Vilhelm Bohr
Affiliate professor, Affiliate Professor
Molecular Aging Program
Panum Instituttet, Blegdamsvej 3, 2200 København N, 07 Bygning 7, Building: 07-3-13
Member of:
- Published
Mitochondrial helicases and mitochondrial genome maintenance
de Souza-Pinto, N. C., Aamann, M. D., Kulikowicz, T., Stevnsner, T. V. & Bohr, Vilhelm, 2010, In: Mechanisms of Ageing and Development. 131, 7-8, p. 503-10 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells
de Souza-Pinto, N. C., Maynard, S., Hashiguchi, K., Hu, J., Muftuoglu, M. & Bohr, Vilhelm, Aug 2009, In: Molecular and Cellular Biology. 29, 16, p. 4441-54 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells
Zheng, Jin, Croteau, D. L., Bohr, Vilhelm & Akbari, M., 2019, In: Nucleic Acids Research. 47, 8, p. 4086–4110Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy
Zheng, Jin, Akbari, M., Schirmer, C., Reynaert, M. L., Loyens, A., Lefebvre, B., Buée, L., Croteau, D. L., Galas, M. C. & Bohr, Vilhelm, 2020, In: Acta Neuropathologica Communications. 8, 1, 23 p., 25.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Salidroside promotes healthy longevity by interfering with HSP90 activity
Zhang, J., Li, Zhiquan, Song, J., Zhou, L., Chen, X., Ge, W., Dong, T., Luo, Y., Mao, T., Li, Z., Tan, D., Rasmussen, Lene Juel, Bohr, Vilhelm, Tong, X. & Dai, F., 2024, In: GeroScience. 46, p. 1641–1655 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1
Yang, J., Tadokoro, T., Keijzers, G., Mattson, M. P. & Bohr, Vilhelm, 2010, In: Journal of Biological Chemistry. 285, 36, p. 28191-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NAD+ supplementation prevents STING-induced senescence in ataxia telangiectasia by improving mitophagy
Yang, B., Dan, X., Hou, Y., Lee, J. H., Wechter, N., Krishnamurthy, S., Kimura, R., Babbar, M., Demarest, T., McDevitt, R., Zhang, S., Zhang, Y., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, 2021, In: Aging Cell. 20, 4, 14 p., e13329.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress
Yang, B., Figueroa, D. M., Hou, Y., Babbar, M., Baringer, S. L., Croteau, D. L. & Bohr, Vilhelm, 2019, In: Free Radical Biology and Medicine. 141, p. 47-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
Wang, H. L., Siow, R., Schmauck-Medina, T., Zhang, J., Sandset, P. M., Filshie, C., Lund, Ø., Partridge, L., Bergersen, L. H., Juel Rasmussen, L., Palikaras, K., Sotiropoulos, I., Storm-Mathisen, J., Rubinsztein, D. C., Spillantini, M. G., De Zeeuw, C. I., Watne, L. O., Vyhnalek, M., Veverova, K., Liang, K. X. & 18 others, , 2024, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 79, 4, 10 p., glae029.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sarcopenia, Aging and Prospective Interventional Strategies
Waltz, T. B., Fivenson, E. M., Morevati, M., Li, C., Becker, K. G., Bohr, Vilhelm & Fang, E. F., 2018, In: Current Medicinal Chemistry. 25, 40, p. 5588-5596 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Modulation of DNA base excision repair during neuronal differentiation
Sykora, P., Yang, J., Ferrarelli, L. K., Tian, J., Tadokoro, T., Kulkarni, A., Weissman, L., Keijzers, G., Wilson, D. M., Mattson, M. P. & Bohr, Vilhelm, Jul 2013, In: Neurobiology of Aging. 34, 7, p. 1717-27 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aprataxin localizes to mitochondria and preserves mitochondrial function
Sykora, P., Croteau, D. L., Bohr, Vilhelm & Wilson, D. M., 3 May 2011, In: Proceedings of the National Academy of Sciences USA (PNAS). 108, 18, p. 7437-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA polymerase beta participates in mitochondrial DNA repair
Sykora, P., Kanno, S., Akbari, M., Kulikowicz, T., Baptiste, B. A., Leandro, G. S., Lu, H., Tian, J., May, A., Becker, K. A., Croteau, D. L., Wilson, D. M., Sobol, R. W., Yasui, A. & Bohr, Vilhelm, Aug 2017, In: Molecular and Cellular Biology. 37, 16, e00237-17.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human RecQL4 helicase plays critical roles in prostate carcinogenesis
Su, Y., Meador, J. A., Calaf, G. M., Proietti De-Santis, L., Zhao, Y., Bohr, Vilhelm & Balajee, A. S., 15 Nov 2010, In: Cancer Research. 70, 22, p. 9207-17 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human RECQL5beta stimulates flap endonuclease 1
Speina, E., Dawut, L., Hedayati, M., Wang, Z., May, A., Schwendener, S., Janscak, P., Croteau, D. L. & Bohr, Vilhelm, 1 May 2010, In: Nucleic Acids Symposium Series. 38, 9, p. 2904-16 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data
Soerensen, M., Dato, S., Christensen, K., McGue, M., Stevnsner, T. V., Bohr, Vilhelm & Christiansen, L., 1 Dec 2010, In: Aging Cell. 9, 6, p. 1010-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The involvement of human RECQL4 in DNA double-strand break repair
Singh, D. K., Karmakar, P., Aamann, M. D., Schurman, S. H., May, A., Croteau, D. L., Burks, L., Plon, S. E. & Bohr, Vilhelm, 1 Jun 2010, In: Aging Cell. 9, 3, p. 358-71 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RECQ HELICASE RECQL4 PARTICIPATES IN NON-HOMOLOGOUS END JOINING AND INTERACTS WITH THE KU COMPLEX
Shamanna, R. A., Singh, D. K., Lu, H., Mirey, G., Keijzers, G., Salles, B., Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In: Carcinogenesis. 35, 11, p. 2415-2424 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology
SenGupta, T., Palikaras, K., Esbensen, Y. Q., Konstantinidis, G., Galindo, F. J. N., Achanta, K., Kassahun, H., Stavgiannoudaki, I., Bohr, Vilhelm, Akbari, M., Gaare, J., Tzoulis, C., Tavernarakis, N. & Nilsen, H., 2021, In: Cell Reports. 36, 10, 109668.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
Schmauck-Medina, T., Molière, A., Lautrup, S., Zhang, J., Chlopicki, S., Madsen, H. B., Cao, S., Soendenbroe, C., Mansell, E., Vestergaard, M. B., Li, Z., Shiloh, Y., Opresko, P. L., Egly, J. M., Kirkwood, T., Verdin, E., Bohr, V. A., Cox, L. S., Stevnsner, T., Rasmussen, L. J. & 1 others, , 2022, In: Aging. 14, 16, p. 6829-6839 11 p.Research output: Contribution to journal › Review › Research › peer-review
Protecting the mitochondrial powerhouse
Scheibye-Knudsen, Morten, Fang, E. F., Croteau, D. L., Wilson, D. M. & Bohr, Vilhelm, 1 Mar 2015, In: Trends in Cell Biology. 25, 3, p. 158-170 13 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy
Scheibye-Knudsen, M., Ramamoorthy, M., Sykora, P., Maynard, S., Lin, P., Minor, R. K., Wilson, D. M., Cooper, M., Spencer, R., de Cabo, R., Croteau, D. L. & Bohr, Vilhelm, Apr 2012, In: The Journal of Experimental Medicine. 209, 4, p. 855-69 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA
Scheibye-Knudsen, M., Tseng, A., Jensen, M. B., Scheibye-Alsing, K., Fang, E. F., Iyama, T., Bharti, S. K., Marosi, K., Froetscher, L., Kassahun, H., Eckley, D. M., Maul, R. W., Bastian, P., De, S., Ghosh, S., Nilsen, H., Goldberg, I. G., Mattson, M. P., Wilson, D. M. . III., Brosh, R. M. . J. & 2 others, , 1 Nov 2016, In: National Academy of Sciences. Proceedings. 113, 44, p. 12502-12507Research output: Contribution to journal › Journal article › Research › peer-review
Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders
Scheibye-Knudsen, Morten, Fang, E. F., Croteau, D. L. & Bohr, Vilhelm, 2014, In: Autophagy. 10, 8, p. 1468-1469 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome
Scheibye-Knudsen, M., Mitchell, S. J., Fang, E. F., Iyama, T., Ward, T., Wang, J., Dunn, C. A., Singh, N., Veith, S., Hasan-Olive, M. M., Mangerich, A., Wilson, M. A., Mattson, M. P., Bergersen, L. H., Cogger, V. C., Warren, A., Le Couteur, D. G., Moaddel, R., Wilson, D. M., Croteau, D. L. & 2 others, , 4 Nov 2014, In: Cell Metabolism. 20, 5, p. 840-855 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Roles of Werner syndrome protein in protection of genome integrity
Rossi, M. L., Ghosh, A. K. & Bohr, Vilhelm, 2 Mar 2010, In: DNA Repair. 9, 3, p. 331-44 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding
Rossi, M. L., Ghosh, A. K., Kulikowicz, T., Croteau, D. L. & Bohr, Vilhelm, 1 Jul 2010, In: DNA Repair. 9, 7, p. 796-804 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1
Rhee, D. B., Ghosh, A., Lu, J., Bohr, Vilhelm & Liu, Y., 2 Jan 2011, In: DNA Repair. 10, 1, p. 34-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population
Rasmussen, Lene Juel, Shiloh, Y., Bergersen, L. H., Sander, M., Bohr, Vilhelm & Tønjum, T., Oct 2013, In: Mechanisms of Ageing and Development. 134, 10, p. 427-33 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Aging, longevity and health
Rasmussen, Lene Juel, Sander, M., Wewer, Ulla M. & Bohr, Vilhelm, 23 Jul 2011, In: Mechanisms of Ageing and Development. p. 522-32 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mitochondria and aging
Prolla, T. A., Bohr, Vilhelm & de Souza-Pinto, N. C., Jul 2010, In: Mechanisms of Ageing and Development. 131, 7-8, p. 449-50 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases
Popuri, V., Croteau, D. L. & Bohr, Vilhelm, 4 Jun 2010, In: DNA Repair. 9, 6, p. 636-42 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy
Palikaras, K., Achanta, K., Choi, S., Akbari, M. & Bohr, Vilhelm, 2021, In: Aging. 13, 21, p. 23876-23894 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long-term NAD+ supplementation prevents the progression of age-related hearing loss in mice
Okur, M. N., Sahbaz, B. D., Kimura, R., Manor, U., Patel, J., Park, J. H., Andrade, L., Puligilla, C., Croteau, D. L. & Bohr, Vilhelm, 2023, In: Aging Cell. 22, 9, 14 p., e13909.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD+ signaling
Okur, M. N., Fang, E. F., Fivenson, E. M., Tiwari, V., Croteau, D. L. & Bohr, Vilhelm, Dec 2020, In: Aging Cell. 19, 12, p. e13268Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation
Okur, M. N., Lee, J., Osmani, W., Kimura, R., Demarest, T. G., Croteau, D. L. & Bohr, Vilhelm, 18 Mar 2020, In: Nucleic Acids Research. 48, 5, p. 2473-2485 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome
Okur, M. N., Mao, B., Kimura, R., Haraczy, S., Fitzgerald, T., Edwards-Hollingsworth, K., Tian, J., Osmani, W., Croteau, D. L., Kelley, M. W. & Bohr, Vilhelm, Jan 2020, In: npj Aging and Mechanisms of Disease. 6, 10 p., 1.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acquired Localized Cutis Laxa due to Increased Elastin Turnover
Nygaard, R. H., Maynard, S., Schjerling, P., Kjær, M., Qvortrup, Klaus, Bohr, Vilhelm, Rasmussen, Lene Juel, Jemec, Gregor & Heidenheim, M., 14 Jun 2016, In: Case Reports in Dermatology. 8, 1, p. 42-51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells
Nguyen, G. H., Dexheimer, T. S., Rosenthal, A. S., Chu, W. K., Singh, D. K., Mosedale, G., Bachrati, C. Z., Schultz, L., Sakurai, M., Savitsky, P., Abu, M., McHugh, P. J., Bohr, Vilhelm, Harris, C. C., Jadhav, A., Gileadi, O., Maloney, D. J., Simeonov, A. & Hickson, Ian David, 24 Jan 2013, In: Chemistry & Biology. 20, 1, p. 55-62 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease
Navarro, J. F., Croteau, D. L., Jurek, A., Andrusivova, Z., Yang, B., Wang, Y., Ogedegbe, B., Riaz, T., Støen, M., Desler, Claus, Rasmussen, Lene Juel, Tønjum, T., Galas, M. C., Lundeberg, J. & Bohr, Vilhelm, 2020, In: iScience. 23, 10, 42 p., 101556.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase
Muftuoglu, M., de Souza-Pinto, N. C., Dogan, A., Aamann, M., Stevnsner, T., Rybanska, I., Kirkali, G., Dizdaroglu, M. & Bohr, Vilhelm, Apr 2009, In: Journal of Biological Chemistry. 284, 14, p. 9270-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acetylation regulates WRN catalytic activities and affects base excision DNA repair
Muftuoglu, M., Kusumoto, R., Speina, E., Beck, G., Cheng, W. & Bohr, Vilhelm, Jan 2008, In: P L o S One. 3, 4, p. e1918Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
McCord, R. A., Michishita, E., Hong, T., Berber, E., Boxer, L. D., Kusumoto, R., Guan, S., Shi, X., Gozani, O., Burlingame, A. L., Bohr, Vilhelm & Chua, K. F., 1 Jan 2009, In: Aging. 1, 1, p. 109-21 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Base excision repair of oxidative DNA damage and association with cancer and aging
Maynard, S., Schurman, S. H., Harboe, C., de Souza-Pinto, N. C. & Bohr, Vilhelm, 1 Jan 2009, In: Carcinogenesis. 30, 1, p. 2-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients
Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, G., Hansen, Åse Marie, Desler, Claus, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In: Aging. 7, 10, p. 793-815 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mitochondrial base excision repair assays
Maynard, S., de Souza-Pinto, N. C., Scheibye-Knudsen, M. & Bohr, Vilhelm, 1 Aug 2010, In: Methods. 51, 4, p. 416-25 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Human embryonic stem cells have enhanced repair of multiple forms of DNA damage
Maynard, S., Swistowska, A. M., Lee, J. W., Liu, Y., Liu, S., Da Cruz, A. B., Rao, M., de Souza-Pinto, N. C., Zeng, X. & Bohr, Vilhelm, 1 Sep 2008, In: Stem Cells. 26, 9, p. 2266-74 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lamin A/C promotes DNA base excision repair
Maynard, S., Keijzers, G., Akbari, M., Ben Ezra, Michael, Hall, A., Morevati, M., Scheibye-Knudsen, Morten, Gonzalo, S., Bartek, J. & Bohr, Vilhelm, 2019, In: Nucleic Acids Research. 47, 22, p. 11709–11728Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1 and the NAMPT-NAD+ pathway
Maynard, S., Hall, A., Galanos, P., Rizza, S., Yamamoto, T., Gram, H. H., Munk, S. H. N., Shoaib, Muhammad, Sørensen, Claus Storgaard, Bohr, Vilhelm, Lerdrup, Mads, Maya-Mendoza, A. & Bartek, J., 2022, In: Nucleic Acids Research. 50, 17, p. 9948-9965 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA Damage, DNA Repair, Aging, and Neurodegeneration
Maynard, S., Fang, E. F., Scheibye-Knudsen, Morten, Croteau, D. L. & Bohr, Vilhelm, Oct 2015, In: Cold Spring Harbor Perspectives in Medicine. 5, 10, a025130.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4975983
Most downloads
-
308
downloads
Mitochondria in the signaling pathways that control longevity and health span
Research output: Contribution to journal › Review › Research › peer-review
Published -
281
downloads
Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
251
downloads
Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis
Research output: Contribution to journal › Journal article › Research › peer-review
Published