Paul Robert Hansen

Paul Robert Hansen

Associate Professor

Paul Robert Hansen earned his MS degree in Chemistry from the University of Copenhagen, Denmark in 1990. He was then a Research Assistant at the Department of Chemistry, Royal Veterinary and Agricultural University (KVL) for two years.
From 1993-1994, he was a visiting Ph.D.-student in the laboratory of Professor George Barany at the Department of Chemistry, University of Minnesota
In 1996, he received his Ph.D., from the Department of Chemistry, Royal Veterinary and Agricultural University, focusing on "New strategies in the synthesis of 2-acetamido-alpha–D–2-deoxy-glucopyranose O-Glycopeptides, neoglycoconjugates and photoreactive peptides" 

In 1997, he joined the Department of Chemsitry, Royal Veterinary and Agricultural University, as an Assistant Professor of Bioorganic Chemistry. He became an Associate Professor in 2000. 
In February 2012, he joined the Natural Products and Peptides Research Group, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences (previously Faculty of Pharmaceutical Sciences), University of Copenhagen.

 

Scientific achievements and Research interest:

From 2001, he has been an independent scientist, heading his own research group first at IGM-Bioorganic Chemistry, Faculty of Life Sciences, University of Copenhagen and from 2012 at the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen. PRH has an extensive documented experience in the field of peptide medicinal chemistry. PRHs research efforts mainly lie within i) peptide-based antibiotics, ii) peptides as probes in immunology and Calcitonin gene-related peptide analogues for treatment of glaucoma. PRH has co-authored 125+ scientific publications in the field of peptide chemistry/bioorganic chemistry. He is the editor of Methods in Molecular Biology: Antimicrobial Peptides published in 2017. Furthermore, PRH is Editorial Board Member for Antibiotics and Reviewer for Innovation Fund Denmark etc, AAC, J. Med. Chem. etc.

Research management:

From 2008-2013, PRH was a member of EPI-EXPOSE funded by the Danish Advanced Technology Foundation, Work package leader and member of steering commitee). From 2010-2015, he was a member of DANCARD (Danish Center for Antibiotic Research and Development) an interdisciplinary collaboration funded the Danish Council for Strategic Research. From 2012-2016, PRH was a partner in FP7-PEOPLE-2011-ITN TRAIN-ASAP (“Training Research AImed at Novel Antibacterial Strategies in Animals and People”, Work package leader and member of steering commitee). Furthermore, he was a partner in University of Copenhagen Research Centre for Control of Antibiotic Resistance UC-CARE.Currently and “Antimicrobial peptides seen by neutrons” funded by Nordforsk. 

Selected publications

  1. Published

    C-locked analogs of the antimicrobial peptide BP214

    Andersen, I. K. L., Thomsen, T. T., Rashid, J., Bobak, T. R., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2022, In: Antibiotics. 11, 8, 10 p., 1080.

    Research output: Contribution to journalJournal articlepeer-review

  2. Published

    Cyclic N-Locked Indolicidin Analogues with Antimicrobial Activity: Effect of Ring Size and Fatty Acid Acylation

    Lone, A. B. N., Nielsen, J. E., Thulstrup, Peter Waaben, Lund, R., Hansen, Paul Robert & Jenssen, H., 2022, In: European Journal of Medicinal Chemistry Reports. 6, 7 p., 100080.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position

    Jensen, S. K., Thomsen, T. T., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences . 21, 16, 18 p., 5829.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Analogues of a Cyclic Antimicrobial Peptide with a Flexible Linker Show Promising Activity Against Pseudomonas aeruginosa and Staphylococcus aureus

    Thomsen, T. T., Mendel, H. C., Al-Mansour, W., Oddo, A., Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, In: Antibiotics. 9, 7, 13 p., 366.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides

    Greco, I., Molchanova, N., Holmedal, E., Jenssen, H., Hummel, B. D., Watts, J. L., Håkansson, J., Hansen, Paul Robert & Svenson, J., 2020, In: Scientific Reports. 10, 13 p., 13206.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Alternating Cationic-Hydrophobic Peptide/Peptoid Hybrids: Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity

    Frederiksen, N., Hansen, Paul Robert, Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Björkling, Fredrik & Franzyk, Henrik, 2020, In: ChemMedChem. 15, 24, p. 2544-2561

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Fluorescent analogues of Human α-Calcitonin Gene-Related Peptide with vasodilator potency

    Zhu, J., Pedersen, M. D., Ahmed, L. S., Abdolalizadeh, B., Grell, A., Berg, Jais Oliver, Thulstrup, Peter Waaben, Franzyk, Henrik, Edvinsson, L., Sams, A., Sheykhzade, Majid & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences (Online). 21, 4, p. 1-15 15 p., 1343.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Structure-Activity Study of an All-D Antimicrobial Octapeptide D2D

    Lone, A., Thomsen, T. T., Nielsen, J. E., Thulstrup, Peter Waaben, Klitgaard, R. N., Løbner-Olesen, Anders, Lund, R., Jenssen, H. & Hansen, Paul Robert, 2019, In: Molecules. 24, 24, 17 p., 4571.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Peptides, antibodies, peptide antibodies and more

    Trier, N., Hansen, Paul Robert & Houen, G., 11 Nov 2019, In: International Journal of Molecular Sciences (Online). 20, 22 p., 6289.

    Research output: Contribution to journalReviewpeer-review

  10. Published

    Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity

    Frederiksen, N., Hansen, Paul Robert, Björkling, Fredrik & Franzyk, Henrik, 4 Dec 2019, In: Molecules (Print Archive Edition). 24, 18 p., 4429.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Fine mapping of glutamate decarboxylase 65 epitopes reveals dependency of hydrophobic amino acids for specific interactions

    Valdarnini, N., Holm, B., Hansen, Paul Robert, Rovero, P., Houen, G. & Trier, N. H., 2019, In: International Journal of Molecular Sciences (Online). 20, 13 p., 2909.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    A Biophysical Study of the Interactions between the Antimicrobial Peptide Indolicidin and Lipid Model Systems

    Nielsen, J. E., Lind, T. K., Lone, A., Gerelli, Y., Hansen, Paul Robert, Jenssen, H., Cárdenas, M. & Lund, R., 2019, In: B B A - Biomembranes. 1861, 7, p. 1355-1364

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients

    Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In: Frontiers in Microbiology. 10, 9 p., 275.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections

    Greco, I., Emborg, A., Jana, B., Molchanova, N., Oddo, A., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2019, In: Scientific Reports. 9, 12 p., 3679.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Specificity of anti-citrullinated protein antibodies in rheumatoid arthritis

    Trier, N., Holm, B. E., Hansen, Paul Robert, Slot, O., Locht, H. & Houen, G., 2019, In: Antibodies. 8, 2, 10 p., 37.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Structure-activity study, characterization and mechanism of action of an antimicrobial peptoid D2 and its D- and L-peptide analogues

    Greco, I., Hansen, J. E., Jana, B., Molchanova, N., Oddo, A., Thulstrup, Peter Waaben, Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2019, In: Molecules. 24, 6, 16 p., 1121.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic

    Kłodzińska, S. N., Molchanova, N., Franzyk, Henrik, Hansen, Paul Robert, Damborg, Peter Panduro & Nielsen, Hanne Mørck, Jul 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 128, p. 1-9 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Fmoc Solid-Phase Synthesis of Human a-Calcitonin Gene- Related Peptide and Two Carboxyfluorescein-labeled Analogs

    Ahmed, L. S., Abdolalizadeh, B., Sheykhzade, Majid & Hansen, Paul Robert, 11 Feb 2018.

    Research output: Contribution to conferencePosterResearchpeer-review

  19. Published

    In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma

    Greco, I., Hummel, B. D., Vasir, J., Watts, J. L., Koch, J., Hansen, J. E., Nielsen, Hanne Mørck, Damborg, Peter Panduro & Hansen, Paul Robert, 10 Mar 2018, In: Molecules. 23, 3, 15 p., 630.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Fluorinated antimicrobial lysine-based peptidomimetics with activity against methicillin-resistant Staphylococcus pseudintermedius

    Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2018, In: Journal of Peptide Science. 24, 7, 8 p., e3098.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing

    Karathanasi, G., Bojer, Martin Saxtorph, Baldry, M., Johannessen, B. A., Wolff, S., Greco, I., Kilstrup, M., Hansen, Paul Robert & Ingmer, Hanne, 2018, In: Scientific Reports. 8, 1, 11 p., 3562.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Review on abyssomicins: Inhibitors of the chorismate pathway and folate biosynthesis

    Sadaka, C., Ellsworth, E., Hansen, Paul Robert, Ewin, R., Damborg, Peter Panduro & Watts, J. L., 2018, In: Molecules. 23, 6, 25 p., 1371.

    Research output: Contribution to journalReviewpeer-review

  23. Published

    The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells

    Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, In: The Journal of Biological Chemistry. 293, p. 1007-1017

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Advances in development of antimicrobial peptidomimetics as potential drugs

    Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 28 Aug 2017, In: Molecules. 22, 9, 60 p., 1430.

    Research output: Contribution to journalReviewpeer-review

  25. Published

    Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes

    Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., Jul 2017, In: Journal of Virology. 91, 14, 18 p., e00130-17.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR

    Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In: Research in Microbiology. 168, 5, p. 443-449

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Methods in Molecular Biology: Antimicrobial Peptides Methods and Protocols

    Hansen, Paul Robert (ed.), 1 Jan 2017, Springer. 439 p.

    Research output: Book/ReportBookpeer-review

  28. Published

    Chemical Synthesis of Antimicrobial Peptides.

    Münzker, L., Oddo, A. & Hansen, Paul Robert, 2017, Chemical Synthesis of Antimicrobial Peptides: Münzker L, Oddo A, Hansen PR. Methods Mol Biol. 2017; . Hansen, P. R. (ed.). Springer, Vol. 1548. p. 35-49.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  29. Published
  30. Published

    Hemolytic Activity of Antimicrobial Peptides

    Oddo, A. & Hansen, Paul Robert, 2017, Methods in molecular biology. Hansen, P. R. (ed.). Springer, Vol. 1548. p. 427-435

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  31. Published

    Structure-activity relationship studies of lysine-based α-peptide/β-peptoid antimicrobial peptidomimetics

    Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2017. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  32. Published

    An amphipathic undecapeptide with all D-amino acids shows promising activity against colistin-resistant strains of Acinetobacter baumannii and a dual mode of action

    Oddo, A., Thomsen, T. T., Kjelstrup, S., Gorey, C., Franzyk, Henrik, Frimodt-Møller, N., Løbner-Olesen, Anders & Hansen, Paul Robert, 2016, In: Antimicrobial Agents and Chemotherapy. 60, 1, p. 592-599 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Modulation of backbone flexibility for effective dissociation of antibacterial and hemolytic activity in cyclic peptides

    Oddo, A., Thomsen, T. T., Britt, H. M., Løbner-Olesen, Anders, Thulstrup, Peter Waaben, Sanderson, J. M. & Hansen, Paul Robert, 2016, In: ACS Medicinal Chemistry Letters. 7, 8, p. 741-745 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published
  35. Published

    Amphibian antimicrobial peptide fallaxin analogue FL9 affects virulence gene expression and DNA replication in Staphylococcus aureus

    Gottschalk, S., Gottlieb, C. T., Vestergaard, M., Hansen, Paul Robert, Gram, L., Ingmer, Hanne & Thomsen, Line Elnif, 1 Dec 2015, In: Journal of Medical Microbiology. 64, 12, p. 1504-1513 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Short linear peptide-peptoid hybrids as potential antimicrobial drugs: Abstract for the 24th American Peptide Symposium

    Greco, I., Damborg, Peter Panduro, Jana, B. & Hansen, Paul Robert, 1 Jun 2015.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  37. Published

    Antibodies with specificity for native and denatured forms of ovalbumin differ in reactivity between enzyme-linked immunosorbent assays.

    Holm, B. E., Bergmann, A. C., Hansen, Paul Robert, Koch, C., Houen, G. & Trier, N. H., 1 Feb 2015, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 123, 2, p. 136–145 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. Published

    An ANOVA-based model to identify the optimal antimicrobial peptide in a combination matrix

    Munk, J. K., Ritz, C., Fliedner, F. P., Frimodt-Moller, N. & Hansen, Paul Robert, 2015.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  39. Published

    Antimicrobial activities of synthetic anoplin analogues against methicillin-resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, vancomycin-resistant Enterococcus faecium and Candida albicans

    Munk, J. K., Uggerhøj, L. E., Poulsen, T. J., Frimodt-Moller, N., Nyberg, N., Wimmer, R. & Hansen, Paul Robert, 2015.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  40. Published

    Characterization of synthetic peptides by mass spectrometry

    Prabhala, B. K., Mirza, Osman Asghar, Højrup, P. & Hansen, Paul Robert, 2015, Methods in Molecular Biology: Peptide Antibiodies. Springer, p. 77-82

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  41. Published

    Contribution of peptide backbone to Anti-citrulline-dependent antibody reactivity

    Trier, N. H., Dam, C., Olsen, D., Hansen, Paul Robert & Houen, G., 2015, In: P L o S One. p. 1-12 12 p., 0144707.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Correlation between centromere protein-F autoantibodies and cancer analyzed by enzyme-linked immunosorbent assay

    Welner, S., Trier, N. H., Morten Frisch, M., Locht, H., Hansen, Paul Robert & Houen, G., 2013, In: Molecular Cancer. 12, 1, 95.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    Efficient, regioselective ring-opening of activated aziridine-2-carboxylates with [18F]fluoride

    Schjøth-Eskesen, C., Hansen, Paul Robert, Kjær, Andreas & Gillings, N., 2015, In: ChemistryOpen. 4, 1, p. 65–71 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Fmoc Solid-Phase Peptide Synthesis

    Hansen, Paul Robert & Oddo, A., 2015, Methods in Molecular Biology: Peptide Antibodies. Vol. 1348. p. 33-50 18 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  45. Published

    Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein.

    Woodworth, J. S., Agger, E. M. & Hansen, Paul Robert, 2015, Proceedings of the 24th American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Editors) American Peptide Society. p. 262-63 2 p.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  46. Published

    Novel classes of antimicrobials in veterinary medicine: Characterizing peptoids as topical agents for dog skin infections

    Greco, I., Damborg, Peter Panduro, Guardabassi, Luca, Vasir, J., Watts, J., Hummel, B. D. & Hansen, Paul Robert, 2015.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  47. Published

    Novel compounds with selective antimicrobial activity against Staphylococcus pseudintermedius and Pseudomonas aeruginosa causing pyoderma in dogs

    Greco, I., Emborg, A., Oddo, A., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2015.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  48. Published

    Peptide Macrocycles Featuring a Backbone Secondary Amine: A Convenient Strategy for the Synthesis of Lipidated Cyclic and Bicyclic Peptides on Solid Support

    Oddo, A., Münzker, L. & Hansen, Paul Robert, 2015, In: Organic Letters. 17, 10, p. 2502-2505 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Peptide-Carrier Conjugation: Methods in Molecular Biology

    Hansen, Paul Robert, 2015, Methods in Molecular Biology: Peptide Antibodies. Vol. 1348. p. 51-57 7 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  50. Published

    Rational Design of alpha-helical antimicrobial peptides: DOs and DON’Ts

    Uggerhøj, L. E., Poulsen, T. J., Munk, J. K., Fredborg, M., Sondergaard, T. E., Frimodt-Møller, N., Hansen, Paul Robert & Wimmer, R., 2015, In: ChemBioChem. 16, 2, p. 242–253 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    Solid-Phase Peptide Synthesis of Human alfa-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs.

    Fuente-Moreno, M., Oddo, A., Sheykhzade, Majid, Pickering, Darryl S & Hansen, Paul Robert, 2015, Proceedings of the 24th American Peptide Symposium . 2 p.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  52. Published

    Structure-Activity Relationship Study of Lysine-Based Antimicrobial α-Peptide/β-Peptoid Oligomers

    Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 2015.

    Research output: Contribution to conferencePosterResearch

  53. Published

    The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide

    Oddo, A., Nyberg, N., Frimodt-Møller, N., Thulstrup, Peter Waaben & Hansen, Paul Robert, 2015, In: European Journal of Medicinal Chemistry. 102, p. 574-581 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    [64Cu]-Labelled Trastuzumab: Optimisation of Labelling by DOTA and NODAGA Conjugation and Initial Evaluation in Mice

    Schjøth-Eskesen, C., Nielsen, Carsten Haagen, Heissel, S., Højrup, P., Hansen, Paul Robert, Gillings, N. & Kjær, A., 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, 6, p. 227-33 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. Published
  56. Published
  57. Published

    Ring flexibility as a key design feature for cyclic antimicrobial peptides

    Oddo, A., Frimodt-Møller, N. & Hansen, Paul Robert, 4 Jun 2014.

    Research output: Contribution to conferencePosterResearchpeer-review

  58. Published

    Identification and fine mapping of a linear B cell epitope of human vimentin

    Dam, C. E., Houen, G., Hansen, Paul Robert & Trier, N., 2014, In: Scandinavian Journal of Clinical & Laboratory Investigation. 74, 6, p. 506-514 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  59. Published

    Identification of a linear epitope recognized by a monoclonal antibody directed to the heterogeneous nucleoriboprotein A2

    Tronstrøm, J., Dragborg, A. H., Hansen, Paul Robert, Houen, G. & Trier, N. H., 2014, In: Protein and Peptide Letters. 21, 1, p. 25-31 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  60. Published

    Invited Lecture: From Host Defence Peptides to New Antibiotics

    Hansen, Paul Robert, 2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  61. Published

    Novel method to identify the optimal antimicrobial peptide in a combination matrix, using anoplin as an example

    Munk, J., Ritz, C., Fliedner, F. P., Frimodt-Møller, N. & Hansen, Paul Robert, 2014, In: Antimicrobial Agents and Chemotherapy. 58, 2, p. 1063-1070 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  62. Published

    Protective CD4 T cells targeting cryptic epitopes of Mycobacterium tuberculosis resist infection-driven terminal differentiation

    Woodworth, J., Aagaard, C., Hansen, Paul Robert, Cassidy, J., Agger, E. M. & Andersen, P., 2014, In: The Journal of Immunology. 192, 7, p. 3247-58

    Research output: Contribution to journalJournal articlepeer-review

  63. Published

    Structural features of peptoid-peptide hybrids in lipid-water interfaces

    Uggerhøj, L. E., Munk, J. K., Hansen, Paul Robert, Güntert, P. & Wimmer, R., 2014, In: F E B S Letters. 588, 17, p. 3291–3297 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  64. Published

    A Novel Peptide-Peptoid Hybrid Active Against MRSP Skin Infections

    Greco, I., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 4 Nov 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  65. Published

    De novo design of novel cyclic antimicrobial peptides

    Oddo, A., Frimodt-Moller, N. & Hansen, Paul Robert, 7 Jul 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  66. Published
  67. Published

    A Minimal Labor Approach to Identifying the Optimal Anoplin Analog using ANOVA.

    Munk, J., Ritz, C., Petrine Fliedner, F., Frimodt-Møller, N. & Hansen, Paul Robert, 2013, Proceedings of the 23rd American Peptide Symposium.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  68. Published

    Cyclic peptide inhibitors of the β-sliding clamp in Staphylococcus aureus

    Kjelstrup, S., Hansen, P. M. P., Thomsen, Line Elnif, Hansen, Paul Robert & Løbner-Olesen, Anders, 2013, In: P L o S One. 8, 9, 13 p., e72273.

    Research output: Contribution to journalJournal articlepeer-review

  69. Published

    Identification and mapping of a linear epitope of centromere protein F using monoclonal antibodies

    Welner, S., Trier, N. H., Houen, G. & Hansen, Paul Robert, 2013, In: Journal of Peptide Science. 19, 2, p. 95-101

    Research output: Contribution to journalJournal articlepeer-review

  70. Published

    Synthesis of antimicrobial peptoids

    Hansen, Paul Robert & Munk, J., 2013, Peptide synthesis and applications. 2nd ed. Vol. 1047. p. 151-159 (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  71. Published

    Synthetic analogs of anoplin show improved antimicrobial activities

    Munk, J., Uggerhøj, L. E., Poulsen, T. J., Frimodt-Møller, N., Wimmer, R., Nyberg, N. T. & Hansen, Paul Robert, 2013, In: Journal of Peptide Science. 19, 11, p. 669-75

    Research output: Contribution to journalJournal articlepeer-review

  72. Published

    The Structure of the Central Side Chain is Crucial for Anoplin Hemolytic Activity

    Munk, J., Thøgersen, L., Uggerhøj, L. E., Wimmer, R., Frimodt-Møller, N., Lindorff-Larsen, Kresten & Hansen, Paul Robert, 2013, Proceedings of the 23rd American Peptide Symposium. Lebl, M. (ed.). American Peptide Society

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  73. Published

    The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus

    Gottschalk, S., Ifrah, D., Søndergaard, S. L., Gottlieb, C. T., Cohn, M. T., Hiasa, H., Hansen, Paul Robert, Gram, L., Ingmer, Hanne & Thomsen, Line Elnif, 2013, In: B M C Microbiology. 13, 8 p., 192.

    Research output: Contribution to journalJournal articlepeer-review

  74. Published

    Cross-reactivity of a human IgG1 anticitrullinated fibrinogen monoclonal antibody to a citrullinated profilaggrin peptide

    Trier, N. H., Leth, M. L., Hansen, Paul Robert & Houen, G., 31 Dec 2012, In: Protein Science. 21, 12, p. 1929-1941

    Research output: Contribution to journalJournal articlepeer-review

  75. Published

    Cytotoxicity and in vivo efficacy of a novel antimicrobial peptoid against Staphylococcus pseudintermedius

    Damborg, Peter Panduro, Skindersø, M. E., Hansen, Paul Robert, Bahnsen, J. S., Nielsen, Hanne Mørck & Guardabassi, Luca, Aug 2012.

    Research output: Contribution to conferencePosterResearchpeer-review

  76. Published

    Antimikrobielle peptider: et nyt våben mod multiresistente bakterier

    Munk, J., Hansen, Paul Robert & Franzyk, Henrik, 2012, In: Lægemiddelforskning. 2012, p. 9-11

    Research output: Contribution to journalJournal article

  77. Published

    Fine mapping of a monoclonal antibody to the N-Methyl D-aspartate receptor reveals a short linear epitope

    Amrutkar, S. D., Trier, N. H., Hansen, Paul Robert & Houen, G., 2012, In: Journal of Peptide Science. 98, 6, p. 567-575 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  78. Published

    Identification of continuous epitopes of HuD antibodies related to paraneoplastic diseases/small cell lung cancer

    Trier, N. H., Hansen, Paul Robert, Vedeler, C. A., Somnier, F. E. & Houen, G., 2012, In: Journal of Neuroimmunology. 243, 1, p. 25-33 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  79. Published

    Production and characterization of peptide antibodies

    Trier, N. H., Hansen, Paul Robert & Houen, G., 2012, In: Methods. 56, 2, p. 136-144 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  80. Published

    Peptide Antibody Reactivity to Homologous Regions in Glutamate Decarboxylase Isoforms and Coxsackievirus B4 P2C

    Trier, N. H., Valdarnini, N., Fanelli, I., Rovero, P., Hansen, Paul Robert, Schafer, C., Ciplys, E., Slibinskas, R., Pociot, F., Friis, T. & Houen, G., 2022, In: International Journal of Molecular Sciences. 23, 8, 16 p., 4424.

    Research output: Contribution to journalJournal articlepeer-review

  81. Published

    Production and characterization of peptide antibodies to the C-terminal of frameshifted calreticulin associated with myeloproliferative diseases

    Mughal , F. P., Bergmann , A. C., Huynh , H. U. B., Jørgensen, S. H., Mansha , I., Kesmeh , M., Schürch, P. M., Theocharides, A. P. A., Hansen, Paul Robert, Friis , T., Holmeren , M. Ö., Ciplys , E., Slibinskas , R., Højrup, P., Houen, G. & Trier, N. H., 2022, In: International Journal of Molecular Sciences. 23, 12, 21 p., 6803.

    Research output: Contribution to journalJournal articlepeer-review

  82. Published

    Reactivity of Rheumatoid Arthritis-Associated Citrulline-Dependent Antibodies to Epstein-Barr Virus Nuclear Antigen1-3

    Fanelli, I., Rovero, P., Hansen, Paul Robert, Frederiksen, J. L., Houen, G. & Trier, N. H., 2022, In: Antibodies. 11, 1, 15 p., 20.

    Research output: Contribution to journalJournal articlepeer-review

  83. Published
  84. Published

    Perfluoro-tert-butanol for selective on-resin detritylation: a mild alternative to traditionally used methods

    Wester, A., Hansen, A. M., Hansen, Paul Robert & Franzyk, Henrik, 2021, In: Amino Acids. 53, p. 1455–1466

    Research output: Contribution to journalJournal articlepeer-review

  85. Published

    Specificity of anti-citrullinated protein antibodies to citrullinated α-enolase peptides as a function of epitope structure and composition

    Fanelli, I., Rovero, P., Hansen, Paul Robert, Fredriksen, Jette Lautrup, Houen, G. & Trier, N. H., 2021, In: Antibodies. 10, 3, 12 p., 27.

    Research output: Contribution to journalJournal articlepeer-review

  86. Published
  87. Published

    Halogenation as a tool to tune antimicrobial activity of peptoids

    Molchanova, N., Nielsen, J. E., Sørensen, K. B., Prabhala, B. K., Hansen, Paul Robert, Lund, R., Barron, A. E. & Jenssen, H., 2020, In: Scientific Reports. 10, 10 p., 14805.

    Research output: Contribution to journalJournal articlepeer-review

  88. Published

    Synthesis of Peptoids Containing MultipleNhtrp andNtrp Residues: A Comparative Study of Resin, Cleavage Conditions and Submonomer Protection

    Lone, A., Arnous, A., Hansen, Paul Robert, Mojsoska, B. & Jenssen, H., 2020, In: Frontiers in Chemistry. 8, 12 p., 370.

    Research output: Contribution to journalJournal articlepeer-review

ID: 4237511