Peter E. Nielsen
Professor
Transcription, RNA, and Gene Medicine Program
Blegdamsvej 3, 2200 København N., 18 Bygning 18, Building: 18-2-16
Member of:
Primary fields of research
The research interests are centered around the DNA mimic PNA (peptide nucleic acid), and the chemical biology and medicinal chemistry properties and applications of derivatives of this molecule. This includes drug discovery (antisense antibiotics, muscular dystrophy, cystic fibrosis), gene targeting and antisense principles in general and cellular and in vivo delivery and administration of biopharmaceuticals. Additional interests cover origin of life prebiotic systems and the effects of oxidative stress on cellular RNA.
Current research
- Discovery of PNA and peptide based antibiotics against resistant Gram-negative bacterial infections
- Quorum sensing inhibitors as cystic fibrosis drugs
- Antisense drugs for Duchenne muscular dystrophy
- Antisense drug delivery and in vivo administration
Possible conflicts of interest
Member of the board of directors for Select Sport a/s, Copenhagen.
Member of Scientific Advisory Board for Neubase Inc. Pennsylvania, USA.
ID: 10736
Most downloads
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209
downloads
Role of Cell-Penetrating Peptides in Intracellular Delivery of Peptide Nucleic Acids Targeting Hepadnaviral Replication
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
206
downloads
Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)(n) Repeats by PNA or LNA Targeting
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
200
downloads
Effective photo-enhancement of cellular activity of fluorophore-octaarginine antisense PNA conjugates correlates with singlet oxygen formation, endosomal escape and chromophore lipophilicity
Research output: Contribution to journal › Journal article › Research › peer-review
Published