Simon Holst Bekker-Jensen
Professor
Molecular Aging Program
Blegdamsvej 3, 2200 København N.
Member of:
Web Track 1: Modifiable pathways of damage and repair in aging
Web: Center for Healthy Aging
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SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling
Airik, R., Schueler, M., Airik, M., Cho, J., Ulanowicz, K. A., Porath, J. D., Hurd, T. W., Bekker-Jensen, Simon Holst, Schrøder, J. M., Andersen, J. S. & Hildebrandt, F., 2016, In: P L o S One. 11, 5, 19 p., e0156081.Research output: Contribution to journal › Journal article › Research › peer-review
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Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response Signaling
Airik, R., Slaats, G. G., Guo, Z., Weiss, A., Khan, N., Ghosh, A., Hurd, T. W., Bekker-Jensen, Simon Holst, Schrøder, J. M., Elledge, S. J., Andersen, J. S., Kispert, A., Castelli, M., Boletta, A., Giles, R. H. & Hildebrandt, F., Nov 2014, In: Journal of the American Society of Nephrology:JASN. 25, 11, p. 2573-83 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein aggregation capture on microparticles enables multi-purpose proteomics sample preparation
Batth, Tanveer Singh, Tollenaere, M. A. X., Rüther, P. L., Gonzalez-Franquesa, A., Prabhakar, B. S., Bekker-Jensen, Simon Holst, Deshmukh, Atul Shahaji & Olsen, Jesper Velgaard, 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 1027-1035Research output: Contribution to journal › Journal article › Research › peer-review
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RNF138 joins the HR team
Bekker-Jensen, Simon Holst & Mailand, Niels, Oct 2015, In: Nature Cell Biology. 17, 11, p. 1375-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks
Bekker-Jensen, Simon Holst, Fugger, K., Danielsen, J. R., Gromova, I., Sehested, M., Celis, J., Bartek, J., Lukas, Jiri & Mailand, Niels, 6 Jul 2007, In: Journal of Biological Chemistry. 282, 27, p. 19638-43 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ubiquitin and the DNA damage response: a new handle on histones
Bekker-Jensen, Simon Holst & Mailand, Niels, 1 Sep 2012, In: Cell Cycle. 11, 17, p. 3153 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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ICLs: a chicken without an egg
Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Reviews. Molecular Cell Biology. 13, 6, p. 342Research output: Contribution to journal › Review › Research › peer-review
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The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks
Bekker-Jensen, Simon Holst & Mailand, Niels, 12 Jun 2011, In: FEBS Letters. 585, p. 2914-2919 6 p.Research output: Contribution to journal › Review › Research › peer-review
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
Bekker-Jensen, Simon Holst, Danielsen, J. M. R., Fugger, K., Gromova, I., Nerstedt, A., Bartek, J., Lukas, Jiri & Mailand, Niels, 2010, In: Nature Cell Biology. 12, 1, p. 80-6; sup pp 1-12Research output: Contribution to journal › Letter › Research › peer-review
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Assembly and function of DNA double-strand break repair foci in mammalian cells
Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Dec 2010, In: D N A Repair. 9, 12, p. 1219-28 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
Borisova, M. E., Voigt, A., Tollenaere, M. A. X., Sahu, S. K., Juretschke, T., Kreim, N., Mailand, Niels, Choudhary, Chunaram, Bekker-Jensen, Simon Holst, Akutsu, M., Wagner, S. A. & Beli, P., 1 Dec 2018, In: Nature Communications. 9, p. 1-16 16 p., 1017.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Hickson, Ian David & Liu, Ying, Jan 2015, In: DNA Repair. 25, p. 84-96 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection
Carson, C. T., Orazio, N. I., Lee, D. V., Suh, J., Bekker-Jensen, Simon Holst, Araujo, F. D., Lakdawala, S. S., Lilley, C. E., Bartek, J., Lukas, Jiri & Weitzman, M. D., 2009, In: EMBO Journal. 28, 6, p. 652-62 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PRMT5-mediated regulatory arginine methylation of RIPK3
Chauhan, C., Martinez Del Val, Ana, Niedenthal, R., Olsen, Jesper Velgaard, Kotlyarov, A., Bekker-Jensen, Simon Holst, Gaestel, M. & Menon, M. B., 2023, In: Cell Death Discovery. 9, 9 p., 14.Research output: Contribution to journal › Journal article › Research › peer-review
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The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity
Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W., Fiil, Berthe Katrine, Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, Simon Holst, Mailand, Niels, Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, Mads, 2012, In: Molecular Cell. 46, 6, p. 746-58 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling
Damgaard, R. B., Fiil, Berthe Katrine, Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, Simon Holst, Jost, P. J., Ehl, S., Mailand, Niels & Gyrd-Hansen, Mads, 1 Jul 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level
Danielsen, J. M. R., Sylvestersen, K. B., Bekker-Jensen, Simon Holst, Szklarczyk, D., Poulsen, J. W., Horn, H., Jensen, Lars Juhl, Mailand, Niels & Nielsen, Michael Lund, 1 Mar 2011, In: Molecular and Cellular Proteomics. 10, 3, p. M110.003590Research output: Contribution to journal › Journal article › Research › peer-review
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DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger
Danielsen, J. M. R., Povlsen, L. K., Villumsen, B. H., Streicher, W., Nilsson, Jakob, Wikström, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Journal of Cell Biology. 197, 2, p. 179-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO
Diehl, C., Akke, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Streicher, W. & Wikström, M., 10 Jun 2016, In: Journal of Biological Chemistry. 291, 24, p. 12658-12672 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Histone displacement during nucleotide excision repair
Dinant, C., Bartek, J. & Bekker-Jensen, Simon Holst, 17 Oct 2012, In: International Journal of Molecular Sciences (Online). 13, 10, p. 13322-13337 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
Doil, C., Mailand, Niels, Bekker-Jensen, Simon Holst, Ménard, Patrice, Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 2009, In: Cell. 136, 3, p. 435-46 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin
Faustrup, H., Bekker-Jensen, Simon Holst, Bartek, J., Lukas, Jiri & Mailand, Niels, 2009, In: Journal of Cell Biology. 184, 1, p. 13-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling
Fiil, Berthe Katrine, Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Komander, D. & Gyrd-Hansen, Mads, 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage
Gibbs-Seymour, I., Oka, Y., Rajendra, E., Weinert, B. T., Passmore, L. A., Patel, K. J., Olsen, Jesper Velgaard, Choudhary, Chunaram, Bekker-Jensen, Simon Holst & Mailand, Niels, Jan 2015, In: Molecular Cell. 57, 1, p. 150-64 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage
Gibbs-Seymour, I., Markiewicz, E., Bekker-Jensen, Simon Holst, Mailand, Niels & Hutchison, C. J., Apr 2015, In: Aging Cell. 14, 2, p. 162-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes
Gudjónsson, Thorkell, Altmeyer, M. F., Savic, V., Toledo Lazaro, L. I., Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, Simon Holst, Mailand, Niels, Neumann, B., Heriche, J., Shearer, R., Saunders, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 17 Aug 2012, In: Cell. 150, 4, p. 697-709 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Haahr, Peter Thorlund, Hoffmann, Saskia, Tollenaere, M. A. X., Ho, T., Toledo Lazaro, L. I., Mann, Matthias, Bekker-Jensen, Simon Holst, Räschle, M. & Mailand, Niels, Nov 2016, In: Nature Cell Biology. 18, 11, p. 1196–1207Research output: Contribution to journal › Journal article › Research › peer-review
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SCAI promotes DNA double-strand break repair in distinct chromosomal contexts
Hansen, R. K., Mund, A., Poulsen, S. L., Sandoval, M., Klement, K., Tsouroula, K., Tollenaere, M. A. X., Räschle, M., Soria, R., Offermanns, S., Worzfeld, T., Grosse, R., Brandt, D. T., Rozell, B., Mann, M., Cole, F., Soutoglou, E., Goodarzi, A. A., Daniel, J. A., Mailand, N. & 1 others, , 7 Nov 2016, In: Nature Cell Biology. 18, 12, p. 1357–1366Research output: Contribution to journal › Letter › Research › peer-review
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TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
Hoffmann, Saskia, Smedegaard, S., Nakamura, K., Mortuza, G. B., Räschle, M., Ibañez de Opakua, A., Oka, Y., Feng, Y., Blanco, F. J., Mann, Matthias, Montoya, Guillermo, Groth, Anja, Bekker-Jensen, Simon Holst & Mailand, Niels, 4 Jan 2016, In: The Journal of Cell Biology. 212, 1, p. 63-75Research output: Contribution to journal › Journal article › Research › peer-review
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Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
Holdgaard, S. G., Cianfanelli, V., Pupo, E., Lambrughi, M., Lubas, M., Nielsen, J. C., Eibes, S., Maiani, E., Harder, L. M., Wesch, N., Foged, M. M., Maeda, K., Nazio, F., de la Ballina, L. R., Dötsch, V., Brech, A., Frankel, L. B., Jäättelä, M., Locatelli, F., Barisic, M. & 8 others, , 2019, In: Nature Communications. 10, 1, p. 1-19 19 p., 4176.Research output: Contribution to journal › Journal article › Research › peer-review
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Computational and Functional Analysis of Structural Features in the ZAKα Kinase
Johansen, Valdemar Brimnes Ingemann, Snieckute, Goda, Vind, Anna Constance, Blasius, Melanie & Bekker-Jensen, Simon Holst, 2023, In: Cells. 12, 6, 969.Research output: Contribution to journal › Journal article › Research › peer-review
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
Liu, S., Bekker-Jensen, Simon Holst, Mailand, Niels, Lukas, Claudia, Bartek, J. & Lukas, Jiri, 2006, In: Molecular and Cellular Biology. 26, 16, p. 6056-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure
Luijsterburg, M. S., Acs, K., Ackermann, L., Wiegant, W. W., Bekker-Jensen, Simon Holst, Larsen, D. H., Khanna, K. K., van Attikum, H., Mailand, Niels & Dantuma, N. P., 2012, In: E M B O Journal. 31, 11, p. 2511-27 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
Lukas, Claudia, Savic, V., Bekker-Jensen, Simon Holst, Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, Ian David, Bartek, J. & Lukas, Jiri, 1 Mar 2011, In: Nature Cell Biology. 13, 3, p. 243-53 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence
López, A. R., Jørgensen, M. H., Havelund, J. F., Arendrup, Frederic Schrøder, Kolapalli, S. P., Nielsen, T. M., Pais, E., Beese, C. J., Abdul-Al, A., Vind, Anna Constance, Bartek, J., Bekker-Jensen, Simon Holst, Montes, M., Galanos, P., Faergeman, N., Happonen, L. & Frankel, Lisa, 2023, In: Cell Reports. 42, 11, 24 p., 113381.Research output: Contribution to journal › Journal article › Research › peer-review
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
Mailand, Niels, Bekker-Jensen, Simon Holst, Bartek, J. & Lukas, Jiri, 2006, In: Molecular Cell. 23, 3, p. 307-18 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of PCNA-protein interactions for genome stability
Mailand, Niels, Gibbs-Seymour, I. & Bekker-Jensen, Simon Holst, May 2013, In: Nature Reviews. Molecular Cell Biology. 14, 5, p. 269-82 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
Mailand, Niels, Bekker-Jensen, Simon Holst, Faustrup, H., Melander, F., Bartek, J., Lukas, Claudia & Lukas, Jiri, 2007, In: Cell. 131, 5, p. 887-900 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
Marteijn, J. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, Jiri & Vermeulen, W., 2009, In: Journal of Cell Biology. 186, 6, p. 835-47 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Spatial-proteomics reveal in-vivo phospho-signaling dynamics at subcellular resolution
Martinez Del Val, Ana, Bekker-Jensen, D. B., Steigerwald, S., Mehta, A., Tran, T., Sikorski, K., Torres Vega, Estefania, Kwasniewicz, E., Brynjólfsdóttir, S. H., Frankel, Lisa, Kjøbsted, Rasmus, Krogh, Nicolai, Lundby, Alicia, Bekker-Jensen, Simon Holst, Lund-Johansen, F. & Olsen, Jesper Velgaard, 2 Feb 2021, bioRxiv, p. 1-34, 34 p.Research output: Working paper › Preprint › Research
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Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution
Martinez Del Val, Ana, Bekker-Jensen, D. B., Steigerwald, S., Koenig, Claire, Østergaard, Ole, Mehta, A., Tran, T., Sikorski, K., Torres Vega, Estefania, Kwasniewicz, E., Brynjólfsdóttir, S. H., Frankel, Lisa, Kjøbsted, Rasmus, Krogh, Nicolai, Lundby, Alicia, Bekker-Jensen, Simon Holst, Lund-Johansen, F. & Olsen, Jesper Velgaard, 2021, In: Nature Communications. 12, 1, 17 p., 7113.Research output: Contribution to journal › Journal article › Research › peer-review
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
Melander, F., Bekker-Jensen, Simon Holst, Falck, J., Bartek, J., Mailand, Niels & Lukas, Jiri, 21 Apr 2008, In: Journal of Cell Biology. 181, 2, p. 213-26 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meeting Report: Aging Research and Drug Discovery
Meron, E., Thaysen, M., Angeli, S., Antebi, A., Barzilai, N., Baur, J. A., Bekker-Jensen, S., Birkisdottir, M., Bischof, E., Bruening, J., Brunet, A., Buchwalter, A., Cabreiro, F., Cai, S., Chen, B. H., Ermolaeva, M., Ewald, C. Y., Ferrucci, L., Florian, M. C., Fortney, K. & 58 others, , 2022, In: Aging. 14, 2, p. 530-543 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms underlying sensing of cellular stress signals by mammalian MAP3 kinases
Mordente, Kelly Christine, Jordan, Laura Ryder & Bekker-Jensen, Simon Holst, 2024, In: Molecular Cell. 84, 1, p. 142-155 14 p.Research output: Contribution to journal › Review › Research › peer-review
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The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases
Mosbech, A., Lukas, Claudia, Bekker-Jensen, Simon Holst & Mailand, Niels, 24 Apr 2013, In: Journal of Biological Chemistry. 288, p. 16579-16587 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks
Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, Claudia, Hartmann-Petersen, Rasmus, Lukas, Jiri, Choudhary, Chunaram, Pocock, R. D. J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Osmotic Stress Blocks Mobility and Dynamic Regulation of Centriolar Satellites
Nielsen, J. C., Nordgaard, C., Tollenaere, M. A. X. & Bekker-Jensen, Simon Holst, 2018, In: Cells. 7, 7, 20 p., 65.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of the golgi apparatus by p38 and JNK kinases during cellular stress responses
Nordgaard, C., Tollenaere, M. A. X., Martinez Del Val, Ana, Bekker-Jensen, D. B., Blasius, Melanie, Olsen, Jesper Velgaard & Bekker-Jensen, Simon Holst, 2021, In: International Journal of Molecular Sciences. 22, 17, 23 p., 9595.Research output: Contribution to journal › Journal article › Research › peer-review
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ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle
Nordgaard, C., Vind, A. C., Stonadge, A., Kjøbsted, R., Snieckute, G., Antas, P., Blasius, M., Reinert, M. S., Del Val, A. M., Bekker-Jensen, D. B., Haahr, P., Miroshnikova, Y. A., Mazouzi, A., Falk, S., Perrier-Groult, E., Tiedje, C., Li, X., Jakobsen, J. R., Jørgensen, N. O., Wojtaszewski, J. & 12 others, , 2022, In: E M B O Journal. 41, 17, 19 p., e111650.Research output: Contribution to journal › Journal article › Research › peer-review
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Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway
Oka, Y., Bekker-Jensen, Simon Holst & Mailand, Niels, 9 Apr 2015, In: E M B O Journal. 34, p. 1385-1398Research output: Contribution to journal › Journal article › Research › peer-review
ID: 14470936
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2013
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
905
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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage
Research output: Contribution to journal › Letter › Research › peer-review
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464
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TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
Research output: Contribution to journal › Journal article › Research › peer-review
Published