Ulla Mandel
Visiting researcher
Glycomics Program
Blegdamsvej 3
2200 København N.
My research is focused on diagnostic/therapeutic applications of monoclonal antibodies (mAbs). We develop mAbs (https://glycomics.ku.dk/research--resources/) to probe biosynthesis of mucin-type O-glycosylation and truncated cancer O-glycans. Our mAbs directed to mucins with truncated O-glycans have cancer-specific reactivity. One mAb designated 5E5 is directed to a cancer-specific epitope on mucin-1, and this is now in a phase 1 clinical trial (CAR-T) at UPENN/Tmunity with collaborators. A novel cell-based mucin display platform is used to explore immunogenicity of human cancer mucins for vaccine developments and to generate novel cancer-specific mAbs. One of these novel mAbs is currently under preclinical evaluation by a company.
ID: 11074
Most downloads
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156
downloads
Mucins and Truncated O-Glycans Unveil Phenotypic Discrepancies between Serous Ovarian Cancer Cell Lines and Primary Tumours
Research output: Contribution to journal › Journal article › peer-review
Published -
154
downloads
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
Research output: Contribution to journal › Journal article › peer-review
Published -
139
downloads
Expression of the O-Glycosylation Enzyme GalNAc-T3 in the Equatorial Segment Correlates with the Quality of Spermatozoa
Research output: Contribution to journal › Journal article › peer-review
Published