Acetylation regulates WRN catalytic activities and affects base excision DNA repair
Research output: Contribution to journal › Journal article › Research › peer-review
The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription.
|Journal||P L o S One|
|Publication status||Published - Jan 2008|
- Aging, Catalysis, Cell Line, DNA, DNA Damage, DNA Repair, Exodeoxyribonucleases, Exonucleases, Hela Cells, Histone Acetyltransferases, Humans, Protein Processing, Post-Translational, Protein Structure, Tertiary, RecQ Helicases, Recombinant Proteins, Transcription, Genetic