Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. / Andersen, Sofie Dabros; Keijzers, Guido; Rampakakis, Emmanouil; Engels, Kim; Luhn, Patricia; El-Shemerly, Mahmoud; Nielsen, Finn Cilius; Du, Yuhong; May, Alfred; Bohr, Vilhelm A; Ferrari, Stefano; Zannis-Hadjopoulos, Maria; Fu, Haian; Rasmussen, Lene Juel.

    In: D N A Repair, Vol. 11, No. 3, 03.2012, p. 267-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients. / Andersen, Sofie Dabros; Liberti, Sascha Emilie; Lützen, Anne; Drost, Mark; Bernstein, Inge; Nilbert, Mef; Dominguez, Mev; Nyström, Minna; Hansen, Thomas Van Overeem; Christoffersen, Janus Wiese; Jäger, Anne Charlotte; de Wind, Niels; Nielsen, Finn Cilius; Tørring, Pernille M; Rasmussen, Lene Juel.

    In: Human Mutation, Vol. 33, No. 12, 12.2012, p. 1647-1655.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli. / Bendtsen, Kristian Moss; Jensen, Martin Borch; May, Alfred; Rasmussen, Lene Juel; Trusina, Ala; Bohr, Vilhelm; Jensen, Mogens Høgh.

    In: European Biophysics Journal, Vol. 43, No. 10-11, 14.11.2014, p. 509-516.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste. / Bouchami, Ons; Sghaier, Haïtham; Madsen, Claus Desler; Lazim, Hadeer; Saidi, Mouldi; Rasmussen, Lene Juel; Ben Hassan, Assia .

    In: Annals of Microbiology, 2011.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia. / Bundgaard, Amanda; Qvortrup, Klaus; Rasmussen, Lene Juel; Fago, Angela.

    In: Journal of Experimental Biology, Vol. 222, No. 11, jeb200410, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. / Cheng, Chang; Edin, Nina F Jeppesen; Lauritzen, Knut H; Aspmodal, Ida; Christoffersen, Stine; Jian, Liu; Rasmussen, Lene Juel; Pettersen, Erik O; Xiaoqun, Gao; Bergersen, Linda H.

    In: Cellular oncology (Dordrecht), Vol. 35, No. 3, 06.2012, p. 217-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published
  8. The role of mitochondrial dNTP levels in cells with reduced TK2 activity. / Desler, C; Munch-Petersen, B; Rasmussen, L J.

    In: Nucleosides, nucleotides & nucleic acids, Vol. 25, No. 9-11, 2006, p. 1171-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The role of mitochondrial dysfunction in the progression of Alzheimer’s disease. / Desler, Claus; Lillenes, Meryl S.; Tønjum, Tone; Rasmussen, Lene Juel.

    In: Current Medicinal Chemistry, Vol. 25, No. 40, 2018, p. 5578 - 5587.

    Research output: Contribution to journalReviewResearchpeer-review

  10. Mitochondria as determinant of nucleotide pools and chromosomal stability. / Desler, Claus; Munch-Petersen, Birgitte; Stevnsner, Tinna; Matsui, Sei-Ichi; Kulawiec, Mariola; Singh, Keshav K; Rasmussen, Lene Juel.

    In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 625, No. 1-2, 01.12.2007, p. 112-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    In Silico screening for functional candidates amongst hypothetical proteins. / Desler, Claus; Suravajhala, Prashanth; Sanderhoff, May; Rasmussen, Merete; Rasmussen, Lene Juel.

    In: BMC Bioinformatics, Vol. 10, 2009, p. 289.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair. / Dherin, Claudine; Gueneau, Emeric; Francin, Mathilde; Nunez, Marcela; Miron, Simona; Liberti, Sascha Emilie; Rasmussen, Lene Juel; Zinn-Justin, Sophie; Gilquin, Bernard; Charbonnier, Jean-Baptiste; Boiteux, Serge.

    In: Molecular and Cellular Biology, Vol. 29, No. 3, 2009, p. 907-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein. / Dominguez-Valentin, Mev; Drost, Mark; Therkildsen, Christina; Rambech, Eva; Ehrencrona, Hans; Angleys, Maria; Lau Hansen, Thomas; de Wind, Niels; Nilbert, Mef; Juel Rasmussen, Lene.

    In: Molecular Genetics & Genomic Medicine, Vol. 2, No. 4, 07.2014, p. 352-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. E-pub ahead of print

    A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome. / Drost, Mark; Tiersma, Yvonne; Thompson, Bryony A.; Frederiksen, Jane H.; Keijzers, Guido; Glubb, Dylan; Kathe, Scott; Osinga, Jan; Westers, Helga; Pappas, Lisa; Boucher, Kenneth M.; Molenkamp, Siska; Zonneveld, José B.; van Asperen, Christi J.; Goldgar, David E.; Wallace, Susan S.; Sijmons, Rolf H.; Spurdle, Amanda B.; Rasmussen, Lene J.; Greenblatt, Marc S.; de Wind, Niels; Tavtigian, Sean V.

    In: Genetics in Medicine, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome. / Drost, Mark; Lützen, Anne; van Hees, Sandrine; Ferreira, Daniel; Calléja, Fabienne; Zonneveld, José B M; Nielsen, Finn Cilius; Rasmussen, Lene Juel; de Wind, Niels.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 110, No. 23, 04.06.2013, p. 9403-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants. / Drost, Mark; Zonneveld, José B M; van Hees, Sandrine; Rasmussen, Lene Juel; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 33, No. 3, 2012, p. 488-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome. / Drost, Mark; Lützen, Anne; van Hees, Sandrine; Ferreira, Daniel; Calléja, Fabienne; Zonneveld, José B M; Nielsen, Finn Cilius; Rasmussen, Lene Juel; de Wind, Niels.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 23, 2013, p. 9403-9408.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published
  19. Published

    From powerhouse to perpetrator—mitochondria in health and disease. / Fakouri, Nima B.; Hansen, Thomas Lau; Desler, Claus; Anugula, Sharath; Rasmussen, Lene Juel.

    In: Biology, Vol. 8, No. 2, 35, 2019.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis. / Fakouri, Nima Borhan; Durhuus, Jon Ambaek; Regnell, Christine Elisabeth; Angleys, Maria; Desler, Claus; Hasan-Olive, Mahdi; Martin-Pardillos, Ana; Tsaalbi-Shtylik, Anastasia; Thomsen, Kirsten; Lauritzen, Martin; Bohr, Vilhelm A.; de Wind, Niels; Bergersen, Linda Hildegard; Rasmussen, Lene Juel.

    In: Scientific Reports, Vol. 7, 12480, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Interventions for age-related diseases : Shifting the paradigm. / Figueira, Inês; Fernandes, Adelaide; Mladenovic Djordjevic, Aleksandra; Lopez-Contreras, Andres; Henriques, Catarina M; Selman, Colin; Ferreiro, Elisabete; Gonos, Efstathios S; Trejo, José Luis; Misra, Juhi; Rasmussen, Lene Juel; Xapelli, Sara; Ellam, Timothy; Bellantuono, Ilaria.

    In: Mechanisms of Ageing and Development, Vol. 160, 12.2016, p. 69-92.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? / Hansen, Thomas Lau; Rasmussen, Lene Juel; Madsen, Claus Desler; Frederiksen, Jane Bruun; Espersen, Maiken Lise Marcker; Singh, Keshav K.

    In: Journal of Aging Research, Vol. 2012, 2012, p. 192503.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis. / Hasan-Olive, Md Mahdi; Lauritzen, Knut H.; Ali, Mohammad; Rasmussen, Lene Juel; Storm-Mathisen, Jon; Bergersen, Linda H.

    In: Neurochemical Research, Vol. 44, No. 1, 2019, p. 22-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays. / Heinen, Christopher D; Juel Rasmussen, Lene.

    In: Hereditary Cancer in Clinical Practice, Vol. 10, No. 1, 07.2012, p. 9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage. / Hopkinson, Branden M; Madsen, Claus Desler; Kalisz, Mark; Vestentoft, Peter Siig; Juel Rasmussen, Lene; Bisgaard, Hanne Cathrine.

    In: Oxidative Medicine and Cellular Longevity, Vol. 2017, 5080128, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms. / Jakobsen, Emil; Lange, Sofie C; Andersen, Jens Velde; Madsen, Claus Desler; Kihl, Henriette Filholm; Hohnholt, Michaela; Stridh, Malin H; Rasmussen, Lene Juel; Waagepetersen, Helle S.; Bak, Lasse Kristoffer.

    In: Biochemical Pharmacology, Vol. 155, 2018, p. 92-101.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages. / Jantzen, Kim; Roursgaard, Martin; Madsen, Claus Desler; Loft, Steffen; Rasmussen, Lene Juel; Møller, Peter.

    In: Mutagenesis, Vol. 27, No. 6, 11.2012, p. 693-701.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients. / Jensen, Martin Borch; Dunn, Christopher A; Keijzers, Guido; Kulikowicz, Tomasz; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Aging, Vol. 4, No. 11, 11.2012, p. 790-802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    The role of RecQ helicases in non-homologous end-joining. / Keijzers, Guido; Maynard, Scott; Shamanna, Raghavendra A; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 49, No. 6, 11.2014, p. 463-472.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures. / Keijzers, Guido; Bohr, Vilhelm A; Juel Rasmussen, Lene.

    In: Bioscience Reports, Vol. 35, No. 3, e00206, 25.04.2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Exonuclease 1 and its versatile roles in DNA repair. / Keijzers, Guido; Liu, Dekang; Rasmussen, Lene Juel.

    In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 51, No. 6, 05.08.2016, p. 440–451.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials : The role of autophagy and apoptosis. / Kermanizadeh, Ali; Jantzen, Kim; Ward, Michael B; Durhuus, Jon Ambæk; Juel Rasmussen, Lene; Loft, Steffen; Møller, Peter.

    In: Nanotoxicology, Vol. 11, No. 2, 03.2017, p. 184-200.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1). / Knudsen, Nina Østergaard; Nielsen, Finn Cilius; Vinther, Lena; Bertelsen, Ronni; Holten-Andersen, Steen; Liberti, Sascha Emilie; Hofstra, Robert; Kooi, Krista; Rasmussen, Lene Juel.

    In: Nucleic Acids Research, Vol. 35, No. 8, 2007, p. 2609-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Nuclear translocation contributes to regulation of DNA excision repair activities. / Knudsen, Nina Østergaard; Andersen, Sofie Dabros; Lützen, Anne; Nielsen, Finn Cilius; Rasmussen, Lene Juel.

    In: DNA Repair, Vol. 8, No. 6, 2009, p. 682-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases. / Larsen, Nicolai Balle; Heiberg Engel, Peter Johan; Rasmussen, Merete; Rasmussen, Lene Juel.

    In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 117, No. 11, 2009, p. 839-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Mitochondrial oxidative phosphorylation capacity of cryopreserved cells. / Lauridsen, Poul Ejner; Rasmussen, Lene Juel; Desler, Claus.

    In: Mitochondrion, Vol. 47, 2019, p. 47-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. / Lauritzen, Knut H.; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald; Haugen, Oyvind P.; Sjaastad, Ivar; Klungland, Arne; Rasmussen, Lene Juel; Attramadal, Havard; Storm-Mathisen, Jon; Bergersen, Linda H.

    In: American Journal of Physiology: Heart and Circulatory Physiology, Vol. 309, No. 3, 01.08.2015, p. H434-H449.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks. / Liberti, Sascha E; Andersen, Sofie Dabros; Wang, Jing; May, Alfred; Miron, Simona; Perderiset, Mylene; Keijzers, Guido; Nielsen, Finn C; Charbonnier, Jean-Baptiste; Bohr, Vilhelm A; Rasmussen, Lene J.

    In: DNA Repair, Vol. 10, No. 1, 02.01.2011, p. 73-86.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Is hEXO1 a cancer predisposing gene? / Liberti, Sascha Emilie; Rasmussen, Lene Juel.

    In: Molecular Cancer Research, Vol. 2, No. 8, 08.2004, p. 427-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    DNA mismatch repair and its many roles in eukaryotic cells. / Liu, Dekang; Keijzers, Guido; Rasmussen, Lene Juel.

    In: Mutation Research - Reviews in Mutation Research, Vol. 773, 07.2017, p. 174-187.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Published

    Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro. / Liu, Dekang; Frederiksen, Jane H; Liberti, Sascha E; Lützen, Anne; Keijzers, Guido; Pena-Diaz, Javier; Rasmussen, Lene Juel.

    In: Nucleic Acids Research, Vol. 45, No. 16, 19.09.2017, p. 9427-9440.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. / Lopez-Contreras, Andres J; Specks, Julia; Barlow, Jacqueline H; Ambrogio, Chiara; Madsen, Claus Desler; Vikingsson, Svante; Rodrigo-Perez, Sara; Green, Henrik; Rasmussen, Lene Juel; Murga, Matilde; Nussenzweig, André; Fernandez-Capetillo, Oscar.

    In: Genes & Development, Vol. 29, No. 7, 01.04.2015, p. 690-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks. / Lu, Huiming; Shamanna, Raghavendra A; Keijzers, Guido; Anand, Roopesh; Rasmussen, Lene Juel; Cejka, Petr; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Cell Reports, Vol. 16, No. 1, 28.06.2016, p. 161-173.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Functional analysis of HNPCC-related missense mutations in MSH2. / Lützen, Anne; de Wind, Niels; Georgijevic, Dubravka; Nielsen, Finn Cilius; Rasmussen, Lene Juel.

    In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 645, No. 1-2, 14.10.2008, p. 44-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Cadmium inhibits human DNA mismatch repair in vivo. / Lützen, Anne; Liberti, Sascha Emilie; Rasmussen, Lene Juel.

    In: Biochemical and Biophysical Research Communications, Vol. 321, No. 1, 13.08.2004, p. 21-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Helicobacter pylori infection generates genetic instability in gastric cells. / Machado, Ana Manuel Dantas; Figueiredo, Céu; Seruca, Raquel; Rasmussen, Lene Juel.

    In: BBA General Subjects, Vol. 1806, No. 1, 2010, p. 58-65.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells. / Machado, Ana Manuel Dantas; Desler, Claus; Boggild, Sisse; Strickertsson, Jesper A. B.; Friis-Hansen, Lennart; Figueiredo, Ceu; Seruca, Raquel; Rasmussen, Lene Juel.

    In: Mechanisms of Ageing and Development, Vol. 134, No. 10, 2013, p. 460-466.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. / Machado, Ana Manuel Dantas; Figueiredo, Ceu; Touati, Eliette; Máximo, Valdemar; Sousa, Sonia; Michel, Valérie; Carneiro, Fátima; Nielsen, Finn Cilius; Seruca, Raquel; Rasmussen, Lene Juel.

    In: Clinical Cancer Research, Vol. 15, No. 9, 2009, p. 2995-3002.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Mitochondria in biology and medicine. / Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 12, No. 4, 07.2012, p. 472-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline. / Madsen, Claus Desler; Frederiksen, Jane H; Olsen, Maria Nathalie Angleys; Maynard, Scott; Keijzers, Guido; Fagerlund, Birgitte; Mortensen, Erik Lykke; Osler, Merete; Lauritzen, Martin; Bohr, Vilhelm A; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 25, 11.2015, p. 34-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

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