Protecting the mitochondrial powerhouse
Research output: Contribution to journal › Review › Research › peer-review
Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation. The use of oxygen is, however, a double-edged sword that on the one hand supplies ATP for cellular survival, and on the other leads to the formation of damaging reactive oxygen species (ROS). Different quality control pathways maintain mitochondria function including mitochondrial DNA (mtDNA) replication and repair, fusion-fission dynamics, free radical scavenging, and mitophagy. Further, failure of these pathways may lead to human disease. We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.
|Journal||Trends in Cell Biology|
|Number of pages||13|
|Publication status||Published - 1 Mar 2015|
- Disease, DNA repair, Mitochondria, Mitophagy, Reactive oxygen species