Heterochromatin: an epigenetic point of view in aging
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- Heterochromatin: an epigenetic point of view in aging
Final published version, 554 KB, PDF document
Aging is an inevitable process of life. Defined by progressive physiological and functional loss of tissues and organs, aging increases the risk of mortality for the organism. The aging process is affected by various factors, including genetic and epigenetic ones. Here, we review the chromatin-specific epigenetic changes that occur during normal (chronological) aging and in premature aging diseases. Taking advantage of the reversible nature of epigenetic modifications, we will also discuss possible lifespan expansion strategies through epigenetic modulation, which was considered irreversible until recently.
Original language | English |
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Journal | Experimental & Molecular Medicine |
Volume | 52 |
Issue number | 9 |
Pages (from-to) | 1466-1474 |
Number of pages | 9 |
ISSN | 1226-3613 |
DOIs | |
Publication status | Published - 2020 |
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