Structure of rat acidic fibroblast growth factor at 1.4 A resolution.

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Fibroblast growth factors (FGFs) constitute a family of 22 structurally related heparin-binding polypeptides that are involved in the regulation of cell growth, survival, differentiation and migration. Here, a 1.4 A resolution X-ray structure of rat FGF1 is presented. Two molecules are present in the asymmetric unit of the crystal and they coordinate a total of five sulfate ions. The structures of human, bovine and newt FGF1 have been published previously. Human and rat FGF1 are found to have very similar structures.
Original languageEnglish
JournalActa Crystallographica. Section F : Structural Biology and Crystallization Communications
Issue numberPt2
Pages (from-to)65-68
Number of pages4
Publication statusPublished - 2007

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