Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. 1994
  2. Published

    Novel growth rate control of dam gene expression in Escherichia coli. / Rasmussen, L J; Marinus, M G; Løbner-Olesen, A.

    In: Molecular Microbiology, Vol. 12, No. 4, 05.1994, p. 631-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 1995
  4. Published

    Growth-rate-dependent transcription initiation from the dam P2 promoter. / Rasmussen, L J; Løbner-Olesen, A; Marinus, M G.

    In: Gene, Vol. 157, No. 1-2, 19.05.1995, p. 213-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2000
  6. Published

    The LipB protein is a negative regulator of dam gene expression in Escherichia coli. / Vaisvila, R; Rasmussen, L J; Lobner-Olesen, A; von Freiesleben, U; Marinus, M G.

    In: B B A - Reviews on Cancer, Vol. 1494, No. 1-2, 15.11.2000, p. 43-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2004
  8. Is hEXO1 a cancer predisposing gene? / Liberti, Sascha Emilie; Rasmussen, Lene Juel.

    In: Molecular Cancer Research, Vol. 2, No. 8, 08.2004, p. 427-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Cadmium inhibits human DNA mismatch repair in vivo. / Lützen, Anne; Liberti, Sascha Emilie; Rasmussen, Lene Juel.

    In: Biochemical and Biophysical Research Communications, Vol. 321, No. 1, 13.08.2004, p. 21-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2006
  11. The role of mitochondrial dNTP levels in cells with reduced TK2 activity. / Desler, C; Munch-Petersen, B; Rasmussen, L J.

    In: Nucleosides, nucleotides & nucleic acids, Vol. 25, No. 9-11, 2006, p. 1171-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2007
  13. Published

    Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1). / Knudsen, Nina Østergaard; Nielsen, Finn Cilius; Vinther, Lena; Bertelsen, Ronni; Holten-Andersen, Steen; Liberti, Sascha Emilie; Hofstra, Robert; Kooi, Krista; Rasmussen, Lene Juel.

    In: Nucleic Acids Research, Vol. 35, No. 8, 2007, p. 2609-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Mitochondria as determinant of nucleotide pools and chromosomal stability. / Desler, Claus; Munch-Petersen, Birgitte; Stevnsner, Tinna; Matsui, Sei-Ichi; Kulawiec, Mariola; Singh, Keshav K; Rasmussen, Lene Juel.

    In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 625, No. 1-2, 01.12.2007, p. 112-24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2008
  16. Published

    Functional analysis of HNPCC-related missense mutations in MSH2. / Lützen, Anne; de Wind, Niels; Georgijevic, Dubravka; Nielsen, Finn Cilius; Rasmussen, Lene Juel.

    In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 645, No. 1-2, 14.10.2008, p. 44-55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2009
  18. Published

    Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome. / Ou, Jianghua; Rasmussen, Merete; Westers, Helga; Andersen, Sofie D; Jager, Paul O; Kooi, Krista A; Niessen, Renée C; Eggen, Bart J L; Nielsen, Finn C; Kleibeuker, Jan H; Sijmons, Rolf H; Rasmussen, Lene J; Hofstra, Robert M W.

    In: Genes, Chromosomes & Cancer, Vol. 48, No. 4, 2009, p. 340-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair. / Dherin, Claudine; Gueneau, Emeric; Francin, Mathilde; Nunez, Marcela; Miron, Simona; Liberti, Sascha Emilie; Rasmussen, Lene Juel; Zinn-Justin, Sophie; Gilquin, Bernard; Charbonnier, Jean-Baptiste; Boiteux, Serge.

    In: Molecular and Cellular Biology, Vol. 29, No. 3, 2009, p. 907-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases. / Larsen, Nicolai Balle; Heiberg Engel, Peter Johan; Rasmussen, Merete; Rasmussen, Lene Juel.

    In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 117, No. 11, 2009, p. 839-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. / Machado, Ana Manuel Dantas; Figueiredo, Ceu; Touati, Eliette; Máximo, Valdemar; Sousa, Sonia; Michel, Valérie; Carneiro, Fátima; Nielsen, Finn Cilius; Seruca, Raquel; Rasmussen, Lene Juel.

    In: Clinical Cancer Research, Vol. 15, No. 9, 2009, p. 2995-3002.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    In Silico screening for functional candidates amongst hypothetical proteins. / Desler, Claus; Suravajhala, Prashanth; Sanderhoff, May; Rasmussen, Merete; Rasmussen, Lene Juel.

    In: BMC Bioinformatics, Vol. 10, 2009, p. 289.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Novel DNA mismatch-repair activity involving YB-1 in human mitochondria. / de Souza-Pinto, Nadja C; Mason, Penelope A; Hashiguchi, Kazunari; Weissman, Lior; Tian, Jingyan; Guay, David; Lebel, Michel; Stevnsner, Tinna V; Rasmussen, Lene Juel; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 8, No. 6, 2009, p. 704-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Nuclear translocation contributes to regulation of DNA excision repair activities. / Knudsen, Nina Østergaard; Andersen, Sofie Dabros; Lützen, Anne; Nielsen, Finn Cilius; Rasmussen, Lene Juel.

    In: DNA Repair, Vol. 8, No. 6, 2009, p. 682-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Repair of DNA damage induced by anthanthrene, a polycyclic aromatic hydrocarbon (PAH) without bay or fjord regions. / Madsen, Claus Desler; Johannessen, Christian; Rasmussen, Lene Juel.

    In: Chemico-Biological Interactions, Vol. 177, No. 3, 2009, p. 212-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2010
  27. Published

    Helicobacter pylori infection generates genetic instability in gastric cells. / Machado, Ana Manuel Dantas; Figueiredo, Céu; Seruca, Raquel; Rasmussen, Lene Juel.

    In: BBA General Subjects, Vol. 1806, No. 1, 2010, p. 58-65.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage. / Skovgaard, T; Rasmussen, Lene Juel; Munch-Petersen, Birgitte.

    In: Nucleosides, Nucleotides and Nucleic Acids, Vol. 29, No. 4-6, 2010, p. 347-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. / Madsen, Claus Desler; Lykke, Anne; Rasmussen, Lene Juel.

    In: Journal of Nucleic Acids, Vol. 2010, 01.01.2010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2011
  31. Published

    Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste. / Bouchami, Ons; Sghaier, Haïtham; Madsen, Claus Desler; Lazim, Hadeer; Saidi, Mouldi; Rasmussen, Lene Juel; Ben Hassan, Assia .

    In: Annals of Microbiology, 2011.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks. / Liberti, Sascha E; Andersen, Sofie Dabros; Wang, Jing; May, Alfred; Miron, Simona; Perderiset, Mylene; Keijzers, Guido; Nielsen, Finn C; Charbonnier, Jean-Baptiste; Bohr, Vilhelm A; Rasmussen, Lene J.

    In: DNA Repair, Vol. 10, No. 1, 02.01.2011, p. 73-86.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    The importance of mitochondrial DNA in aging and cancer. / Madsen, Claus Desler; Espersen, Maiken Lise Marcker; Singh, Keshav K; Rasmussen, Lene Juel.

    In: Journal of Aging Research, Vol. 2011, 30.03.2011, p. 407536.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Aging, longevity and health. / Rasmussen, Lene Juel; Sander, Miriam; Wewer, Ulla M.; Bohr, Vilhelm A.

    In: Mechanisms of Ageing and Development, 23.07.2011, p. 522-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2012
  36. Published

    A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants. / Drost, Mark; Zonneveld, José B M; van Hees, Sandrine; Rasmussen, Lene Juel; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 33, No. 3, 2012, p. 488-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Genome-wide screens for expressed hypothetical proteins. / Madsen, Claus Desler; Durhuus, Jon Ambæk; Rasmussen, Lene Juel.

    In: Methods in molecular biology (Clifton, N.J.), Vol. 815, 2012, p. 25-38.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? / Hansen, Thomas Lau; Rasmussen, Lene Juel; Madsen, Claus Desler; Frederiksen, Jane Bruun; Espersen, Maiken Lise Marcker; Singh, Keshav K.

    In: Journal of Aging Research, Vol. 2012, 2012, p. 192503.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. / Andersen, Sofie Dabros; Keijzers, Guido; Rampakakis, Emmanouil; Engels, Kim; Luhn, Patricia; El-Shemerly, Mahmoud; Nielsen, Finn Cilius; Du, Yuhong; May, Alfred; Bohr, Vilhelm A; Ferrari, Stefano; Zannis-Hadjopoulos, Maria; Fu, Haian; Rasmussen, Lene Juel.

    In: D N A Repair, Vol. 11, No. 3, 03.2012, p. 267-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. / Cheng, Chang; Edin, Nina F Jeppesen; Lauritzen, Knut H; Aspmodal, Ida; Christoffersen, Stine; Jian, Liu; Rasmussen, Lene Juel; Pettersen, Erik O; Xiaoqun, Gao; Bergersen, Linda H.

    In: Cellular oncology (Dordrecht), Vol. 35, No. 3, 06.2012, p. 217-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays. / Heinen, Christopher D; Juel Rasmussen, Lene.

    In: Hereditary Cancer in Clinical Practice, Vol. 10, No. 1, 07.2012, p. 9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Mitochondria in biology and medicine. / Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 12, No. 4, 07.2012, p. 472-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages. / Jantzen, Kim; Roursgaard, Martin; Madsen, Claus Desler; Loft, Steffen; Rasmussen, Lene Juel; Møller, Peter.

    In: Mutagenesis, Vol. 27, No. 6, 11.2012, p. 693-701.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients. / Jensen, Martin Borch; Dunn, Christopher A; Keijzers, Guido; Kulikowicz, Tomasz; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Aging, Vol. 4, No. 11, 11.2012, p. 790-802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients. / Andersen, Sofie Dabros; Liberti, Sascha Emilie; Lützen, Anne; Drost, Mark; Bernstein, Inge; Nilbert, Mef; Dominguez, Mev; Nyström, Minna; Hansen, Thomas Van Overeem; Christoffersen, Janus Wiese; Jäger, Anne Charlotte; de Wind, Niels; Nielsen, Finn Cilius; Tørring, Pernille M; Rasmussen, Lene Juel.

    In: Human Mutation, Vol. 33, No. 12, 12.2012, p. 1647-1655.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Pathological assessment of mismatch repair gene variants in Lynch syndrome : Past, present, and future. / Rasmussen, Lene Juel; Heinen, Christopher D; Royer-Pokora, Brigitte; Drost, Mark; Tavtigian, Sean; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 33, No. 12, 12.2012, p. 1617-25.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2013
  48. Published

    Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells. / Machado, Ana Manuel Dantas; Desler, Claus; Boggild, Sisse; Strickertsson, Jesper A. B.; Friis-Hansen, Lennart; Figueiredo, Ceu; Seruca, Raquel; Rasmussen, Lene Juel.

    In: Mechanisms of Ageing and Development, Vol. 134, No. 10, 2013, p. 460-466.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells. / Strickertsson, Jesper A B; Madsen, Claus Desler; Martin-Bertelsen, Tomas; Machado, Ana Manuel Dantas; Wadstrøm, Torkel; Winther, Ole; Rasmussen, Lene Juel; Friis-Hansen, Lennart.

    In: PLOS ONE, Vol. 8, No. 4, e63147, 2013, p. 1-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients. / Petersen, Sanne M; Dandanell, Mette; Rasmussen, Lene J; Gerdes, Anne-Marie; Krogh, Lotte Nylandsted; Bernstein, Inge; Okkels, Henrik; Wikman, Friedrik; Nielsen, Finn C; Hansen, Thomas V O.

    In: BMC Medical Genetics, Vol. 14, 2013, p. 103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome. / Drost, Mark; Lützen, Anne; van Hees, Sandrine; Ferreira, Daniel; Calléja, Fabienne; Zonneveld, José B M; Nielsen, Finn Cilius; Rasmussen, Lene Juel; de Wind, Niels.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 23, 2013, p. 9403-9408.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Natural selection of mitochondria during somatic lifetime promotes healthy aging. / Rodell, Anders; Rasmussen, Lene J; Bergersen, Linda H; Singh, Keshav K; Gjedde, Albert.

    In: Frontiers in Neuroenergetics, Vol. 5, 2013, p. 1-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Response to : Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance. / Rasmussen, Lene Juel; Heinen, Christopher D; Royer-Pokora, Brigitte; Drost, Mark; Tavtigian, Sean; Hofstra, Robert M W; de Wind, Niels.

    In: Human Mutation, Vol. 34, No. 6, 06.2013, p. 923-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome. / Drost, Mark; Lützen, Anne; van Hees, Sandrine; Ferreira, Daniel; Calléja, Fabienne; Zonneveld, José B M; Nielsen, Finn Cilius; Rasmussen, Lene Juel; de Wind, Niels.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 110, No. 23, 04.06.2013, p. 9403-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    DNA damage response, bioenergetics, and neurological disease : the challenge of maintaining brain health in an aging human population. / Rasmussen, Lene Juel; Shiloh, Yosef; Bergersen, Linda H; Sander, Miriam; Bohr, Vilhelm A; Tønjum, Tone.

    In: Mechanisms of Ageing and Development, Vol. 134, No. 10, 10.2013, p. 427-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells. / Maynard, Scott; Keijzers, Guido; Gram, Martin; Madsen, Claus Desler; Bendix, Laila; Budtz-Jørgensen, Esben; Molbo, Drude; Croteau, Deborah L; Osler, Merete; Stevnsner, Tinna V.; Rasmussen, Lene Juel; Dela, Flemming; Avlund, Kirsten; Bohr, Vilhelm A.

    In: Aging, 30.11.2013, p. 850-864.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. 2014
  58. Published

    Introducing the hypothome : a way to integrate predicted proteins in interactomes. / Madsen, Claus Desler; Zambach, Sine; Suravajhala, Prashanth; Rasmussen, Lene Juel.

    In: International Journal of Bioinformatics Research and Applications, Vol. 10, No. 6, 2014, p. 647-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database. / Thompson, Bryony A; Spurdle, Amanda B; Plazzer, John-Paul; Greenblatt, Marc S; Akagi, Kiwamu; Al-Mulla, Fahd; Bapat, Bharati; Bernstein, Inge; Capellá, Gabriel; den Dunnen, Johan T; du Sart, Desiree; Fabre, Aurelie; Farrell, Michael P; Farrington, Susan M; Frayling, Ian M; Frebourg, Thierry; Goldgar, David E; Heinen, Christopher D; Holinski-Feder, Elke; Kohonen-Corish, Maija; Robinson, Kristina Lagerstedt; Leung, Suet Yi; Martins, Alexandra; Moller, Pal; Morak, Monika; Nystrom, Minna; Peltomaki, Paivi; Pineda, Marta; Qi, Ming; Ramesar, Rajkumar; Rasmussen, Lene Juel; Royer-Pokora, Brigitte; Scott, Rodney J; Sijmons, Rolf; Tavtigian, Sean V; Tops, Carli M; Weber, Thomas; Wijnen, Juul; Woods, Michael O; Macrae, Finlay; Genuardi, Maurizio; Castillejo, Adela; Sexton, Adrienne; Chan, Anthony K W; Viel, Alessandra; Blanco, Amie; French, Amy; Laner, Andreas; Wagner, Anja; van den Ouweland, Ans; on behalf of InSiGHT.

    In: Nature Genetics, Vol. 46, No. 2, 02.2014, p. 107-115.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome. / Rasmussen, Lene Juel; Heinen, Christopher D.

    2014, eLS.

    Research output: Other contributionNet publication - Internet publicationCommunication

  61. Published

    Mitochondria in biology and medicine--2012. / Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 16, 05.2014, p. 2-6.

    Research output: Contribution to journalReviewResearchpeer-review

  62. Published

    Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein. / Dominguez-Valentin, Mev; Drost, Mark; Therkildsen, Christina; Rambech, Eva; Ehrencrona, Hans; Angleys, Maria; Lau Hansen, Thomas; de Wind, Niels; Nilbert, Mef; Juel Rasmussen, Lene.

    In: Molecular Genetics & Genomic Medicine, Vol. 2, No. 4, 07.2014, p. 352-355.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Impact of bacterial infections on aging and cancer : Impairment of DNA repair and mitochondrial function of host cells. / Strickertsson, Jesper A B; Madsen, Claus Desler; Rasmussen, Lene Juel.

    In: Experimental Gerontology, Vol. 56, 08.2014, p. 164-174.

    Research output: Contribution to journalJournal articleResearchpeer-review

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