Jette Sandholm Jensen Kastrup
Professor
Structural Biology
Universitetsparken 2
2100 København Ø
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Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus
Wang, X., Hald, H., Ernst, H. A., Egebjerg, J., Christensen, K. V., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Mirza, Osman Asghar, 2010, In: Protein Expression and Purification. 71, 2, p. 179-183Research output: Contribution to journal › Journal article › Research › peer-review
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Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues
Wang, S., Larsen, Y., Navarrete, C. V., Jensen, Anders A., Nielsen, Birgitte, Al-Musaed, A., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen, Pickering, Darryl S & Clausen, Rasmus Prætorius, 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2244-2254 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A tetrazolyl-substituted subtype-selective AMPA receptor agonist
Vogensen, S. B., Frydenvang, Karla Andrea, Greenwood, J. R., Postorino, G., Nielsen, Birgitte, Pickering, Darryl S, Ebert, B., Bølcho, U., Egebjerg, J., Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Johansen, Tommy Nørskov, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2007, In: Journal of Medicinal Chemistry. 50, 10, p. 2408-2414Research output: Contribution to journal › Journal article › Research › peer-review
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The SAXS Solution Structure of RF1 Differs from Its Crystal Structure and Is Similar to Its Ribosome Bound Cryo-EM Structure
Vestergaard, Bente, Sanyal, S., Roessle, M., Mora, L., Buckingham, R., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Svergun, D. I. & Ehrenberg, M., 2005, In: Molecular Cell. 20, p. 929-938Research output: Contribution to journal › Journal article › Research › peer-review
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A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils
Vestergaard, Bente, Jensen, M. G., Roessle, M., Kastrup, Jette Sandholm Jensen, van de Weert, Marco, Flink, J. M., Frøkjær, Sven, Gajhede, Michael & Svergun, D. I., 2007, In: PLoS - Biology. 5, 5, p. 1089-1097Research output: Contribution to journal › Journal article › Research › peer-review
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Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate
Venskutonyte, R., Frydenvang, Karla Andrea, Gajhede, Michael, Bunch, Lennart, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, Dec 2011, In: Journal of Structural Biology. 176, 3, p. 307-314Research output: Contribution to journal › Journal article › Research › peer-review
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Corrigendum to "Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate" [J. Struct. Biol. 176 (2011) 307-314]
Venskutonyte, R., Frydenvang, Karla Andrea, Gajhede, Michael, Bunch, Lennart, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, Nov 2013, In: Journal of Structural Biology. 184, 2, p. 381 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Kainate induces various domain closures in AMPA and kainate receptors
Venskutonyte, R., Frydenvang, Karla Andrea, Hald, H., Rabassa, A. C. D., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, Sep 2012, In: Neurochemistry International. 61, 4, p. 536-545Research output: Contribution to journal › Journal article › Research › peer-review
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Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization
Venskutonyte, R., Butini, S., Coccone, S. S., Gemma, S., Brindisi, M., Kumar, V., Guarino, E., Maramai, S., Valenti, S., Amir, A., Valades, E. A., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen, Novellino, E., Campiani, G. & Pickering, Darryl S, 14 Jul 2011, In: Journal of Medicinal Chemistry. 54, 13, p. 4793-4805Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain
Venskutonyte, R., Larsen, A. P., Frydenvang, Karla Andrea, Gajhede, Michael, Gefflaut, T., Pickering, Darryl S, Bunch, Lennart & Kastrup, Jette Sandholm Jensen, 2014, In: ChemMedChem. 9, 10, p. 2254-2259 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors
Venskutonyte, R., Frydenvang, Karla Andrea, Valadés, E. A., Szymanska, E. M., Johansen, Tommy Nørskov, Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, Oct 2012, In: ChemMedChem. 7, 10, p. 1793-1798 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists
Ussing, C. A., Hansen, C. P., Petersen, J. G., Jensen, Anders A., Rohde, L. A. H., Ahring, P. K., Nielsen, E. Ø., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Frølund, Bente & Balle, T., 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 940-951Research output: Contribution to journal › Journal article › Research › peer-review
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The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region
Tapken, D., Steffensen, T. B., Leth, R., Kristensen, L. B., Gerbola, A., Gajhede, Michael, Jørgensen, Flemming Steen, Olsen, L. & Kastrup, Jette Sandholm Jensen, 7 Apr 2017, In: Scientific Reports. 7, 12 p., 46145.Research output: Contribution to journal › Journal article › Research › peer-review
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Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors
Szymanska, E., Frydenvang, Karla Andrea, Pickering, Darryl S, Krintel, C., Nielsen, Birgitte, Kooshki, A., Zachariassen, L. G., Olsen, L., Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 2016, In: Journal of Medicinal Chemistry. 59, 1, p. 448-461 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: Synthesis, resolution, pharmacology, and crystal structure
Szymanska, E., Frydenvang, Karla Andrea, Contreras-Sanz, A., Pickering, Darryl S, Frola, E., Serafimoska, Z., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 4 Oct 2011, In: Journal of Medicinal Chemistry. 54, 20, p. 7289-7298Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis
Sprogøe, D., van den Broek, L. A. M., Mirza, Osman Asghar, Kastrup, Jette Sandholm Jensen, Voragen, A. G. J., Gajhede, Michael & Skov, L., 10 Feb 2004, In: Biochemistry. 43, 5, p. 1156-62 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion
Soroka, V., Kolkova, K., Kastrup, Jette Sandholm Jensen, Diederichs, K., Breed, J., Kiselyov, V., Poulsen, F. M., Larsen, I. K., Welte, W., Berezin, V., Bock, E. & Kasper, C., 2003, In: Structure. 10, p. 1291-1301Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom
Skov, L. K., Seppälä, U., Coen, J. J. F., Crickmore, N., King, T. P., Monsalve, R., Kastrup, Jette Sandholm Jensen, Spangfort, M. D. & Gajhede, Michael, 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, Pt 6, p. 595-604 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Snegleprotein øger forståelsen af vigtige receptorer i hjernen
Shahsavar, Azadeh, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael, Balle, T. & Kastrup, Jette Sandholm Jensen, 2012, In: Lægemiddelforskning. 2012, p. 48-50 3 p.Research output: Contribution to journal › Journal article › Communication
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Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine Binding Protein as a Structural Surrogate
Shahsavar, A., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 17 Nov 2015, In: Basic & Clinical Pharmacology & Toxicology Online. 118, 6, p. 399–407 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism
Shahsavar, Azadeh, Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In: P L o S One. 7, 8, p. e40757Research output: Contribution to journal › Journal article › Research › peer-review
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Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity
Shahsavar, A., Ahring, P. K., Olsen, J. A., Krintel, C., Kastrup, Jette Sandholm Jensen, Balle, T. & Gajhede, Michael, Oct 2015, In: Molecular Pharmacology. 88, 4, p. 697-707 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool for the Development of Ionotropic Glutamate Receptor Ligands
Sainas, S., Temperini, P., Farnsworth, J. C., Yi, F., Møllerud, S., Jensen, Anders A., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen, Hansen, K. B., Boschi, D., Pickering, Darryl S, Clausen, Rasmus Prætorius & Lolli, M., 2019, In: Journal of Medicinal Chemistry. 62, p. 4467-4482Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype
Røder, G., Blicher, T., Justesen, S., Johannesen, B., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, Pt 11, p. 1300-10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501
Røder, G., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt 6, p. 459-62 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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High resolution crystal structures of the p120 RasGAP SH3 domain
Ross, B., Kristensen, O., Favre, D., Walicki, J., Kastrup, Jette Sandholm Jensen, Widmann, C. & Gajhede, Michael, 2007, In: Biochemical and Biophysical Research Communications. 353, 2, p. 463-468Research output: Contribution to journal › Journal article › Research › peer-review
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Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed
Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 3 Feb 2012, In: The Journal of Biological Chemistry. 287, 6, p. 4248-4259Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3950 (1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane)
Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. O., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 14 Dec 2011Research output: Other contribution › Research
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Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.
Rasmussen, K. K., Kulahin, N., Kristensen, O., Poulsen, Jens-Christian Navarro, Sigurskjold, B. W., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 2008, In: Journal of Molecular Biology. 382, 5, p. 1113-20 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 Å resolution
Rasmussen, H. B., Kastrup, Jette Sandholm Jensen, Nielsen, J. N., Nielsen, J. M. & Nielsen, Peter E., 1997, In: Nature Structural and Molecular Biology. 4, p. 98-101 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The influence of a chiral amino acid on the helical handedness of PNA in solution and in crystals
Rasmussen, H. B., Liljefors, T., Petersson, B., Nielsen, Peter E., Liljefors, T. & Kastrup, Jette Sandholm Jensen, Feb 2004, In: Journal of Biomolecular Structure & Dynamics. 21, 4, p. 495-502 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators
Pøhlsgaard, J., Frydenvang, Karla Andrea, Madsen, Ulf & Kastrup, Jette Sandholm Jensen, 1 Jan 2011, In: Neuropharmacology. 60, 1, p. 135-150Research output: Contribution to journal › Review › Research › peer-review
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Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network
Petersson, B., Nielsen, B. B., Rasmussen, H., Larsen, I. K., Gajhede, Michael, Nielsen, Peter E. & Kastrup, Jette Sandholm Jensen, 9 Feb 2005, In: Journal of the American Chemical Society. 127, 5, p. 1424-30 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis
Pedersen, A. K., Guo, X., Møller, K. B., Peters, G. H., Andersen, H. S., Kastrup, Jette Sandholm Jensen, Mortensen, T. S., Iversen, L. F., Zhang, Z. & Møller, N. P. H., 1 Mar 2004, In: Biochemical Journal. 378, Pt 2, p. 421-33 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B
Pedersen, A. K., Peters G, G. Ü. H., Møller, K. B., Iversen, L. F. & Kastrup, Jette Sandholm Jensen, Sep 2004, In: Acta Crystallographica. Section D: Biological Crystallography. 60, Pt 9, p. 1527-34 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit
Paës, G., Skov, L. K., O'Donohue, M. J., Rémond, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2008, In: Biochemistry. 47, 28, p. 7441-7451Research output: Contribution to journal › Journal article › Research › peer-review
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N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology
Pallesen, J. S., Møllerud, S., Frydenvang, Karla Andrea, Pickering, Darryl S, Bornholt, J., Nielsen, Birgitte, Pasini, D., Han, L., Marconi, L., Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 20 Mar 2019, In: A C S Chemical Neuroscience. 10, p. 1841-1853 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor
Owczarek, S., Kiryushko, D., Hald Larsen, M., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sandi, C., Berezin, V., Bock, E. & Soroka, V., 2010, In: The FASEB Journal. 24, 4, p. 1139-1150 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Hvad har varme at gøre med lægemidler?
Olsen, L., Kasper, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Jørgensen, Flemming Steen, 2006, In: Lægemiddelforskning. p. 31-33Research output: Contribution to journal › Journal article › Communication
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Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.
Olsen, J. A., Kastrup, Jette Sandholm Jensen, Peters, D., Gajhede, Michael, Balle, T. & Ahring, P. K., 13 Dec 2013, In: Journal of Biological Chemistry. 288, 50, p. 35997 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors
Olsen, J. A., Balle, T., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, 17 Mar 2014, In: PLOS ONE. 9, 3, p. e91232 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors
Olsen, J. A., Ahring, P. K., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Balle, T., 5 Sep 2014, In: The Journal of Biological Chemistry. 289, 36, p. 24911-21 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces
Nørholm, A., Francotte, P., Goffin, E., Botez, I., Danober, L., Lestage, P., Pirotte, B., Kastrup, Jette Sandholm Jensen, Olsen, L. & Oostenbrink, C., 22 Dec 2014, In: Journal of Chemical Information and Modeling. 54, 12, p. 3404-16 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold
Nørholm, A., Francotte, P., Olsen, L., Krintel, C., Frydenvang, Karla Andrea, Goffin, E., Challal, S., Danober, L., Botez-Pop, I., Lestage, P., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 14 Nov 2013, In: Journal of Medicinal Chemistry. 56, 21, p. 8736-45 10 p.Research output: Contribution to journal › Journal article › Research
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Crystal structure of tetranectin, a trimeric plasminogen binding protein with an alpha-helical coiled coil
Nielsen, B. B., Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Las Holtet, T., Graversen, J. H., Etzerodt, M., Thøgersen, H. C. & Larsen, I. K., 1997, In: FEBS Letters. 412, p. 388-396 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP
Nielsen, B. B., Pickering, Darryl S, Greenwood, J. R., Brehm, L., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In: FEBS Journal. 272, 7, p. 1639-48 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystallization and molecular-replacement solution of a truncated form of human recombinant tetranectin
Nielsen, B. B., Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Graversen, J. H., Etzerodt, M., Thøgersen, H. C. & Larsen, I. K., May 2000, In: Acta Crystallographica. Section D: Biological Crystallography. 56, Pt 5, p. 637-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Jagten på et signalstof til hjernens delta2-receptor
Naur, P., Olsen, L., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Lægemiddelforskning. p. 32-33Research output: Contribution to journal › Journal article › Communication
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Ionotropic glutamate-like receptor d2 binds D-serine and glycine.
Naur, P., Hansen, K. B., Kristensen, Anders Skov, Dravid, S. M., Pickering, Darryl S, Olsen, L., Vestergaard, Bente, Egebjerg, J., Gajhede, Michael, Traynelis, S. F. & Kastrup, Jette Sandholm Jensen, 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 35, p. 14116-14121Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate
Naur, P., Vestergaard, Bente, Skov, L., Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2005, In: FEBS Letters. 579, p. 1154-60Research output: Contribution to journal › Journal article › Research › peer-review
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Lessons from crystal structures of kainate receptors
Møllerud, S., Frydenvang, Karla Andrea, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 1 Jan 2017, In: Neuropharmacology. 112, Part A, p. 16-28 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide - a new kainate receptor selective antagonist and analgesic: Synthesis, X-ray crystallography, structure-affinity relationships, in vitro and in vivo pharmacology
Møllerud, S., Hansen, R. B., Pallesen, J. S., Temperini, Piero, Pasini, D., Bornholdt, J., Nielsen, Birgitte, Mamedova, Esmira, Chalupnik, P., Paternain, A. V., Lerma, J., Del Castillo, M. D., Andreasen T., Jesper, Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen, Johansen, Tommy Nørskov & Pickering, Darryl S, 2019, In: ACS Chemical Neuroscience. 10, p. 4685-4695 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A pharmacological profile of the high-affinity GluK5 kainate receptor
Møllerud, S., Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, 2016, In: European Journal of Pharmacology. 788, p. 315-320 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and affinity of two bicyclic glutamate analogues at AMPA and kainate receptors
Møllerud, S., Pinto, A., Marconi, L., Frydenvang, Karla Andrea, Thorsen, T. S., Laulumaa, S. K., Venskutonyte, R., Winther, Nikolaj Sebastian, Cunado Moral, A. M., Tamborini, L., Conti, P., Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2017, In: A C S Chemical Neuroscience. 8, 9, p. 2056-2064 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors
Møllerud, S., Pallesen, J. S., Pasini, D., Marconi, L., Han, L., Bornholt, J., Johansen, Tommy Nørskov, Kastrup, Jette Sandholm Jensen, Pickering, Darryl S & Frydenvang, Karla Andrea, Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 124 1 p., MTU07-13.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Targeting specific sub-domains of the GluA4 ionotropic glutamate receptor by murine Fab fragments
Mohr, A. Ø., Riise, E. S., Pickering, Darryl S, Jensen, A. A., Madden, D., Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius & Skottrup, P. D., 16 Jun 2011.Research output: Contribution to conference › Poster › Research › peer-review
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Establishment of an immunized murine Fab library for selection of iGluR6 binders by phage display
Mohr, A. Ø., Skottrup, P. D., Jensen, A. A., Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius & Riise, E. S., 28 May 2009.Research output: Contribution to conference › Poster › Research
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Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion
Mirza, Osman Asghar, Henriksen, L. S., Sprogøe, D., van den Broek, L. A. M., Beldman, G., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2006, In: Journal of Biological Chemistry. 281, 46, p. 35576-84 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering
Midtgaard, S. R., Darwish, T. A., Pedersen, M. C., Huda, P., Larsen, A. H., Jensen, G. V., Kynde, S. A. R., Skar-Gislinge, N., Nielsen, A. J. Z., Olesen, C., Blaise, M., Dorosz, J. J., Thorsen, T. S., Venskutonytė, R., Krintel, C., Møller, J. V., Frielinghaus, H., Gilbert, E. P., Martel, A., Kastrup, J. S. J. & 3 others, , Jan 2018, In: F E B S Journal. 285, 2, p. 357-371 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1
Meno, K. H., Kastrup, Jette Sandholm Jensen, Kuo, I., Chua, K. Y. & Gajhede, Michael, 1 Apr 2017, In: Allergy. 72, 4, p. 665-670 6 p., 13111.Research output: Contribution to journal › Journal article › Research › peer-review
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Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics
Masternak, Magdalena, Koch, A., Laulumaa, S., Tapken, D., Hollmann, M., Jørgensen, Flemming Steen & Kastrup, Jette Sandholm Jensen, 2023, In: F E B S Journal. 290, 15, p. 3781-3801Research output: Contribution to journal › Journal article › Research › peer-review
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Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity
Lunn, M., Hogner, A., Stensbøl, T. B., Gouaux, E., Egebjerg, J. & Kastrup, Jette Sandholm Jensen, 27 Feb 2003, In: Journal of Medicinal Chemistry. 46, 5, p. 872-5 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lipopolysaccharide affinity measurement by scintillation proximity assay: application to human heparin binding protein
Linde, V., Bjørn, S., Kastrup, Jette Sandholm Jensen & Flodgaard, H., Feb 2000, In: BioTechniques. 28, 2, p. 218-20, 222Research output: Contribution to journal › Journal article › Research › peer-review
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Measurement of apoptosis by the TUNEL method using scintillating microplates
Linde, V., Flodgaard, H., Kastrup, Jette Sandholm Jensen & Bjørn, S., 10 Apr 2000, In: Analytical Biochemistry. 280, 1, p. 186-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel Guaiane Esters from Thapsia villosa
Lemmich, E., Smitt, U. W., Kastrup, Jette Sandholm Jensen & Christensen, Søren Brøgger, 1991, In: Phytochemistry. 30, p. 2987-2990 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor
Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, Karla Andrea & Kastrup, Jette Sandholm Jensen, 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 243-247 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors
Larsen, A. P., Francotte, P., Frydenvang, Karla Andrea, Tapken, D., Goffin, E., Fraikin, P., Caignard, D., Lestage, P., Danober, L., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 16 Mar 2016, In: A C S Chemical Neuroscience. 7, 3, p. 378-90 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors
Larsen, A. P., Fièvre, S., Frydenvang, Karla Andrea, Francotte, P., Pirotte, B., Kastrup, Jette Sandholm Jensen & Mulle, C., Jun 2017, In: Molecular Pharmacology. 91, 6, p. 576-585 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Recovery from desensitization in GluA2 AMPA receptors is affected by a single mutation in the N-terminal domain interface
Nørgrd Larsen, Andreas, Perozzo, A. M., Biggin, P. C., Bowie, D. & Kastrup, Jette Sandholm Jensen, 2024, In: Journal of Biological Chemistry. 300, 3, 10 p., 105717.Research output: Contribution to journal › Journal article › Research › peer-review
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Small-angle neutron scattering studies on the AMPA receptor GluA2 in the resting, AMPA-bound and GYKI-53655-bound states
Nørgrd Larsen, Andreas, Dorosz, J., Thorsen, T. S., Johansen, Nicolai Tidemand, Darwish, T., Midtgaard, S. R., Arleth, Lise & Kastrup, Jette Sandholm Jensen, Nov 2018, In: IUCrJ. 5, p. 780-793Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site
Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner, Hans, 2013, In: The Journal of Biological Chemistry. 288, p. 33124-35 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of NCAM2 IgIV-Fn3I
Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009Research output: Non-textual form › Dataset › Research
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Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I-IV and F3 modules I-III of the neural cell-adhesion molecule L1
Kulahin, N., Kasper, C., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. & Gajhede, Michael, 2005, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 61, Pt 9, p. 858-60 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal Structure of NCAM2 Ig1 (I4122 Cell Unit)
Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Poulsen, Jens-Christian Navarro, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008Research output: Non-textual form › Dataset › Research
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Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2007, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 63, Pt2, p. 65-68 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dimerization effect of sucrose octasulfate on rat FGF1.
Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt6, p. 448-452 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of NCAM2 IgIV-Fn3II
Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009Research output: Non-textual form › Dataset › Research
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Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1
Kulahin, N., Kasper, C., Gajhede, Michael, Berezin, V., Bock, E. & Kastrup, Jette Sandholm Jensen, Mar 2004, In: Acta Crystallographica. Section D: Biological Crystallography. 60, Pt 3, p. 591-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule
Kulahin, N., Kristensen, O., Rasmussen, K. K., Olsen, L., Rydberg, P., Vestergaard, Bente, Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 9 Feb 2011, In: Structure. 19, 2, p. 203-211Research output: Contribution to journal › Journal article › Research › peer-review
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Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid
Krogsgaard-Larsen, N., Delgar, C., Koch, K., Brown, P. M. G. E., Møller, C., Han, L., Huynh, Tri Hien Viet, Hansen, S. W., Nielsen, Birgitte, Bowie, D., Pickering, Darryl S, Kastrup, Jette Sandholm Jensen, Frydenvang, Karla Andrea & Bunch, Lennart, 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 441-457 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid
Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, Birgitte, Tapken, D., Pickering, Darryl S, Kastrup, Jette Sandholm Jensen, Frydenvang, Karla Andrea & Bunch, Lennart, 2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6131-50 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family
Kristensen, O., Laurberg, M., Liljas, A., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2004, In: Biochemistry. 43, 28, p. 8894-900 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate
Kristensen, O., Kristensen, L. B., Møllerud, S., Frydenvang, Karla Andrea, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2016, In: Structure. 24, 9, p. 1582-1589 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A unique set of SH3-SH3 interactions controls IB1 homodimerization
Kristensen, O., Guenat, S., Dar, I., Allaman-Pillet, N., Abderrahmani, A., Ferdaoussi, M., Roduit, R., Maurer, F., Beckmann, J. S., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Bonny, C., 2006, In: E M B O Journal. 25, 4, p. 785-97 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor
Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, P., Kastrup, Jette Sandholm Jensen, Helin, K., Olsen, L. & Gajhede, Michael, Jun 2012, In: F E B S Journal. 279, 11, p. 1905-1914Research output: Contribution to journal › Journal article › Research › peer-review
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Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases
Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In: F E B S Letters. 585, 12, p. 1951-1956Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors
Kristensen, Anders Skov, Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, Rasmus Prætorius, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., Feb 2016, In: Molecular Pharmacology. 89, 2, p. 253-262 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain
Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In: F E B S Journal. p. 2422–2430 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2
Krintel, C., Francotte, P., Pickering, Darryl S, Juknaite, L., Pøhlsgaaard, J., Olsen, L., Frydenvang, Karla Andrea, Goffin, E., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 2016, In: Biophysical Journal. 110, 11, p. 2397-2406 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2
Krintel, C., Dorosz, J., Larsen, A. H., Thorsen, T. S., Venskutonytė, R., Mirza, Osman Asghar, Gajhede, Michael, Boesen, T. & Kastrup, Jette Sandholm Jensen, 2021, In: The FEBS Journal. 288, p. 995-1007 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
Krintel, C., Harpsøe, Kasper, Zachariassen, L. G., Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In: Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2
Krintel, C., Frydenvang, Karla Andrea, Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 1 Jan 2012, In: Biochemical Journal. 441, 1, p. 173-178Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of the C-type lectin carbohydrate recognition domain of human Tetranectin
Kastrup, Jette Sandholm Jensen, Nielsen, B. B., Rasmussen, H. B., Las Holtet, T., Graversen, J. H., Etzerodt, M., Thøgersen, H. C. & Larsen, I. K., 1998, In: Acta Crystallographica. Section D: Biological Crystallography. 54, p. 757-766 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human plasminogen binding protein tetranectin: crystallization and preliminary X-ray analysis of the C-type lectin CRD and the full-length protein
Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Nielsen, B. B., Larsen, I. K., Las Holtet, T., Graversen, J. H., Etzerodt, M. & Thøgersen, H. C., 1997, In: Acta Crystallographica. Section D: Biological Crystallography. 53, p. 108-111 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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X-ray structure of the 154-amino-acid form of recombinant human basic fibroblast growth factor. Comparison with the truncated 146-amino-acid Form
Kastrup, Jette Sandholm Jensen, Eriksson, E. S., Dalbøge, H. & Flodgaard, H., 1997, In: Acta Crystallographica. Section D: Biological Crystallography. 53, p. 160-168 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystallization and preliminary X-ray analysis of a PNA-DNA complex
Kastrup, Jette Sandholm Jensen, Pilgaard, M., Jørgensen, Flemming Steen, Nielsen, Peter E. & Rasmussen, H. B., 1995, In: FEBS Letters. 363, 1-2, p. 115-117 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209
Kasper, C., Pickering, Darryl S, Mirza, Osman Asghar, Olsen, L., Kristensen, Anders Skov, Greenwood, J. R., Liljefors, T., Schousboe, Arne, Wätjen, F., Gajhede, Michael, Sigurskjold, B. W. & Kastrup, Jette Sandholm Jensen, 2006, In: Journal of Molecular Biology. 357, 4, p. 1184-201 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4
Kasper, C., Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In: FEBS Letters. 582, 29, p. 4089-4094Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural basis of cell-cell adhesion by NCAM
Kasper, C., Rasmussen, H., Kastrup, Jette Sandholm Jensen, Ikemizu, S., Jones, E. Y., Berezin, V., Bock, E. & Larsen, I. K., 2000, In: Nature Structural and Molecular Biology. 7, 5, p. 389-393 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists
Kasper, C., Lunn, M., Liljefors, T., Gouaux, E., Egebjerg, J. & Kastrup, Jette Sandholm Jensen, 6 Nov 2002, In: F E B S Letters. 531, 2, p. 173-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
Research output: Contribution to journal › Journal article › Research › peer-review
Published