63.

Research output: Contribution to journal › Journal article › Research › peer-review

Intrinsically Disordered Proteins as an Instrument for Research-Integrating Teaching

Skriver, K., Sjørup, S. A., Langkilde, A. E., Balouka, E., Christensen, C. S., Carbel, K., Decker, J. N. V., Essenbæk, D. N., Gräf, J. F., Jessen, C. H., Kristensen, P., Merrild, C., Mortensen, T. S., Nalepa, I. F., Nordsteen, B. W., Svoren, S. K., van Hall, M., Weicher, J., Wind, M. L., Zhang, D. & 8 others, Saar, Daniel, Blæsild, H., Stahlhut, M., Andersen, K. V., Dagil, Robert, Vestergaard, Bente, Ryberg, Marie L. & Kragelund, Birthe Brandt, 2023, In: The Biophysicist. 4 , 2, p. 1-7 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Molecular insights into alginate beta-lactoglobulin A multivalencies: The foundation for their amorphous aggregates and coacervation

Madsen, M., Prestel, Andreas, Madland, E., Westh, P., Tondervik, A., Sletta, H., Peters, G. H. J., Aachmann, F. L. L., Kragelund, Birthe Brandt & Svensson, B., 2023, In: Protein Science. 32, 2, 15 p., 4556.

Research output: Contribution to journal › Journal article › Research › peer-review

Monomeric α-synuclein activates the plasma membrane calcium pump

Kowalski, A., Betzer, C., Larsen, S. T., Gregersen, E., Newcombe, Estella Anne, Bermejo, M. C., Bendtsen, V. W., Diemer, J., Ernstsen, C. V., Jain, S., Bou, A. E., Langkilde, Annette Eva, Nejsum, L. N., Klipp, E., Edwards, R., Kragelund, Birthe Brandt, Jensen, P. H. & Nissen, Poul, 2023, In: EMBO Journal. 42, 23, 21 p., e111122.

Research output: Contribution to journal › Journal article › Research › peer-review

Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin-ligase Dma1 in vitro

Jacobsen, Nina Louise, Bloch, Magnus Borup, Millard, P. S., Ruidiaz, Sarah Frederiksen, Elsborg, Jonas Damgaard, Boomsma, Wouter, Hendus-Altenburger, R., Hartmann-Petersen, Rasmus & Kragelund, Birthe Brandt, 2023, In: Protein Science. 32, 9, 16 p., e4733.

Research output: Contribution to journal › Journal article › Research › peer-review

Realizing integration in structural biology: The 2022 ISBUC Annual Meeting

Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754

Research output: Contribution to journal › Journal article › Research › peer-review

Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand

Vedel, I. M., Prestel, Andreas, Zhang, Z., Skawinska, N. T., Stark, H., Harris, Pernille, Kragelund, Birthe Brandt & Peters, G. H. J., 2023, In: Structure (London, England : 1993). 31, 6, p. 689-699e6 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Targeted imaging of uPAR expression in vivo with cyclic AE105 variants

Leth, Julie Maja, Newcombe, Estella Anne, Grønnemose, A. L., Jørgensen, Jesper Tranekjær, Qvist, K., Clausen, Anne Skovsbo, Knudsen, Line Bruhn Schneider, Kjær, Andreas, Kragelund, Birthe Brandt, Jørgensen, Thomas Jørgen Dyreborg & Ploug, Michael, 2023, In: Scientific Reports. 13, 17 p., 17248.

Research output: Contribution to journal › Journal article › Research › peer-review

The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

Araya-Secchi, R., Bugge, K., Seiffert, P., Petry, A., Haxholm, G. W., Lindorff-Larsen, Kresten, Pedersen, Stine Helene Falsig, Arleth, Lise & Kragelund, Birthe Brandt, 2023, In: eLife. 12, 27 p., e84645.

Research output: Contribution to journal › Journal article › Research › peer-review

Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

Chhabra, Y., Seiffert, P., Gormal, R. S., Vullings, M., Lee, C. M. M., Wallis, T. P., Dehkhoda, F., Indrakumar, S., Jacobsen, Nina Louise, Lindorff-Larsen, Kresten, Durisic, N., Waters, M. J., Meunier, F. A., Kragelund, Birthe Brandt & Brooks, A. J., 2023, In: Cell Reports. 42, 5, 26 p., 112490.

Research output: Contribution to journal › Journal article › Research › peer-review

A context-dependent and disordered ubiquitin-binding motif

Dreier, Jesper Elmsted, Prestel, Andreas, Martins, J. M., Brøndum, S. S., Nielsen, Olaf, Garbers, Anna Engstrøm, Suga, H., Boomsma, Wouter, Rogers, Joseph Matthew, Hartmann-Petersen, Rasmus & Kragelund, Birthe Brandt, 2022, In: Cellular and molecular life sciences : CMLS. 79, 9, 21 p., 484.

Research output: Contribution to journal › Journal article › Research › peer-review

A glutamine-based single α-helix scaffold to target globular proteins

Escobedo, A., Piccirillo, J., Aranda, J., Diercks, T., Mateos, B., Garcia-Cabau, C., Sanchez-Navarro, M., Topal, B., Biesaga, M., Staby, L., Kragelund, Birthe Brandt, Garcia, J., Millet, O., Orozco, M., Coles, M., Crehuet, R. & Salvatella, X., 2022, In: Nature Communications. 13, 18 p., 7073.

Research output: Contribution to journal › Journal article › Research › peer-review

Deciphering the Alphabet of Disorder-Glu and Asp Act Differently on Local but Not Global Properties

Roesgaard, M. A., Lundsgaard, J. E., Newcombe, Estella Anne, Jacobsen, Nina Louise, Pesce, Francesco, Tranchant, E. E., Lindemose, Søren, Prestel, Andreas, Hartmann-Petersen, Rasmus, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2022, In: Biomolecules. 12, 10, 19 p., 1426.

Research output: Contribution to journal › Journal article › Research › peer-review

How phosphorylation impacts intrinsically disordered proteins and their function

Newcombe, Estella Anne, Delaforge, Elise, Hartmann-Petersen, Rasmus, Skriver, Karen & Kragelund, Birthe Brandt, 2022, In: Essays in Biochemistry. 66, 7, p. 901-913 13 p.

Research output: Contribution to journal › Review › Research › peer-review

PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation

Madsen, M. S., Broekema, M. F., Madsen, M. R., Koppen, A., Borgman, A., Grawe, C., Thomsen, E. G. K., Westland, D., Kranendonk, M. E. G., Koerkamp, M. G., Hamers, N., Bonvin, A. M. J. J., Pittol, J. M. R., Natarajan, K. N., Kersten, S., Holstege, F. C. P., Monajemi, H., van Mil, S. W. C., Vermeulen, M., Kragelund, B. B. & 3 others, Cassiman, D., Mandrup, S. & Kalkhoven, E., 2022, In: Nature Communications. 13, 19 p., 7090.

Research output: Contribution to journal › Journal article › Research › peer-review

Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges

Martinsen, J. H., Saar, Daniel, Fernandes, Catarina, Schuler, B., Bugge, K. & Kragelund, Birthe Brandt, 2022, In: Protein Science. 31, 4, p. 918-932 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The denatured state of HIV-1 protease under native conditions

Rösner, Heike Ilona, Caldarini, M., Potel, G., Malmodin, D., Vanoni, M. A., Aliverti, A., Broglia, R. A., Kragelund, Birthe Brandt & Tiana, G., 2022, In: Proteins: Structure, Function, and Bioinformatics. 90, 1, p. 96-109

Research output: Contribution to journal › Journal article › Research › peer-review

αα-hub coregulator structure and flexibility determine transcription factor binding and selection in regulatory interactomes

Theisen, Frederik Friis, Salladini, Edoardo, Davidsen, R., Rasmussen, C. J., Staby, L., Kragelund, Birthe Brandt & Skriver, Karen, 2022, In: Journal of Biological Chemistry. 298, 6, 16 p., 101963.

Research output: Contribution to journal › Journal article › Research › peer-review

Binding Sites for Oligosaccharide Repeats from Lactic Acid Bacteria Exopolysaccharides on Bovine β-Lactoglobulin Identified by NMR Spectroscopy

Birch, J., Khan, S., Madsen, M., Kjeldsen, C., Møller, M. S., Stender, E. G. P., Peters, G. H. J., Duus, J. Ø., Kragelund, Birthe Brandt & Svensson, B., 2021, In: ACS Omega. 6, 13, p. 9039-9052 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Connecting the αα-hubs: same fold, disordered ligands, new functions

Staby, L., Bugge, K., Falbe-Hansen, R. G., Salladini, Edoardo, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Cell Communication and Signaling. 19, 5 p., 2.

Research output: Contribution to journal › Letter › Research › peer-review

Disorder in a two-domain neuronal Ca²⁺-binding protein regulates domain stability and dynamics using ligand mimicry

Staby, L., Kemplen, K. R., Stein, Amelie, Ploug, Michael, Clarke, J., Skriver, Karen, Heidarsson, P. O. & Kragelund, Birthe Brandt, 2021, In: Cellular and molecular life sciences : CMLS. 78, p. 2263-2278 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Dynamic Na⁺/H⁺ exchanger 1 (NHE1) - calmodulin complexes of varying stoichiometry and structure regulate Ca²⁺-dependent NHE1 activation

Sjøgaard-Frich, Lise Margrethe, Prestel, Andreas, Pedersen, E. S., Severin, M., Kristensen, Kristian Kølby, Olsen, Johan Gotthardt, Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2021, In: eLife. 10, 29 p., e60889.

Research output: Contribution to journal › Journal article › Research › peer-review

Evolution of A bHLH Interaction Motif

Millard, P. S., Kragelund, Birthe Brandt & Burow, Meike, 2021, In: International Journal of Molecular Sciences. 22, 1, 18 p., 447.

Research output: Contribution to journal › Journal article › Research › peer-review

Flanking Disorder of the Folded αα-Hub Domain from Radical Induced Cell Death1 Affects Transcription Factor Binding by Ensemble Redistribution: Flanking disorder tunes the RCD1-RST ensemble

Staby, L., Due, Amanda Duncan, Kunze, M. B. A., Jørgensen, M. L. M., Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Journal of Molecular Biology. 433, 24, 15 p., 167320.

Research output: Contribution to journal › Journal article › Research › peer-review

Insight into Calcium-Binding Motifs of Intrinsically Disordered Proteins

Newcombe, Estella Anne, Fernandes, Catarina, Lundsgaard, J. E., Brakti, Inna, Lindorff-Larsen, Kresten, Langkilde, Annette Eva, Skriver, Karen & Kragelund, Birthe Brandt, 2021, In: Biomolecules. 11, 8, 17 p., 1173.

Research output: Contribution to journal › Journal article › Research › peer-review

On the Potential of Machine Learning to Examine the Relationship Between Sequence, Structure, Dynamics and Function of Intrinsically Disordered Proteins

Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2021, In: Journal of Molecular Biology. 433, 20, 22 p., 167196.

Research output: Contribution to journal › Review › Research › peer-review

On the specificity of protein-protein interactions in the context of disorder

Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2021, In: Biochemical Journal. 478, 11, p. 2035-2050 16 p.

Research output: Contribution to journal › Review › Research › peer-review

Order and disorder - An integrative structure of the full-length human growth hormone receptor

Kassem, N., Araya-Secchi, R., Bugge, K., Barclay, A., Steinocher, H., Khondker, A., Wang, Yong, Lenard, A. J., Bürck, J., Sahin, Cagla, Ulrich, A. S., Landreh, M., Pedersen, Martin Cramer, Rheinstädter, M. C., Pedersen, Per Amstrup, Lindorff-Larsen, Kresten, Arleth, Lise & Kragelund, Birthe Brandt, 2021, In: Science Advances. 7, 27, 20 p., eabh3805.

Research output: Contribution to journal › Journal article › Research › peer-review

Quantification of Conformational Entropy Unravels Effect of Disordered Flanking Region in Coupled Folding and Binding

Theisen, Frederik Friis, Staby, L., Tidemand, Frederik Grønbæk, O'Shea, Charlotte, Prestel, Andreas, Willemoës, Martin, Kragelund, Birthe Brandt & Skriver, Karen, 2021, In: Journal of the American Chemical Society. 143, 36, p. 14540-14550 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Refinement of α-Synuclein Ensembles Against SAXS Data: Comparison of Force Fields and Methods

Ahmed, M. C., Skaanning, L. K., Jussupow, A., Newcombe, Estella Anne, Kragelund, Birthe Brandt, Camilloni, C., Langkilde, Annette Eva & Lindorff-Larsen, Kresten, 2021, In: Frontiers in Molecular Biosciences. 8, 13 p., 654333.

Research output: Contribution to journal › Journal article › Research › peer-review

The disordered PCI-binding human proteins CSNAP and DSS1 have diverged in structure and function

Ruidiaz, Sarah Frederiksen, Dreier, Jesper Elmsted, Hartmann-Petersen, Rasmus & Kragelund, Birthe Brandt, 2021, In: Protein Science. 30, 10, p. 2069-2082 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs

Lambrughi, M., Maiani, E., Fas, B. A., Shaw, G. S., Kragelund, Birthe Brandt, Lindorff-Larsen, Kresten, Teilum, Kaare, Invernizzi, G. & Papaleo, E., 2021, In: Frontiers in Molecular Biosciences. 8, 14 p., 676235.

Research output: Contribution to journal › Journal article › Research › peer-review

αα-Hub domains and intrinsically disordered proteins: a decisive combo

Bugge, K., Staby, L., Salladini, Edoardo, Falbe-Hansen, R. G., Kragelund, Birthe Brandt & Skriver, Karen, 2021, In: Journal of Biological Chemistry. 296, 18 p., 100226.

Research output: Contribution to journal › Review › Research › peer-review

The intracellular lipid-binding domain of human Na⁺/H⁺ exchanger 1 forms a lipid-protein co-structure essential for activity

Hendus-Altenburger, R., Vogensen, J., Pedersen, E. S., Luchini, A., Araya-Secchi, R., Bendsoe, A. H., Prasad, N. S., Prestel, Andreas, Cardenas, M., Pedraz-Cuesta, E., Arleth, Lise, Pedersen, Stine Helene Falsig & Kragelund, Birthe Brandt, 3 Dec 2020, In: Communications Biology . 3, 1, 18 p., 731.

Research output: Contribution to journal › Journal article › Research › peer-review

Orchestration of signaling by structural disorder in class 1 cytokine receptors

Seiffert, P., Bugge, K., Nygaard, M., Haxholm, G. W., Martinsen, J. H., Pedersen, M. N., Arleth, Lise, Boomsma, Wouter & Kragelund, Birthe Brandt, 24 Aug 2020, In: Cell Communication and Signaling. 18, 1, 30 p., 132.

Research output: Contribution to journal › Journal article › Research › peer-review

Exploring the Protein-Membrane Interactions on the Intracellular Side of PRLR

Araya-Secchi, R., Bugge, K., Kragelund, Birthe Brandt & Arleth, Lise, 7 Feb 2020, In: Biophysical Journal. 118, 3, Suppl.1, p. 57A-57A 1 p.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Avidity within the N-terminal anchor drives α-synuclein membrane interaction and insertion

Cholak, E., Bugge, K., Khondker, A., Gauger, K., Pedraz-Cuesta, E., Pedersen, M. E., Bucciarelli, S., Vestergaard, Bente, Pedersen, Stine Helene Falsig, Rheinstädter, M. C., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 6, p. 7462-7482 21 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Context Matters in Disorder Based Protein Communication

Kragelund, Birthe Brandt, Prestel, Andreas, Wickmann, N., Martins, J., Boomsma, Wouter, Staby, L., Hendus-Altenburger, R. & Skriver, Karen, 2020, In: Biophysical Journal. 118, 3, suppl. 1, p. 491A 2407-Plat.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Effects of Ligand Binding on the Energy Landscape of Acyl-CoA-Binding Protein

Sonar, P., Bellucci, L., Mossa, A., Heidarsson, P. O., Kragelund, Birthe Brandt & Cecconi, C., 2020, In: Biophysical Journal. 119, 9, p. 1821-1832 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Efficient refolding and reconstitution of tissue factor into nanodiscs facilitates structural investigation of a multicomponent system on a lipid bilayer

Tidemand, Frederik Grønbæk, Østergaard, H., Ploug, Michael, Kragelund, Birthe Brandt & Arleth, Lise, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 10 p., 183214.

Research output: Contribution to journal › Journal article › Research › peer-review

IDDomainSpotter: Compositional bias reveals domains in long disordered protein regions—Insights from transcription factors

Millard, P. S., Bugge, K., Marabini, R., Boomsma, Wouter, Burow, Meike & Kragelund, Birthe Brandt, 2020, In: Protein Science. 29, 1, p. 169-183 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Interactions by Disorder - A Matter of Context

Bugge, K., Brakti, Inna, Fernandes, Catarina, Dreier, J. E., Lundsgaard, J. E., Olsen, Johan Gotthardt, Skriver, Karen & Kragelund, Birthe Brandt, 2020, In: Frontiers in Molecular Biosciences. 7, 16 p., 110.

Research output: Contribution to journal › Review › Research › peer-review

Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water

Kampmeyer, Caroline, Johansen, Jens Vilstrup, Holmberg, Christian, Karlson, M., Andersen, Sarah Gersing, Nunes Bordallo, Heloisa, Kragelund, Birthe Brandt, Lerche, M. H., Jourdain, I., Winther, Jakob R. & Hartmann-Petersen, Rasmus, 2020, In: A C S Synthetic Biology. 9, 4, p. 733-748 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis

Nedal, A., Ræder, S. B., Dalhus, B., Helgesen, E., Forstrøm, R. J., Lindland, K., Sumabe, B. K., Martinsen, J. H., Kragelund, Birthe Brandt, Skarstad, K., Bjørås, M. & Otterlei, M., 2020, In: Nucleic Acids Research. 48, 10, p. 5540-5554 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes

Sottini, A., Borgia, A., Borgia, M. B., Bugge, K., Nettels, D., Chowdhury, A., Heidarsson, P. O., Zosel, F., Best, R. B., Kragelund, Birthe Brandt & Schuler, B., 2020, In: Nature Communications. 11, 14 p., 5736.

Research output: Contribution to journal › Journal article › Research › peer-review

The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

Skaanning, L. K., Santoro, A., Skamris, T., Martinsen, J. H., D’Ursi, A. M., Bucciarelli, S., Vestergaard, Bente, Bugge, K., Langkilde, Annette Eva & Kragelund, Birthe Brandt, 2020, In: Biomolecules. 10, 8, 23 p., 1192.

Research output: Contribution to journal › Journal article › Research › peer-review

Yeast recombinant production of intact human membrane proteins with long intrinsically disordered intracellular regions for structural studies

Kassem, N., Kassem, M. M., Pedersen, Stine Helene Falsig, Pedersen, Per Amstrup & Kragelund, Birthe Brandt, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 14 p., 183272.

Research output: Contribution to journal › Journal article › Research › peer-review

Distinct α-Synuclein:Lipid Co-Structure Complexes Affect Amyloid Nucleation through Fibril Mimetic Behavior

Cholak, E., Bucciarelli, S., Bugge, K., Johansen, Nicolai Tidemand, Vestergaard, Bente, Arleth, Lise, Kragelund, Birthe Brandt & Langkilde, Annette Eva, Nov 2019, In: Biochemistry. 58, 50, p. 5052-5065

Research output: Contribution to journal › Journal article › Research › peer-review

Alginate Trisaccharide Binding Sites on the Surface of β-Lactoglobulin Identified by NMR Spectroscopy: Implications for Molecular Network Formation

Stender, E. G. P., Birch, J., Kjeldsen, C., Nielsen, L. D., Duus, J. Ø., Kragelund, Birthe Brandt & Svensson, B., 2019, In: ACS Omega. 4, 4, p. 6165-6174 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Dynamical Oligomerisation of Histidine Rich Intrinsically Disordered Proteins Is Regulated through Zinc-Histidine Interactions

Cragnell, C., Staby, L., Lenton, S., Kragelund, Birthe Brandt & Skepö, M., 2019, In: Biomolecules. 9, 5, 20 p., 168.

Research output: Contribution to journal › Journal article › Research › peer-review

Evolutionary conservation of the intrinsic disorder-based Radical-Induced Cell Death1 hub interactome

Christensen, L. F., Staby, L., Bugge, K., O'Shea, Charlotte, Kragelund, Birthe Brandt & Skriver, Karen, 2019, In: Scientific Reports. 9, 15 p., 18927.

Research output: Contribution to journal › Journal article › Research › peer-review

Molecular basis for the binding and selective dephosphorylation of Na⁺/H⁺ exchanger 1 by calcineurin

Hendus-Altenburger, R., Wang, X., Sjøgaard-Frich, Lise Margrethe, Pedraz Cuesta, E., Sheftic, S. R., Bendsøe, A. H., Page, R., Kragelund, Birthe Brandt, Pedersen, Stine Helene Falsig & Peti, W., 2019, In: Nature Communications. 10, 13 p., 3489.

Research output: Contribution to journal › Journal article › Research › peer-review

R2R3 MYB Transcription Factors - Functions outside the DNA-Binding Domain

Millard, P. S., Kragelund, Birthe Brandt & Burow, Meike, 2019, In: Trends in Plant Science. 24, 10, p. 934-946

Research output: Contribution to journal › Review › Research › peer-review

Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range

Hendus-Altenburger, R., Fernandes, Catarina, Bugge, K., Kunze, M. B. A., Boomsma, Wouter & Kragelund, Birthe Brandt, 2019, In: Journal of Biomolecular NMR. 73, 12, p. 713–725 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Specificity of MYB interactions relies on motifs in ordered and disordered contexts

Millard, P. S., Weber, K., Kragelund, Birthe Brandt & Burow, Meike, 2019, In: Nucleic Acids Research. 47, 18, p. 9592-9608 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Temperature Dependence of Intrinsically Disordered Proteins in Simulations: What are We Missing?

Jephthah, S., Staby, L., Kragelund, Birthe Brandt & Skepö, M., 2019, In: Journal of Chemical Theory and Computation. 15, 4, p. 2672-2683

Research output: Contribution to journal › Journal article › Research › peer-review

The PCNA interaction motifs revisited: thinking outside the PIP-box

Prestel, Andreas, Wichmann, N., Martins, J. M., Marabini, R., Kassem, N., Broendum, S. S., Otterlei, M., Nielsen, Olaf, Willemoës, Martin, Ploug, Michael, Boomsma, Wouter & Kragelund, Birthe Brandt, 2019, In: Cellular and Molecular Life Sciences. 76, 24, p. 4923-4943

Research output: Contribution to journal › Journal article › Research › peer-review

The transmembrane autophagy cargo receptors ATI1 and ATI2 interact with ATG8 through intrinsically disordered regions with distinct biophysical properties

Sjøgaard, Ida Marie Zobbe, Bressendorff, Simon, Prestel, Andreas, Kausika, S., Oksbjerg, Emilie Duus, Kragelund, Birthe Brandt & Brodersen, Peter, 2019, In: Biochemical Journal. 476, 3, p. 449-465 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit

He, L., Cohen, E. B., Edwards, A. P. B., Xavier-Ferrucio, J., Bugge, K., Federman, R. S., Absher, D., Myers, R. M., Kragelund, Birthe Brandt, Krause, D. S. & DiMaio, D., 2019, In: iScience. 17, p. 167-181 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Expanded Interactome of the Intrinsically Disordered Protein Dss1

Schenstrøm, S. M., Rebula, C. A., Tatham, M. H., Hendus-Altenburger, R., Jourdain, I., Hay, R. T., Kragelund, Birthe Brandt & Hartmann-Petersen, Rasmus, 23 Oct 2018, In: Cell Reports. 25, 4, p. 862-870

Research output: Contribution to journal › Journal article › Research › peer-review

Extreme disorder in an ultrahigh-affinity protein complex

Borgia, A., Borgia, M. B., Bugge, K. Ø., Kissling, V. M., Heidarsson, P. O., Fernandes, Catarina, Sottini, A., Soranno, A., Buholzer, K. J., Nettels, D., Kragelund, Birthe Brandt, Best, R. B. & Schuler, B., 1 Mar 2018, In: Nature. 555, p. 61-66 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase

Kristensen, Kristian Kølby, Midtgaard, S. R., Mysling, S., Kovrov, O., Hansen, L. B., Skar-Gislinge, Nicholas, Beigneux, A. P., Kragelund, Birthe Brandt, Olivecrona, G., Young, S. G., Jørgensen, T. J. D., Fong, L. G. & Ploug, Michael, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 26, p. E6020-E6029 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

Chhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, Birthe Brandt, Brooks, A. J. & Waters, M. J., 2018, In: Oncogene. 37, p. 489-501 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Role of protein dynamics in transmembrane receptor signalling

Wang, Yong, Bugge, K. Ø., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2018, In: Current Opinion in Structural Biology. 48, p. 74-82 9 p.

Research output: Contribution to journal › Review › Research › peer-review

Structure of radical-induced cell death1 hub domain reveals a common αα-scaffold for disorder in transcriptional networks

Bugge, K. Ø., Staby, L., Kemplen, K. R., O'Shea, Charlotte, Bendsen, S. K., Jensen, M. K., Olsen, Johan Gotthardt, Skriver, Karen & Kragelund, Birthe Brandt, 2018, In: Structure. 26, 5, p. 734-746 21 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The Complex Conformational Dynamics of Neuronal Calcium Sensor-1: A Single Molecule Perspective

Choudhary, D., Kragelund, Birthe Brandt, Heidarsson, P. O. & Cecconi, C., 2018, In: Frontiers in Molecular Neuroscience. 11, p. 1-8 468.

Research output: Contribution to journal › Review › Research › peer-review

Single methyl groups can act as toggle switches to specify transmembrane protein-protein interactions

He, L., Steinocher, H., Shelar, A., Cohen, E. B., Heim, E. N., Kragelund, Birthe Brandt, Grigoryan, G. & DiMaio, D., 4 Sep 2017, In: eLife. 6, 28 p., e27701.

Research output: Contribution to journal › Journal article › Research › peer-review

A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)

Hendus-Altenburger, R., Lambrughi, M., Terkelsen, Thilde Bagger, Pedersen, Stine Helene Falsig, Papaleo, E., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Sep 2017, In: Cellular Signalling. 37, p. 40-51 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Behaviour of intrinsically disordered proteins in protein-protein complexes with an emphasis on fuzziness

Olsen, Johan Gotthardt, Teilum, Kaare & Kragelund, Birthe Brandt, Sep 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3175-3183 9 p.

Research output: Contribution to journal › Review › Research › peer-review

Functions of intrinsic disorder in transmembrane proteins

Kjærgaard, M. & Kragelund, Birthe Brandt, Sep 2017, In: Cellular and Molecular Life Sciences. 74, 17, p. 3205-3224 20 p.

Research output: Contribution to journal › Review › Research › peer-review

An efficient method for estimating the hydrodynamic radius of disordered protein conformations

Nygaard, M., Kragelund, Birthe Brandt, Papaleo, E. & Lindorff-Larsen, Kresten, 8 Aug 2017, In: Biophysical Journal. 113, 3, p. 550-557 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Eukaryotic transcription factors: paradigms of protein intrinsic disorder

Staby, L., O'Shea, Charlotte, Willemoës, Martin, Theisen, F., Kragelund, Birthe Brandt & Skriver, Karen, 12 Jul 2017, In: Biochemical Journal. 474, 15, p. 2509-2532 24 p.

Research output: Contribution to journal › Review › Research › peer-review

Deoxynucleoside salvage in fission yeast allows rescue of ribonucleotide reductase deficiency but not Spd1-mediated inhibition of replication

Fleck, O., Fahnøe, Ulrik, Løvschal, K. V., Gasasira, M. U., Marinova, I. N., Kragelund, Birthe Brandt, Carr, A. M., Hartsuiker, E., Holmberg, Christian & Nielsen, Olaf, 25 Apr 2017, In: Genes. 8, 5, 14 p., 128.

Research output: Contribution to journal › Journal article › Research › peer-review

(S)Pinning down protein interactions by NMR

Teilum, Kaare, Kunze, M. B. A., qrc243, qrc243 & Kragelund, Birthe Brandt, Mar 2017, In: Protein Science. 26, 3, p. 436-451 16 p.

Research output: Contribution to journal › Review › Research › peer-review

Cold denaturation of the HIV-1 protease monomer

Rösner, Heike Ilona, Caldarini, M., Prestel, Andreas, Vanoni, M. A., Broglia, R. A., Aliverti, A., Tiana, G. & Kragelund, Birthe Brandt, 7 Feb 2017, In: Biochemistry. 56, 8, p. 1029-1032 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Structures and short linear motif of disordered transcription factor regions provide clues to the interactome of the cellular hub radical-induced cell death1

O'Shea, Charlotte, Staby, L., Bendsen, S. K., Tidemand, Frederik Grønbæk, Redsted, A., Willemoës, Martin, Kragelund, Birthe Brandt & Skriver, Karen, 13 Jan 2017, In: Journal of Biological Chemistry. 292, 2, p. 512-527 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Choreography by Structural Disorder in Membrane Proteins

Kragelund, Birthe Brandt, 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3, suppl. 1, p. 12A 1 p., 65-Subg.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Class I Cytokine Receptors: Towards the Inside

Steinocher, H., Bugge, K. Ø., Nikolajsen, L. F., Lindorff-Larsen, Kresten, Brooks, A. & Kragelund, Birthe Brandt, 2017, In: Biophysical Society. Annual Meeting. Abstracts. 112, 3. Suppl. 1, p. 171A 1 p., 845-Plat.

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Understanding single-pass transmembrane receptor signaling from a structural viewpoint—what are we missing?

Bugge, K. Ø., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, Dec 2016, In: The FEBS Journal. 283, 24, p. 4424-4451 28 p.

Research output: Contribution to journal › Review › Research › peer-review

A combined computational and structural model of the full-length human prolactin receptor

Bugge, K. Ø., Papaleo, E., Haxholm, G. W., Hopper, J. T. S., Robinson, C. V., Olsen, Johan Gotthardt, Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2016, In: Nature Communications. 7, 11 p., 11578.

Research output: Contribution to journal › Journal article › Research › peer-review

An efficient arabinoxylan-debranching α-L-arabinofuranosidase of family GH62 from Aspergillus nidulans contains a secondary carbohydrate binding site

Wilkens, C., Andersen, S., Petersen, B. O., Li, A., Busse-Wicher, M., Birch, J., Cockburn, D., Nakai, H., Christensen, H. E. M., Kragelund, Birthe Brandt, Dupree, P., McCleary, B., Hindsgaul, O., Abou Hachem, M. & Svensson, B., 2016, In: Applied Microbiology and Biotechnology. 100, 14, p. 6265-6277 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

DSS1/Sem1, a multifunctional and intrinsically disordered protein

Kragelund, Birthe Brandt, Schenstrøm, S. M., Rebula, C. A., Panse, V. G. & Hartmann-Petersen, Rasmus, 2016, In: Trends in Biochemical Sciences. 41, 5, p. 446-459 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Prolactin signaling stimulates invasion via Na⁺/H⁺ exchanger NHE1 in T47D human breast cancer cells

Pedraz Cuesta, E., Fredsted, J., Jensen, H. H., Bornebusch, A., Nejsum, L. N., Kragelund, Birthe Brandt & Pedersen, Stine Helene Falsig, 2016, In: Molecular Endocrinology. 30, 7, p. 693-708 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The Ku70/80 ring in Non-Homologous End-Joining: easy to slip on, hard to remove

Kragelund, Birthe Brandt, Weterings, E., Hartmann-Petersen, Rasmus & Keijzers, G., 2016, In: Frontiers in Bioscience. 21, 3, p. 514-527 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The human Na⁺/H⁺ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2

Hendus-Altenburger, R., Pedraz Cuesta, E., Olesen, C. W., Papaleo, E., Schnell, J. A., Hopper, J. T. S., Robinson, C. V., Pedersen, Stine Helene Falsig & Kragelund, Birthe Brandt, 2016, In: BMC Biology. 14, 17 p., 31.

Research output: Contribution to journal › Journal article › Research › peer-review

A de novo designed monomeric, compact three helix bundle protein on a carbohydrate template

Malik, L., Nygård, Jesper, Christensen, Niels Johan, Madsen, C. S., Rösner, Heike Ilona, Kragelund, Birthe Brandt, Høiberg-Nielsen, R., Streicher, W., Arleth, Lise, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2015, In: ChemBioChem. 16, 13, p. 1905-1918 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

A residue quartet in the extracellular domain of the prolactin receptor selectively controls mitogen-activated protein kinase signaling

Zhang, C., Nygaard, M., Haxholm, G. W., Boutillon, F., Bernadet, M., Hoos, S., England, P., Broutin, I., Kragelund, Birthe Brandt & Goffin, V., 2015, In: Journal of Biological Chemistry. 290, 19, p. 11890-11904 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

A two-step protein quality control pathway for a misfolded DJ-1 variant in fission yeast

Mathiassen, S. G., Larsen, I. B., Poulsen, E. G., Madsen, C. T., Papaleo, E., Lindorff-Larsen, Kresten, Kragelund, Birthe Brandt, Nielsen, Michael Lund, Kriegenburg, F. & Hartmann-Petersen, Rasmus, 2015, In: The Journal of Biological Chemistry. 290, 34, p. 21141-21153 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exploiting hydrophobicity for efficient production of transmembrane helices for structure determination by NMR spectroscopy

Bugge, K. Ø., Steinocher, H., Brooks, A. J., Lindorff-Larsen, Kresten & Kragelund, Birthe Brandt, 2015, In: Analytical Chemistry. 87, 18, p. 9126–9131 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Functional characterization of a conserved archaeal viral operon revealing single-stranded DNA binding, annealing and nuclease activities

Guo, Y., Kragelund, Birthe Brandt, White, M. F. & Peng, Xu, 2015, In: Journal of Molecular Biology. 427, 12, p. 2179-2191 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Globular and disordered-the non-identical twins in protein-protein interactions

Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2015, In: Frontiers in Bioscience. 2, 6 p., 40.

Research output: Contribution to journal › Journal article › Research › peer-review

Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes

Haxholm, G. W., Nikolajsen, L. F., Olsen, Johan Gotthardt, Fredsted, J., Larsen, F. H., Goffin, V., Pedersen, Stine Helene Falsig, Brooks, A. J., Waters, M. J. & Kragelund, Birthe Brandt, 2015, In: Biochemical Journal. 468, 3, p. 495-506 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Protein intrinsic disorder in Arabidopsis NAC transcription factors: transcriptional activation by ANAC013 and ANAC046 and their interactions with RCD1

O'Shea, Charlotte, Jensen, M. K., Stender, E. G. P., Kragelund, Birthe Brandt, Willemoës, Martin & Skriver, Karen, 2015, In: Biochemical Journal. 465, 2, p. 281-294 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Residue 146 regulates prolactin receptor folding, basal activity and ligand-responsiveness: potential implications in breast tumorigenesis

Zhang, C., Cherifi, I., Nygaard, M., Haxholm, G. W., Bogorad, R. L., Bernadet, M., England, P., Broutin, I., Kragelund, Birthe Brandt, Guidotti, J. & Goffin, V., 2015, In: Molecular and Cellular Endocrinology. 401, p. 173-188 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing

Marinova, I. N., Engelbrecht, J., Ewald, A., Langholm, L. L., Holmberg, Christian, Kragelund, Birthe Brandt, Gordon, C., Nielsen, Olaf & Hartmann-Petersen, Rasmus, 2015, In: P L o S One. 10, 2, 15 p., e0117779.

Research output: Contribution to journal › Journal article › Research › peer-review

Single-molecule folding mechanisms of the apo- and Mg²⁺-bound states of human neuronal calcium sensor-1

Naqvi, M. M., Heiðarsson, P. O., Otazo, M. R., Mossa, A., Kragelund, Birthe Brandt & Cecconi, C., 2015, In: Biophysical Journal. 109, 1, p. 113-123 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

CECAM workshop on intrinsically disordered proteins

Rösner, Heike Ilona, Papaleo, E., Haxholm, G. W., Best, R. B., Kragelund, Birthe Brandt & Lindorff-Larsen, Kresten, 2014, In: Intrinsically Disordered Proteins. 2, 1, p. 1-5 5 p.

Research output: Contribution to journal › Conference abstract in journal › Research

Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1

Heiðarsson, P. O., Naqvi, M. M., Otazo, M. R., Mossa, A., Kragelund, Birthe Brandt & Cecconi, C., 2014, In: Proceedings of the National Academy of Sciences U.S.A.. 111, 36, p. 13069-13074 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Dss1 is a 26S proteasome ubiquitin receptor

Paraskevopoulos, K., Kriegenburg, F., Tatham, M. H., Rösner, Heike Ilona, Medina, B., Larsen, I. B., Brandstrup, R., Hardwick, K. G., Hay, R. T., Kragelund, Birthe Brandt, Hartmann-Petersen, Rasmus & Gordon, C., 2014, In: Molecular Cell. 56, 3, p. 453-461 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Exploring the minimally frustrated energy landscape of unfolded ACBP

Ozenne, V., Noel, J. K., Heiðarsson, P. O., Brander, S., Poulsen, F. M., Jensen, M. R., Kragelund, Birthe Brandt, Blackledge, M. & Danielsson, J. A., 2014, In: Journal of Molecular Biology. 426, 3, p. 722-734 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools

Vejrup-Hansen, R., Fleck, O., Landvad, K., Fahnøe, Ulrik, Broendum, S. S., Schreurs, A., Kragelund, Birthe Brandt, Carr, A. M., Holmberg, Christian & Nielsen, Olaf, 2014, In: Journal of Cell Science. 127, p. 2460-2470 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Who climbs the tryptophan ladder? On the structure and function of the WSXWS motif in cytokine receptors and thrombospondin repeats

Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2014, In: Cytokine & Growth Factor Reviews. 25, 3, p. 337-341 5 p.

Research output: Contribution to journal › Review › Research › peer-review

Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin

Dagil, Robert, O'Shea, Charlotte, Nykjær, A., Bonvin, A. M. J. J. & Kragelund, Birthe Brandt, 2013, In: The Journal of Biological Chemistry. 288, 6, p. 4424-35 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

New horizons for lipoprotein receptors: communication by β-propellers

Andersen, O. M., Dagil, Robert & Kragelund, Birthe Brandt, 2013, In: Journal of Lipid Research. 54, p. 2763-2774 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Single-molecule folding mechanism of an EF-hand neuronal calcium sensor

Heiðarsson, P. O., Otazo, M. R., Bellucci, L., Mossa, A., Imparato, A., Paci, E., Corni, S., Felice, R. D., Kragelund, Birthe Brandt & Cecconi, C., 2013, In: Structure. 21, 10, p. 1812-1821 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Solution properties of the archaeal CRISPR DNA repeat-binding homeodomain protein Cbp2

Kenchappa, C., Heiðarsson, P. O., Kragelund, Birthe Brandt, Garrett, Roger Antony & Poulsen, F., 2013, In: Nucleic Acids Research. 41, 5, p. 3424-3435 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Strains of the soil fungus Mortierella show different degradation potentials for the phenylurea herbicide diuron

Ellegaard-Jensen, L., Aamand, J., Kragelund, Birthe Brandt, Johnsen, A. H. & Rosendahl, Søren, 2013, In: Biodegradation. 24, 6, p. 765-774 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The transcriptional repressor domain of Gli3 is intrinsically disordered

Tsanev, R., Vanatalu, K., Jarvet, J., Tanner, R., Laur, K., Tiigimägi, P., Kragelund, Birthe Brandt, Østerlund, T. & Kogerman, P., 2013, In: PLoS ONE. 8, 10, 9 p., e76972.

Research output: Contribution to journal › Journal article › Research › peer-review

A highly compliant protein native state with a spontaneous-like mechanical unfolding pathway

Heiðarsson, P. O., Valpapuram, I., Camilloni, C., Imparato, A., Tiana, G., Poulsen, F. M., Kragelund, Birthe Brandt & Cecconi, C., 2012, In: Journal of the American Chemical Society. 134, 41, p. 17068-17075 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Order by disorder in plant signaling

Kragelund, Birthe Brandt, Jensen, M. K. & Skriver, Karen, 2012, In: Trends in Plant Science. 17, 11, p. 625-632 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Structure and Dynamic Properties of Membrane Proteins using NMR

Rösner, Heike Ilona & Kragelund, Birthe Brandt, 2012, In: Comprehensive Physiology. 2, 2, p. 1491-1539 49 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The C-terminal tail of human neuronal calcium sensor 1 regulates the conformational stability of the Ca²⁺-activated state

Heiðarsson, P. O., Bjerrum-Bohr, I. J., Jensen, G. A., Pongs, O., Finn, B. E., Poulsen, F. M. & Kragelund, Birthe Brandt, 2012, In: Journal of Molecular Biology. 417, 1-2, p. 51-64 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor

Dagil, Robert, Knudsen, M. J., Olsen, Johan Gotthardt, O'Shea, Charlotte, Franzmann, M., Goffin, V., Teilum, Kaare, Breinholt, J. & Kragelund, Birthe Brandt, 2012, In: Structure. 20, 2, p. 270-282 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

β-Microseminoprotein endows post coital seminal plasma with potent candidacidal activity by a calcium- and pH-dependent mechanism.

Edström Hägerwall, A., Rydengård, V., Fernlund, P., Mörgelin, M., Baumgarten, M., Cole, A. M., Malmsten, M., Kragelund, Birthe Brandt & Sørensen, O. E., 2012, In: P L o S Pathogens. 8, 4, p. 1-12 12 p., e1002625.

Research output: Contribution to journal › Journal article › Research › peer-review

Development of prolactin receptor antagonists with reduced pH-dependence of receptor binding.

Hansen, M. J. K., Olsen, Johan Gotthardt, Bernichtein, S., O'Shea, Charlotte, Sigurskjold, B. W., Goffin, V. & Kragelund, Birthe Brandt, 2011, In: Journal of Molecular Recognition. 24, 4, p. 533-547 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Protein stability, flexibility and function

Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2011, In: B B A - Proteins and Proteomics. 1814, 8, p. 969-76 8 p.

Research output: Contribution to journal › Review › Research › peer-review

Senescence-associated barley NAC (NAM, ATAF1,2, CUC) transcription factor interacts with radical-induced cell death 1 through a disordered regulatory domain

Kjaersgaard, T., Jensen, M. K., Christiansen, M. W., Gregersen, P. L., Kragelund, Birthe Brandt & Skriver, Karen, 2011, In: Journal of Biological Chemistry. 286, 41, p. 35418-29 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Streptococcal pyogenic exotoxin B (SpeB) boosts the contact system via binding of a-1 antitrypsin

Meinert Niclasen, L., Olsen, Johan Gotthardt, Dagil, Robert, Qing, Z., Sørensen, O. E. & Kragelund, Birthe Brandt, 2011, In: Biochemical Journal. 434, 1, p. 123-32 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The Intracellular Distal Tail of the Na⁺/H⁺ Exchanger NHE1 Is Intrinsically Disordered: Implications for NHE1 Trafficking

Nørholm, A., Hendus-Altenburger, R., Bjerre, G., Kjærgaard, M., Pedersen, Stine Helene Falsig & Kragelund, Birthe Brandt, 2011, In: Biochemistry. 50, 17, p. 3469-80 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Temperature-dependent structural changes in intrinsically disordered proteins: formation of alpha-helices or loss of polyproline II?

Kjærgaard, M., Nørholm, A., Hendus-Altenburger, R., Pedersen, Stine Helene Falsig, Poulsen, F. M. & Kragelund, Birthe Brandt, 1 Aug 2010, In: Protein Science. 19, 8, p. 1555-64 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms

Nestoras, K., Mohammed, A. H., Schreurs, A., Fleck, O., Watson, A. T., Poitelea, M., O'Shea, Charlotte, Chahwan, C., Holmberg, Christian, Kragelund, Birthe Brandt, Nielsen, Olaf, Osborne, M., Carr, A. M. & Liu, C., 1 Jun 2010, In: Genes & Development. 24, 11, p. 1145-1159 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

A Far UV CD study of de novo designed antimicrobial coiled coils upon interaction with model membranes

Søndergaard, S. L., Kragelund, Birthe Brandt, Thulstrup, Peter Waaben, Brahm, Jesper, Siegumfeldt, Henrik, Frimodt-Møller, N. & Hansen, Paul Robert, 2010, In: Journal of Peptide Science. S2

Research output: Contribution to journal › Conference abstract in journal › Research

Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.

Broutin, I., Jomain, J., Tallet, E., Van Agthoven, J., Raynal, B., Hoos, S., Kragelund, Birthe Brandt, Kelly, P., Ducroix, A., England, P. & Goffin, V., 2010, In: Journal of Biological Chemistry. 285, 11, p. 8422-8433 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Functional aspects of protein flexibility

Teilum, Kaare, Olsen, Johan Gotthardt & Kragelund, Birthe Brandt, 2009, In: Cellular and Molecular Life Sciences. 66, 14, p. 2231-47 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Metabolites of the phenylurea herbicides chlorotoluron, diuron, isoproturonand linuron produced by the soil fungus Mortierella sp.

Badawi, N., Rønhede, S., Olsson, S., Kragelund, Birthe Brandt, Johnsen, A. H., Jacobsen, O. S. & Aamand, J., 2009, In: Environmental Pollution. 157, 10, p. 2806-2812 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Structure of the Mature Streptococcal Cysteine Protease Exotoxin mSpeB in Its Active Dimeric Form

Olsen, Johan Gotthardt, Dagil, Robert, Niclasen, L. M., Sørensen, O. E. & Kragelund, Birthe Brandt, 2009, In: Journal of Molecular Biology. 393, 3, p. 693-703 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells.

Hansen, J. S., Færgeman, N. J., Kragelund, Birthe Brandt & Knudsen, J., 2008, In: Biochemical Journal. 410, 3, p. 463-472 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity

Bjelke, J. R., Olsen, O. H., Fodje, M., Svensson, L. A., Bang, S., Bolt, G., Kragelund, Birthe Brandt & Persson, E., 2008, In: Journal of Biological Chemistry. 283, 38, p. 25863-70 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Phosphate Selective Uranyl Photo-Affinity Cleavage of Proteins. Determination of Phosphorylation Sites.

Kristensen, L. H., Nielsen, Peter E., Jørgensen, C. I., Kragelund, Birthe Brandt & Møllegaard, Niels Erik, 2008, In: ChemBioChem. 9, 15, p. 2377-81 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The intrinsically disordered RNR inhibitor Sml1 is a dynamic dimer

Danielsson, J., Liljedahl, L., Ba´ra´ny-Wallje, E., Sønderby, P., Kristensen, L. H., Martinez-Yamout, M. A., Dyson, H. J., Wright, P. E., Poulsen, F. M., Ma¨ler, L., Gra¨slund, A. & Kragelund, Birthe Brandt, 2008, In: Biochemistry. 47, 50, p. 13428-13437 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase

Christensen, Caspar Elo, Kragelund, Birthe Brandt, Von Wettstein-Knowles, P. & Henriksen, A., Feb 2007, In: Protein Science. 16, 2, p. 261-272

Research output: Contribution to journal › Journal article › Research › peer-review

Acyl-CoA binding proteins; structural and functional conservation over 2000 MYA.

Faergeman, N. J., Wadum, M., Feddersen, S., Burton, M., Kragelund, Birthe Brandt & Knudsen, J., 2007, In: Molecular and Cellular Biochemistry. 299, 1-2, p. 55-65 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa.

Larsen, K. S., Østergaard, H., Bjelke, J. R., Olsen, O. H., Rasmussen, H. B., Christensen, L., Kragelund, Birthe Brandt & Stennicke, H. R., 2007, In: Biochemical Journal. 405, 3, p. 429-38 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL.

Jomain, J., Tallet, E., Broutin, I., Hoos, S., van Agthoven, J., Ducruix, A., Kelly, P. A., Kragelund, Birthe Brandt, England, P. & Goffin, V., 2007, In: Journal of Biological Chemistry. 282, 45, p. 33118-31 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Structure-activity study of the antibacterial peptide fallaxin

Søndergaard, S. L., Frimodt-Møller, N., Kragelund, Birthe Brandt & Hansen, Paul Robert, 2007, In: Protein Science. 16, 9, p. 1969-1976 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

A loop of coagulation factor VIIa influencing macromolecular substrate specificity.

Bjelke, J. R., Persson, E., Rasmussen, H. B., Kragelund, Birthe Brandt & Olsen, O. H., 2006, In: FEBS Letters. 581, 1, p. 71-6 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif.

Jensen, G. A., Andersen, O. M., Bonvin, A. M. J. J., Bjerrum-Bohr, I., Etzerodt, M., Thøgersen, H. C., O'Shea, Charlotte, Poulsen, F. M. & Kragelund, Birthe Brandt, 2006, In: Journal of Molecular Biology. 362, 4, p. 700-16 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Different secondary structure elements as scaffolds for protein folding transition states of two homologous four-helix bundles

Teilum, Kaare, Thormann, T., Caterer, N. R., Poulsen, H. I., Jensen, P. H., Knudsen, J., Kragelund, Birthe Brandt & Poulsen, F. M., 2005, In: Proteins - Structure Function and Bioinformatics. 59, 1, p. 80-90

Research output: Contribution to journal › Journal article › Research › peer-review

Hydroxylation of the Herbicide Isoproturon by Fungi Isolated from Agricultural soil

Rønhede, S., Jensen, B., Rosendahl, Søren, Kragelund, Birthe Brandt, Juhler, R. K. & Aamand, J., 2005, In: Applied and Environmental Microbiology. 71, 12, p. 7927-7932

Research output: Contribution to journal › Journal article › Research › peer-review

Protein folding: Defining a standard set of experimental conditions and a preliminary kinetic data set of two-state proteins

Maxwell, K. L., Wildes, D., Zarrine-Afsar, A., Rivos, M. A. D. L. R., Brown, A. G., Friel, C. T., Hedberg, L., Horng, J-C., Bona, D., Miller, E. J., Vallée-Bélisle, A., Main, E. R. G., Bemporad, F., Qiu, L., Teilum, K., Vu, N-D., Edwards, A. M., Ruczinski, I., Poulsen, F. M., Kragelund, B. B. & 14 others, Michnick, S. W., Chiti, F., Bai, Y., Hagen, S. J., Serrano, L., Oliveberg, M., Raleigh, D. P., Stafshede, P. W., Radford, S. E., Jackson, S. E., Sosnick, T. R., Margusee, S., Davidson, A. R. & Plaxco, K. W., 2005, In: Protein Science. 14, 3, p. 602-616

Research output: Contribution to journal › Journal article › Research › peer-review

Reversible Dimerization of Acid-Denatured ACBP Controlled by Helix A4

Fieber, W., Kragelund, Birthe Brandt, Meldal, Morten Peter & Poulsen, F. M., 2005, In: Biochemistry. 44, 5, p. 1375-1384

Research output: Contribution to journal › Journal article › Research › peer-review

Solution structure of human prolactin

Teilum, Kaare, Hoch, J. C., Goffin, V., Kinet, S., Martial, J. A. & Kragelund, Birthe Brandt, 2005, In: Journal of Molecular Biology. 351, 4, p. 810-23 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Structure and biochemical function of a prototypical Arabidopsis U-box domain

Andersen, P., Kragelund, Birthe Brandt, Olsen, A. N., Larsen, F. H., Chua, N., Poulsen, F. M. & Skriver, Karen, 2004, In: Journal of Biological Chemistry. 279, 38, p. 40053-40061 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Universitetsstuderendes tilgang til eksperimentelt udstyr - kønslige og faglige aspekter

Bruun, G. M., Kragelund, Birthe Brandt & Oddershede, L. B., 2003, In: Center for Naturfagenes Didaktiks Tidsskriftserie. 9, p. .

Research output: Contribution to journal › Journal article › Research

Early kinetic intermediate in the folding of acyl-CoA binding protein detected by fluorescence labeling and ultrarapid mixing

Teilum, Kaare, Maki, K., Kragelund, Birthe Brandt, Poulsen, F. M. & Roder, H., 2002, In: Proceedings of the National Academy of Science of the United States of America. 99, 15, p. 9807-12 5 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Fluorescently labelled bovine acyl-CoA-binding protein acting as an acyl-CoA sensor: interaction with CoA and acyl-CoA esters and its use in measuring free acyl-CoA esters and non-esterified fatty acids

Wadum, M. C., Villadsen, J. K., Feddersen, S., Moller, R. S., Neergaard, T. B., Kragelund, Birthe Brandt, Hojrup, P., Faergeman, N. J. & Knudsen, J., 2002, In: Biochemical Journal. 365, p. 165-172 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Transient intermediary states with high and low folding probabilities in the apparent two-state folding equilibrium of ACBP at low pH

Thomsen, J. K., Kragelund, Birthe Brandt, Teilum, Kaare, Knudsen, J. & Poulsen, F. M., 2002, In: Journal of Molecular Biology. 318, 3, p. 805-14 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Transient structure formation in unfolded acyl-coenzyme A-binding protein observed by site-directed spin labelling

Teilum, Kaare, Kragelund, Birthe Brandt & Poulsen, F. M., 2002, In: Journal of Molecular Biology. 324, 2, p. 349-57 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

1H, 13C, and 15N assignments of un-myristoylated Ca2+-frequenin, a synaptic efficacy modulator

Kragelund, Birthe Brandt, Hauenschild, A., Carlström, G., Pongs, O. & Finn, B. E., Jan 2000, In: Journal of Biomolecular N M R. 16, 1, p. 85-6 2 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Formation of hydrogen bonds precedes the rate-limiting formation of persistent structure in the folding of ACBP

Teilum, Kaare, Kragelund, Birthe Brandt, Knudsen, J. & Poulsen, F. M., 2000, In: Journal of Molecular Biology. 301, 5, p. 1307-14 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Acyl-coenzyme A binding protein (ACBP)

Kragelund, Birthe Brandt, Knudsen, J. & Poulsen, F. M., 23 Nov 1999, In: B B A - Reviews on Cancer. 1441, 2-3, p. 150-61 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Mapping the lifetimes of local opening events in a native state protein

Kragelund, Birthe Brandt, Heinemann, B., Knudsen, J. & Poulsen, F., 1998, In: Protein Sci.. 7, p. 2237-2248

Research output: Contribution to journal › Journal article › Research › peer-review

Structure of lipid-transfer protein complexed with palmitoyl-CoA. A hydrophobic binding site expandable to fit both large and small lipid-like ligands

Lerche, M. H., Kragelund, Birthe Brandt, Bech, L. & Poulsen, F., 1997, In: Structure. 5, p. 291-306

Research output: Contribution to journal › Journal article › Research › peer-review

Fast and one-step folding of closely and distantly related homologous proteins of a four-helix bundle family

Kragelund, Birthe Brandt, Højrup, P., Jensen, M. S., Schjerling, C. K., Juul, E., Knudsen, J. & Poulsen, F., 1996, In: J. Mol. Biol.. 256, p. 187-200

Research output: Contribution to journal › Journal article › Research › peer-review

Probing the nature of non-covalent interactions by mass spectrometry. A study of protein-CoA ligand interactions and assembly

Robinson, C. R., Chung, E. W., Kragelund, Birthe Brandt, Knudsen, J., Aplin, R. T., Poulsen, F. & Dobson, C. M., 1996, In: J. Amer. Chem.. 118, p. 8646-8653

Research output: Contribution to journal › Journal article › Research › peer-review

Thermodynamics of ligand binding to acyl-coenzyme, A binding protein studied by titration calometry

Færgeman, N. J., Sigurskjold, B. W., Kragelund, Birthe Brandt, Andersen, K. V. & Knudsen, J., 1996, In: Biochemistry. 35, p. 14118-14126

Research output: Contribution to journal › Journal article › Research › peer-review