Peter E. Nielsen
Blegdamsvej 3, 2200 København N., 18 Bygning 18, Building: 18-2-16
Primary fields of research
The research interests are centered around the DNA mimic PNA (peptide nucleic acid), and the chemical biology and medicinal chemistry properties and applications of derivatives of this molecule. This includes drug discovery (antisense antibiotics, muscular dystrophy, cystic fibrosis), gene targeting and antisense principles in general and cellular and in vivo delivery and administration of biopharmaceuticals. Additional interests cover origin of life prebiotic systems and the effects of oxidative stress on cellular RNA.
- Discovery of PNA and peptide based antibiotics against resistant Gram-negative bacterial infections
- Quorum sensing inhibitors as cystic fibrosis drugs
- Antisense drugs for Duchenne muscular dystrophy
- Antisense drug delivery and in vivo administration