Lene Juel Rasmussen

Lene Juel Rasmussen

Professor

Member of:


  1. Published

    Cytosolic self-DNA—A potential source of chronic inflammation in aging

    Akbari, M., Shanley, D. P., Bohr, Vilhelm & Rasmussen, Lene Juel, 2021, In: Cells. 10, 12, 3544.

    Research output: Contribution to journalReviewpeer-review

  2. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, L. H., Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In: Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

    Andersen, S. D., Keijzers, G., Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In: D N A Repair. 11, 3, p. 267-77 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients

    Andersen, S. D., Liberti, S. E., Lützen, A., Drost, M., Bernstein, I., Nilbert, M., Dominguez, M., Nyström, M., Hansen, Thomas van Overeem, Christoffersen, J. W., Jäger, A. C., de Wind, N., Nielsen, Finn Cilius, Tørring, P. M. & Rasmussen, Lene Juel, Dec 2012, In: Human Mutation. 33, 12, p. 1647-1655 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    RANKL regulates testicular cancer growth and Denosumab treatment has suppressive effects on GCNIS and advanced seminoma

    Andreassen, C. H., Lorenzen, M., Nielsen, J. E., Kafai Yahyavi, S., Toft, Birgitte Grønkær, Ingerslev, L. R., Clemmensen, Christoffer, Rasmussen, Lene Juel, Bokemeyer, C., Juul, Anders, Jørgensen, A. & Jensen, M. B., 2022, In: British Journal of Cancer. 127, p. 408-421

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Rev1 deficiency induces a metabolic shift in MEFs that can be manipulated by the NAD+ precursor nicotinamide riboside

    Anugula, Sharath, Li, Zhiquan, Li, Yuan, Hendriksen, A., Christensen, P. B., Wang, L., Monk, J. M., de Wind, N., Bohr, Vilhelm, Desler, Claus, Naviaux, R. K. & Rasmussen, Lene Juel, 2023, In: Heliyon. 9, 6, e17392.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

    Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In: European Biophysics Journal. 43, 10-11, p. 509-516

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor

    Bisgaard, Hanne Cathrine, Holmskov, U., Santoni Rugiu, Eric, Nagy, P., Nielsen, O., Ott, P., Hage, E., Dalhoff, Kim, Rasmussen, Lene Juel & Tygstrup, N., 2002, In: American Journal of Pathology. 161, 4, p. 1187-1198 12 p., 64395.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor

    Bisgaard, Hanne Cathrine, Holmskov, U., Santoni Rugiu, Eric, Nagy, P., Nielsen, O., Ott, P., Hage, E., Dalhoff, Kim, Rasmussen, Lene Juel & Tygstrup, N., 2002, In: American Journal of Pathology. 161, 4, p. 1187-1198 12 p., 64395.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    Mitochondrial Function in Gilles de la Tourette Syndrome Patients With and Without Intragenic IMMP2L Deletions

    Bjerregaard, V. A., Schönewolf-Greulich, B., Rasmussen, Lene Juel, Desler, Claus & Tümer, Asuman Zeynep, 2020, In: Frontiers in Neurology. 11, 9 p., 163.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste

    Bouchami, O., Sghaier, H., Desler, Claus, Lazim, H., Saidi, M., Rasmussen, Lene Juel & Ben Hassan, A., 2011, In: Annals of Microbiology.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia

    Bundgaard, A., Qvortrup, Klaus, Rasmussen, Lene Juel & Fago, A., 2019, In: Journal of Experimental Biology. 222, 11, 9 p., jeb200410.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells

    Cheng, C., Edin, N. F. J., Lauritzen, K. H., Aspmodal, I., Christoffersen, S., Jian, L., Rasmussen, Lene Juel, Pettersen, E. O., Xiaoqun, G. & Bergersen, L. H., Jun 2012, In: Cellular oncology (Dordrecht). 35, 3, p. 217-27 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Societal need for interdisciplinary ageing research

    Cherbuin, N., Lijima, K., Kalula, S., Malhotrad, R., Rasmussen, Lene Juel, Chan, A., Lafortune, L., Harper, S., Zheng, X., Lindeman, D., Walsh, E., Hussain, R., Burns, R., Kristiansen, Maria, Sugawara, I., Son, B., Tanaka, T., Buckner, S., Hoffman, J. & Combrinck, M., 25 Feb 2021, In: Biomedicine Hub. 6, 1, p. 42-47 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Cognitive Function Is Associated with the Genetically Determined Efficiency of DNA Repair Mechanisms

    Cherbuin, N., Patel, H., Walsh, E. I., Ambikairajah, A., Burns, R., Brüstle, A. & Rasmussen, Lene Juel, 2024, In: Genes. 15, 2, 15 p., 153.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published
  17. The role of mitochondrial dNTP levels in cells with reduced TK2 activity

    Desler, C., Munch-Petersen, B. & Rasmussen, Lene Juel, 2006, In: Nucleosides, nucleotides & nucleic acids. 25, 9-11, p. 1171-5 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    The role of mitochondrial dysfunction in the progression of Alzheimer’s disease

    Desler, Claus, Lillenes, M. S., Tønjum, T. & Rasmussen, Lene Juel, 2018, In: Current Medicinal Chemistry. 25, 40, p. 5578 - 5587

    Research output: Contribution to journalReviewpeer-review

  19. Published

    Partial inhibition of mitochondrial-linked pyrimidine synthesis increases tumorigenic potential and lysosome accumulation

    Desler, Claus, Durhuus, J. A., Hansen, T. L. L., Anugula, Sharath, Zelander, N. T., Bøggild, S. & Rasmussen, Lene Juel, 2022, In: Mitochondrion. 64, p. 73-81 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    In Silico screening for functional candidates amongst hypothetical proteins

    Desler, Claus, Suravajhala, P., Sanderhoff, M., Rasmussen, M. & Rasmussen, Lene Juel, 2009, In: BMC Bioinformatics. 10, p. 289

    Research output: Contribution to journalJournal articlepeer-review

  21. Mitochondria as determinant of nucleotide pools and chromosomal stability

    Desler, C., Munch-Petersen, B., Stevnsner, T., Matsui, S., Kulawiec, M., Singh, K. K. & Rasmussen, Lene Juel, 1 Dec 2007, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 625, 1-2, p. 112-24 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair

    Dherin, C., Gueneau, E., Francin, M., Nunez, M., Miron, S., Liberti, S. E., Rasmussen, Lene Juel, Zinn-Justin, S., Gilquin, B., Charbonnier, J. & Boiteux, S., 2009, In: Molecular and Cellular Biology. 29, 3, p. 907-18 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein

    Dominguez-Valentin, M., Drost, M., Therkildsen, C., Rambech, E., Ehrencrona, H., Angleys, M., Lau Hansen, T., de Wind, N., Nilbert, M. & Rasmussen, Lene Juel, Jul 2014, In: Molecular Genetics & Genomic Medicine. 2, 4, p. 352-355 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome

    Drost, M., Tiersma, Y., Thompson, B. A., Frederiksen, J. H., Keijzers, G., Glubb, D., Kathe, S., Osinga, J., Westers, H., Pappas, L., Boucher, K. M., Molenkamp, S., Zonneveld, J. B., van Asperen, C. J., Goldgar, D. E., Wallace, S. S., Sijmons, R. H., Spurdle, A. B., Rasmussen, L. J., Greenblatt, M. S. & 2 others, de Wind, N. & Tavtigian, S. V., 2019, In: Genetics in Medicine. 21, p. 1486–1496

    Research output: Contribution to journalJournal articlepeer-review

  25. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 4 Jun 2013, In: Proceedings of the National Academy of Science of the United States of America. 110, 23, p. 9403-8 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants

    Drost, M., Zonneveld, J. B. M., van Hees, S., Rasmussen, Lene Juel, Hofstra, R. M. W. & de Wind, N., 2012, In: Human Mutation. 33, 3, p. 488-94 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome

    Drost, M., Tiersma, Y., Glubb, D., Kathe, S., van Hees, S., Calléja, F., Zonneveld, J. B. M., Boucher, K. M., Ramlal, R. P. E., Thompson, B. A., Rasmussen, Lene Juel, Greenblatt, M. S., Lee, A., Spurdle, A. B., Tavtigian, S. V. & de Wind, N., 2020, In: Genetics in Medicine. 22, p. 847–856

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 23, p. 9403-9408 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    MRE11A: a novel negative regulator of human DNA mismatch repair

    Du, D., Yang, Y., Wang, G., Chen, L., Guan, X., Rasmussen, Lene Juel & Liu, D., 2023, bioRxiv, 34 p.

    Research output: Working paperPreprintResearch

  30. Published

    Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

    Duan, S., Han, X., Akbari, M., Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 2020, In: Nucleic Acids Research. 48, 12, p. 6530–6546

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    EX-vivo whole blood stimulation with A2E does not elicit an inflammatory cytokine response in patients with age-related macular degeneration

    Durhuus, J. A., Rozing, Maarten Pieter, Nielsen, M. K., Molbech, C. R., Keijzers, G., Scheibye-Knudsen, Morten, Rasmussen, Lene Juel, Westendorp, Rudi GJ & Sørensen, Torben Lykke, 2021, In: Scientific Reports. 11, 1, 8226.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Simvastatin improves mitochondrial respiration in peripheral blood cells

    Durhuus, J. A., Hansson, Svenja, Morville, T., Kuhlman, A. B., Dohlmann, T. L., Larsen, Steen, Helge, Jørn Wulff, Angleys, M., Muniesa-Vargas, A., Bundgaard, J. R., Hickson, Ian David, Dela, Flemming, Desler, Claus & Rasmussen, Lene Juel, 2020, In: Scientific Reports. 10, 1, 17012.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Mitochondria in health and disease: 3rd annual conference of society for mitochondrial research and medicine - 19-20 december 2013 - bengaluru, India

    Durhuus, J. A., Desler, Claus & Rasmussen, Lene Juel, Jan 2015, In: Mitochondrion. 20, p. 7-12 6 p.

    Research output: Contribution to journalConference articlepeer-review

  34. Published

    From powerhouse to perpetrator—mitochondria in health and disease

    Fakouri, N. B., Hansen, T. L., Desler, Claus, Anugula, Sharath & Rasmussen, Lene Juel, 2019, In: Biology. 8, 2, 15 p., 35.

    Research output: Contribution to journalReviewpeer-review

  35. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Desler, Claus, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, L. H. & Rasmussen, Lene Juel, 2017, In: Scientific Reports. 7, 14 p., 12480.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Interventions for age-related diseases: Shifting the paradigm

    Figueira, I., Fernandes, A., Mladenovic Djordjevic, A., Lopez-Contreras, Andres, Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, Lene Juel, Xapelli, S., Ellam, T. & Bellantuono, I., Dec 2016, In: Mechanisms of Ageing and Development. 160, p. 69-92 24 p.

    Research output: Contribution to journalReviewpeer-review

  37. Published

    Systems modelling predicts chronic inflammation and genomic instability prevent effective mitochondrial regulation during biological ageing

    Guimera, A. M., Clark, P., Wordsworth, J., Anugula, Sharath, Rasmussen, Lene Juel & Shanley, D. P., 2022, In: Experimental Gerontology. 166, 9 p., 111889.

    Research output: Contribution to journalReviewpeer-review

  38. Published

    Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

    Hansen, T. L., Rasmussen, Lene Juel, Desler, Claus, Frederiksen, J. B., Espersen, M. L. M. & Singh, K. K., 2012, In: Journal of Aging Research. 2012, p. 192503 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours

    Harpelunde Poulsen, K., Nielsen, J. E., Grønkær Toft, B., Joensen, Ulla Nordström, Rasmussen, Lene Juel, Blomberg Jensen, M., Mitchell, R. T., Juul, Anders, Rajpert-De Meyts, E. & Jørgensen, Anders, 2020, In: BMC Cancer. 20, 1, 14 p., 349.

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis

    Hasan-Olive, M. M., Lauritzen, K. H., Ali, M., Rasmussen, Lene Juel, Storm-Mathisen, J. & Bergersen, L. H., 2019, In: Neurochemical Research. 44, 1, p. 22-37 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays

    Heinen, C. D. & Rasmussen, Lene Juel, Jul 2012, In: Hereditary Cancer in Clinical Practice. 10, 1, p. 9

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage

    Hopkinson, B. M., Desler, Claus, Kalisz, M., Vestentoft, P. S., Rasmussen, Lene Juel & Bisgaard, Hanne Cathrine, 2017, In: Oxidative Medicine and Cellular Longevity. 2017, 11 p., 5080128.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms

    Jakobsen, Emil, Lange, S. C., Andersen, Jens Velde, Desler, Claus, Kihl, H. F., Hohnholt, M., Stridh, M. H., Rasmussen, Lene Juel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, 2018, In: Biochemical Pharmacology. 155, p. 92-101 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

    Jantzen, K., Roursgaard, Martin, Desler, Claus, Loft, Steffen, Rasmussen, Lene Juel & Møller, Peter, Nov 2012, In: Mutagenesis. 27, 6, p. 693-701 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

    Jensen, M. B., Dunn, C. A., Keijzers, G., Kulikowicz, T., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2012, In: Aging. 4, 11, p. 790-802 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Exonuclease 1 and its versatile roles in DNA repair

    Keijzers, G., Liu, D. & Rasmussen, Lene Juel, 5 Aug 2016, In: Critical Reviews in Biochemistry and Molecular Biology. 51, 6, p. 440–451 12 p.

    Research output: Contribution to journalReviewpeer-review

  47. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures

    Keijzers, G., Bohr, Vilhelm & Rasmussen, Lene Juel, 2015, In: Bioscience Reports. 35, 3, 13 p., e00206.

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    The role of RecQ helicases in non-homologous end-joining

    Keijzers, G., Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In: Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.

    Research output: Contribution to journalReviewpeer-review

  49. Published

    Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis

    Kermanizadeh, A., Jantzen, K., Ward, M. B., Durhuus, J. A., Rasmussen, Lene Juel, Loft, Steffen & Møller, Peter, Mar 2017, In: Nanotoxicology. 11, 2, p. 184-200 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Nuclear translocation contributes to regulation of DNA excision repair activities

    Knudsen, N. Ø., Andersen, S. D., Lützen, A., Nielsen, Finn Cilius & Rasmussen, Lene Juel, 2009, In: DNA Repair. 8, 6, p. 682-9 7 p.

    Research output: Contribution to journalJournal articlepeer-review

Previous 1 2 3 Next

ID: 13558388