Morten Frödin

Morten Frödin

Associate Professor

Member of:

    ORCID: 0000-0003-3691-9820

    Publication year:
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    1 - 44 out of 44Page size: 50
    1. 2023
    2. Published

      Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

      Green, A. C., Marttila, P., Kiweler, N., Chalkiadaki, C., Wiita, E., Cookson, V., Lesur, A., Eiden, K., Bernardin, F., Vallin, K. S. A., Borhade, S., Long, M., Ghahe, E. K., Jiménez-Alonso, J. J., Jemth, A-S., Loseva, O., Mortusewicz, O., Meyers, M., Viry, E., Johansson, A. I. & 14 others, Hodek, O., Homan, E., Bonagas, N., Ramos, L., Sandberg, L., Frödin, Morten, Moussay, E., Slipicevic, A., Letellier, E., Paggetti, J., Sørensen, Claus Storgaard, Helleday, T., Henriksson, M. & Meiser, J., 2023, In: Nature Metabolism. 5, p. 642-659

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Frequency and Functional Characterization of RUNX1 Germline Variants in Myeloid Neoplasms

      Nitschke, N. J., Almosailleakh, M., Niu, Yiyuan, Hansen, Jakob Werner, Raaschou-Jensen, K., Jespersen, Jakob Schmidt, Severinsen, M. T., Roug, A. S., Frödin, Morten, Weischenfeldt, Joachim Lütken, Andersen, M. K. & Grønbæk, Kirsten, 2023, In: Human Mutation. 2023, 11 p., 4738660.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. 2022
    5. Published

      Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select

      Niu, Yiyuan, Ferreira Azevedo, Catarina A, Li, Xin, Kamali, E., Nielsen, Ole Haagen, Sørensen, Claus Storgaard & Frödin, Morten, 2022, In: Nature Genetics. 54, 28 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. 2021
    7. Published

      CRISPR/Cas9-mediated knockout of clinically relevant alloantigenes in human primary T cells

      Kamali, E., Rahbarizadeh, F., Hojati, Z. & Frödin, Morten, 2021, In: BMC Biotechnology. 21, 1, 9.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. 2020
    9. Published

      INDEL detection, the 'Achilles heel' of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels

      Bennett, Eric Paul, Petersen, B. L., Johansen, I. E., Niu, Yiyuan, Yang, Zhang, Chamberlain, C. A., Met, Özcan, Wandall, Hans H. & Frödin, Morten, 2020, In: Nucleic Acids Research. 48, 21, p. 11958-11981 24 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth

      Ouyang, H., Luong, P., Frödin, Morten & Hansen, S. H., 2020, In: Oncogene. 39, 33, p. 5570-5587

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. 2019
    12. Published

      In Vivo Editing of the Adult Mouse Liver Using CRISPR/Cas9 and Hydrodynamic Tail Vein Injection

      Niola, Francesco, Dagnæs-Hansen, F. & Frödin, Morten, 2019, CRISPR Gene Editing: Methods and Protocols. Luo, Y. (ed.). New York, NY: Humana Press, Vol. 1961. p. 329-341 13 p. 20. (Methods in molecular biology (Clifton, N.J.)).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    13. 2018
    14. Published

      Correction: p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity

      Frank, S. R., Köllmann, C. P., Luong, P., Galli, G. G., Zou, L., Bernards, A., Getz, G., Calogero, R. A., Frödin, Morten & Hansen, S. H., 2018, In: The Journal of Cell Biology. 217, 9, p. 3313 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    15. Published

      De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium

      Lavrsen, K., Dabelsteen, Sally, Vakhrushev, Sergey, Levann, Asha Maria Rudjord, Haue, Amalie Dahl, Dylander, A., Mandel, Ulla, Hansen, Lars, Frödin, Morten, Bennett, Eric Paul & Wandall, Hans H., 2018, In: The Journal of Biological Chemistry. 293, p. 1298-1314

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity

      Frank, S. R., Köllmann, C. P., Luong, P., Galli, G. G., Zou, L., Bernards, A., Getz, G., Calogero, R. A., Frödin, Morten & Hansen, S. H., 2018, In: The Journal of Cell Biology. 217, 9, p. 3183-3201 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. 2017
    18. Published

      CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1–Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma

      Engelholm, Lars Henning, Riaz, A., Serra, Denise, Dagnæs-Hansen, F., Johansen, Jens Vilstrup, Santoni Rugiu, Eric, Hansen, S. H., Niola, Francesco & Frödin, Morten, 1 Dec 2017, In: Gastroenterology. 153, 6, p. 1662-1673.e10

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion

      Frank, S. R., Köllmann, C. P., van Lidth de Jeude, J. F., Thiagarajah, J. R., Engelholm, Lars Henning, Frödin, Morten & Hansen, S. H., 30 Mar 2017, In: Oncogene. 36, 13, p. 1816-1828 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis

      Lonowski, Lindsey Allison, Narimatsu, Yoshiki, Riaz, A., Delay, C. M. E., Yang, Zhang, Niola, Francesco, Duda, K., Ober, Elke, Clausen, Henrik, Wandall, Hans H., Hansen, S. H., Bennett, Eric Paul & Frödin, Morten, Mar 2017, In: Nature Protocols. 12, 3, p. 581-603 23 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. 2015
    22. Published

      Engineered CHO cells for production of diverse, homogeneous glycoproteins

      Yang, Zhang, Wang, S., Halim, Adnan, Schulz, M. A., Frödin, Morten, Rahman, S. H., Vester-Christensen, M. B., Behrens, C., Kristensen, C., Vakhrushev, Sergey, Bennett, Eric Paul, Wandall, Hans H. & Clausen, Henrik, 20 Jul 2015, In: Nature Biotechnology. 33, 8, p. 842-844 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment

      Nyegaard, M., Rendtorff, N. D., Nielsen, M. S., Corydon, T. J., Demontis, D., Starnawska, A., Hedemand, A., Buniello, A., Niola, F., Overgaard, M. T., Leal, S. M., Ahmad, W., Wikman, F. P., Petersen, K. B., Crueger, D. G., Oostrik, J., Kremer, H., Tommerup, N., Froedin, M., Steel, K. P. & 2 others, Tranebjærg, Lisbeth & Borglum, A. D., Jul 2015, In: P L o S Genetics. 11, 7, p. 1-25 25 p., e1005386.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Fast and sensitive detection of indels induced by precise gene targeting

      Yang, Zhang, Steentoft, C., Hauge, C., Hansen, Lars, Thomsen, A. L., Niola, Francesco, Vester-Christensen, M. B., Frödin, Morten, Clausen, Henrik, Wandall, Hans H. & Bennett, Eric Paul, 2015, In: Nucleic Acids Research. 43, 9, p. 1-8 8 p., e59.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. 2014
    26. Published

      High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs

      Duda, K., Lonowski, Lindsey Allison, Kofoed-Nielsen, M., Ibarra, A., Delay, C. M., Kang, Q., Yang, Zhang, Pruett-Miller, S. M., Bennett, Eric Paul, Wandall, Hans H., Davis, G. D., Hansen, S. H. & Frödin, Morten, 21 Apr 2014, In: Nucleic Acids Research. 42, 10, p. 1-16 16 p., e84.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. 2012
    28. Published

      A βPIX-PAK2 complex confers protection against Scrib-dependent and cadherin-mediated apoptosis

      Frank, S. R., Bell, J. H., Frödin, Morten & Hansen, S. H., 9 Oct 2012, In: Current biology : CB. 22, 19, p. 1747-54 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

      Serafimova, I. M., Pufall, M. A., Krishnan, S., Duda, K., Cohen, M. S., Maglathlin, R. L., McFarland, J. M., Miller, R. M., Frödin, Morten & Taunton, J., May 2012, In: Nature Chemical Biology. 8, 5, p. 471-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. 2011
    31. Published

      High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

      Chen, F., Pruett-Miller, S. M., Huang, Y., Gjoka, M., Duda, K., Taunton, J., Collingwood, T. N., Frödin, Morten & Davis, G. D., Sep 2011, In: Nature Methods. 8, 9, p. 753-5 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. 2009
    33. Published

      RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells

      Doehn, U., Hauge, C., Frank, S. R., Jensen, C. A. J., Duda, K., Nielsen, J. V., Cohen, M. S., Johansen, Jens Vilstrup, Winther, B. R., Lund, L. R., Winther, Ole, Taunton, J., Hansen, S. H. & Frödin, Morten, 2009, In: Molecular Cell. 35, 4, p. 511-22 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1)

      Dettori, R., Sonzogni, S., Meyer, L., Lopez-Garcia, L. A., Morrice, N. A., Zeuzem, S., Engel, M., Piiper, A., Neimanis, S., Frödin, Morten & Biondi, R. M., 2009, In: Journal of Biological Chemistry. 284, 44, p. 30318-27 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. 2007
    36. Published

      A RSK kinase inhibitor reporting its selectivity in vivo.

      Frödin, Morten, 2007, In: Nature Chemical Biology. 3, 3, p. 138-9 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

      Sapkota, G. P., Cummings, L., Newell, F. S., Armstrong, C., Bain, J., Frödin, Morten, Grauert, M., Hoffmann, M., Schnapp, G., Steegmaier, M., Cohen, P. & Alessi, D. R., 2007, In: Biochemical Journal. 401, 1, p. 29-38 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Heregulin-induced epigenetic regulation of the utrophin-A promoter.

      Basu, U., Gyrd-Hansen, Mads, Baby, S. M., Lozynska, O., Krag, T. O. B., Jensen, C. J., Frödin, Morten & Khurana, T. S., 2007, In: FEBS Letters. 581, 22, p. 4153-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation.

      Hauge, C., Antal, T. L., Hirschberg, D., Doehn, U., Thorup, K., Idrissova, L., Hansen, K., Jensen, O. N., Jørgensen, T. J., Biondi, R. M. & Frödin, Morten, 2007, In: EMBO Journal. 26, 9, p. 2251-61 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. 2006
    41. Published

      RSK and MSK in MAP kinase signalling.

      Hauge, C. & Frödin, Morten, 2006, In: Journal of Cell Science. 119, Pt 15, p. 3021-3 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. 2005
    43. Published

      Analysis of 65 tuberous sclerosis complex (TSC) patients by TSC2 DGGE, TSC1/RSC2 MLPA, and TSC1 long-range PCR sequencing, and report of 28 novel mutations

      Rendtorff, N. D., Bjerregaard, B., Frödin, Morten, Kjaergaard, S., Hove, H., Skovby, F., Brøndum-Nielsen, T. D. T. S. G. K. & Schwartz, M., 2005, In: Human Mutation. 26, 4, p. 374-383 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.

      Dümmler, B. A., Hauge, C., Silber, J., Yntema, H. G., Kruse, L. S., Kofoed, B., Hemmings, B. A., Alessi, D. R. & Frödin, Morten, 2005, In: Journal of Biological Chemistry. 280, 14, p. 13304-14 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein.

      Artus, J., Vandormael-Pournin, S., Frödin, Morten, Nacerddine, K., Babinet, C. & Cohen-Tannoudji, M., 2005, In: Molecular and Cellular Biology. 25, 14, p. 6289-302 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. 2004
    47. Published

      Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells.

      Silverman, E., Frödin, Morten, Gammeltoft, S. & Maller, J. L., 2004, In: Molecular and Cellular Biology. 24, 24, p. 10573-83 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. 2003
    49. Published

      ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

      Zhao, J., Yuan, X., Frödin, Morten & Grummt, I., 2003, In: Molecular Cell. 11, 2, p. 405-13 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Xp38gamma/SAPK3 promotes meiotic G(2)/M transition in Xenopus oocytes and activates Cdc25C.

      Perdiguero, E., Pillaire, M., Bodart, J., Hennersdorf, F., Frödin, Morten, Duesbery, N. S., Alonso, G. & Nebreda, A. R., 2003, In: EMBO Journal. 22, 21, p. 5746-56 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. 2002
    52. Published

      A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.

      Frödin, Morten, Antal, T. L., Dümmler, B. A., Jensen, C. J., Deak, M., Gammeltoft, S. & Biondi, R. M., 2002, In: EMBO Journal. 21, 20, p. 5396-407 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. 2001
    54. Published

      Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation.

      Rendtorff, N. D., Frödin, Morten, Attié-Bitach, T., Vekemans, M. & Tommerup, Niels, 2001, In: Genomics. 71, 1, p. 40-52 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. 2000
    56. Published

      A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

      Frödin, Morten, Jensen, C. A. J., Merienne, K. & Gammeltoft, S., 2000, In: EMBO Journal. 19, 12, p. 2924-34 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. 1999
    58. Published

      90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

      Jensen, C. A. J., Buch, M. B., Krag, T. O., Hemmings, B. A., Gammeltoft, S. & Frödin, Morten, 1999, In: Journal of Biological Chemistry. 274, 38, p. 27168-76 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.

      Frödin, Morten & Gammeltoft, S., 1999, In: Molecular and Cellular Endocrinology. 151, 1-2, p. 65-77 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Transforming growth factor-beta, but not ciliary neurotrophic factor, inhibits DNA synthesis of adrenal medullary cells in vitro.

      Wolf, N., Krohn, K., Bieger, S., Frödin, Morten, Gammeltoft, S., Krieglstein, K. & Unsicker, K., 1999, In: Neuroscience. 90, 2, p. 629-41 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. 1995
    62. Published

      Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.

      Frödin, Morten, Sekine, N., Roche, E., Filloux, C., Prentki, M., Wollheim, C. B. & Van Obberghen, E., 1995, In: Journal of Biological Chemistry. 270, 14, p. 7882-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Neuronal localization of pituitary adenylate cyclase-activating polypeptide 38 in the adrenal medulla and growth-inhibitory effect on chromaffin cells.

      Frödin, Morten, Hannibal, J., Wulff, B. S., Gammeltoft, S. & Fahrenkrug, J., 1995, In: Neuroscience. 65, 2, p. 599-608 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP.

      Peraldi, P., Frödin, Morten, Barnier, J. V., Calleja, V., Scimeca, J. C., Filloux, C., Calothy, G. & Van Obberghen, E., 1995, In: FEBS Letters. 357, 3, p. 290-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. 1994
    66. Published

      Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.

      Frödin, Morten, Peraldi, P. & Van Obberghen, E., 1994, In: Journal of Biological Chemistry. 269, 8, p. 6207-14 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Published

      Insulin-like growth factors act synergistically with basic fibroblast growth factor and nerve growth factor to promote chromaffin cell proliferation.

      Frödin, Morten & Gammeltoft, S., 1994, In: Proceedings of the National Academy of Science of the United States of America. 91, 5, p. 1771-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    ID: 9576