Brice Emanuelli

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The prevalence of obesity and type 2 diabetes is rising at alarming rates worldwide, and urges for the discovery of new therapeutic options. These metabolic disorders are characterized by insulin resistance, i.e. an inappropriate response to insulin in its target tissues, including muscle, adipose tissues and liver.

The main research area of my group is the investigation of the molecular mechanisms involved in the transduction of insulin signalling and the regulation of metabolic processes.

In particular, we are interested in:

-          Dissecting the signaling events mediating the various actions of insulin to control metabolic outcomes and cellular differentiation.

-          Studying how the complex nature of the insulin signaling network is perturbed in conditions of insulin resistance.

Our molecular interrogation of the insulin signalling cascades aims to identify new avenues for the development of therapeutic strategies to treat insulin resistance with the long-term goal of preventing type 2 diabetes.

Selected publications

1. Published

   Full activation of thermogenesis in brown adipocytes requires Basigin action

   Rupar, K., Isidor, Marie Sophie, Argemi Muntadas, Lidia, Agueda Oyarzabal, Marina, Plucinska, Kaja, Brown, E. L., Mattanovich, M., Bossi, Simone, Tozzi, M., Tandio, David, Petersen, P. S. S., Henriksen, T. I., Trošt, K., Hansen, Jacob B., Gerhart-Hines, Zach, Nielsen, S., Moritz, Thomas & Emanuelli, Brice, 2023, In: F E B S Journal. 290, 10, p. 2673-2691

   Research output: Contribution to journal › Journal article › Research › peer-review

2. Published

   Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes

   Isidor, Marie Sophie, Dong, W., Servin-Uribe, R. I., Villarroel, J., Altıntaş, Ali, Ayala-Sumuano, J. T., Varela-Echavarría, A., Barrès, Romain, Stephanopoulos, G., Macotela, Y. & Emanuelli, Brice, 2022, In: International Journal of Obesity. 46, 3, p. 535-543

   Research output: Contribution to journal › Journal article › Research › peer-review

3. Published

   White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment

   Rabiee, A., Plucinska, Kaja, Isidor, Marie Sophie, Brown, E. L., Tozzi, M., Sidoli, S., Petersen, P. S. S., Agueda Oyarzabal, Marina, Torsetnes, S. B., Chehabi, G. N., Lundh, M., Altıntaş, Ali, Barrès, Romain, Jensen, O. N., Gerhart-Hines, Zach & Emanuelli, Brice, 2021, In: Molecular Metabolism. 44, 17 p., 101137.

   Research output: Contribution to journal › Journal article › Research › peer-review