Peter E. Nielsen
Professor
RNA and Gene Medicine Program
Panum, Building: 18.2.16
2200 København N
Primary fields of research
The research interests are centered around the DNA mimic PNA (peptide nucleic acid), and the chemical biology and medicinal chemistry properties and applications of derivatives of this molecule. This includes drug discovery (antisense antibiotics, muscular dystrophy, cystic fibrosis), gene targeting and antisense principles in general and cellular and in vivo delivery and administration of biopharmaceuticals. Additional interests cover origin of life prebiotic systems and the effects of oxidative stress on cellular RNA.
Current research
- Discovery of PNA and peptide based antibiotics against resistant Gram-negative bacterial infections
- Quorum sensing inhibitors as cystic fibrosis drugs
- Antisense drugs for Duchenne muscular dystrophy
- Antisense drug delivery and in vivo administration
ID: 10736
Most downloads
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372
downloads
Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)(n) Repeats by PNA or LNA Targeting
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
172
downloads
Role of Cell-Penetrating Peptides in Intracellular Delivery of Peptide Nucleic Acids Targeting Hepadnaviral Replication
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
167
downloads
Effective photo-enhancement of cellular activity of fluorophore-octaarginine antisense PNA conjugates correlates with singlet oxygen formation, endosomal escape and chromophore lipophilicity
Research output: Contribution to journal › Journal article › Research › peer-review
Published