Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. 2016
  2. Published

    Oxidative Stress-Induced Dysfunction of Muller Cells During Starvation. / Toft-Kehler, Anne Katrine; Gurubaran, Iswariyaraja Sridevi; Madsen, Claus Desler; Rasmussen, Lene J.; Skytt, Dorte Marie; Kolko, Miriam.

    In: Investigative Ophthalmology & Visual Science, Vol. 57, No. 6, 05.2016, p. 2721-2728.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Approaches to diagnose DNA mismatch repair gene defects in cancer. / Peña-Diaz, Javier; Rasmussen, Lene Juel.

    In: DNA Repair, Vol. 38, 02.2016, p. 147-154.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published
  5. 2015
  6. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline. / Madsen, Claus Desler; Frederiksen, Jane H; Olsen, Maria Nathalie Angleys; Maynard, Scott; Keijzers, Guido; Fagerlund, Birgitte; Mortensen, Erik Lykke; Osler, Merete; Lauritzen, Martin; Bohr, Vilhelm A; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 25, 11.2015, p. 34-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients. / Maynard, Scott; Hejl, Anne-Mette; Dinh, Tran Thuan Son; Keijzers, Guido; Hansen, Åse M; Madsen, Claus Desler; Moreno-Villanueva, Maria; Bürkle, Alexander; Rasmussen, Lene J; Waldemar, Gunhild; Bohr, Vilhelm A.

    In: Aging, Vol. 7, No. 10, 10.2015, p. 793-815.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. / Lauritzen, Knut H.; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald; Haugen, Oyvind P.; Sjaastad, Ivar; Klungland, Arne; Rasmussen, Lene Juel; Attramadal, Havard; Storm-Mathisen, Jon; Bergersen, Linda H.

    In: American Journal of Physiology: Heart and Circulatory Physiology, Vol. 309, No. 3, 01.08.2015, p. H434-H449.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures. / Keijzers, Guido; Bohr, Vilhelm A; Juel Rasmussen, Lene.

    In: Bioscience Reports, Vol. 35, No. 3, e00206, 25.04.2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. / Lopez-Contreras, Andres J; Specks, Julia; Barlow, Jacqueline H; Ambrogio, Chiara; Madsen, Claus Desler; Vikingsson, Svante; Rodrigo-Perez, Sara; Green, Henrik; Rasmussen, Lene Juel; Murga, Matilde; Nussenzweig, André; Fernandez-Capetillo, Oscar.

    In: Genes & Development, Vol. 29, No. 7, 01.04.2015, p. 690-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The challenges of human population ageing. / Sander, Miriam; Oxlund, Bjarke; Jespersen, Astrid; Krasnik, Allan; Mortensen, Erik Lykke; Westendorp, Rudi Gerardus Johannes; Rasmussen, Lene Juel.

    In: Age and Ageing, Vol. 44, No. 2, 03.2015, p. 185-7.

    Research output: Contribution to journalJournal articleCommunication

  12. Published

    Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance. / Maynard, S; Keijzers, G; Hansen, Åse Marie; Osler, M; Molbo, D; Bendix, L; Møller, P; Loft, S; Moreno-Villanueva, M; Bürkle, A; Hvitby, Christina Poulsen; Schurman, S H; Stevnsner, Tinna V.; Rasmussen, L J; Avlund, K; Bohr, V A.

    In: Acta Physiologica (Print), Vol. 213, No. 1, 01.2015, p. 156-170.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published
  14. 2014
  15. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli. / Bendtsen, Kristian Moss; Jensen, Martin Borch; May, Alfred; Rasmussen, Lene Juel; Trusina, Ala; Bohr, Vilhelm; Jensen, Mogens Høgh.

    In: European Biophysics Journal, Vol. 43, No. 10-11, 14.11.2014, p. 509-516.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The role of RecQ helicases in non-homologous end-joining. / Keijzers, Guido; Maynard, Scott; Shamanna, Raghavendra A; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 49, No. 6, 11.2014, p. 463-472.

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    Enterococcus faecalis Infection and Reactive Oxygen Species Down-Regulates the miR-17-92 Cluster in Gastric Adenocarcinoma Cell Culture. / Strickertsson, Jesper A B; Rasmussen, Lene Juel; Friis-Hansen, Lennart.

    In: Genes, Vol. 5, No. 3, 28.08.2014, p. 726-38.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Impact of bacterial infections on aging and cancer : Impairment of DNA repair and mitochondrial function of host cells. / Strickertsson, Jesper A B; Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Experimental Gerontology, Vol. 56, 08.2014, p. 164-174.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein. / Dominguez-Valentin, Mev; Drost, Mark; Therkildsen, Christina; Rambech, Eva; Ehrencrona, Hans; Angleys, Maria; Lau Hansen, Thomas; de Wind, Niels; Nilbert, Mef; Juel Rasmussen, Lene.

    In: Molecular Genetics & Genomic Medicine, Vol. 2, No. 4, 07.2014, p. 352-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Mitochondria in biology and medicine--2012. / Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 16, 05.2014, p. 2-6.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome. / Rasmussen, Lene Juel; Heinen, Christopher D.

    2014, eLS.

    Research output: Other contributionNet publication - Internet publicationCommunication

  22. Published

    Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database. / Thompson, Bryony A; Spurdle, Amanda B; Plazzer, John-Paul; Greenblatt, Marc S; Akagi, Kiwamu; Al-Mulla, Fahd; Bapat, Bharati; Bernstein, Inge; Capellá, Gabriel; den Dunnen, Johan T; du Sart, Desiree; Fabre, Aurelie; Farrell, Michael P; Farrington, Susan M; Frayling, Ian M; Frebourg, Thierry; Goldgar, David E; Heinen, Christopher D; Holinski-Feder, Elke; Kohonen-Corish, Maija; Robinson, Kristina Lagerstedt; Leung, Suet Yi; Martins, Alexandra; Moller, Pal; Morak, Monika; Nystrom, Minna; Peltomaki, Paivi; Pineda, Marta; Qi, Ming; Ramesar, Rajkumar; Rasmussen, Lene Juel; Royer-Pokora, Brigitte; Scott, Rodney J; Sijmons, Rolf; Tavtigian, Sean V; Tops, Carli M; Weber, Thomas; Wijnen, Juul; Woods, Michael O; Macrae, Finlay; Genuardi, Maurizio; Castillejo, Adela; Sexton, Adrienne; Chan, Anthony K W; Viel, Alessandra; Blanco, Amie; French, Amy; Laner, Andreas; Wagner, Anja; van den Ouweland, Ans; on behalf of InSiGHT.

    In: Nature Genetics, Vol. 46, No. 2, 02.2014, p. 107-115.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Introducing the hypothome : a way to integrate predicted proteins in interactomes. / Madsen, Claus Desler; Zambach, Sine; Suravajhala, Prashanth; Rasmussen, Lene Juel.

    In: International Journal of Bioinformatics Research and Applications, Vol. 10, No. 6, 2014, p. 647-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2013
  25. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells. / Maynard, Scott; Keijzers, Guido; Gram, Martin; Madsen, Claus Desler; Bendix, Laila; Budtz-Jørgensen, Esben; Molbo, Drude; Croteau, Deborah L; Osler, Merete; Stevnsner, Tinna V.; Rasmussen, Lene Juel; Dela, Flemming; Avlund, Kirsten; Bohr, Vilhelm A.

    In: Aging, 30.11.2013, p. 850-864.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    DNA damage response, bioenergetics, and neurological disease : the challenge of maintaining brain health in an aging human population. / Rasmussen, Lene Juel; Shiloh, Yosef; Bergersen, Linda H; Sander, Miriam; Bohr, Vilhelm A; Tønjum, Tone.

    In: Mechanisms of Ageing and Development, Vol. 134, No. 10, 10.2013, p. 427-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome. / Drost, Mark; Lützen, Anne; van Hees, Sandrine; Ferreira, Daniel; Calléja, Fabienne; Zonneveld, José B M; Nielsen, Finn Cilius; Rasmussen, Lene Juel; de Wind, Niels.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 110, No. 23, 04.06.2013, p. 9403-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Response to : Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance. / Rasmussen, Lene Juel; Heinen, Christopher D; Royer-Pokora, Brigitte; Drost, Mark; Tavtigian, Sean; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 34, No. 6, 06.2013, p. 923-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells. / Machado, Ana Manuel Dantas; Desler, Claus; Boggild, Sisse; Strickertsson, Jesper A. B.; Friis-Hansen, Lennart; Figueiredo, Ceu; Seruca, Raquel; Rasmussen, Lene Juel.

    In: Mechanisms of Ageing and Development, Vol. 134, No. 10, 2013, p. 460-466.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 13558388