Jette Sandholm Jensen Kastrup
Professor
Peptides and Proteins
Jagtvej 162
2100 København Ø
CV: Jette Sandholm Kastrup
Work address: Department of Drug Design and Pharmacology
Biostructural Research
Faculty of Health and Medical Sciences
University of Copenhagen
Universitetsparken 2, DK-2100 CPH Ø, Denmark
Phone: +45 3533 6486; E-mail: jsk@sund.ku.dk
Academic Degrees
1986: M.Sc. (pharm.), The Royal Danish School of Pharmacy (RDSP)
1988: PhD, RDSP & Cheminova Agro A/S
Considered professorable 2002 (”well qualified, broad crystallographic expertise, experience in leading a successful research group, research activities on a broad spectrum of biologically important problems”). After application of professorship within protein crystallography at the Danish University of Pharmaceutical Sciences
Employments
1981-1982: 11 Months work experience at Tårnby Apotek
1982-1986: Periodic substitute at Tårnby Apotek
1986-1988: Industrial PhD student (Erhvervsforsker). RDSP & Cheminova Agro
1988: Teaching assistant. Dept. of Organic Chemistry, RDSP (3 months)
1989-1992: Post doc. Dept. of Medicinal Chemistry, RDSP
1993-1994: Senior scientist. Dept. of Medicinal Chemistry, RDSP
1995-2008: Associate professor. Dept. of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences (DUPS)
2008-present: Professor (MSO) in structure-based drug design. Dept. of Drug Design and Pharmacology, The Faculty of Health and Medical Sciences, University of Copenhagen
Stays as visiting research fellow
1989-1991: Novo Nordisk A/S, dr. Hans Flodgaard. Protein purification (in total 2 months)
1990: University of Oregon, USA, Professor Brian W. Matthews. Proteinmcrystallography (1 month)
1991: University of Oregon, USA, Professor Brian W. Matthews. Protein crystallography (2 weeks)
1991: Uppsala University, Sweden, Dr. Elisabeth S. Eriksson. Protein crystallography (1 week)
1992: DAKO A/S, Dr. Inge Clemmensen. Protein purification (3 months)
Maternity leaves
1991: 6 months (January-June)
1997-1998: 7 months (November 1997 – May 1998)
Research prizes
45.000 kr. from ”Valborg and Edith Larsens Foundation" 2005
20.000 kr from the Faculty of Pharmaceuitcal Sciences, University of Copenhagen 2007
Major Administrative Responsibilities
1999-2002: Member of Board, the Dansync Center for synchrotron radiation
2002-2008: Member of departmental board, Dept. of Medicinal Chemistry, DUPS
2004-2008: Deputy Head of Dept. of Medicinal Chemistry. DUPS and the Faculty of Pharmaceutical Sciences, University of Copenhagen
2004-2006: Member of Academic Council, DUPS
2004-2006: Member of committee for defining central and prioritized research areas, DUPS
2004-2006: Member of committee for evaluation of VIP assessment committees, DUPS
2005-2007: Member of scientific committee, Dept. of Medicinal Chemistry, DUPS
2007-2011: Member of Academic Council, Faculty of Pharmaceutical Sciences, University of Copenhagen
2007: Appointed director of Drug Research Academy, an industry-oriented research education programme at the Faculty of Pharmaceutical Sciences, University of Copenhagen (August-October)
2007: Member of committee for preparation of strategy plan 2007-2010, Faculty of Pharmaceutical Sciences, University of Copenhagen
2007-2008: Participant in project on competence development, The Ministry of Science, Technology and Innovation (3 days)
2007-2012: Director of Drug Research Academy
2008-present: Head of GluTarget, project within the Programme of Excellence at the University of Copenhagen (2008-2013). 24.5 mio. kr. Project title: Ionotropic glutamate receptors as targets for structure-based drug research: A multidisciplinary programme in structural biology, chemical biology, medicinal chemistry, molecular pharmacology and ex vivo/in vivo pharmacology
2010-2012: Member of board, SHARE's Cross Faculty PhD Initiative, University of Copenhagen
2010-2012: Coordinator of mobility PhD grant on project “Ion channel receptors in brain diseases”
2012: Member of Academic Council, Faculty of Health and Medical Sciences, University of Copenhagen
2012-present: Member of Research and Innovation Committee, Dept. of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen
Organizer of symposia
Co-organizer of Alfred Benzon Symposium no. 39, 1995: Structure and Function of 7TM Receptors
Co-Organizer of 9. CoLuAa-meeting, Royal Danish School of Pharmacy, 16-17 Nov. 2000 (between protein crystallographers at Lund, Copenhagen and Aarhus Universities and Novo Nordisk A/S, Carlsberg Laboratorium and Royal Danish School of Pharmacy)
Organizer of symposium on Receptor Structure and Function, Royal Danish School of Pharmacy 2001
Organizer of DANSYNC annual meeting, Royal Danish School of Pharmacy, 23. May 2001
Organizer of symposium on Receptor Structure and Function, Danish University of Pharmaceutical Sciences 2002
Organizer of mini-symposium on Protein Crystallography in Structural Biology, Danish University of Pharmaceutical Sciences, 18. June 2002
Organizer of symposium on Receptor Structure and Function, Danish University of Pharmaceutical Sciences 2003
Co-organizer of the 33. Danske Krystallograf/5. DANSYNC meeting, Danish University of Pharmaceutical Sciences, May 27-28 2003
Organizer of symposium on Receptor Structure and Function, Danish University of Pharmaceutical Sciences 2004
Organizer of symposium on Receptor Structure and Function, Danish University of Pharmaceutical Sciences 2005
Organizer of symposium on Receptor Structure and Function, Danish University of Pharmaceutical Sciences 2006
Co-organizer of Academic Council strategy seminar, Danish University of Pharmaceutical Sciences 2006
Co-Organizer of the 15. CoLuAa meeting, Danish University of Pharmaceutical Sciences, Nov. 9-10 2006
Organizer of symposium on Receptor Structure and Function, Faculty of Pharmaceutical Sciences, University of Copenhagen 2007
Organizer of symposium on Receptor Structure and Function, Faculty of Pharmaceutical Sciences, University of Copenhagen 2008
Organizer of Symposium on iGluRs, Faculty of Pharmaceutical Sciences, University of Copenhagen, November 2008
Organizer of GluTarget General Meeting for members, May 2009
Organizer of symposium on Receptor Structure and Function, Faculty of Pharmaceutical Sciences, University of Copenhagen 2009
Organizer of symposium on Receptor Structure and Function, Faculty of Pharmaceutical Sciences, University of Copenhagen 2010
Organizer of GluTarget Day of Research, April 2010
Organizer of symposium with presentations by the members of the Advisory Board and GluTarget members, June 2010
Organizer of symposium on Receptor Structure and Function, Faculty of Pharmaceutical Sciences, University of Copenhagen 2011
Organizer of GluTarget symposium on ionotropic glutamate receptors, February 2012
Organizer of symposium on Receptor Structure and Function, Faculty of Health and Medical Sciences, University of Copenhagen 2012
Organizer of symposium with presentations by the members of the Advisory Board and GluTarget members, October 2012
Organizer of symposium on Receptor Structure and Function, Faculty of Health and Medical Sciences, University of Copenhagen 2013
Reviewer at several international journals and of international grant applications
Conferences and symposia
Participation in numerous conferences and meetings. Numerous poster presentations with abstracts. Examples of invited speaker within recent years at international conferences:
Gordon Conference on Excitatory synapses & brain function, Colby-Sawyer College, New London, NH, June 10-15, 2007
Physiology 2010 Conference, University Place, Manchester, UK, June 30-July 2, 2010
20th Neuropharmacology Conference - High Resolution Neuropharmacology: Structure Changes the Paradigm, San Diego, USA, November 10-12, 2010
Membrane Proteins: Structure & Function,Lady Margaret Hall, Oxford, April 6-8, 2011
Glutamatergic Synapse ISN Satelite meeting, Crete Island, Greece, September 2-5, 2011
Present central research projects
Group leader on BR core project on ion channel receptors (ionotropic glutamate receptors and Cys-loop receptors)
Active in BR core project on Chromatin modifying enzymes
Expertise
Structural biology, protein crystallography
National and international collaborations on iGluRs
Emory University School of Medicine, Georgia, USA
Northwestern Univ. Feinberg School of Medicine, Illinois, USA
University of Sienna, Italy
University of Jyväskylä, Finland
Oregon Health and Science University, Oregon, USA
Dartmouth Medical School, New Hampshire, USA
Yokohama City University, Japan
University of Liege, Belgium
Neurosearch A/S, Denmark
H. Lundbeck A/S, Denmark
The Faculty of Science, University of Copenhagen, Denmark
National and international collaborations on Cys-loop receptors
University of Sydney, Australia
University of Milano, Italy
Aniona, Denmark
Grants – as main applicant (excl. internal and industrial PhD stipends)
Alfred Benzon's Fond; Augustinus Foundation; Carlsberg Foundation; Danish Agency for Science Technology and Innovation; Danish Council for Independent Research, Medical Sciences; Danish Council for Independent Research, Natural Sciences; Danish Research Academy;Hede Nielsen Foundation; Lundbeck Foundation; Novo Nordisk A/S; Programme of Excellence at the University of Copenhagen
Grants – as co-applicant
Apotekerfonden of 1991; Copenhagen 2016, University of Copenhagen; Danish Agency for Science, Technology and Innovation; Danish Medical Research Council; Danish Natural Science Research Council; Ib Henriksens Fond; Lundbeck Foundation, Novo Nordisk Fond
Publications 1988-2013
Peer-reviewed: 93
1990-1994: 4
1995-1999: 12
2000-2004: 17
2005-2009: 37
2010-May 2013: 23
Books (editor, chapters): 7
Patents: 2
Other publications: 28
PhD thesis: 1
Structures deposited in the Protein Data Bank: 106
Education
Cand. pharm., PhD
ID: 1298590
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Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
Research output: Contribution to journal › Journal article › Research › peer-review
Published