Invited Lecture: From Host Defence Peptides to New Antibiotics
Research output: Contribution to conference › Conference abstract for conference › Research
Antimicrobial peptides hold promise as the next generation of antimicrobial agents. However, the potential is weakened by their susceptibility to proteolytic degradation, poor bioavailabillity , toxicity and high cost. Our research interest is in determining the structure/activity relationships of these antimicrobial peptides, which enables us to better understand their mechanism of action and facilitates the development of lead antimicrobial agents. As an example, in this talk I will focus on our work on anoplin and analogues, a decapeptide isolated from the Japanese wasp Anoplius samariensis. I will describe the elucidation of their structure/activity relationships, and our efforts towards developing them into antibiotics.
|Publication status||Published - 2014|
|Event||Antibiotic alternatives for the new millennium - London, London, United Kingdom|
Duration: 5 Nov 2014 → 7 Nov 2014
|Conference||Antibiotic alternatives for the new millennium|
|Period||05/11/2014 → 07/11/2014|