Line Elnif Thomsen

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Research Fields

• Molecular approaches to identifyand characterize virulence factors in human and animal pathogenic bacteria (Streptococcus, Listeria, Staphylococcus, Salmonella). Currently, my focus is on Streptococcus surface proteins and their importance for virulence and possible use for vaccine development
• Bacterial adaptation and molecular response to environmental changes.
• Host-Pathogen interactions.
• Antimicrobial peptides: due to the increase in antibiotic resistant pathogens, new compounds are investigated for their possible use as antimicrobials. Host defence peptides (HDPs), also known as antimicrobial peptides (AMPs), have emerged as potential new therapeutics and their antimicrobial spectrum covers a wide range of target organisms. we investigate the mode of action of natural and synthetic AMPs to elucidate their potential as lead structures of new compounds
• The application of C. elegans as virulence model. There is a continuing need for the development of simple animal models for the study of host-pathogen interactions. The implementation of nonmammalian model organisms such as Caenorhabditis elegans has proven successful, thereby reducing both cost and the ethical constraints associated with virulence studies using mammalian hosts.