Søren-Peter Olesen

Søren-Peter Olesen

Professor


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  1. Published

    A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation

    Olesen, Morten Steen Salling, Refsgaard, L., Holst, A. G., Larsen, A. P., Grubb, Søren, Haunsø, Stig, Svendsen, Jesper Hastrup, Olesen, Søren-Peter, Schmitt, Nicole & Callø, Kirstine, 2013, In: Cardiovascular Research. 98, 3, p. 488-495 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein

    Andersen, M. N., Krzystanek, K., Petersen, F., Bomholtz, Sofia Hammami, Olesen, Søren-Peter, Abriel, H., Jespersen, Thomas & Rasmussen, Hanne Borger, 8 Nov 2013, In: The Journal of Biological Chemistry. 288, 52, p. 36841-54 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1.

    Angelo, K., Korolkova, Y. V., Grunnet, Morten, Grishin, E. V., Pluzhnikov, K. A., Klærke, Dan Arne, Knaus, H., Møller, Morten & Olesen, Søren-Peter, 2003, In: Pflügers Archiv: European Journal of Physiology. 447, 1, p. 55-63 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome

    Callø, Kirstine, Cordeiro, J. M., Di Diego, J. M., Hansen, R. S., Grunnet, Morten, Olesen, Søren-Peter & Antzelevitch, C., 2008, In: Cardiovascular Research. 81, 4, p. 686-94 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    AMP-activated protein kinase downregulates Kv7.1 cell surface expression

    Andersen, M. N., Krzystanek, K., Jespersen, Thomas, Olesen, Søren-Peter & Rasmussen, Hanne Borger, 2012, In: Traffic. 13, 1, p. 143-56 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Acrylamides as potassium channel openers

    Nardit, A. & Olesen, Søren-Peter, 2007, In: Expert Opinion on Therapeutic Patents. 17, 10, p. 1215-1226 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Activation of ERG2 potassium channels by the diphenylurea NS1643.

    Elmedyb, P., Olesen, Søren-Peter & Grunnet, Morten, 2007, In: Neuropharmacology. 53, 2, p. 283-94 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Activation of HERG potassium channels by the diphenylurea NS1643

    Hansen, R. S., Diness, T. G., Christ, T., Demnitz, J., Ravens, U. & Olesen, Søren-Peter, 2006, In: Molecular Pharmacology. 69, p. 266-277

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352.

    Dupuis, D. S., Schrøder, R. L., Jespersen, Thomas, Christensen, J. K., Christophersen, P., Jensen, B. S. & Olesen, Søren-Peter, 2002, In: European Journal of Pharmacology. 437, 3, p. 129-37 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury

    Bentzen, Bo Hjorth, Osadchii, O., Jespersen, Thomas, Hansen, R. S., Olesen, Søren-Peter & Grunnet, Morten, 2009, In: Pflügers Archiv: European Journal of Physiology. 457, 5, p. 979-88 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

    Strøbaek, D., Teuber, L., Jørgensen, T. D., Ahring, P. K., Kjaer, K., Hansen, R. S., Olesen, Søren-Peter, Christophersen, P. & Skaaning-Jensen, B., 2004, In: BBA General Subjects. 1665, 1-2, p. 1-5 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).

    Hansen, R. S., Diness, T. G., Christ, T., Demnitz, J., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2005, In: Molecular Pharmacology. 69, 1, p. 266-77 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Activation of the human intermediate-conductance Ca2+-activated K+ channel by 1-ethyl-2-benzimidazolinone is strongly Ca2+-dependent

    Pedersen, K. A., Schrøder, R. L. K., Skanning-Jensen, B., Strøbæk, D., Olesen, Søren-Peter & Christophersen, P., 1999, In: BBA General Subjects. 77660, p. 01-10

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Activation of the human, intermediate-conductance, Ca2+-activated K+ channel by methylxanthines

    Schrøder, R. L. K., Jensen, B. S., Strøbaek, D., Olesen, Søren-Peter & Christophersen, P., 2000, In: Pflügers Archiv: European Journal of Physiology. 440, p. 809-818

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    An ERG channel inhibitor from the scorpion Buthus eupeus

    Korolkova, Y. V., Kozlov, S. A., Lipkin, A. V., Pluzhnikov, K. A., Hadley, J. K., Filippov, A. K., Brown, D. A., Pedersen, K. A., Strøbaek, D., Jespersen, Thomas, Olesen, Søren-Peter, Jensen Skanning, B. & Grishin, E. V., 30 Mar 2001, In: Journal of Biological Chemistry. 276, 13, p. 9868-76 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Analysis of the Antitumor Activity of Clotrimazole on A375 Human Melanoma Cells

    Adinolfi, B., Carpi, S., Romanini, A., Da Pozzo, E., Castagna, M., Costa, B., Martini, C., Olesen, Søren-Peter, Schmitt, Nicole, Breschi, M. C., Nieri, P. & Fogli, S., Jul 2015, In: Anticancer Research. 35, 7, p. 3781-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

    Lundby, A., Rossin, E. J., Steffensen, A. B., Acha, M. R., Newton-Cheh, C., Pfeufer, A., Lynch, S. N., Olesen, S-P., Brunak, S., Ellinor, P. T., Jukema, J. W., Trompet, S., Ford, I., Macfarlane, P. W., Krijthe, B. P., Hofman, A., Uitterlinden, A. G., Stricker, B. H., Nathoe, H. M., Spiering, W. & 8 others, Daly, M. J., Asselbergs, F. W., van der Harst, P., Milan, D. J., de Bakker, P. I. W., Hansen, K. L., Olsen, Jesper Velgaard & The QT Interval International GWAS Consortium (QT-IGC), T. Q. I. I. G. C. (., 22 Jun 2014, In: Nature Methods. 11, 8, p. 868-874 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.

    Diness, T. G., Yeh, Y., Qi, X. Y., Chartier, D., Tsuji, Y., Hansen, R. S., Olesen, Søren-Peter, Grunnet, Morten & Nattel, S., 2008, In: Cardiovascular Research. 79, 1, p. 61-69 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Apamin interacts with all subtypes of cloned small-conductance Ca2+-activated K+ channels

    Grunnet, Morten, Jensen, B. S., Olesen, Søren-Peter & Klærke, Dan Arne, 2001, In: Pflügers Archiv: European Journal of Physiology. 441, p. 544-550

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Arvelige hjertesygdomme forårsaget af natriumkanalmutationer

    Tfelt-Hansen, J., Olesen, Søren-Peter, Svendsen, Jesper Hastrup & Jespersen, Thomas, 2009, In: Ugeskrift for læger. 171, 15, p. 1261-5 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle

    Layne, J. J., Nausch, B., Olesen, Søren-Peter & Nelson, M. T., 2009, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 298, 2, p. R378-84

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    BK channel activators and their therapeutic perspectives

    Bentzen, Bo Hjorth, Olesen, Søren-Peter, Rønn, L. C. B. & Grunnet, Morten, 2014, In: Frontiers in Physiology. 5, p. 1-12 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    BK channel modulators: a comprehensive overview.

    Nardi, A. & Olesen, Søren-Peter, 2008, In: Current Medicinal Chemistry. 15, 11, p. 1126-46 20 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif.

    Jespersen, Thomas, Rasmussen, Hanne Borger, Grunnet, Morten, Jensen, H. S., Angelo, K., Dupuis, D. S., Vogel, L. K., Jorgensen, N. K., Klærke, Dan Arne & Olesen, Søren-Peter, 2004, In: Journal of Cell Science. 117, Pt 19, p. 4517-26 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623[N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N '-(3 '-trifluoromethylphenyl)urea]

    Hansen, R. S., Diness, T. G., Christ, T., Wettwer, E., Ravens, U., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Molecular Pharmacology. 70, 4, p. 1319-1329 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Biophysical characterization of the short QT mutation hERG-N588K reveals a mixed gain-and loss-of-function

    Grunnet, Morten, Diness, T. G., Hansen, R. S. & Olesen, Søren-Peter, 2008, In: Cellular Physiology and Biochemistry. 22, 5-6, p. 611-624 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?

    Madsen, L. S., Christophersen, P. & Olesen, Søren-Peter, 2005, In: European Journal of Immunology. 35, 4, p. 1023-6 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Bureaukrati, Bogholderi og Bullshit

    Harder, Peter, Bache, C., Flensted-Jensen, M., Koch, Lene, Olesen, Søren-Peter & Sand-Jensen, Kaj, 30 Oct 2009, In: Weekendavisen.

    Research output: Contribution to journal › Contribution to newspaper - Newspaper article › Communication

  29. Published

    CNTF inhibits high voltage activated Ca2+ currents in fetal mouse cortical neurones.

    Holm, N. R., Christophersen, P., Hounsgaard, Jørn Dybkjær, Gammeltoft, S. & Olesen, Søren-Peter, 2002, In: Journal of Neurochemistry. 82, 3, p. 495-503 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia

    Schmitt, Nicole, Grunnet, Morten & Olesen, Søren-Peter, Apr 2014, In: Physiological Reviews. 94, 2, p. 609-53 45 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Cell swelling activates cloned Ca(2+)-activated K(+) channels: a role for the F-actin cytoskeleton.

    Jorgensen, N. K., Pedersen, Stine Helene Falsig, Rasmussen, Hanne Borger, Grunnet, Morten, Klærke, Dan Arne & Olesen, Søren-Peter, 2003, In: BBA General Subjects. 1615, 1-2, p. 115-25 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Chamber-specific effects of hypokalaemia on ventricular arrhythmogenicity in isolated, perfused guinea-pig heart

    Osadchii, O. E., Bentzen, Bo Hjorth & Olesen, Søren-Peter, 2009, In: Experimental Physiology. 94, 4, p. 434-46 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Characterization of cardiac repolarization in the Göttingen minipig

    Laursen, M., Olesen, Søren-Peter, Grunnet, Morten, Mow, T., Jespersen, T. & Jespersen, Thomas, 2011, In: Journal of Pharmacological and Toxicological Methods. 63, 2, p. 186-95 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current.

    Larsen, A. P., Olesen, Søren-Peter, Grunnet, Morten & Jespersen, Thomas, 2008, In: Pflügers Archiv: European Journal of Physiology. 456, 6, p. 1137-48 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Characterization of the cloned human intermediate-conductance Ca*O2*O+-activated K*O+ channel

    Jensen, B. S., Strøbæk, D., Christophersen, P., Jørgensen, T. D., Hansen, C., Silahtaroglu, Asli, Olesen, Søren-Peter & Ahring, P. K., 1998, In: The American Physiological Society. p. 848-856

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Characterization of two new dominant ClC-1 channel mutations associated with myotonia.

    Grunnet, Morten, Jespersen, Thomas, Colding-Jørgensen, E., Schwartz, M., Klærke, Dan Arne, Vissing, John, Olesen, Søren-Peter & Dunø, M., 2003, In: Muscle & Nerve. 28, 6, p. 722-32 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.

    Callø, Kirstine, Ravn, L. S., Schmitt, Nicole, Sui, J. L., Duno, M., Haunso, S., Grunnet, Morten, Svendsen, J. H. & Olesen, Søren-Peter, 2007, In: Biochemical and Biophysical Research Communications. 364, 4, p. 889-95 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Chronic sympathetic activation promotes downregulation of ß-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction

    Soltysinska, E., Thiele, S., Osadchiy, O. & Olesen, Søren-Peter, 2011, In: Pflügers Archiv - European Journal of Physiology. 462, 4, p. 529-43 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Comparison of the Effects of a Transient Outward Potassium Channel Activator on Currents Recorded from Atrial and Ventricular Cardiomyocytes.

    Callø, Kirstine, Nof, E., Jespersen, Thomas, Di Diego, J. M., Chlus, N., Olesen, Søren-Peter, Antzelevitch, C. & Cordeiro, J. M., 2011, In: Journal of Cardiovascular Electrophysiology. 22, 9, p. 1057-1066 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model.

    Peitersen, T., Grunnet, Morten, Benson, A. P., Holden, A. V., von Holstein-Rathlou, Niels-Henrik & Olesen, Søren-Peter, 2008, In: Heart Rhythm. 5, 5, p. 734-41 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Contribution of KV7 Channels to Basal Coronary Flow and Active Response to Ischemia

    Khanamiri, S., Soltysinska, E., Jepps, Thomas Andrew Qvistgaard, Bentzen, Bo Hjorth, Chadha, P. S., Schmitt, Nicole, Greenwood, I. A. & Olesen, Søren-Peter, 30 Sep 2013, In: Hypertension. 62, 6, p. 1090-1097 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels

    Krzystanek, K., Rasmussen, Hanne Borger, Grunnet, Morten, Staub, O., Olesen, Søren-Peter, Abriel, H. & Jespersen, Thomas, 2012, In: Heart Rhythm. 9, 3, p. 440-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Development of heart failure is independent of K+ channel-interacting protein 2 expression

    Speerschneider, T., Grubb, Søren, Metoska, A., Olesen, Søren-Peter, Callø, Kirstine & Thomsen, Morten Bækgaard, 1 Dec 2013, In: Journal of Physiology. 591, 23, p. 5923-37 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Differential effects of the transient outward K(+) current activator NS5806 in the canine left ventricle

    Callø, Kirstine, Soltysinska, E., Jespersen, Thomas, Lundby, Alicia, Antzelevitch, C., Olesen, Søren-Peter & Cordeiro, J. M., 2009, In: Journal of Molecular and Cellular Cardiology. 48, 1, p. 191-200 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics

    Larsen, A. P. & Olesen, Søren-Peter, 2010, In: P L o S One. 5, 2, p. e9021

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Effect of beta-adrenoceptor blockers on human ether-a-go-go-related gene (HERG) potassium channels.

    Dupuis, D. S., Klærke, Dan Arne & Olesen, Søren-Peter, 2005, In: Basic & Clinical Pharmacology & Toxicology. 96, 2, p. 123-30 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart

    Killeen, M. J., Thomas, G., Olesen, Søren-Peter, Demnitz, J., Stokoe, K. S., Grace, A. A. & Huang, C. L. H., 2008, In: Acta Physiologica (Print Edition). 193, 1, p. 25-36 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state

    Larsen, A. P., Steffensen, Annette Buur, Grunnet, Morten & Olesen, Søren-Peter, 2011, In: Biophysical Journal. 101, 4, p. 818-27 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Familial Aggregation of Lone Atrial Fibrillation in Young Persons

    Oyen, N., Ranthe, M. F., Carstensen, L., Boyd, H. A., Olesen, M. S., Olesen, Søren-Peter, Wohlfahrt, J. & Melbye, M., 2012, In: Journal of the American College of Cardiology. 60, 10, p. 917-21

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Forskeren i samfundet: Forskningspolitisk årsmøde 2008

    Kærgård, Niels, Harder, Peter, Bache, C., Flensted-Jensen, M., Koch, Lene, Olesen, Søren-Peter & Sand-Jensen, Kaj, 2008, Det Kongelige Danske Videnskabernes Selskab. 42 p.

    Research output: Book/Report › Book › Communication

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