Nikos Hatzakis

Nikos Hatzakis

Professor

ORCID: 0000-0003-4202-0328

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  1. Published

    Making the undetectable detectable: Pushing limits of biomolecular recognition by ultra-sensitive multiplexed single-particle liposome readouts

    Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 231a-232a 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Membrane Curvature Regulates the Localization of G Protein Coupled Receptors and Ras Isoforms

    Stamou, Dimitrios, Rosholm, K. R., Damalas, A., Hatzakis, Nikos, Wirth, V. F., Martinez, Karen Laurence, Leijnse, Natascha, Oddershede, L. B., Bendix, Poul Martin & Pedersen, S. L., 27 Jan 2015, In: Biophysical Journal. 108, 2, p. 95a-96a

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Membrane Curvature and Lipid Composition Synergize To Regulate N-Ras Anchor Recruitment

    Larsen, J. B., Kennard, C., Pedersen, S. L., Jensen, Knud Jørgen, Uline, M. J., Hatzakis, Nikos & Stamou, Dimitrios, 2017, In: Biophysical Journal. 113, 6, p. 1269-1279 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

    Larsen, J. B., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Bjørnholm, T., Iversen, L., Uline, M., Szleifer, I., Jensen, Knud Jørgen, Hatzakis, Nikos & Stamou, Dimitrios, 2015, In: Nature Chemical Biology. 11, 3, p. 192-194 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells

    Rosholm, K. R., Leijnse, Natascha, Mantsiou, A., Tkach, Vadym, Pedersen, S. L., Wirth, V. F., Oddershede, L. B., Jensen, Knud Jørgen, Martinez, Karen Laurence, Hatzakis, Nikos, Bendix, Poul Martin, Callan-Jones, A. & Stamou, Dimitrios, 8 May 2017, In: Nature Chemical Biology. 13, 7, p. 724-729

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Mixing subattolitre volumes in a quantitative and highly parallel manner with soft matter nanofluidics

    Christensen, S. M., Bolinger, P., Hatzakis, Nikos, Mortensen, M. W. & Stamou, Dimitrios, 2012, In: Nature Nanotechnology. 7, p. 51-55 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  7. Published

    Monitoring shifts in the conformation equilibrium of the membrane protein cytochrome P450 reductase (POR) in nanodiscs

    Wadsäter, M. H., Laursen, Tomas, Singha, A., Hatzakis, Nikos, Stamou, Dimitrios, Barker, R., Mortensen, Kell, Feidenhans'l, Robert Krarup, Møller, Birger Lindberg & Cardenas Gomez, M., 2012, In: Journal of Biological Chemistry. 287, 41, p. 34596-34603 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Morphological integrity of insulin amyloid-like aggregates depends on preparation methods and post-production treatments

    Thorlaksen, C., Stanciu, A., Neergaard, M. B., Hatzakis, Nikos, Foderà, Vito & Groenning, M., 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 179, p. 147-155 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    N-RAS lipid anchor adsorption to membranes as a function of lipid composition and curvature

    Larsen, J. B., Kennard, C., Pedersen, S. L., Jensen, Knud Jørgen, Hatzakis, Nikos, Uline, M. J. & Stamou, Dimitrios, 2016, In: Biophysical Society. Annual Meeting. Abstracts. 110, 3, p. 579A 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  10. Published

    Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation

    Mortensen, Janni Støvring, Bohr, S. S. R., Krog, Lasse Skjoldborg, Bøtker, Johan Peter, Kapousidou, V., Saaby, Lasse, Hatzakis, Nikos, Nielsen, Hanne Mørck, Nguyen, Duc Ninh & Rønholt, Stine, 2024, In: Scientific Reports. 14, 1, 17 p., 7665.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Observation of Inhomogeneity in the Lipid Composition of Individual Nanoscale Liposomes

    Larsen, J., Hatzakis, Nikos, Elizondo, E., Cabrera, I., Veciana, J., Ventosa, N. & Stamou, Dimitrios, 2012, In: Biophysical Journal. p. 426a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  12. Published

    Observation of inhomogeneity in the lipid composition of individual nanoscale liposomes

    Larsen, J., Hatzakis, Nikos & Stamou, Dimitrios, 20 Jul 2011, In: Journal of the American Chemical Society. 133, 28, p. 10685-10687 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  13. Published

    Optically Induced Linking of Protein and Nanoparticles to Gold Surfaces

    Moth-Poulsen, K., Kofod-Hansen, V., S. Kamounah, F., Hatzakis, Nikos, Stamou, Dimitrios, Schaumburg, K. & Christensen, Jørn Bolstad, 2010, In: Bioconjugate Chemistry. 21, p. 1056 1061 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Oxidation of benzyl alcohols by dimethyldioxirane. The question of concerted versus stepwise mechanisms probed by kinetic isotope effects

    Angelis, Y. S., Hatzakis, Nikos, Smonou, I. & Orfanopoulos, M., 2001, In: Tetrahedron Letters. 42, 22, p. 3753-3756 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. POLY 391-Assembly strategies for enzyme immobilization

    Lambermon, M., Hendriks, L. J., Schoffelen, S., Vos, M., Hatzakis, Nikos, Carette, N., Rowan, A. E., Cornelissen, J., Michon, T., Sommerdijk, N. A. J. M. & van Hest, J. C. M., 2006, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

    Research output: Contribution to journal › Conference abstract in journal › Research

  16. POLY 553-Biohybrid block copolymer architectures by "click" chemistry

    Opsteen, J. A., Dirks, A. J., van Berkel, S. S., Hatzakis, Nikos, Brinkhuis, R. P., Reijnders, M. E. G. & van Hest, J. C. M., 2006, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY.

    Research output: Contribution to journal › Conference abstract in journal › Research

  17. Published

    Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)

    Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Positional assembly of enzymes in polymersome nanoreactors for cascade reactions

    Vriezema, D. M., Garcia, P. M. L., Oltra, N. S., Hatzakis, Nikos, Kuiper, S. M., Nolte, R. J. M., Rowan, A. E. & van Hest, J. C. M., 2007, In: Angewandte Chemie International Edition. 46, 39, p. 7378-7382 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  19. Preparation of biohybrid amphiphiles via the copper catalysed Huisgen [3 + 2] dipolar cycloaddition reaction

    Dirks, A. J., Van Berkel, S. S., Hatzakis, Nikos, Opsteen, J. A., Van Delft, F. L., Cornelissen, J. J. L. M., Rowan, A. E., Van Hest, J. C. M., Rutjes, F. P. J. T. & Nolte, R. J. M., 7 Sep 2005, In: Chemical Communications. 33, p. 4172-4174 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Probing Activation and Conformational Dynamics of the Vesicle-Reconstituted β2 Adrenergic Receptor at the Single-Molecule Level

    Tutkus, M., Lundgaard, C. V., Veshaguri, S., Tønnesen, A., Hatzakis, Nikos, Rasmussen, Søren Gøgsig Faarup & Stamou, Dimitrios, 2024, In: Journal of Physical Chemistry B. 128, 9, p. 2124–2133 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Protein Tracking: Everything, everywhere, almost at once

    Kæstel-Hansen, Jacob & Hatzakis, Nikos, 2024, In: eLife. 13, 3 p., e95362.

    Research output: Contribution to journal › Editorial › Research › peer-review

  22. Published

    Quantification of functional dynamics of membrane proteins reconstituted in nanodiscs membranes by single turnover functional readout

    Moses, M. E., Hedegård, Per & Hatzakis, Nikos, 2016, Single-molecule enzymology: fluorescence-based and high-throughput methods. Spies, M. & Chemla, Y. R. (eds.). Academic Press, p. 227-256 30 p. (Methods in Enzymology, Vol. 581).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  23. Published

    Rapid extraction of time-dependent behaviors of endo-lysosomal structures and their cargo aided by deep learning

    Kæstel-Hansen, Jacob, Kreutzberger, A., Kirchhausen, T. & Hatzakis, Nikos, 2023, In: Biophysical Journal. 122, 3 Supplement 1, p. 517a 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Realizing integration in structural biology: The 2022 ISBUC Annual Meeting

    Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Regulation of Enzymatic Activity Occurs by Selection of Discrete Activity States

    Hatzakis, Nikos, Wei, L., Jorgensen, S. K., Kunding, A. H., Hedegard, P. & Stamou, Dimitrios, 2011, In: Biophysical Journal. 100, 3 suppl 1, p. 194a 1 p.

    Research output: Contribution to journal › Journal article › Research

  26. Published

    Reply to: On the statistical foundation of a recent single molecule FRET benchmark

    Götz, M., Barth, A., Bohr, S. S. R., Börner, R., Chen, J., Cordes, T., Erie, D. A., Gebhardt, C., Hadzic, M. C. A. S., Hamilton, G. L., Hatzakis, N. S., Hugel, T., Kisley, L., Lamb, D. C., de Lannoy, C., Mahn, C., Dunukara, D., de Ridder, D., Sanabria, H., Schimpf, J. & 9 others, Seidel, C. A. M., Sigel, R. K. O., Sletfjerding, M. B., Thomsen, J., Vollmar, L., Wanninger, S., Weninger, K. R., Xu, P. & Schmid, S., 2024, In: Nature Communications. 15, 1, 4 p., 3626.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  27. Published

    Resolving active ion transport at the single molecule level for the first time

    Veshaguri, S., Christensen, S. M., Kemmer, G. C., Møller, M. P., Ghale, G., Lohr, C., Christensen, A. L., Justesen, B. H., Jørgensen, I. L., Schiller, J., Hatzakis, Nikos, Grabe, M., Pomorski, Thomas Guenther & Stamou, Dimitrios, 2016, In: Biophysical Journal. 110, 3, p. 179A 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Robust Dual Optical Sensor for pH and Dissolved Oxygen

    Wang, L., Jensen, K., Hatzakis, Nikos, Zhang, Min & Sørensen, Thomas Just, 2022, In: ACS Sensors. 7, 5, p. 1506–1513

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    SEMORE: SEgmentation and MORphological fingErprinting by machine learning automates super-resolution data analysis

    Bender, S. W. B., Dreisler, M. W., Zhang, Min, Kæstel-Hansen, Jacob & Hatzakis, Nikos, 2024, In: Nature Communications. 15, 1, 13 p., 1763.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Shedding light on protein folding, structural and functional dynamics by single molecule studies

    Bavishi, K. & Hatzakis, Nikos, 2014, In: Molecules. 19, 12, p. 19407-19434 28 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Single Enzyme Studies Reveal the Existence of Discrete Functional States for Monomeric Enzymes and How they are "Selected'' upon Allosteric Regulation

    Hatzakis, Nikos, Wei, L., Jørgensen, S. K., Kunding, A. H., Bolinger, P., Ehrlich, N., Makarov, I., Skjot, M., Svendsen, A., Hedegård, Per, Walsh, S. M. & Stamou, Dimitrios, 29 Jan 2013, In: Biophysical Journal. 104, 2, p. 231A-231A

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Single Liposome Measurements for the Study of Proton-Pumping Membrane Enzymes Using Electrochemistry and Fluorescent Microscopy

    Mazurenko, I., Hatzakis, Nikos & Jeuken, L. J. C., 2019, In: Journal of Visualized Experiments. 144

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Single Proton Pump Activity Measurements on Single Vesicles for a Quinol Heme-Copper Oxidase

    Jorgensen, S. K., McMillan, D., Krzeminski, L., Stamou, Dimitrios, Jeuken, L. J. C. & Hatzakis, Nikos, 2013, In: Biophysical Journal. 104, 2, Sppl. 1, p. 277a-278a

    Research output: Contribution to journal › Conference abstract in journal › Research

  34. Published

    Single Vesicle Fluorescence-Bleaching Assay for Multi-Parameter Analysis of Proteoliposomes by Total Internal Reflection Fluorescence Microscopy

    Veit, S., Paweletz, L. C., Bohr, S. S., Menon, A. K., Hatzakis, Nikos & Pomorski, Thomas Guenther, 2022, In: ACS applied materials & interfaces. 14, 26, p. 29659−29667 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Single enzyme experiments reveal a long-lifetime proton leak state in a heme-copper oxidase

    Li, M., Jørgensen, S. K., McMillan, D. G. G., Krzemiński, Ł., Daskalakis, N. N., Partanen, R. H., Tutkus, M., Tuma, R., Stamou, Dimitrios, Hatzakis, Nikos & Jeuken, L. J. C., 2015, In: Journal of the American Chemical Society. 137, 51, p. 16055-16063 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Single enzyme studies reveal the existence of discrete functional states for monomeric enzymes and how they are "selected" upon allosteric regulation

    Hatzakis, Nikos, Wei, L., Jørgensen, S. K., Kunding, A. H., Makarov, I., Skjot, M., Svendsen, A., Hedegård, Per & Stamou, Dimitrios, 2012, In: Journal of the American Chemical Society. 134, 22, p. 9296-9302 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Single molecule activity measurements of cytochrome P450 oxidoreductase reveal the existence of two discrete functional states

    Laursen, Tomas, Singha, A., Rantzau, N., Tutkus, M., Borch-Jensen, J., Hedegård, Per, Stamou, Dimitrios, Møller, Birger Lindberg & Hatzakis, Nikos, 2014, In: ACS chemical biology. 9, 3, p. 630-634 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Single molecule insights on conformational selection and induced fit mechanism

    Hatzakis, Nikos, 2014, In: Biophysical Chemistry. 186, p. 46-54 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Single-Molecule Study of Thermomyces lanuginosus Lipase in a Detergency Application System Reveals Diffusion Pattern Remodeling by Surfactants and Calcium

    Moses, M. E., Lund, P. M., Bohr, S. S., Iversen, J. F., Kæstel-Hansen, J., Kallenbach, A. S., Iversen, L., Christensen, S. M. & Hatzakis, Nikos, 2021, In: A C S Applied Materials and Interfaces. 13, 28, 9 p., 33704.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Single-Particle Tracking of Thermomyces lanuginosus Lipase Reveals How Mutations in the Lid Region Remodel Its Diffusion

    Iversen, J. F., Bohr, S. S. R., Pinholt, H. D., Moses, M. E., Iversen, L., Christensen, S. M., Hatzakis, Nikos & Zhang, Min, 2023, In: Biomolecules. 13, 4, 11 p., 631.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Single-particle combinatorial multiplexed liposome fusion mediated by DNA

    Malle, M., Loffler, P., Bohr, S. S., Sletfjerding, M., Risgaard, N., Jensen, S., Zhang, Min, Hedegård, Per, Vogel, S. & Hatzakis, Nikos, 2022, In: Nature Chemistry. 14, 5, p. 558–565 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Single-particle diffusional fingerprinting: A machine-learning framework for quantitative analysis of heterogeneous diffusion

    Pinholt, H. D., Bohr, S. S. R., Iversen, J. F., Boomsma, Wouter & Hatzakis, Nikos, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 7 p., e2104624118.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Soft Matter Based Nanofluidic Platform for Highly Parallel Mixing of Sub-Attoliter Total Volumes

    Christensen, S., Bolinger, P., Hatzakis, Nikos, Mortensen, M. W. & Stamou, Dimitrios, 2012, In: Biophysical Journal. 102, 3 Supplement 1, p. 600a-601a 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  44. Published

    Sorting of tN-Ras by Membrane Curvature in Lipid Vesicles and Tubes

    Rosholm, K. R., Larsen, J., Pedersen, S. L., Munch, H. K., Jensen, Knud Jørgen, Hatzakis, Nikos & Stamou, Dimitrios, 2013, In: Biophysical Journal. 104, Supplement 1, p. 549A 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  45. Published

    Static and Dynamic Disorder Observed in the Phase Transition Behavior of Individual Small Unilamellar Vesicles

    Stamou, Dimitrios, Bendix, Poul Martin, Wibroe, P. P. & Hatzakis, Nikos, 2011, In: Biophysical Journal. 100, 3 suppl 1, p. 35a 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  46. Published

    Synergy between membrane-curvature and liquid ordered phase-state effectively sorts amphiphilic protein-anchoring motifs

    Larsen, J., Jensen, M. B., Hatzakis, Nikos, Bhatia, V. K. & Stamou, Dimitrios, 2011, In: European Biophysics Journal. 40, Suppl 1, p. S200 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  47. Published

    Synergy of Liquid Ordered "Raft Like" Domains and Membrane Curvature in Promoting Sorting of Lipidated Proteins Such As NRas

    Hatzakis, Nikos, Larsen, J. K., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Jensen, Knud Jørgen & Stamou, Dimitrios, 2012, In: Biophysical Journal. 102, 3 Supplement 1, p. 18a-19a 2 p.

    Research output: Contribution to journal › Conference abstract in journal › Research

  48. Synthesis and single enzyme activity of a clicked lipase-BSA hetero-dimer

    Hatzakis, Nikos, Engelkamp, H., Velonia, K., Hofkens, J., Christianen, P. C. M., Svendsen, A., Patkar, S. A., Vind, J., Maan, J. C., Rowan, A. E. & Nolte, R. J. M., 2006, In: Chemical Communications. 19, p. 2012-2014 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    The dopamine transporter antiports potassium to increase the uptake of dopamine

    Schmidt, S. G., Malle, M. G., Nielsen, A. K., Bohr, S. S., Pugh, Ciara Frances, Nielsen, Jeppe Cederholm, Poulsen, I. H., Rand, Kasper Dyrberg, Hatzakis, Nikos & Loland, Claus Juul, 2022, In: Nature Communications. 13, 1, 12 p., 2446.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    The enzyme mechanism of nitrite reductase studied at single-molecule level

    Kuznetsova, S., Zauner, G., Aartsma, T., Engelkamp, H., Hatzakis, Nikos, Rowan, A., Nolte, R., Christianen, P. & Canters, G., 2008, In: Proceedings of the National Academy of Sciences USA (PNAS). 105, 9, p. 3250-3255

    Research output: Contribution to journal › Journal article › Research › peer-review

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