Vilhelm Bohr

Vilhelm Bohr

Affiliate professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 3: Individualized health


  1. Published

    Mitochondria and aging. / Prolla, Tomas A; Bohr, Vilhelm A; de Souza-Pinto, Nadja C.

    In: Mechanisms of Ageing and Development, Vol. 131, No. 7-8, 07.2010, p. 449-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. E-pub ahead of print

    Mitochondria in the signaling pathways that control longevity and health span. / Akbari, Mansour; Kirkwood, Thomas B L; Bohr, Vilhelm A.

    In: Ageing Research Reviews, 12.08.2019, p. 100940.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    Mitochondrial DNA repair and association with aging--an update. / Diaz, Ricardo Gredilla; Bohr, Vilhelm A; Stevnsner, Tinna V.

    In: Experimental Gerontology, Vol. 45, No. 7-8, 01.08.2010, p. 478-88.

    Research output: Contribution to journalReviewResearchpeer-review

  4. Published

    Mitochondrial base excision repair assays. / Maynard, Scott; de Souza-Pinto, Nadja C; Scheibye-Knudsen, Morten; Bohr, Vilhelm A.

    In: Methods, Vol. 51, No. 4, 01.08.2010, p. 416-25.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease. / Diaz, Ricardo Gredilla; Weissman, Lior; Yang, Jenq-Lin; Bohr, Vilhelm A; Stevnsner, Tinna V.

    In: Neurobiology of Aging, 12.08.2010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Mitochondrial helicases and mitochondrial genome maintenance. / de Souza-Pinto, Nadja C; Aamann, Maria Diget; Kulikowicz, Tomasz; Stevnsner, Tinna V.; Bohr, Vilhelm A.

    In: Mechanisms of Ageing and Development, Vol. 131, No. 7-8, 2010, p. 503-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Mitophagy and Alzheimer's Disease : Cellular and Molecular Mechanisms. / Kerr, Jesse S.; Adriaanse, Bryan A.; Greig, Nigel H.; Mattson, Mark P.; Cader, M. Zameel; Bohr, Vilhelm A.; Fang, Evandro F.

    In: Trends in Neurosciences, Vol. 40, No. 3, 2017, p. 151-166.

    Research output: Contribution to journalReviewResearchpeer-review

  8. Published

    Mitophagy in neurodegeneration and aging. / Fivenson, Elayne M; Lautrup, Sofie; Sun, Nuo; Scheibye-Knudsen, Morten; Stevnsner, Tinna; Nilsen, Hilde; Bohr, Vilhelm A; Fang, Evandro Fei.

    In: Neurochemistry International, Vol. 109, 2017, p. 202-209.

    Research output: Contribution to journalReviewResearchpeer-review

  9. E-pub ahead of print

    Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. / Fang, Evandro F; Hou, Yujun; Palikaras, Konstantinos; Adriaanse, Bryan A; Kerr, Jesse S; Yang, Beimeng; Lautrup, Sofie; Hasan-Olive, Md Mahdi; Caponio, Domenica; Dan, Xiuli; Rocktäschel, Paula; Croteau, Deborah L; Akbari, Mansour; Greig, Nigel H; Fladby, Tormod; Nilsen, Hilde; Cader, M Zameel; Mattson, Mark P; Tavernarakis, Nektarios; Bohr, Vilhelm A.

    In: Nature Neuroscience, 11.02.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Modulation of DNA base excision repair during neuronal differentiation. / Sykora, Peter; Yang, Jenq-Lin; Ferrarelli, Leslie K; Tian, Jingyan; Tadokoro, Takashi; Kulkarni, Avanti; Weissman, Lior; Keijzers, Guido; Wilson, David M; Mattson, Mark P; Bohr, Vilhelm A.

    In: Neurobiology of Aging, Vol. 34, No. 7, 07.2013, p. 1717-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. / Fang, Evandro Fei; Kassahun, Henok; Croteau, Deborah L; Scheibye-Knudsen, Morten; Marosi, Krisztina; Lu, Huiming; Shamanna, Raghavendra A; Kalyanasundaram, Sumana; Bollineni, Ravi Chand; Wilson, Mark A; Iser, Wendy B; Wollman, Bradley N; Morevati, Marya; Li, Jun; Kerr, Jesse S; Lu, Qiping; Waltz, Tyler B; Tian, Jane; Sinclair, David A; Mattson, Mark P; Nilsen, Hilde; Bohr, Vilhelm A.

    In: Cell Metabolism, Vol. 24, No. 4, 11.10.2016, p. 566-581.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    NAD+ in Aging : Molecular Mechanisms and Translational Implications. / Fang, Evandro F.; Lautrup, Sofie; Hou, Yujun; Demarest, Tyler G.; Croteau, Deborah L.; Mattson, Mark P.; Bohr, Vilhelm A.

    In: Trends in Molecular Medicine, Vol. 23, No. 10, 2017, p. 899-916.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. / Hou, Yujun; Lautrup, Sofie; Cordonnier, Stephanie; Wang, Yue; Croteau, Deborah L.; Zavala, Eduardo; Zhang, Yongqing; Moritoh, Kanako; O’Connell, Jennifer F.; Baptiste, Beverly A.; Stevnsner, Tinna V.; Mattson, Mark P.; Bohr, Vilhelm A.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 8, 2018, p. E1876-E1885.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein. / Bernier, Michel; Paul, Rajib K; Martin-Montalvo, Alejandro; Scheibye-Knudsen, Morten; Song, Shaoming; He, Hua-Jun; Armour, Sean M; Hubbard, Basil P; Bohr, Vilhelm A; Wang, Lili; Zong, Yaping; Sinclair, David A; de Cabo, Rafael.

    In: The Journal of Biological Chemistry, Vol. 286, No. 22, 03.06.2011, p. 19270-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. / Yang, Jenq-Lin; Tadokoro, Takashi; Keijzers, Guido; Mattson, Mark P; Bohr, Vilhelm.

    In: Journal of Biological Chemistry, Vol. 285, No. 36, 2010, p. 28191-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells. / Bacolla, Albino; Wang, Guliang; Jain, Aklank; Chuzhanova, Nadia A; Cer, Regina Z; Collins, Jack R; Cooper, David N; Bohr, Vilhelm A; Vasquez, Karen M.

    In: The Journal of Biological Chemistry, Vol. 286, No. 12, 25.03.2011, p. 10017-26.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Nuclear DNA damage signalling to mitochondria in ageing. / Fang, Evandro Fei; Scheibye-Knudsen, Morten; Chua, Katrin F; Mattson, Mark P; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Nature Reviews. Molecular Cell Biology, Vol. 17, No. 5, 05.2016, p. 308-321.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Nutrition and aging. / Cheng, Wen-Hsing; Bohr, Vilhelm A; de Cabo, Rafael.

    In: Mechanisms of Ageing and Development, Vol. 131, No. 4, 01.04.2010, p. 223-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair. / Akbari, Mansour; Keijzers, Guido; Maynard, Scott; Scheibye-Knudsen, Morten; Madsen, Claus Desler; Hickson, Ian D; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 16, 04.2014, p. 44-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Protecting the mitochondrial powerhouse. / Scheibye-Knudsen, Morten; Fang, Evandro F.; Croteau, Deborah L.; Wilson, David M.; Bohr, Vilhelm A.

    In: Trends in Cell Biology, Vol. 25, No. 3, 01.03.2015, p. 158-170.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples. / Lachapelle, Sophie; Gagné, Jean-Philippe; Garand, Chantal; Desbiens, Myriam; Coulombe, Yan; Bohr, Vilhelm A; Hendzel, Michael J; Masson, Jean-Yves; Poirier, Guy G; Lebel, Michel.

    In: Journal of Proteome Research, Vol. 10, No. 3, 04.03.2011, p. 1216-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    RECQ HELICASE RECQL4 PARTICIPATES IN NON-HOMOLOGOUS END JOINING AND INTERACTS WITH THE KU COMPLEX. / Shamanna, Raghavendra A; Singh, Dharmendra Kumar; Lu, Huiming; Mirey, Gladys; Keijzers, Guido; Salles, Bernard; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Carcinogenesis, Vol. 35, No. 11, 11.2014, p. 2415-2424.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks. / Lu, Huiming; Shamanna, Raghavendra A; Keijzers, Guido; Anand, Roopesh; Rasmussen, Lene Juel; Cejka, Petr; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Cell Reports, Vol. 16, No. 1, 28.06.2016, p. 161-173.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity. / Croteau, Deborah L; Rossi, Marie L; Canugovi, Chandrika; Tian, Jane; Sykora, Peter; Ramamoorthy, Mahesh; Wang, Zheng Ming; Singh, Dharmendra Kumar; Akbari, Mansour; Kasiviswanathan, Rajesh; Copeland, William C; Bohr, Vilhelm A.

    In: Aging Cell, Vol. 11, No. 3, 2012, p. 456-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells. / Maynard, Scott; Keijzers, Guido; Gram, Martin; Madsen, Claus Desler; Bendix, Laila; Budtz-Jørgensen, Esben; Molbo, Drude; Croteau, Deborah L; Osler, Merete; Stevnsner, Tinna V.; Rasmussen, Lene Juel; Dela, Flemming; Avlund, Kirsten; Bohr, Vilhelm A.

    In: Aging, 30.11.2013, p. 850-864.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. / Soerensen, Mette; Dato, Serena; Christensen, Kaare; McGue, Matt; Stevnsner, Tinna V.; Bohr, Vilhelm A; Christiansen, Lene.

    In: Aging Cell, Vol. 9, No. 6, 01.12.2010, p. 1010-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis. / Fakouri, Nima Borhan; Durhuus, Jon Ambaek; Regnell, Christine Elisabeth; Angleys, Maria; Desler, Claus; Hasan-Olive, Mahdi; Martin-Pardillos, Ana; Tsaalbi-Shtylik, Anastasia; Thomsen, Kirsten; Lauritzen, Martin; Bohr, Vilhelm A.; de Wind, Niels; Bergersen, Linda Hildegard; Rasmussen, Lene Juel.

    In: Scientific Reports, Vol. 7, 12480, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Roles of Werner syndrome protein in protection of genome integrity. / Rossi, Marie L; Ghosh, Avik K; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 9, No. 3, 02.03.2010, p. 331-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. / McCord, Ronald A; Michishita, Eriko; Hong, Tao; Berber, Elisabeth; Boxer, Lisa D; Kusumoto, Rika; Guan, Shenheng; Shi, Xiaobing; Gozani, Or; Burlingame, Alma L; Bohr, Vilhelm A; Chua, Katrin F.

    In: Aging, Vol. 1, No. 1, 01.01.2009, p. 109-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Sarcopenia, Aging and Prospective Interventional Strategies. / Waltz, Tyler B; Fivenson, Elayne M; Morevati, Marya; Li, Chuanhao; Becker, Kevin G; Bohr, Vilhelm A; Fang, Evandro F.

    In: Current Medicinal Chemistry, Vol. 25, No. 40, 2018, p. 5588-5596.

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells. / Akbari, Mansour; Sykora, Peter; Bohr, Vilhelm A.

    In: Scientific Reports, Vol. 5, 12876 , 10.08.2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases. / Popuri, Venkateswarlu; Croteau, Deborah L; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 9, No. 6, 04.06.2010, p. 636-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Telomerer--begyndelsen og enden. / Bohr, Vilhelm A.

    In: Ugeskrift for Laeger, Vol. 172, No. 40, 04.10.2010, p. 2744.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients. / Jensen, Martin Borch; Dunn, Christopher A; Keijzers, Guido; Kulikowicz, Tomasz; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Aging, Vol. 4, No. 11, 11.2012, p. 790-802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    The involvement of human RECQL4 in DNA double-strand break repair. / Singh, Dharmendra Kumar; Karmakar, Parimal; Aamann, Maria Diget; Schurman, Shepherd H; May, Alfred; Croteau, Deborah L; Burks, Lynnette; Plon, Sharon E; Bohr, Vilhelm A.

    In: Aging Cell, Vol. 9, No. 3, 01.06.2010, p. 358-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    The mitochondrial transcription factor A functions in mitochondrial base excision repair. / Canugovi, Chandrika; Maynard, Scott; Bayne, Anne-Cécile V; Sykora, Peter; Tian, Jingyan; de Souza-Pinto, Nadja C; Croteau, Deborah L; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 9, No. 10, 05.10.2010, p. 1080-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells. / de Souza-Pinto, Nadja C; Maynard, Scott; Hashiguchi, Kazunari; Hu, Jingping; Muftuoglu, Meltem; Bohr, Vilhelm A.

    In: Molecular and Cellular Biology, Vol. 29, No. 16, 08.2009, p. 4441-54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    The role of DNA base excision repair in brain homeostasis and disease. / Akbari, Mansour; Morevati, Marya; Croteau, Deborah; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 32, 08.2015, p. 172-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The role of RecQ helicases in non-homologous end-joining. / Keijzers, Guido; Maynard, Scott; Shamanna, Raghavendra A; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 49, No. 6, 11.2014, p. 463-472.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. / Fang, Evandro Fei; Waltz, Tyler B; Kassahun, Henok; Lu, Qiping; Kerr, Jesse S; Morevati, Marya; Fivenson, Elayne M; Wollman, Bradley N; Marosi, Krisztina; Wilson, Mark A; Iser, Wendy B; Eckley, David Mark; Zhang, Yongqing; Lehrmann, Elin; Goldberg, Ilya G.; Scheibye-Knudsen, Morten; Mattson, Mark P.; Nilsen, Hilde; Bohr, Vilhelm A; Becker, Kevin G.

    In: Scientific Reports, Vol. 7, 46208, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

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