Paul Robert Hansen

Paul Robert Hansen

Associate Professor

Member of:

    ORCID: 0000-0001-9357-8001

    Paul Robert Hansen earned his MS degree in Chemistry from the University of Copenhagen, Denmark in 1990. He was then a Research Assistant at the Department of Chemistry, Royal Veterinary and Agricultural University (KVL) for two years.
    From 1993-1994, he was a visiting Ph.D.-student in the laboratory of Professor George Barany at the Department of Chemistry, University of Minnesota
    In 1996, he received his Ph.D., from the Department of Chemistry, Royal Veterinary and Agricultural University, focusing on "New strategies in the synthesis of 2-acetamido-alpha–D–2-deoxy-glucopyranose O-Glycopeptides, neoglycoconjugates and photoreactive peptides" 

    In 1997, he joined the Department of Chemsitry, Royal Veterinary and Agricultural University, as an Assistant Professor of Bioorganic Chemistry. He became an Associate Professor in 2000. 
    In February 2012, he joined the Natural Products and Peptides Research Group, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences (previously Faculty of Pharmaceutical Sciences), University of Copenhagen.

     

    Scientific achievements and Research interest:

    From 2001, he has been an independent scientist, heading his own research group first at IGM-Bioorganic Chemistry, Faculty of Life Sciences, University of Copenhagen and from 2012 at the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen. PRH has an extensive documented experience in the field of peptide medicinal chemistry. PRHs research efforts mainly lie within i) peptide-based antibiotics, ii) peptides as probes in immunology and Calcitonin gene-related peptide analogues for treatment of glaucoma. PRH has co-authored 125+ scientific publications in the field of peptide chemistry/bioorganic chemistry. He is the editor of Methods in Molecular Biology: Antimicrobial Peptides published in 2017. Furthermore, PRH is Editorial Board Member for Antibiotics and Reviewer for Innovation Fund Denmark etc, AAC, J. Med. Chem. etc.

    Research management:

    From 2008-2013, PRH was a member of EPI-EXPOSE funded by the Danish Advanced Technology Foundation, Work package leader and member of steering commitee). From 2010-2015, he was a member of DANCARD (Danish Center for Antibiotic Research and Development) an interdisciplinary collaboration funded the Danish Council for Strategic Research. From 2012-2016, PRH was a partner in FP7-PEOPLE-2011-ITN TRAIN-ASAP (“Training Research AImed at Novel Antibacterial Strategies in Animals and People”, Work package leader and member of steering commitee). Furthermore, he was a partner in University of Copenhagen Research Centre for Control of Antibiotic Resistance UC-CARE.Currently and “Antimicrobial peptides seen by neutrons” funded by Nordforsk. 

    Selected publications

    1. Published

      C-locked analogs of the antimicrobial peptide BP214

      Andersen, I. K. L., Thomsen, T. T., Rashid, J., Bobak, T. R., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2022, In: Antibiotics. 11, 8, 10 p., 1080.

      Research output: Contribution to journal › Journal article › peer-review

    2. Published

      Cyclic N-Locked Indolicidin Analogues with Antimicrobial Activity: Effect of Ring Size and Fatty Acid Acylation

      Lone, A. B. N., Nielsen, J. E., Thulstrup, Peter Waaben, Lund, R., Hansen, Paul Robert & Jenssen, H., 2022, In: European Journal of Medicinal Chemistry Reports. 6, 7 p., 100080.

      Research output: Contribution to journal › Journal article › peer-review

    3. Published

      Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position

      Jensen, S. K., Thomsen, T. T., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences . 21, 16, 18 p., 5829.

      Research output: Contribution to journal › Journal article › peer-review

    4. Published

      Analogues of a Cyclic Antimicrobial Peptide with a Flexible Linker Show Promising Activity Against Pseudomonas aeruginosa and Staphylococcus aureus

      Thomsen, T. T., Mendel, H. C., Al-Mansour, W., Oddo, A., Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, In: Antibiotics. 9, 7, 13 p., 366.

      Research output: Contribution to journal › Journal article › peer-review

    5. Published

      Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides

      Greco, I., Molchanova, N., Holmedal, E., Jenssen, H., Hummel, B. D., Watts, J. L., Håkansson, J., Hansen, Paul Robert & Svenson, J., 2020, In: Scientific Reports. 10, 13 p., 13206.

      Research output: Contribution to journal › Journal article › peer-review

    6. Published

      Alternating Cationic-Hydrophobic Peptide/Peptoid Hybrids: Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity

      Frederiksen, N., Hansen, Paul Robert, Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Björkling, Fredrik & Franzyk, Henrik, 2020, In: ChemMedChem. 15, 24, p. 2544-2561

      Research output: Contribution to journal › Journal article › peer-review

    7. Published

      Fluorescent analogues of Human α-Calcitonin Gene-Related Peptide with vasodilator potency

      Zhu, J., Pedersen, M. D., Ahmed, L. S., Abdolalizadeh, B., Grell, A., Berg, Jais Oliver, Thulstrup, Peter Waaben, Franzyk, Henrik, Edvinsson, L., Sams, A., Sheykhzade, Majid & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences (Online). 21, 4, p. 1-15 15 p., 1343.

      Research output: Contribution to journal › Journal article › peer-review

    8. Published

      Structure-Activity Study of an All-D Antimicrobial Octapeptide D2D

      Lone, A., Thomsen, T. T., Nielsen, J. E., Thulstrup, Peter Waaben, Klitgaard, R. N., Løbner-Olesen, Anders, Lund, R., Jenssen, H. & Hansen, Paul Robert, 2019, In: Molecules. 24, 24, 17 p., 4571.

      Research output: Contribution to journal › Journal article › peer-review

    9. Published

      Peptides, antibodies, peptide antibodies and more

      Trier, N., Hansen, Paul Robert & Houen, G., 11 Nov 2019, In: International Journal of Molecular Sciences (Online). 20, 22 p., 6289.

      Research output: Contribution to journal › Review › peer-review

    10. Published

      Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity

      Frederiksen, N., Hansen, Paul Robert, Björkling, Fredrik & Franzyk, Henrik, 4 Dec 2019, In: Molecules (Print Archive Edition). 24, 18 p., 4429.

      Research output: Contribution to journal › Journal article › peer-review

    11. Published

      Fine mapping of glutamate decarboxylase 65 epitopes reveals dependency of hydrophobic amino acids for specific interactions

      Valdarnini, N., Holm, B., Hansen, Paul Robert, Rovero, P., Houen, G. & Trier, N. H., 2019, In: International Journal of Molecular Sciences (Online). 20, 13 p., 2909.

      Research output: Contribution to journal › Journal article › peer-review

    12. Published

      A Biophysical Study of the Interactions between the Antimicrobial Peptide Indolicidin and Lipid Model Systems

      Nielsen, J. E., Lind, T. K., Lone, A., Gerelli, Y., Hansen, Paul Robert, Jenssen, H., Cárdenas, M. & Lund, R., 2019, In: B B A - Biomembranes. 1861, 7, p. 1355-1364

      Research output: Contribution to journal › Journal article › peer-review

    13. Published

      Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients

      Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In: Frontiers in Microbiology. 10, 9 p., 275.

      Research output: Contribution to journal › Journal article › peer-review

    14. Published

      Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections

      Greco, I., Emborg, A., Jana, B., Molchanova, N., Oddo, A., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2019, In: Scientific Reports. 9, 12 p., 3679.

      Research output: Contribution to journal › Journal article › peer-review

    15. Published

      Specificity of anti-citrullinated protein antibodies in rheumatoid arthritis

      Trier, N., Holm, B. E., Hansen, Paul Robert, Slot, O., Locht, H. & Houen, G., 2019, In: Antibodies. 8, 2, 10 p., 37.

      Research output: Contribution to journal › Journal article › peer-review

    16. Published

      Structure-activity study, characterization and mechanism of action of an antimicrobial peptoid D2 and its D- and L-peptide analogues

      Greco, I., Hansen, J. E., Jana, B., Molchanova, N., Oddo, A., Thulstrup, Peter Waaben, Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2019, In: Molecules. 24, 6, 16 p., 1121.

      Research output: Contribution to journal › Journal article › peer-review

    17. Published

      Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic

      Kłodzińska, S. N., Molchanova, N., Franzyk, Henrik, Hansen, Paul Robert, Damborg, Peter Panduro & Nielsen, Hanne Mørck, Jul 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 128, p. 1-9 9 p.

      Research output: Contribution to journal › Journal article › peer-review

    18. Published

      Fmoc Solid-Phase Synthesis of Human a-Calcitonin Gene- Related Peptide and Two Carboxyfluorescein-labeled Analogs

      Ahmed, L. S., Abdolalizadeh, B., Sheykhzade, Majid & Hansen, Paul Robert, 11 Feb 2018.

      Research output: Contribution to conference › Poster › Research › peer-review

    19. Published

      In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma

      Greco, I., Hummel, B. D., Vasir, J., Watts, J. L., Koch, J., Hansen, J. E., Nielsen, Hanne Mørck, Damborg, Peter Panduro & Hansen, Paul Robert, 10 Mar 2018, In: Molecules. 23, 3, 15 p., 630.

      Research output: Contribution to journal › Journal article › peer-review

    20. Published

      Fluorinated antimicrobial lysine-based peptidomimetics with activity against methicillin-resistant Staphylococcus pseudintermedius

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2018, In: Journal of Peptide Science. 24, 7, 8 p., e3098.

      Research output: Contribution to journal › Journal article › peer-review

    21. Published

      Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing

      Karathanasi, G., Bojer, Martin Saxtorph, Baldry, M., Johannessen, B. A., Wolff, S., Greco, I., Kilstrup, M., Hansen, Paul Robert & Ingmer, Hanne, 2018, In: Scientific Reports. 8, 1, 11 p., 3562.

      Research output: Contribution to journal › Journal article › peer-review

    22. Published

      Review on abyssomicins: Inhibitors of the chorismate pathway and folate biosynthesis

      Sadaka, C., Ellsworth, E., Hansen, Paul Robert, Ewin, R., Damborg, Peter Panduro & Watts, J. L., 2018, In: Molecules. 23, 6, 25 p., 1371.

      Research output: Contribution to journal › Review › peer-review

    23. Published

      The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells

      Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, In: The Journal of Biological Chemistry. 293, p. 1007-1017

      Research output: Contribution to journal › Journal article › peer-review

    24. Published

      Advances in development of antimicrobial peptidomimetics as potential drugs

      Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 28 Aug 2017, In: Molecules. 22, 9, 60 p., 1430.

      Research output: Contribution to journal › Review › peer-review

    25. Published

      Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes

      Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., Jul 2017, In: Journal of Virology. 91, 14, 18 p., e00130-17.

      Research output: Contribution to journal › Journal article › peer-review

    26. Published

      Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR

      Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In: Research in Microbiology. 168, 5, p. 443-449

      Research output: Contribution to journal › Journal article › peer-review

    27. Published

      Methods in Molecular Biology: Antimicrobial Peptides Methods and Protocols

      Hansen, Paul Robert (ed.), 1 Jan 2017, Springer. 439 p.

      Research output: Book/Report › Book › peer-review

    28. Published

      Chemical Synthesis of Antimicrobial Peptides.

      Münzker, L., Oddo, A. & Hansen, Paul Robert, 2017, Chemical Synthesis of Antimicrobial Peptides: Münzker L, Oddo A, Hansen PR. Methods Mol Biol. 2017; . Hansen, P. R. (ed.). Springer, Vol. 1548. p. 35-49.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    29. Published

      Lysine-Based α-peptide/β-peptoid peptidomimetics: Influence of hydrophobicity, fluorination and distribution of cationic charge on antimicrobial activity and cytotoxicity

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro, Nielsen, Hanne Mørck & Franzyk, Henrik, 2017, In: ChemMedChem. 12, p. 312-318 7 p.

      Research output: Contribution to journal › Journal article › peer-review

    30. Published

      Hemolytic Activity of Antimicrobial Peptides

      Oddo, A. & Hansen, Paul Robert, 2017, Methods in molecular biology. Hansen, P. R. (ed.). Springer, Vol. 1548. p. 427-435

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    31. Published

      Structure-activity relationship studies of lysine-based α-peptide/β-peptoid antimicrobial peptidomimetics

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2017. 1 p.

      Research output: Contribution to conference › Poster › Research › peer-review

    32. Published

      An amphipathic undecapeptide with all D-amino acids shows promising activity against colistin-resistant strains of Acinetobacter baumannii and a dual mode of action

      Oddo, A., Thomsen, T. T., Kjelstrup, S., Gorey, C., Franzyk, Henrik, Frimodt-Møller, N., Løbner-Olesen, Anders & Hansen, Paul Robert, 2016, In: Antimicrobial Agents and Chemotherapy. 60, 1, p. 592-599 8 p.

      Research output: Contribution to journal › Journal article › peer-review

    33. Published

      Modulation of backbone flexibility for effective dissociation of antibacterial and hemolytic activity in cyclic peptides

      Oddo, A., Thomsen, T. T., Britt, H. M., Løbner-Olesen, Anders, Thulstrup, Peter Waaben, Sanderson, J. M. & Hansen, Paul Robert, 2016, In: ACS Medicinal Chemistry Letters. 7, 8, p. 741-745 5 p.

      Research output: Contribution to journal › Journal article › peer-review

    34. Published

      Roles of hydrophobicity, fluorination and distribution of cationic residues in α-peptide/β-peptoids for antibacterial and hemolytic properties

      Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2016. 1 p.

      Research output: Contribution to conference › Poster › Research

    35. Published

      Amphibian antimicrobial peptide fallaxin analogue FL9 affects virulence gene expression and DNA replication in Staphylococcus aureus

      Gottschalk, S., Gottlieb, C. T., Vestergaard, M., Hansen, Paul Robert, Gram, L., Ingmer, Hanne & Thomsen, Line Elnif, 1 Dec 2015, In: Journal of Medical Microbiology. 64, 12, p. 1504-1513 10 p.

      Research output: Contribution to journal › Journal article › peer-review

    36. Published

      Short linear peptide-peptoid hybrids as potential antimicrobial drugs: Abstract for the 24th American Peptide Symposium

      Greco, I., Damborg, Peter Panduro, Jana, B. & Hansen, Paul Robert, 1 Jun 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    37. Published

      Antibodies with specificity for native and denatured forms of ovalbumin differ in reactivity between enzyme-linked immunosorbent assays.

      Holm, B. E., Bergmann, A. C., Hansen, Paul Robert, Koch, C., Houen, G. & Trier, N. H., 1 Feb 2015, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 123, 2, p. 136–145 10 p.

      Research output: Contribution to journal › Journal article › peer-review

    38. Published

      An ANOVA-based model to identify the optimal antimicrobial peptide in a combination matrix

      Munk, J. K., Ritz, C., Fliedner, F. P., Frimodt-Moller, N. & Hansen, Paul Robert, 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    39. Published

      Antimicrobial activities of synthetic anoplin analogues against methicillin-resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, vancomycin-resistant Enterococcus faecium and Candida albicans

      Munk, J. K., Uggerhøj, L. E., Poulsen, T. J., Frimodt-Moller, N., Nyberg, N., Wimmer, R. & Hansen, Paul Robert, 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    40. Published

      Characterization of synthetic peptides by mass spectrometry

      Prabhala, B. K., Mirza, Osman Asghar, Højrup, P. & Hansen, Paul Robert, 2015, Methods in Molecular Biology: Peptide Antibiodies. Springer, p. 77-82

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    41. Published

      Contribution of peptide backbone to Anti-citrulline-dependent antibody reactivity

      Trier, N. H., Dam, C., Olsen, D., Hansen, Paul Robert & Houen, G., 2015, In: P L o S One. p. 1-12 12 p., 0144707.

      Research output: Contribution to journal › Journal article › peer-review

    42. Published

      Correlation between centromere protein-F autoantibodies and cancer analyzed by enzyme-linked immunosorbent assay

      Welner, S., Trier, N. H., Morten Frisch, M., Locht, H., Hansen, Paul Robert & Houen, G., 2013, In: Molecular Cancer. 12, 1, 95.

      Research output: Contribution to journal › Journal article › peer-review

    43. Published

      Efficient, regioselective ring-opening of activated aziridine-2-carboxylates with [18F]fluoride

      Schjøth-Eskesen, C., Hansen, Paul Robert, Kjær, Andreas & Gillings, N., 2015, In: ChemistryOpen. 4, 1, p. 65–71 7 p.

      Research output: Contribution to journal › Journal article › peer-review

    44. Published

      Fmoc Solid-Phase Peptide Synthesis

      Hansen, Paul Robert & Oddo, A., 2015, Methods in Molecular Biology: Peptide Antibodies. Vol. 1348. p. 33-50 18 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    45. Published

      Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein.

      Woodworth, J. S., Agger, E. M. & Hansen, Paul Robert, 2015, Proceedings of the 24th American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Editors) American Peptide Society. p. 262-63 2 p.

      Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

    46. Published

      Novel classes of antimicrobials in veterinary medicine: Characterizing peptoids as topical agents for dog skin infections

      Greco, I., Damborg, Peter Panduro, Guardabassi, Luca, Vasir, J., Watts, J., Hummel, B. D. & Hansen, Paul Robert, 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    47. Published

      Novel compounds with selective antimicrobial activity against Staphylococcus pseudintermedius and Pseudomonas aeruginosa causing pyoderma in dogs

      Greco, I., Emborg, A., Oddo, A., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

    48. Published

      Peptide Macrocycles Featuring a Backbone Secondary Amine: A Convenient Strategy for the Synthesis of Lipidated Cyclic and Bicyclic Peptides on Solid Support

      Oddo, A., Münzker, L. & Hansen, Paul Robert, 2015, In: Organic Letters. 17, 10, p. 2502-2505 4 p.

      Research output: Contribution to journal › Journal article › peer-review

    49. Published

      Peptide-Carrier Conjugation: Methods in Molecular Biology

      Hansen, Paul Robert, 2015, Methods in Molecular Biology: Peptide Antibodies. Vol. 1348. p. 51-57 7 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    50. Published

      Rational Design of alpha-helical antimicrobial peptides: DOs and DON’Ts

      Uggerhøj, L. E., Poulsen, T. J., Munk, J. K., Fredborg, M., Sondergaard, T. E., Frimodt-Møller, N., Hansen, Paul Robert & Wimmer, R., 2015, In: ChemBioChem. 16, 2, p. 242–253 12 p.

      Research output: Contribution to journal › Journal article › peer-review

    51. Published

      Solid-Phase Peptide Synthesis of Human alfa-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs.

      Fuente-Moreno, M., Oddo, A., Sheykhzade, Majid, Pickering, Darryl S & Hansen, Paul Robert, 2015, Proceedings of the 24th American Peptide Symposium . 2 p.

      Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

    52. Published

      Structure-Activity Relationship Study of Lysine-Based Antimicrobial α-Peptide/β-Peptoid Oligomers

      Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 2015.

      Research output: Contribution to conference › Poster › Research

    53. Published

      The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide

      Oddo, A., Nyberg, N., Frimodt-Møller, N., Thulstrup, Peter Waaben & Hansen, Paul Robert, 2015, In: European Journal of Medicinal Chemistry. 102, p. 574-581 8 p.

      Research output: Contribution to journal › Journal article › peer-review

    54. Published

      [64Cu]-Labelled Trastuzumab: Optimisation of Labelling by DOTA and NODAGA Conjugation and Initial Evaluation in Mice

      Schjøth-Eskesen, C., Nielsen, Carsten Haagen, Heissel, S., Højrup, P., Hansen, Paul Robert, Gillings, N. & Kjær, A., 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, 6, p. 227-33 7 p.

      Research output: Contribution to journal › Journal article › peer-review

    55. Published

      Pepping up Antibiotics: Industry and academia are turning to antimicrobial peptides and their relatives to find new antibiotics, Andy Extance discovers..

      Hansen, Paul Robert, 1 Oct 2014, Chemistry World.

      Research output: Other contribution › Research

    56. Published

      AMP mimics with bactericidal activity against Staphylococci and Pseudomonas as novel drugs for topical use in veterinary medicine

      Greco, I., Damborg, Peter Panduro, Guardabassi, Luca, Nielsen, Hanne Mørck & Hansen, Paul Robert, 4 Jun 2014.

      Research output: Contribution to conference › Poster › Research › peer-review

    57. Published

      Ring flexibility as a key design feature for cyclic antimicrobial peptides

      Oddo, A., Frimodt-Møller, N. & Hansen, Paul Robert, 4 Jun 2014.

      Research output: Contribution to conference › Poster › Research › peer-review

    58. Published

      Identification and fine mapping of a linear B cell epitope of human vimentin

      Dam, C. E., Houen, G., Hansen, Paul Robert & Trier, N., 2014, In: Scandinavian Journal of Clinical & Laboratory Investigation. 74, 6, p. 506-514 9 p.

      Research output: Contribution to journal › Journal article › peer-review

    59. Published

      Identification of a linear epitope recognized by a monoclonal antibody directed to the heterogeneous nucleoriboprotein A2

      Tronstrøm, J., Dragborg, A. H., Hansen, Paul Robert, Houen, G. & Trier, N. H., 2014, In: Protein and Peptide Letters. 21, 1, p. 25-31 7 p.

      Research output: Contribution to journal › Journal article › peer-review

    60. Published

      Invited Lecture: From Host Defence Peptides to New Antibiotics

      Hansen, Paul Robert, 2014.

      Research output: Contribution to conference › Conference abstract for conference › Research

    61. Published

      Novel method to identify the optimal antimicrobial peptide in a combination matrix, using anoplin as an example

      Munk, J., Ritz, C., Fliedner, F. P., Frimodt-Møller, N. & Hansen, Paul Robert, 2014, In: Antimicrobial Agents and Chemotherapy. 58, 2, p. 1063-1070 8 p.

      Research output: Contribution to journal › Journal article › peer-review

    62. Published

      Protective CD4 T cells targeting cryptic epitopes of Mycobacterium tuberculosis resist infection-driven terminal differentiation

      Woodworth, J., Aagaard, C., Hansen, Paul Robert, Cassidy, J., Agger, E. M. & Andersen, P., 2014, In: The Journal of Immunology. 192, 7, p. 3247-58

      Research output: Contribution to journal › Journal article › peer-review

    63. Published

      Structural features of peptoid-peptide hybrids in lipid-water interfaces

      Uggerhøj, L. E., Munk, J. K., Hansen, Paul Robert, Güntert, P. & Wimmer, R., 2014, In: F E B S Letters. 588, 17, p. 3291–3297 8 p.

      Research output: Contribution to journal › Journal article › peer-review

    64. Published

      A Novel Peptide-Peptoid Hybrid Active Against MRSP Skin Infections

      Greco, I., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 4 Nov 2013.

      Research output: Contribution to conference › Poster › Research › peer-review

    65. Published

      De novo design of novel cyclic antimicrobial peptides

      Oddo, A., Frimodt-Moller, N. & Hansen, Paul Robert, 7 Jul 2013.

      Research output: Contribution to conference › Poster › Research › peer-review

    66. Published

      Peptide-peptoid hybrids active against methicillin-resistant Staphylococci and Pseudomonas aeruginosa

      Greco, I., Damborg, Peter Panduro, Guardabassi, Luca, Nielsen, Hanne Mørck & Hansen, Paul Robert, 7 Jul 2013.

      Research output: Contribution to conference › Poster › Research › peer-review

    67. Published

      A Minimal Labor Approach to Identifying the Optimal Anoplin Analog using ANOVA.

      Munk, J., Ritz, C., Petrine Fliedner, F., Frimodt-Møller, N. & Hansen, Paul Robert, 2013, Proceedings of the 23rd American Peptide Symposium.

      Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

    68. Published

      Cyclic peptide inhibitors of the β-sliding clamp in Staphylococcus aureus

      Kjelstrup, S., Hansen, P. M. P., Thomsen, Line Elnif, Hansen, Paul Robert & Løbner-Olesen, Anders, 2013, In: P L o S One. 8, 9, 13 p., e72273.

      Research output: Contribution to journal › Journal article › peer-review

    69. Published

      Identification and mapping of a linear epitope of centromere protein F using monoclonal antibodies

      Welner, S., Trier, N. H., Houen, G. & Hansen, Paul Robert, 2013, In: Journal of Peptide Science. 19, 2, p. 95-101

      Research output: Contribution to journal › Journal article › peer-review

    70. Published

      Synthesis of antimicrobial peptoids

      Hansen, Paul Robert & Munk, J., 2013, Peptide synthesis and applications. 2nd ed. Vol. 1047. p. 151-159 (Methods in Molecular Biology).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    71. Published

      Synthetic analogs of anoplin show improved antimicrobial activities

      Munk, J., Uggerhøj, L. E., Poulsen, T. J., Frimodt-Møller, N., Wimmer, R., Nyberg, N. T. & Hansen, Paul Robert, 2013, In: Journal of Peptide Science. 19, 11, p. 669-75

      Research output: Contribution to journal › Journal article › peer-review

    72. Published

      The Structure of the Central Side Chain is Crucial for Anoplin Hemolytic Activity

      Munk, J., Thøgersen, L., Uggerhøj, L. E., Wimmer, R., Frimodt-Møller, N., Lindorff-Larsen, Kresten & Hansen, Paul Robert, 2013, Proceedings of the 23rd American Peptide Symposium. Lebl, M. (ed.). American Peptide Society

      Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

    73. Published

      The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus

      Gottschalk, S., Ifrah, D., Søndergaard, S. L., Gottlieb, C. T., Cohn, M. T., Hiasa, H., Hansen, Paul Robert, Gram, L., Ingmer, Hanne & Thomsen, Line Elnif, 2013, In: B M C Microbiology. 13, 8 p., 192.

      Research output: Contribution to journal › Journal article › peer-review

    74. Published

      Cross-reactivity of a human IgG1 anticitrullinated fibrinogen monoclonal antibody to a citrullinated profilaggrin peptide

      Trier, N. H., Leth, M. L., Hansen, Paul Robert & Houen, G., 31 Dec 2012, In: Protein Science. 21, 12, p. 1929-1941

      Research output: Contribution to journal › Journal article › peer-review

    75. Published

      Cytotoxicity and in vivo efficacy of a novel antimicrobial peptoid against Staphylococcus pseudintermedius

      Damborg, Peter Panduro, Skindersø, M. E., Hansen, Paul Robert, Bahnsen, J. S., Nielsen, Hanne Mørck & Guardabassi, Luca, Aug 2012.

      Research output: Contribution to conference › Poster › Research › peer-review

    76. Published

      Antimikrobielle peptider: et nyt våben mod multiresistente bakterier

      Munk, J., Hansen, Paul Robert & Franzyk, Henrik, 2012, In: Lægemiddelforskning. 2012, p. 9-11

      Research output: Contribution to journal › Journal article

    77. Published

      Fine mapping of a monoclonal antibody to the N-Methyl D-aspartate receptor reveals a short linear epitope

      Amrutkar, S. D., Trier, N. H., Hansen, Paul Robert & Houen, G., 2012, In: Journal of Peptide Science. 98, 6, p. 567-575 9 p.

      Research output: Contribution to journal › Journal article › peer-review

    78. Published

      Identification of continuous epitopes of HuD antibodies related to paraneoplastic diseases/small cell lung cancer

      Trier, N. H., Hansen, Paul Robert, Vedeler, C. A., Somnier, F. E. & Houen, G., 2012, In: Journal of Neuroimmunology. 243, 1, p. 25-33 9 p.

      Research output: Contribution to journal › Journal article › peer-review

    79. Published

      Production and characterization of peptide antibodies

      Trier, N. H., Hansen, Paul Robert & Houen, G., 2012, In: Methods. 56, 2, p. 136-144 9 p.

      Research output: Contribution to journal › Journal article › peer-review

    80. Published

      Peptide Antibody Reactivity to Homologous Regions in Glutamate Decarboxylase Isoforms and Coxsackievirus B4 P2C

      Trier, N. H., Valdarnini, N., Fanelli, I., Rovero, P., Hansen, Paul Robert, Schafer, C., Ciplys, E., Slibinskas, R., Pociot, F., Friis, T. & Houen, G., 2022, In: International Journal of Molecular Sciences. 23, 8, 16 p., 4424.

      Research output: Contribution to journal › Journal article › peer-review

    81. Published

      Production and characterization of peptide antibodies to the C-terminal of frameshifted calreticulin associated with myeloproliferative diseases

      Mughal , F. P., Bergmann , A. C., Huynh , H. U. B., Jørgensen, S. H., Mansha , I., Kesmeh , M., Schürch, P. M., Theocharides, A. P. A., Hansen, Paul Robert, Friis , T., Holmeren , M. Ö., Ciplys , E., Slibinskas , R., Højrup, P., Houen, G. & Trier, N. H., 2022, In: International Journal of Molecular Sciences. 23, 12, 21 p., 6803.

      Research output: Contribution to journal › Journal article › peer-review

    82. Published

      Reactivity of Rheumatoid Arthritis-Associated Citrulline-Dependent Antibodies to Epstein-Barr Virus Nuclear Antigen1-3

      Fanelli, I., Rovero, P., Hansen, Paul Robert, Frederiksen, J. L., Houen, G. & Trier, N. H., 2022, In: Antibodies. 11, 1, 15 p., 20.

      Research output: Contribution to journal › Journal article › peer-review

    83. Published

      Dual high-resolution α-glucosidase and PTP1B profiling combined with HPLC-PDA-HRMS-SPE-NMR analysis for the identification of potentially antidiabetic chromene meroterpenoids in Rhododendron capitatum

      Liang, C., Kjaerulff, Louise, Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 2021, In: Journal of Natural Products. 84, p. 2454-2467

      Research output: Contribution to journal › Journal article › peer-review

    84. Published

      Perfluoro-tert-butanol for selective on-resin detritylation: a mild alternative to traditionally used methods

      Wester, A., Hansen, A. M., Hansen, Paul Robert & Franzyk, Henrik, 2021, In: Amino Acids. 53, p. 1455–1466

      Research output: Contribution to journal › Journal article › peer-review

    85. Published

      Specificity of anti-citrullinated protein antibodies to citrullinated α-enolase peptides as a function of epitope structure and composition

      Fanelli, I., Rovero, P., Hansen, Paul Robert, Fredriksen, Jette Lautrup, Houen, G. & Trier, N. H., 2021, In: Antibodies. 10, 3, 12 p., 27.

      Research output: Contribution to journal › Journal article › peer-review

    86. Published

      Structure elucidation of prenyl- and geranyl substituted coumarins in Gerbera piloselloides by NMR spectroscopy, electronic circular dichroism calculations, and single crystal X-ray crystallography

      Li, T., Ma, X., Fedotov, D., Kjaerulff, Louise, Frydenvang, Karla Andrea, Coriani, S., Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 8 Apr 2020, In: Molecules. 25, 25 p., 1706.

      Research output: Contribution to journal › Journal article › peer-review

    87. Published

      Halogenation as a tool to tune antimicrobial activity of peptoids

      Molchanova, N., Nielsen, J. E., Sørensen, K. B., Prabhala, B. K., Hansen, Paul Robert, Lund, R., Barron, A. E. & Jenssen, H., 2020, In: Scientific Reports. 10, 10 p., 14805.

      Research output: Contribution to journal › Journal article › peer-review

    88. Published

      Synthesis of Peptoids Containing MultipleNhtrp andNtrp Residues: A Comparative Study of Resin, Cleavage Conditions and Submonomer Protection

      Lone, A., Arnous, A., Hansen, Paul Robert, Mojsoska, B. & Jenssen, H., 2020, In: Frontiers in Chemistry. 8, 12 p., 370.

      Research output: Contribution to journal › Journal article › peer-review

    ID: 4237511