Paul Robert Hansen

Associate Professor

Biopharmaceuticals
Jagtvej 162, 2100 København Ø
- prh@sund.ku.dk
- https://drug.ku.dk/clusters/cancer-and-infectious-diseases/
- https://drug.ku.dk/
Phone: +4535336625

Member of:

Paul Robert Hansen earned his MS degree in Chemistry from the University of Copenhagen, Denmark in 1990. He was then a Research Assistant at the Department of Chemistry, Royal Veterinary and Agricultural University (KVL) for two years.
From 1993-1994, he was a visiting Ph.D.-student in the laboratory of Professor George Barany at the Department of Chemistry, University of Minnesota
In 1996, he received his Ph.D., from the Department of Chemistry, Royal Veterinary and Agricultural University, focusing on "New strategies in the synthesis of 2-acetamido-alpha–D–2-deoxy-glucopyranose O-Glycopeptides, neoglycoconjugates and photoreactive peptides"

In 1997, he joined the Department of Chemsitry, Royal Veterinary and Agricultural University, as an Assistant Professor of Bioorganic Chemistry. He became an Associate Professor in 2000.
In February 2012, he joined the Natural Products and Peptides Research Group, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences (previously Faculty of Pharmaceutical Sciences), University of Copenhagen.

Scientific achievements and Research interest:

From 2001, he has been an independent scientist, heading his own research group first at IGM-Bioorganic Chemistry, Faculty of Life Sciences, University of Copenhagen and from 2012 at the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen. PRH has an extensive documented experience in the field of peptide medicinal chemistry. PRHs research efforts mainly lie within i) peptide-based antibiotics, ii) peptides as probes in immunology and Calcitonin gene-related peptide analogues for treatment of glaucoma. PRH has co-authored 125+ scientific publications in the field of peptide chemistry/bioorganic chemistry. He is the editor of Methods in Molecular Biology: Antimicrobial Peptides published in 2017. Furthermore, PRH is Editorial Board Member for Antibiotics and Reviewer for Innovation Fund Denmark etc, AAC, J. Med. Chem. etc.

Research management:

From 2008-2013, PRH was a member of EPI-EXPOSE funded by the Danish Advanced Technology Foundation, Work package leader and member of steering commitee). From 2010-2015, he was a member of DANCARD (Danish Center for Antibiotic Research and Development) an interdisciplinary collaboration funded the Danish Council for Strategic Research. From 2012-2016, PRH was a partner in FP7-PEOPLE-2011-ITN TRAIN-ASAP (“Training Research AImed at Novel Antibacterial Strategies in Animals and People”, Work package leader and member of steering commitee). Furthermore, he was a partner in University of Copenhagen Research Centre for Control of Antibiotic Resistance UC-CARE.Currently and “Antimicrobial peptides seen by neutrons” funded by Nordforsk.

Selected publications

Published
C-locked analogs of the antimicrobial peptide BP214
Andersen, I. K. L., Thomsen, T. T., Rashid, J., Bobak, T. R., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2022, In: Antibiotics. 11, 8, 10 p., 1080.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Cyclic N-Locked Indolicidin Analogues with Antimicrobial Activity: Effect of Ring Size and Fatty Acid Acylation
Lone, A. B. N., Nielsen, J. E., Thulstrup, Peter Waaben, Lund, R., Hansen, Paul Robert & Jenssen, H., 2022, In: European Journal of Medicinal Chemistry Reports. 6, 7 p., 100080.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position
Jensen, S. K., Thomsen, T. T., Oddo, A., Franzyk, Henrik, Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences . 21, 16, 18 p., 5829.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Analogues of a Cyclic Antimicrobial Peptide with a Flexible Linker Show Promising Activity Against Pseudomonas aeruginosa and Staphylococcus aureus
Thomsen, T. T., Mendel, H. C., Al-Mansour, W., Oddo, A., Løbner-Olesen, Anders & Hansen, Paul Robert, 2020, In: Antibiotics. 9, 7, 13 p., 366.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides
Greco, I., Molchanova, N., Holmedal, E., Jenssen, H., Hummel, B. D., Watts, J. L., Håkansson, J., Hansen, Paul Robert & Svenson, J., 2020, In: Scientific Reports. 10, 13 p., 13206.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Alternating Cationic-Hydrophobic Peptide/Peptoid Hybrids: Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity
Frederiksen, N., Hansen, Paul Robert, Zabicka, D., Tomczak, M., Urbas, M., Domraceva, I., Björkling, Fredrik & Franzyk, Henrik, 2020, In: ChemMedChem. 15, 24, p. 2544-2561
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Fluorescent analogues of Human α-Calcitonin Gene-Related Peptide with vasodilator potency
Zhu, J., Pedersen, M. D., Ahmed, L. S., Abdolalizadeh, B., Grell, A., Berg, Jais Oliver, Thulstrup, Peter Waaben, Franzyk, Henrik, Edvinsson, L., Sams, A., Sheykhzade, Majid & Hansen, Paul Robert, 2020, In: International Journal of Molecular Sciences (Online). 21, 4, p. 1-15 15 p., 1343.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Structure-Activity Study of an All-D Antimicrobial Octapeptide D2D
Lone, A., Thomsen, T. T., Nielsen, J. E., Thulstrup, Peter Waaben, Klitgaard, R. N., Løbner-Olesen, Anders, Lund, R., Jenssen, H. & Hansen, Paul Robert, 2019, In: Molecules. 24, 24, 17 p., 4571.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Peptides, antibodies, peptide antibodies and more
Trier, N., Hansen, Paul Robert & Houen, G., 11 Nov 2019, In: International Journal of Molecular Sciences (Online). 20, 22 p., 6289.
Research output: Contribution to journal › Review › Research › peer-review
Published
Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity
Frederiksen, N., Hansen, Paul Robert, Björkling, Fredrik & Franzyk, Henrik, 4 Dec 2019, In: Molecules (Print Archive Edition). 24, 18 p., 4429.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Fine mapping of glutamate decarboxylase 65 epitopes reveals dependency of hydrophobic amino acids for specific interactions
Valdarnini, N., Holm, B., Hansen, Paul Robert, Rovero, P., Houen, G. & Trier, N. H., 2019, In: International Journal of Molecular Sciences (Online). 20, 13 p., 2909.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A Biophysical Study of the Interactions between the Antimicrobial Peptide Indolicidin and Lipid Model Systems
Nielsen, J. E., Lind, T. K., Lone, A., Gerelli, Y., Hansen, Paul Robert, Jenssen, H., Cárdenas, M. & Lund, R., 2019, In: B B A - Biomembranes. 1861, 7, p. 1355-1364
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients
Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In: Frontiers in Microbiology. 10, 9 p., 275.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections
Greco, I., Emborg, A., Jana, B., Molchanova, N., Oddo, A., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2019, In: Scientific Reports. 9, 12 p., 3679.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Specificity of anti-citrullinated protein antibodies in rheumatoid arthritis
Trier, N., Holm, B. E., Hansen, Paul Robert, Slot, O., Locht, H. & Houen, G., 2019, In: Antibodies. 8, 2, 10 p., 37.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Structure-activity study, characterization and mechanism of action of an antimicrobial peptoid D2 and its D- and L-peptide analogues
Greco, I., Hansen, J. E., Jana, B., Molchanova, N., Oddo, A., Thulstrup, Peter Waaben, Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2019, In: Molecules. 24, 6, 16 p., 1121.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic
Kłodzińska, S. N., Molchanova, N., Franzyk, Henrik, Hansen, Paul Robert, Damborg, Peter Panduro & Nielsen, Hanne Mørck, Jul 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 128, p. 1-9 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Fmoc Solid-Phase Synthesis of Human a-Calcitonin Gene- Related Peptide and Two Carboxyfluorescein-labeled Analogs
Ahmed, L. S., Abdolalizadeh, B., Sheykhzade, Majid & Hansen, Paul Robert, 11 Feb 2018.
Research output: Contribution to conference › Poster › Research › peer-review
Published
In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma
Greco, I., Hummel, B. D., Vasir, J., Watts, J. L., Koch, J., Hansen, J. E., Nielsen, Hanne Mørck, Damborg, Peter Panduro & Hansen, Paul Robert, 10 Mar 2018, In: Molecules. 23, 3, 15 p., 630.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Fluorinated antimicrobial lysine-based peptidomimetics with activity against methicillin-resistant Staphylococcus pseudintermedius
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2018, In: Journal of Peptide Science. 24, 7, 8 p., e3098.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing
Karathanasi, G., Bojer, Martin Saxtorph, Baldry, M., Johannessen, B. A., Wolff, S., Greco, I., Kilstrup, M., Hansen, Paul Robert & Ingmer, Hanne, 2018, In: Scientific Reports. 8, 1, 11 p., 3562.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Review on abyssomicins: Inhibitors of the chorismate pathway and folate biosynthesis
Sadaka, C., Ellsworth, E., Hansen, Paul Robert, Ewin, R., Damborg, Peter Panduro & Watts, J. L., 2018, In: Molecules. 23, 6, 25 p., 1371.
Research output: Contribution to journal › Review › Research › peer-review
Published
The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells
Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, In: The Journal of Biological Chemistry. 293, p. 1007-1017
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Advances in development of antimicrobial peptidomimetics as potential drugs
Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 28 Aug 2017, In: Molecules. 22, 9, 60 p., 1430.
Research output: Contribution to journal › Review › Research › peer-review
Published
Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes
Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., Jul 2017, In: Journal of Virology. 91, 14, 18 p., e00130-17.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR
Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In: Research in Microbiology. 168, 5, p. 443-449
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Methods in Molecular Biology: Antimicrobial Peptides Methods and Protocols
Hansen, Paul Robert (ed.), 1 Jan 2017, Springer. 439 p.
Research output: Book/Report › Book › Research › peer-review
Published
Chemical Synthesis of Antimicrobial Peptides.
Münzker, L., Oddo, A. & Hansen, Paul Robert, 2017, Chemical Synthesis of Antimicrobial Peptides: Münzker L, Oddo A, Hansen PR. Methods Mol Biol. 2017; . Hansen, P. R. (ed.). Springer, Vol. 1548. p. 35-49.
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Published
Lysine-Based α-peptide/β-peptoid peptidomimetics: Influence of hydrophobicity, fluorination and distribution of cationic charge on antimicrobial activity and cytotoxicity
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro, Nielsen, Hanne Mørck & Franzyk, Henrik, 2017, In: ChemMedChem. 12, p. 312-318 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Hemolytic Activity of Antimicrobial Peptides
Oddo, A. & Hansen, Paul Robert, 2017, Methods in molecular biology. Hansen, P. R. (ed.). Springer, Vol. 1548. p. 427-435
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Published
Structure-activity relationship studies of lysine-based α-peptide/β-peptoid antimicrobial peptidomimetics
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2017. 1 p.
Research output: Contribution to conference › Poster › Research › peer-review
Published
An amphipathic undecapeptide with all D-amino acids shows promising activity against colistin-resistant strains of Acinetobacter baumannii and a dual mode of action
Oddo, A., Thomsen, T. T., Kjelstrup, S., Gorey, C., Franzyk, Henrik, Frimodt-Møller, N., Løbner-Olesen, Anders & Hansen, Paul Robert, 2016, In: Antimicrobial Agents and Chemotherapy. 60, 1, p. 592-599 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Modulation of backbone flexibility for effective dissociation of antibacterial and hemolytic activity in cyclic peptides
Oddo, A., Thomsen, T. T., Britt, H. M., Løbner-Olesen, Anders, Thulstrup, Peter Waaben, Sanderson, J. M. & Hansen, Paul Robert, 2016, In: ACS Medicinal Chemistry Letters. 7, 8, p. 741-745 5 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Roles of hydrophobicity, fluorination and distribution of cationic residues in α-peptide/β-peptoids for antibacterial and hemolytic properties
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro & Franzyk, Henrik, 2016. 1 p.
Research output: Contribution to conference › Poster › Research
Published
Amphibian antimicrobial peptide fallaxin analogue FL9 affects virulence gene expression and DNA replication in Staphylococcus aureus
Gottschalk, S., Gottlieb, C. T., Vestergaard, M., Hansen, Paul Robert, Gram, L., Ingmer, Hanne & Thomsen, Line Elnif, 1 Dec 2015, In: Journal of Medical Microbiology. 64, 12, p. 1504-1513 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Short linear peptide-peptoid hybrids as potential antimicrobial drugs: Abstract for the 24th American Peptide Symposium
Greco, I., Damborg, Peter Panduro, Jana, B. & Hansen, Paul Robert, 1 Jun 2015.
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published
Antibodies with specificity for native and denatured forms of ovalbumin differ in reactivity between enzyme-linked immunosorbent assays.
Holm, B. E., Bergmann, A. C., Hansen, Paul Robert, Koch, C., Houen, G. & Trier, N. H., 1 Feb 2015, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 123, 2, p. 136–145 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
An ANOVA-based model to identify the optimal antimicrobial peptide in a combination matrix
Munk, J. K., Ritz, C., Fliedner, F. P., Frimodt-Moller, N. & Hansen, Paul Robert, 2015.
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published
Antimicrobial activities of synthetic anoplin analogues against methicillin-resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, vancomycin-resistant Enterococcus faecium and Candida albicans
Munk, J. K., Uggerhøj, L. E., Poulsen, T. J., Frimodt-Moller, N., Nyberg, N., Wimmer, R. & Hansen, Paul Robert, 2015.
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published
Characterization of synthetic peptides by mass spectrometry
Prabhala, B. K., Mirza, Osman Asghar, Højrup, P. & Hansen, Paul Robert, 2015, Methods in Molecular Biology: Peptide Antibiodies. Springer, p. 77-82
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Published
Contribution of peptide backbone to Anti-citrulline-dependent antibody reactivity
Trier, N. H., Dam, C., Olsen, D., Hansen, Paul Robert & Houen, G., 2015, In: P L o S One. p. 1-12 12 p., 0144707.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Correlation between centromere protein-F autoantibodies and cancer analyzed by enzyme-linked immunosorbent assay
Welner, S., Trier, N. H., Morten Frisch, M., Locht, H., Hansen, Paul Robert & Houen, G., 2013, In: Molecular Cancer. 12, 1, 95.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Efficient, regioselective ring-opening of activated aziridine-2-carboxylates with [¹⁸F]fluoride
Schjøth-Eskesen, C., Hansen, Paul Robert, Kjær, Andreas & Gillings, N., 2015, In: ChemistryOpen. 4, 1, p. 65–71 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Fmoc Solid-Phase Peptide Synthesis
Hansen, Paul Robert & Oddo, A., 2015, Methods in Molecular Biology: Peptide Antibodies. Vol. 1348. p. 33-50 18 p.
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Published
Identifying immunogenic CD4+ T-cell epitopes of Myeloid cell leukemia 1 using overlapping 20-mer peptides spanning the whole protein.
Woodworth, J. S., Agger, E. M. & Hansen, Paul Robert, 2015, Proceedings of the 24th American Peptide Symposium Ved Srivastava, Andrei Yudin, and Michal Lebl (Editors) American Peptide Society. p. 262-63 2 p.
Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
Published
Novel classes of antimicrobials in veterinary medicine: Characterizing peptoids as topical agents for dog skin infections
Greco, I., Damborg, Peter Panduro, Guardabassi, Luca, Vasir, J., Watts, J., Hummel, B. D. & Hansen, Paul Robert, 2015.
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published
Novel compounds with selective antimicrobial activity against Staphylococcus pseudintermedius and Pseudomonas aeruginosa causing pyoderma in dogs
Greco, I., Emborg, A., Oddo, A., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 2015.
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published
Peptide Macrocycles Featuring a Backbone Secondary Amine: A Convenient Strategy for the Synthesis of Lipidated Cyclic and Bicyclic Peptides on Solid Support
Oddo, A., Münzker, L. & Hansen, Paul Robert, 2015, In: Organic Letters. 17, 10, p. 2502-2505 4 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Peptide-Carrier Conjugation: Methods in Molecular Biology
Hansen, Paul Robert, 2015, Methods in Molecular Biology: Peptide Antibodies. Vol. 1348. p. 51-57 7 p.
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Published
Rational Design of alpha-helical antimicrobial peptides: DOs and DON’Ts
Uggerhøj, L. E., Poulsen, T. J., Munk, J. K., Fredborg, M., Sondergaard, T. E., Frimodt-Møller, N., Hansen, Paul Robert & Wimmer, R., 2015, In: ChemBioChem. 16, 2, p. 242–253 12 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Solid-Phase Peptide Synthesis of Human alfa-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs.
Fuente-Moreno, M., Oddo, A., Sheykhzade, Majid, Pickering, Darryl S & Hansen, Paul Robert, 2015, Proceedings of the 24th American Peptide Symposium . 2 p.
Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
Published
Structure-Activity Relationship Study of Lysine-Based Antimicrobial α-Peptide/β-Peptoid Oligomers
Molchanova, N., Hansen, Paul Robert & Franzyk, Henrik, 2015.
Research output: Contribution to conference › Poster › Research
Published
The effect of glycine replacement with flexible ω-amino acids on the antimicrobial and haemolytic activity of an amphipathic cyclic heptapeptide
Oddo, A., Nyberg, N., Frimodt-Møller, N., Thulstrup, Peter Waaben & Hansen, Paul Robert, 2015, In: European Journal of Medicinal Chemistry. 102, p. 574-581 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
[64Cu]-Labelled Trastuzumab: Optimisation of Labelling by DOTA and NODAGA Conjugation and Initial Evaluation in Mice
Schjøth-Eskesen, C., Nielsen, Carsten Haagen, Heissel, S., Højrup, P., Hansen, Paul Robert, Gillings, N. & Kjær, A., 2015, In: Journal of Labelled Compounds and Radiopharmaceuticals. 58, 6, p. 227-33 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Pepping up Antibiotics: Industry and academia are turning to antimicrobial peptides and their relatives to find new antibiotics, Andy Extance discovers..
Hansen, Paul Robert, 1 Oct 2014, Chemistry World.
Research output: Other contribution › Research
Published
AMP mimics with bactericidal activity against Staphylococci and Pseudomonas as novel drugs for topical use in veterinary medicine
Greco, I., Damborg, Peter Panduro, Guardabassi, Luca, Nielsen, Hanne Mørck & Hansen, Paul Robert, 4 Jun 2014.
Research output: Contribution to conference › Poster › Research › peer-review
Published
Ring flexibility as a key design feature for cyclic antimicrobial peptides
Oddo, A., Frimodt-Møller, N. & Hansen, Paul Robert, 4 Jun 2014.
Research output: Contribution to conference › Poster › Research › peer-review
Published
Identification and fine mapping of a linear B cell epitope of human vimentin
Dam, C. E., Houen, G., Hansen, Paul Robert & Trier, N., 2014, In: Scandinavian Journal of Clinical & Laboratory Investigation. 74, 6, p. 506-514 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Identification of a linear epitope recognized by a monoclonal antibody directed to the heterogeneous nucleoriboprotein A2
Tronstrøm, J., Dragborg, A. H., Hansen, Paul Robert, Houen, G. & Trier, N. H., 2014, In: Protein and Peptide Letters. 21, 1, p. 25-31 7 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Invited Lecture: From Host Defence Peptides to New Antibiotics
Hansen, Paul Robert, 2014.
Research output: Contribution to conference › Conference abstract for conference › Research
Published
Novel method to identify the optimal antimicrobial peptide in a combination matrix, using anoplin as an example
Munk, J., Ritz, C., Fliedner, F. P., Frimodt-Møller, N. & Hansen, Paul Robert, 2014, In: Antimicrobial Agents and Chemotherapy. 58, 2, p. 1063-1070 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Protective CD4 T cells targeting cryptic epitopes of Mycobacterium tuberculosis resist infection-driven terminal differentiation
Woodworth, J., Aagaard, C., Hansen, Paul Robert, Cassidy, J., Agger, E. M. & Andersen, P., 2014, In: The Journal of Immunology. 192, 7, p. 3247-58
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Structural features of peptoid-peptide hybrids in lipid-water interfaces
Uggerhøj, L. E., Munk, J. K., Hansen, Paul Robert, Güntert, P. & Wimmer, R., 2014, In: F E B S Letters. 588, 17, p. 3291–3297 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A Novel Peptide-Peptoid Hybrid Active Against MRSP Skin Infections
Greco, I., Damborg, Peter Panduro, Guardabassi, Luca & Hansen, Paul Robert, 4 Nov 2013.
Research output: Contribution to conference › Poster › Research › peer-review
Published
De novo design of novel cyclic antimicrobial peptides
Oddo, A., Frimodt-Moller, N. & Hansen, Paul Robert, 7 Jul 2013.
Research output: Contribution to conference › Poster › Research › peer-review
Published
Peptide-peptoid hybrids active against methicillin-resistant Staphylococci and Pseudomonas aeruginosa
Greco, I., Damborg, Peter Panduro, Guardabassi, Luca, Nielsen, Hanne Mørck & Hansen, Paul Robert, 7 Jul 2013.
Research output: Contribution to conference › Poster › Research › peer-review
Published
A Minimal Labor Approach to Identifying the Optimal Anoplin Analog using ANOVA.
Munk, J., Ritz, C., Petrine Fliedner, F., Frimodt-Møller, N. & Hansen, Paul Robert, 2013, Proceedings of the 23rd American Peptide Symposium.
Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
Published
Cyclic peptide inhibitors of the β-sliding clamp in Staphylococcus aureus
Kjelstrup, S., Hansen, P. M. P., Thomsen, Line Elnif, Hansen, Paul Robert & Løbner-Olesen, Anders, 2013, In: P L o S One. 8, 9, 13 p., e72273.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Identification and mapping of a linear epitope of centromere protein F using monoclonal antibodies
Welner, S., Trier, N. H., Houen, G. & Hansen, Paul Robert, 2013, In: Journal of Peptide Science. 19, 2, p. 95-101
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Synthesis of antimicrobial peptoids
Hansen, Paul Robert & Munk, J., 2013, Peptide synthesis and applications. 2nd ed. Vol. 1047. p. 151-159 (Methods in Molecular Biology).
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Published
Synthetic analogs of anoplin show improved antimicrobial activities
Munk, J., Uggerhøj, L. E., Poulsen, T. J., Frimodt-Møller, N., Wimmer, R., Nyberg, N. T. & Hansen, Paul Robert, 2013, In: Journal of Peptide Science. 19, 11, p. 669-75
Research output: Contribution to journal › Journal article › Research › peer-review
Published
The Structure of the Central Side Chain is Crucial for Anoplin Hemolytic Activity
Munk, J., Thøgersen, L., Uggerhøj, L. E., Wimmer, R., Frimodt-Møller, N., Lindorff-Larsen, Kresten & Hansen, Paul Robert, 2013, Proceedings of the 23rd American Peptide Symposium. Lebl, M. (ed.). American Peptide Society
Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
Published
The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus
Gottschalk, S., Ifrah, D., Søndergaard, S. L., Gottlieb, C. T., Cohn, M. T., Hiasa, H., Hansen, Paul Robert, Gram, L., Ingmer, Hanne & Thomsen, Line Elnif, 2013, In: B M C Microbiology. 13, 8 p., 192.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Cross-reactivity of a human IgG1 anticitrullinated fibrinogen monoclonal antibody to a citrullinated profilaggrin peptide
Trier, N. H., Leth, M. L., Hansen, Paul Robert & Houen, G., 31 Dec 2012, In: Protein Science. 21, 12, p. 1929-1941
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Cytotoxicity and in vivo efficacy of a novel antimicrobial peptoid against Staphylococcus pseudintermedius
Damborg, Peter Panduro, Skindersø, M. E., Hansen, Paul Robert, Bahnsen, J. S., Nielsen, Hanne Mørck & Guardabassi, Luca, Aug 2012.
Research output: Contribution to conference › Poster › Research › peer-review
Published
Antimikrobielle peptider: et nyt våben mod multiresistente bakterier
Munk, J., Hansen, Paul Robert & Franzyk, Henrik, 2012, In: Lægemiddelforskning. 2012, p. 9-11
Research output: Contribution to journal › Journal article › Communication
Published
Fine mapping of a monoclonal antibody to the N-Methyl D-aspartate receptor reveals a short linear epitope
Amrutkar, S. D., Trier, N. H., Hansen, Paul Robert & Houen, G., 2012, In: Journal of Peptide Science. 98, 6, p. 567-575 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Identification of continuous epitopes of HuD antibodies related to paraneoplastic diseases/small cell lung cancer
Trier, N. H., Hansen, Paul Robert, Vedeler, C. A., Somnier, F. E. & Houen, G., 2012, In: Journal of Neuroimmunology. 243, 1, p. 25-33 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Production and characterization of peptide antibodies
Trier, N. H., Hansen, Paul Robert & Houen, G., 2012, In: Methods. 56, 2, p. 136-144 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Peptide Antibody Reactivity to Homologous Regions in Glutamate Decarboxylase Isoforms and Coxsackievirus B4 P2C
Trier, N. H., Valdarnini, N., Fanelli, I., Rovero, P., Hansen, Paul Robert, Schafer, C., Ciplys, E., Slibinskas, R., Pociot, F., Friis, T. & Houen, G., 2022, In: International Journal of Molecular Sciences. 23, 8, 16 p., 4424.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Production and characterization of peptide antibodies to the C-terminal of frameshifted calreticulin associated with myeloproliferative diseases
Mughal , F. P., Bergmann , A. C., Huynh , H. U. B., Jørgensen, S. H., Mansha , I., Kesmeh , M., Schürch, P. M., Theocharides, A. P. A., Hansen, Paul Robert, Friis , T., Holmeren , M. Ö., Ciplys , E., Slibinskas , R., Højrup, P., Houen, G. & Trier, N. H., 2022, In: International Journal of Molecular Sciences. 23, 12, 21 p., 6803.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Reactivity of Rheumatoid Arthritis-Associated Citrulline-Dependent Antibodies to Epstein-Barr Virus Nuclear Antigen1-3
Fanelli, I., Rovero, P., Hansen, Paul Robert, Frederiksen, J. L., Houen, G. & Trier, N. H., 2022, In: Antibodies. 11, 1, 15 p., 20.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Dual high-resolution α-glucosidase and PTP1B profiling combined with HPLC-PDA-HRMS-SPE-NMR analysis for the identification of potentially antidiabetic chromene meroterpenoids in Rhododendron capitatum
Liang, Chao, Kjaerulff, Louise, Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 2021, In: Journal of Natural Products. 84, p. 2454-2467
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Perfluoro-tert-butanol for selective on-resin detritylation: a mild alternative to traditionally used methods
Wester, A., Hansen, A. M., Hansen, Paul Robert & Franzyk, Henrik, 2021, In: Amino Acids. 53, p. 1455–1466
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Specificity of anti-citrullinated protein antibodies to citrullinated α-enolase peptides as a function of epitope structure and composition
Fanelli, I., Rovero, P., Hansen, Paul Robert, Fredriksen, Jette Lautrup, Houen, G. & Trier, N. H., 2021, In: Antibodies. 10, 3, 12 p., 27.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Structure elucidation of prenyl- and geranyl substituted coumarins in Gerbera piloselloides by NMR spectroscopy, electronic circular dichroism calculations, and single crystal X-ray crystallography
Li, T., Ma, X., Fedotov, D., Kjaerulff, Louise, Frydenvang, Karla Andrea, Coriani, S., Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 8 Apr 2020, In: Molecules. 25, 25 p., 1706.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Halogenation as a tool to tune antimicrobial activity of peptoids
Molchanova, N., Nielsen, J. E., Sørensen, K. B., Prabhala, B. K., Hansen, Paul Robert, Lund, R., Barron, A. E. & Jenssen, H., 2020, In: Scientific Reports. 10, 10 p., 14805.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Synthesis of Peptoids Containing MultipleNhtrp andNtrp Residues: A Comparative Study of Resin, Cleavage Conditions and Submonomer Protection
Lone, A., Arnous, A., Hansen, Paul Robert, Mojsoska, B. & Jenssen, H., 2020, In: Frontiers in Chemistry. 8, 12 p., 370.
Research output: Contribution to journal › Journal article › Research › peer-review

ID: 4237511

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Cyclic peptide inhibitors of the β-sliding clamp in Staphylococcus aureus
Research output: Contribution to journal › Journal article › Research › peer-review
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Two novel synthetic peptoids exhibit rapid in vitro killing of methicillin-resistant Staphylococcus pseudintermedius
Research output: Contribution to conference › Poster › Research
Published
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Peptoid analogs of the antibacterial peptide anoplin
Research output: Contribution to conference › Poster › Research
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