Invited Lecture: From Host Defence Peptides to New Antibiotics

Research output: Contribution to conferenceConference abstract for conferenceResearch

Antimicrobial peptides hold promise as the next generation of antimicrobial agents. However, the potential is weakened by their susceptibility to proteolytic degradation, poor bioavailabillity , toxicity and high cost. Our research interest is in determining the structure/activity relationships of these antimicrobial peptides, which enables us to better understand their mechanism of action and facilitates the development of lead antimicrobial agents. As an example, in this talk I will focus on our work on anoplin and analogues, a decapeptide isolated from the Japanese wasp Anoplius samariensis. I will describe the elucidation of their structure/activity relationships, and our efforts towards developing them into antibiotics.
Original languageEnglish
Publication date2014
Publication statusPublished - 2014
EventAntibiotic alternatives for the new millennium - London, London, United Kingdom
Duration: 5 Nov 20147 Nov 2014


ConferenceAntibiotic alternatives for the new millennium
CountryUnited Kingdom

ID: 127141479